Food addiction as a proxy for eating disorder and obesity severity, trauma history, PTSD symptoms, and comorbidity

Timothy D. Brewerton1,2
1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
2Mount Pleasant, USA

Tóm tắt

Food addiction (FA) is a newly defined yet still controversial condition that has important etiological, developmental, treatment, prevention, and social policy implications. In this review, the case is made that FA (or high scores on the Yale Food Addiction Scale) may be used as a proxy measure for a matrix of interrelated clinical features, including greater eating disorder severity, greater obesity severity, more severe trauma histories, greater symptoms of posttraumatic stress disorder (PTSD), greater psychiatric comorbidity, as well as greater medical morbidity and mortality. A Medline search was undertaken using the following terms: food addiction cross-referenced with eating disorders (anorexia nervosa, bulimia nervosa, binge eating disorder, and binge eating), obesity, trauma, posttraumatic stress disorder, and comorbidity. The thesis is that the identification and acknowledgment of the concept of FA, when integrated into an overall, trauma-focused and transdiagnostic treatment approach, are supported and can be useful in understanding clinically the “big picture.” Food addiction (FA) may be used as a proxy for (1) bulimic eating disorder severity, (2) complex trauma histories, (3) severity of PTSD and PTSD symptoms, (4) intensity of psychiatric comorbidity, (5) severity of obesity, as well as (6) their combination. Implications for developing treatment strategies are discussed. The case for a comprehensive management that requires careful attention to medical and psychiatric assessment and integrated care that incorporates trauma-focused treatment is made.

