Nutritional factors, cognitive decline, and dementia

Brain Research Bulletin - Tập 69 - Trang 1-19 - 2006
Angelo Del Parigi1, Francesco Panza2, Cristiano Capurso3,4, Vincenzo Solfrizzi3
1National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Obesity and Diabetes Clinical Research Section, 4212N 16 Street, Room 5-41A, Phoenix, AZ 85016, USA
2Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
3Department of Geriatrics, Center for Aging Brain-Memory Unit, University of Bari, Bari, Italy
4Department of Geriatrics, University of Foggia, Foggia, Italy

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American Psychiatric Association Committee on Nomenclature and Statistics, Diagnostic and Statistical Manual of Mental Disorders, Washington, D.C., 1994. Ames, 1993, Oxidants, antioxidants, and the degenerative diseases of aging, Proc. Natl. Acad. Sci. U.S.A., 90, 7915, 10.1073/pnas.90.17.7915 Amorim Cruz, 1996, Longitudinal changes in the intake of vitamins and minerals of elderly Europeans. SENECA Investigators, Eur. J. Clin. Nutr., 50, S77 Azzi, 1992, The protein kinase C family, Eur. J. Biochem., 208, 547, 10.1111/j.1432-1033.1992.tb17219.x Barberger-Gateau, 2002, Fish, meat, and risk of dementia: cohort study, BMJ, 325, 932, 10.1136/bmj.325.7370.932 Behl, 1997, Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease, Cell Tissue Res., 290, 471, 10.1007/s004410050955 Bell, 1992, Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people, Acta Psychiatr. Scand., 86, 386, 10.1111/j.1600-0447.1992.tb03285.x Bender, 1992, Trends in prevalence and magnitude of vitamin and mineral supplement usage and correlation with health status, J. Am. Diet. Assoc., 92, 1096, 10.1016/S0002-8223(21)00771-9 Benton, 1997, Thiamine supplementation mood and cognitive functioning, Psychopharmacology (Berl), 129, 66, 10.1007/s002130050163 Bertoni-Freddari, 1995, Vitamin E deficiency as a model of precocious brain aging: assessment by X-ray microanalysis and morphometry, Scanning Microsc., 9, 289 Birge, 1997, The role of estrogen in the treatment of Alzheimer's disease, Neurology, 48, S36, 10.1212/WNL.48.5_Suppl_7.36S Birge, 1998, Hormones and the aging brain, Geriatrics, 53, S28 Birkhauser, 2000, Oestrogens and Alzheimer's disease, Int. J. Geriatr. Psychiatry, 15, 600, 10.1002/1099-1166(200007)15:7<600::AID-GPS155>3.0.CO;2-7 Bjorkegren, 2001, Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes—a population-based study, J. Intern. Med., 249, 423, 10.1046/j.1365-2796.2001.00819.x Borroni, 2002, Homocysteine, vitamin B6, and vascular disease in patients with AD, Neurology, 59, 1475, 10.1212/WNL.59.9.1475 Bottiglieri, 1996, Folate, vitamin B12, and neuropsychiatric disorders, Nutr. Rev., 54, 382, 10.1111/j.1753-4887.1996.tb03851.x Braak, 1998, Evolution of neuronal changes in the course of Alzheimer's disease, J. Neural Transm., 127, 10.1007/978-3-7091-6467-9_11 Bronner, 1993, Nutrient bioavailability, with special reference to calcium, J. Nutr., 123, 797, 10.1093/jn/123.5.797 Budge, 2000, Plasma total homocysteine and cognitive performance in a volunteer elderly population, Ann. N.Y. Acad. Sci., 903, 407, 10.1111/j.1749-6632.2000.tb06392.x Cao, 1997, Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships, Free Radic. Biol. Med., 22, 749, 10.1016/S0891-5849(96)00351-6 Cardoso, 2001, Functional mitochondria are required for amyloid beta-mediated neurotoxicity, FASEB J., 15, 1439, 10.1096/fj.00-0561fje Cattin, 1997, Factors associated with cognitive impairment among older Italian inpatients. Gruppo Italiano di Farmacovigilanza nell’Anziano (G.I.F.A.), J. Am. Geriatr. Soc., 45, 1324, 10.1111/j.1532-5415.1997.tb02931.x Chandra, 2001, Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects, Nutrition, 17, 709, 10.1016/S0899-9007(01)00610-4 Christen, 2000, Oxidative stress and Alzheimer disease, Am. J. Clin. Nutr., 71, 621S, 10.1093/ajcn/71.2.621s Chui, 1992, Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers, Neurology, 42, 473, 10.1212/WNL.42.3.473 Clarke, 1998, Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease, Arch. Neurol., 55, 1449, 10.1001/archneur.55.11.1449 Commenges, 2000, Intake of flavonoids and risk of dementia, Eur. J. Epidemiol., 16, 357, 10.1023/A:1007614613771 Cutler, 2004, Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A., 101, 