Aging and hormones of the hypothalamo-pituitary axis: Gonadotropic axis in men and somatotropic axes in men and women
Tài liệu tham khảo
Arvat, 1998, Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRP's in human aging, Pituitary, 1, 51, 10.1023/A:1009970909015
Bowers, 2004, J. Clin. Endocrinol. Metab., 89, 2290, 10.1210/jc.2003-031799
Brill, 2002, Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men, J. Clin. Endocrinol. Metab., 87, 5649, 10.1210/jc.2002-020098
Chen, 2002, Low bone density and high percentage of body fat among men who were treated with androgen deprivation therapy for prostate carcinoma, Cancer, 95, 2136, 10.1002/cncr.10967
Dufau, 1987, Pathophysiological relationships between the biological and immunological activities of luteinizing hormone, 153
Erickson, 2005, Determinants of dual secretagogue drive of burst-like GH secretion in premenopausal women studied under a selective estradiol clamp, J. Clin. Endocrinol. Metab., 90, 1741, 10.1210/jc.2004-1621
Erickson, 2004, Dual secretagogue drive of burst-like growth hormone secretion in postmenopausal compared with premenopausal women studied under an experimental estradiol clamp, J. Clin. Endocrinol. Metab., 89, 4746, 10.1210/jc.2004-0424
Farhy, 2007, Model-projected mechanistic bases for sex differences in growth-hormone regulation in humans, Am. J. Physiol. Regul. Integr. Comp. Physiol., 292, R1577, 10.1152/ajpregu.00584.2006
Farhy, 2005, Deterministic construct of amplifying actions of ghrelin on pulsatile GH secretion, Am. J. Physiol. Regul. Integr. Comp. Physiol., 288, R1649, 10.1152/ajpregu.00451.2004
Friend, 1996, Both oral and transdermal estrogen increase growth hormone release in postmenopausal women—a clinical research center study, J. Clin. Endocrinol. Metab., 81, 2250, 10.1210/jc.81.6.2250
Gentili, 2002, Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men, J. Clin. Endocrinol. Metab., 87, 825, 10.1210/jc.87.2.825
Gibney, 2005, Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men, Am. J. Physiol. Endocrinol. Metab., 289, 266, 10.1152/ajpendo.00483.2004
Gray, 1991, An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis, J. Clin. Epidemiol., 44, 671, 10.1016/0895-4356(91)90028-8
Haji, 1980, Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland of the rat, Brain Res., 204, 373, 10.1016/0006-8993(81)90596-5
Harman, 2001, Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging, J. Clin. Endocrinol. Metab., 86, 724, 10.1210/jc.86.2.724
Huang, 1987, Restoration of sexual function and fertility by fetal hypothalamic transplant in impotent aged male rats, Neurobiol. Aging, 8, 465, 10.1016/0197-4580(87)90042-X
Iranmanesh, 1998, Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men, Eur. J. Endocrinol., 139, 59, 10.1530/eje.0.1390059
Isidori, 2005, Effects of testosterone on sexual function in men: results of a meta-analysis, Clin. Endocrinol. (Oxf), 63, 381, 10.1111/j.1365-2265.2005.02350.x
Keenan, 2004, Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements, Proc. Natl. Acad. Sci. U.S.A., 101, 6740, 10.1073/pnas.0300619101
Keenan, 2005, Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood, J. Theor. Biol., 236, 242, 10.1016/j.jtbi.2005.03.008
Keenan, 2001, A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis, Proc. Natl. Acad. Sci. U.S.A., 98, 4028, 10.1073/pnas.051624198
Keenan, 2003, Physiological control of pituitary hormone secretory-burst mass, frequency and waveform: a statistical formulation and analysis, Am. J. Physiol., 285, R664
Keenan, 2006, An ensemble model of the male gonadal axis: illustrative application in aging men, Endocrinology, 147, 2817, 10.1210/en.2005-1356