Tài liệu tham khảo

Anda RF, Dong M, Brown DW, Felitti VJ, Giles WH, Perry GS, Dube SR (2009) The relationship of adverse childhood experiences to a history of premature death of family members. BMC Public Health 9:106. doi:10.1186/1471-2458-9-106 Avena NM, Gold JA, Kroll C, Gold MS (2012) Further developments in the neurobiology of food and addiction: update on the state of the science. Nutrition 28(4):341–343. doi:10.1016/j.nut.2011.11.002 Avena NM, Rada P, Hoebel BG (2009) Sugar and fat bingeing have notable differences in addictive-like behavior. J Nutr 139(3):623–628. doi:10.3945/jn.108.097584 Avena NM, Wang M, Gold MS (2011) Implications of food addiction and drug use in obesity. Psychiatr Ann 41(10):478–482. doi:10.3928/00485713-20110921-06 Baker DG, Nievergelt CM, O’Connor DT (2012) Biomarkers of PTSD: neuropeptides and immune signaling. Neuropharmacology 62(2):663–673. doi:10.1016/j.neuropharm.2011.02.027 Benton D (2010) The plausibility of sugar addiction and its role in obesity and eating disorders. Clin Nutr 29(3):288–303. doi:10.1016/j.clnu.2009.12.001 Bick J, Nguyen V, Leng L, Piecychna M, Crowley MJ, Bucala R, Grigorenko EL (2015) Preliminary associations between childhood neglect, MIF, and cortisol: potential pathways to long-term disease risk. Dev Psychobiol 57(1):131–139. doi:10.1002/dev.21265 Brady KT, Killeen TK, Brewerton T, Lucerini S (2000) Comorbidity of psychiatric disorders and posttraumatic stress disorder. J Clin Psychiatry 61(suppl 7):22–32 Brewerton TD (2004) Eating disorders, victimization, and comorbidity: principles of treatment. In Brewerton TD (ed), Clinical handbook of eating disorders: an integrated approach. Marcel Decker, New York, pp 509–545 Brewerton TD (2007) Eating disorders, trauma, and comorbidity: focus on PTSD. Eat Disord 15(4):285–304. doi:10.1080/10640260701454311 Brewerton TD (2011) Posttraumatic stress disorder and disordered eating: food addiction as self-medication. J Womens Health (Larchmt) 20(8):1133–1134. doi:10.1089/jwh.2011.3050 Brewerton TD (2015) Stress, trauma, and adversity as risk factors in the development of eating disorders. In: Smolak L, Levine M (eds) Wiley handbook of eating disorders. Guilford, New York, pp 445–460 Brewerton TD, Brady K (2014) The role of stress, trauma, and PTSD in the etiology and treatment of eating disorders, addictions, and substance use disorders. In: Brewerton TD, Dennis AB (eds) Eating disorders, addictions, and substance use disorders: research, clinical and treatment perspectives. Springer, Berlin, pp 379–404 Brewerton TD, Dansky BS, Kilpatrick DG, O’Neil PM (1999) Bulimia nervosa, PTSD, and forgetting results from the National Women’s Study. In: Williams LM, Banyard VL (eds) Trauma and memory. Sage, Durham, pp 127–138 Brewerton TD, Dansky BS, O’Neil PM, Kilpatrick DG (2015) The number of divergent purging behaviors is associated with histories of trauma, PTSD, and comorbidity in a national sample of women. Eat Disord 1-8 doi:10.1080/10640266.2015.1013394 Brewerton TD, O’Neil PM, Dansky BS, Kilpatrick DG (2015) Extreme obesity and its associations with victimization, PTSD, major depression and eating disorders in a national sample of women. J Obes Eat Disord 1(2):1–9 Brewerton TD, Rance SJ, Dansky BS, O’Neil PM, Kilpatrick DG (2014) A comparison of women with child-adolescent versus adult onset binge eating: results from the National Women’s Study. Int J Eat Disord 47(7):836–843. doi:10.1002/eat.22309 Brown DW, Anda RF, Tiemeier H, Felitti VJ, Edwards VJ, Croft JB, Giles WH (2009) Adverse childhood experiences and the risk of premature mortality. Am J Prev Med 37(5):389–396. doi:10.1016/j.amepre.2009.06.021 Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS, Turner RB (2012) Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA 109(16):5995–5999. doi:10.1073/pnas.1118355109 Danese A, Moffitt TE, Harrington H, Milne BJ, Polanczyk G, Pariante CM, Caspi A (2009) Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med 163(12):1135–1143. doi:10.1001/archpediatrics.2009.214 Danese A, Moffitt TE, Pariante CM, Ambler A, Poulton R, Caspi A (2008) Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 65(4):409–415. doi:10.1001/archpsyc.65.4.409 Dansky BS, Brewerton TD, O’Neil PM, Kilpatrick DG (1997) The National Womens Study: relationship of victimization and posttraumatic stress disorder to bulimia nervosa. Int J Eat Disord 21:213–228 Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 101(49):17312–17315. doi:10.1073/pnas.0407162101 Felitti VJ (1991) Long-term medical consequences of incest, rape, and molestation. South Med J 84:328–331 Felitti VJ (1993) Chldhood sexual abuse, depression and family dysfunction in adult obese patients: a case control study. South Med J 86:732–736 Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Marks JS (1998) Relationshiop of childhood abuse and household dysfunction to many of the leading causes of death in adults. Am J Prev Med 14:245–258 Fortuna JL (2012) The obesity epidemic and food addiction: clinical similarities to drug dependence. J Psychoactive Drugs 44(1):56–63. doi:10.1080/02791072.2012.662092 Gearhardt AN, Corbin WR, Brownell KD (2009) Preliminary validation of the yale food addiction scale. Appetite 52(2):430–436. doi:10.1016/j.appet.2008.12.003 Gearhardt AN, Davis C, Kuschner R, Brownell KD (2011) The addiction potential of hyperpalatable foods. Curr Drug Abuse Rev 4(3):140–145 Gearhardt AN, Grilo CM, DiLeone RJ, Brownell KD, Potenza MN (2011) Can food be addictive? Public health and policy implications. Addiction 106(7):1208–1212. doi:10.1111/j.1360-0443.2010.03301.x Gearhardt AN, Roberto CA, Seamans MJ, Corbin WR, Brownell KD (2013) Preliminary validation of the yale food addiction scale for children. Eat Behav 14(4):508–512. doi:10.1016/j.eatbeh.2013.07.002 Gearhardt AN, White MA, Masheb RM, Grilo CM (2013) An examination of food addiction in a racially diverse sample of obese patients with binge eating disorder in primary