A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

Cancer Cell - Tập 29 - Trang 117-129 - 2016
John Y. Li1, Samuel R. Perry1, Vanessa Muniz-Medina1, Xinzhong Wang1, Leslie K. Wetzel2, Marlon C. Rebelatto3, Mary Jane Masson Hinrichs3, Binyam Z. Bezabeh4, Ryan L. Fleming4, Nazzareno Dimasi4, Hui Feng4, Dorin Toader4, Andy Q. Yuan4, Lan Xu4, Jia Lin4, Changshou Gao4, Herren Wu4, Rakesh Dixit3, Jane K. Osbourn1,5, Steven R. Coats1
1Biosuperiors, MedImmune LLC, Gaithersburg, MD 20878, USA
2Oncology, MedImmune LLC, Gaithersburg, MD 20878, USA
3Biologics Safety Assessment, MedImmune LLC, Gaithersburg, MD 20878, USA
4Antibody Discovery & Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA
5MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK

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