Keenan, 2001, Disruption of the hypothalamic luteinizing-hormone pulsing mechanism in aging men, Am. J. Physiol., 281, R1917
Keenan, 2004, Divergent gonadotropin-gonadal dose-responsive coupling in healthy young and aging men, Am. J. Physiol., 286, R381
Kenny, 2001, Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, J. Gerontol. A Biol. Sci. Med. Sci., 56, M266, 10.1093/gerona/56.5.M266
Kojima, 1999, Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature, 402, 656, 10.1038/45230
Lissett, 2003, The insulin-like growth factor-I generation test: peripheral responsiveness to growth hormone is not decreased with ageing, Clin. Endocrinol. (Oxf), 58, 238, 10.1046/j.1365-2265.2003.01703.x
Liu, 2005, Mechanisms of hypoandrogenemia in healthy aging men, 34, 935
Liu, 2004, The rationale, efficacy and safety of androgen therapy in older men: future research and current practice recommendations, J. Clin. Endocrinol. Metab., 89, 4789, 10.1210/jc.2004-0807
Liu, 2005, Aging in healthy men impairs recombinant human LH-stimulated testosterone secretion monitored under a two-day intravenous pulsatile LH clamp, J. Clin. Endocrinol. Metab., 90, 5544, 10.1210/jc.2005-0909
Liverman, 2004
Meier, 2005, Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans, Diabetes, 54, 1649, 10.2337/diabetes.54.6.1649
Moffat, 2002, Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men, J. Clin. Endocrinol. Metab., 87, 5001, 10.1210/jc.2002-020419
Morley, 1997, Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men, Metab. Clin. Exp., 46, 410, 10.1016/S0026-0495(97)90057-3
Mulligan, 1999, Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig-cell) defects in the healthy aging male gonadotropic axis, Eur. J. Endocrinol., 141, 257, 10.1530/eje.0.1410257
Muniyappa, 2007, Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men, Am. J. Physiol. Endocrinol. Metab., 293, E769, 10.1152/ajpendo.00709.2006
Nagaya, 2004, Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure, Circulation, 110, 3674, 10.1161/01.CIR.0000149746.62908.BB
Pantel, 2006, Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature, J. Clin. Invest., 116, 760, 10.1172/JCI25303
Pincus, 1996, Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males, Proc. Natl. Acad. Sci. U.S.A., 93, 14100, 10.1073/pnas.93.24.14100
Pons, 1993, Estradiol modulates insulin-like growth factor I receptors and binding proteins in neurons from the hypothalamus, J. Neuroendocrinol., 5, 267, 10.1111/j.1365-2826.1993.tb00482.x
Roth, 1982, Changes in the mechanisms of hormone and neurotransmitter action during aging: current status of the role of receptor and post-receptor alterations, Mech. Ageing Dev., 20, 175, 10.1016/0047-6374(82)90086-0
Schroeder, 2004, Effects of androgen therapy on adipose tissue and metabolism in older men, J. Clin. Endocrinol. Metab., 89, 4863, 10.1210/jc.2004-0784
Shah, 1999, Actions of estrogen on the pulsatile, nyctohemeral, and entropic modes of growth hormone secretion, Am. J. Physiol., 276, R1351
Shuto, 2002, Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity, J. Clin. Invest., 109, 1429, 10.1172/JCI0213300
Sjogren, 2001, Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism, Diabetes, 50, 1539, 10.2337/diabetes.50.7.1539
Slootweg, 1997, Estrogen enhances growth hormone receptor expression and growth hormone action in rat osteosarcoma cells and human osteoblast-like cells, J. Endocrinol., 155, 159, 10.1677/joe.0.1550159
Veldhuis, 2007, Tripartite control of growth hormone secretion in women during controlled estradiol repletion, J. Clin. Endocrinol. Metab., 92, 2336, 10.1210/jc.2007-0043