care settings. Compr Psychiatry 54(5):500–505. doi:10.1016/j.comppsych.2012.12.009 Gearhardt AN, White MA, Masheb RM, Morgan PT, Crosby RD, Grilo CM (2012) An examination of the food addiction construct in obese patients with binge eating disorder. Int J Eat Disord 45(5):657–663. doi:10.1002/eat.20957 Gearhardt AN, White MA, Potenza MN (2011) Binge eating disorder and food addiction. Curr Drug Abuse Rev 4:201–207 Gold MS, Graham NA, Cocores JA, Nixon SJ (2009) Food addiction? J Addict Med 3(1):42–45. doi:10.1097/ADM.0b013e318199cd20 Granero R, Hilker I, Aguera Z, Jimenez-Murcia S, Sauchelli S, Islam MA, Fernandez-Aranda F (2014) Food addiction in a Spanish sample of eating disorders: DSM-5 diagnostic subtype differentiation and validation data. Eur Eat Disord Rev 22(6):389–396. doi:10.1002/erv.2311 Hirth JM, Rahman M, Berenson AB (2011) The association of posttraumatic stress disorder with fast food and soda consumption and unhealthy weight loss behaviors among young women. J Womens Health (Larchmt) 20(8):1141–1149. doi:10.1089/jwh.2010.2675 Hoebel BG, Avena NM, Bocarsly ME, Rada P (2009) Natural addiction: a behavioral and circuit model based on sugar addiction in rats. J Addict Med 3(1):33–41. doi:10.1097/ADM.0b013e31819aa621 Imperatori C, Innamorati M, Contardi A, Continisio M, Tamburello S, Lamis DA, Fabbricatore M (2014) The association among food addiction, binge eating severity and psychopathology in obese and overweight patients attending low-energy-diet therapy. Compr Psychiatry 55(6):1358–1362. doi:10.1016/j.comppsych.2014.04.023 Imperatori C, Innamorati M, Lamis DA, Farina B, Pompili M, Contardi A, Fabbricatore M (2016) Childhood trauma in obese and overweight women with food addiction and clinical-level of binge eating. Child Abuse Negl 58:180–190. doi:10.1016/j.chiabu.2016.06.023 Joranby, L, Pineda, KF, Gold, MS (2005). Addiction to Food and Brain Reward Systems. Sexual Addict Compulsivity 12(2–3), 201–217. doi:10.1080/10720160500203765 Lee NM, Lucke J, Hall WD, Meurk C, Boyle FM, Carter A (2013) Public views on food addiction and obesity: implications for policy and treatment. PLoS One 8(9):e74836. doi:10.1371/journal.pone.0074836 Liu Y, von Deneen KM, Kobeissy FH, Gold MS (2010) Food addiction and obesity: evidence from bench to bedside. J Psychoactive Drugs 42(2):133–145. doi:10.1080/02791072.2010.10400686 Logan DE, Marlatt GA (2010) Harm reduction therapy: a practice-friendly review of research. J Clin Psychol 66(2):201–214. doi:10.1002/jclp.20669 Lustig RH (2010) Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc 110(9):1307–1321. doi:10.1016/j.jada.2010.06.008 Mason SM, Bryn Austin S, Bakalar JL, Boynton-Jarrett R, Field AE, Gooding HC, Rich-Edwards JW (2016) Child Maltreatment’s Heavy Toll: The Need for Trauma-Informed Obesity Prevention. Am J Prev Med 50(5):646–649. doi:10.1016/j.amepre.2015.11.004 Mason SM, Flint AJ, Field AE, Austin SB, Rich-Edwards JW (2013) Abuse victimization in childhood or adolescence and risk of food addiction in adult women. Obesity (Silver Spring) 21(12):E775–E781. doi:10.1002/oby.20500 Mason SM, Flint AJ, Roberts AL, Agnew-Blais J, Koenen KC, Rich-Edwards JW (2014) Posttraumatic stress disorder symptoms and food addiction in women by timing and type of trauma exposure. JAMA Psychiatry 71(11):1271–1278. doi:10.1001/jamapsychiatry.2014.1208 Mason, SM, MacLehose, RF, Katz-Wise, SL, Austin, SB, Neumark-Sztainer, D, Harlow, BL, Rich-Edwards, JW (2015). Childhood abuse victimization, stress-related eating, and weight status in young women. Ann Epidemiol, 25(10), 760–766 e762. doi:10.1016/j.annepidem.2015.06.081 Mason SM, Prescott J, Tworoger SS, DeVivo I, Rich-Edwards JW (2015) Childhood physical and sexual abuse history and leukocyte telomere length among women in middle adulthood. PLoS One 10(6):e0124493. doi:10.1371/journal.pone.0124493 Menard, C, Pfau, ML, Hodes, GE, Russo, SJ (2016) Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacology 1–19. doi:10.1038/npp.2016.90 Meule A, Gearhardt AN (2014) Food addiction in the light of DSM-5. Nutrients 6(9):3653–3671. doi:10.3390/nu6093653 Meule A, von Rezori V, Blechert J (2014) Food addiction and bulimia nervosa. Eur Eat Disord Rev 22(5):331–337. doi:10.1002/erv.2306 Michopoulos V, Norrholm SD, Jovanovic T (2015) Diagnostic biomarkers for posttraumatic stress disorder: promising horizons from translational neuroscience research. Biol Psychiatry 78(5):344–353. doi:10.1016/j.biopsych.2015.01.005 Mitchell KS, Mazzeo SE, Schlesinger MR, Brewerton TD, Smith BN (2012) Comorbidity of partial and subthreshold ptsd among men and women with eating disorders in the national comorbidity survey-replication study. Int J Eat Disord 45(3):307–315. doi:10.1002/eat.20965 Mitchell KS, Wolf EJ (2016) PTSD, food addiction, and disordered eating in a sample of primarily older veterans: the mediating role of emotion regulation. Psychiatry Res 243:23–29. doi:10.1016/j.psychres.2016.06.013 Pace TW, Heim CM (2011) A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities. Brain Behav Immun 25(1):6–13. doi:10.1016/j.bbi.2010.10.003 Pursey KM, Stanwell P, Gearhardt AN, Collins CE, Burrows TL (2014) The prevalence of food addiction as assessed by the yale food addiction scale: a systematic review. Nutrients 6(10):4552–4590. doi:10.3390/nu6104552 Randolph TG (1956) The descriptive features of food addiction; addictive eating and drinking. Q J Stud Alcohol 17(2):198–224 Rooks C, Veledar E, Goldberg J, Bremner JD, Vaccarino V (2012) Early trauma and inflammation: role of familial factors in a study of twins. Psychosom Med 74(2):146–152. doi:10.1097/PSY.0b013e318240a7d8 The National Center on Addiction and Substance Abuse (2016). Understanding and addressing food addiction. A science-based approach to policy, practice and research Wonderlich SA, Brewerton TD, Jocic Z, Dansky BS, Abbott DW (1997) Relationship of childhood sexual abuse and eating disorders. J Am Acad Child Adolesc Psychiatry 36(8):1107–1115