Veldhuis, 2005, Sex-steroid control of the aging somatotropic axis, Endocrinol Metab Clin. North America, 34, 877, 10.1016/j.ecl.2005.07.006
Veldhuis, 2005, Distinctive inhibitory mechanisms of age and relative visceral adiposity on GH secretion in pre- and postmenopausal women studied under a hypogonadal clamp, J. Clin. Endocrinol. Metab., 90, 6006, 10.1210/jc.2005-0854
Veldhuis, 2003, Estradiol supplementation enhances submaximal feedforward drive of growth hormone (GH) secretion by recombinant human GH-releasing hormone-1,44-amide in a putatively somatostatin-withdrawn milieu, J. Clin. Endocrinol. Metab., 88, 5484, 10.1210/jc.2003-030410
Veldhuis, 2004, Short-term testosterone supplementation relieves growth hormone autonegative feedback in men, J. Clin. Endocrinol. Metab., 89, 1285, 10.1210/jc.2003-031017
Veldhuis, 2005, Short-term aromatase-enzyme blockade unmasks impaired feedback adaptations in luteinizing hormone and testosterone secretion in older men, J. Clin. Endocrinol. Metab., 90, 211, 10.1210/jc.2004-0834
Veldhuis, 2005, Joint mechanisms of impaired GH pulse renewal in aging men, J. Clin. Endocrinol. Metab., 90, 4177, 10.1210/jc.2005-0336
Veldhuis, 2000, Older men manifest multifold synchrony disruption of reproductive neurohormone outflow, J. Clin. Endocrinol. Metab., 85, 1477, 10.1210/jc.85.4.1477
Veldhuis, 2004, Erosion of endogenous testosterone-driven negative feedback on pulsatile LH secretion in healthy aging men, J. Clin. Endocrinol. Metab., 89, 5753, 10.1210/jc.2004-0399
Veldhuis, 2005, Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men, J. Clin. Endocrinol. Metab., 90, 302, 10.1210/jc.2004-1313
Veldhuis, 2007, The ensemble male hypothalamo-pituitary-gonadal axis
Veldhuis, 2005, Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy, Eur. J. Endocrinol., 153, 577, 10.1530/eje.1.02001
Veldhuis, 2005, Administration of recombinant human GHRH-1,44-amide for three months reduces abdominal visceral fat mass and increases physical-performance measures in postmenopausal women, Eur. J. Endocrinol., 153, 669, 10.1530/eje.1.02019
Veldhuis, 2004, Sustained GH and IGF-I responses to prolonged high-dose twice-daily GHRH stimulation in middle-aged and older men, J. Clin. Endocrinol. Metab., 89, 6325, 10.1210/jc.2004-0430
Veldhuis, 2006, Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition, Endocr. Rev., 27, 101, 10.1210/er.2005-0006
Veldhuis, 1992, Attenuation of luteinizing hormone secretory burst amplitude is a proximate basis for the hypoandrogenism of healthy aging in men, J. Clin. Endocrinol. Metab., 75, 52, 10.1210/jc.75.3.707
Veldhuis, 2005, Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men, Am. J. Physiol., 288, E775
Veldhuis, 2001, Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men, J. Clin. Endocrinol. Metab., 86, 529, 10.1210/jc.86.2.529
Wang, 1996, Testosterone replacement therapy improves mood in hypogonadal men—a clinical research center study, J. Clin. Endocrinol. Metab., 81, 3578, 10.1210/jc.81.10.3578
Weltman, 1994, Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender, J. Clin. Endocrinol. Metab., 78, 543, 10.1210/jc.78.3.543
Winters, 1982, Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion, J. Clin. Endocrinol. Metab., 55, 560, 10.1210/jcem-55-3-560
Witkin, 1987, Aging changes in synaptology of luteinizing hormone-releasing hormone neurons in male rat preoptic area, Neuroscience, 22, 1003, 10.1016/0306-4522(87)92976-9
Yakar, 2001, Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity, Diabetes, 50, 1110, 10.2337/diabetes.50.5.1110
Yu, 2003, Joint effect of insulin-like growth factors and sex steroids on breast cancer risk, Cancer Epidemiol. Biomarkers Prev., 12, 1067