2070, 10.1073/pnas.0305799101 Del Parigi, 2004, Nutritional deficiency, cognitive decline, and dementia, 135 Delanty, 2000, Antioxidant therapy in neurologic disease, Arch. Neurol., 57, 1265, 10.1001/archneur.57.9.1265 Den Heijer, 2003, Homocysteine and brain atrophy on MRI of non-demented elderly, Brain, 126, 170, 10.1093/brain/awg006 Doty, 1991, Olfactory dysfunction in three neurodegenerative diseases, Geriatrics, 46, 47 Dufouil, 2003, Homocysteine, white matter hyperintensities, and cognition in healthy elderly people, Ann. Neural., 53, 214, 10.1002/ana.10440 Duthie, 2002, Homocysteine, B vitamin status, and cognitive function in the elderly, Am. J. Clin. Nutr., 75, 908, 10.1093/ajcn/75.5.908 Engelhart, 2002, Dietary intake of antioxidants and risk of Alzheimer disease, J. Am. Med. Assoc., 287, 3223, 10.1001/jama.287.24.3223 Engelhart, 2002, Diet and risk of dementia: does fat matter? The Rotterdam Study, Neurology, 59, 1915, 10.1212/01.WNL.0000038345.77753.46 Farber, 1988, Predicting intellectual level from the Mini-Mental State Examination, J. Am. Geriatr. Soc., 36, 509, 10.1111/j.1532-5415.1988.tb04020.x Fassbender, 1999, Homocysteine in cerebral macroangiography and microangiopathy, Lancet, 353, 1586, 10.1016/S0140-6736(99)00309-8 Fekkes, 1998, Abnormal amino acid metabolism in patients with early stage Alzheimer dementia, J. Neural Transm., 105, 287, 10.1007/s007020050058 Femstrom, 1972, Brain serotonin content: physiological regulation by plasma neutral amino acids, Science, 178, 414, 10.1126/science.178.4059.414 Figueroa, 2001, Abetapp secretases are co-expressed with Abetapp in the pancreatic islets, J. Alzheimers Dis., 3, 393, 10.3233/JAD-2001-3405 Flicker, 1991, Mild cognitive impairment in the elderly: predictors of dementia, Neurology, 41, 1006, 10.1212/WNL.41.7.1006 Foley, 2002, Dietary intake of antioxidants and risk of Alzheimer disease: food for thought, J. Am. Med. Assoc., 287, 3261, 10.1001/jama.287.24.3261 Fraser, 1996, Variables associated with cognitive function in elderly California Seventh-day Adventists, Am. J. Epidemiol., 143, 1181, 10.1093/oxfordjournals.aje.a008705 Frisoni, 2000, Mild cognitive impairment in the population and physical health: data on 1,435 individuals aged 75 to 95, J. Gerontol. A Biol. Sci. Med. Sci., 55, M322, 10.1093/gerona/55.6.M322 Gale, 1996, Cognitive impairment and mortality in a cohort of elderly people, BMJ, 312, 608, 10.1136/bmj.312.7031.608 Gold, 2002, Clinicopathological validation study of four sets of clinical criteria for vascular dementia, Am. J. Psychiatry, 159, 82, 10.1176/appi.ajp.159.1.82 Goodwin, 1983, Association between nutritional status and cognitive functioning in a healthy elderly population, J. Am. Med. Assoc., 249, 2917, 10.1001/jama.249.21.2917 Grant, 1999, Dietary links to Alzheimer's disease: 1999 update, J. Alzheimers Dis., 1, 197, 10.3233/JAD-1999-14-501 Green, 1999, Folate deficiency beyond megaloblastic anemia: hyperhomocysteinemia and other manifestations of dysfunctional folate status, Semin. Hematol., 36, 47 Haan, 2004, Can dementia be prevented? Brain aging in a population-based context, Annu. Rev. Public Health, 25, 1, 10.1146/annurev.publhealth.25.101802.122951 Halder, 1998, Protective role of black tea against oxidative damage of human red blood cells, Biochem. Biophys. Res. Commun., 244, 903, 10.1006/bbrc.1998.8366 Haller, 1996, Changes in the vitamin status of elderly Europeans: plasma vitamins A, E, B-6, B-12, folic acid and carotenoids. SENECA Investigators, Eur. J. Clin. Nutr., 50, S32 Hogervorst, 2002, Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease, Arch. Neurol., 59, 787, 10.1001/archneur.59.5.787 Honda, 2004, Oxidative stress and redox-active iron in Alzheimer's disease, Ann. N.Y. Acad. Sci., 1012, 179, 10.1196/annals.1306.015 Jack, 1999, Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment, Neurology, 52, 1397, 10.1212/WNL.52.7.1397 Jacques, 1999, The effect of folic acid fortification on plasma folate and total homocysteine concentrations, N. Engl. J. Med., 340, 1449, 10.1056/NEJM199905133401901 Jama, 1996, Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam Study, Am. J. Epidemiol., 144, 275, 10.1093/oxfordjournals.aje.a008922 Joosten, 1993, Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people, Am. J. Clin. Nutr., 58, 468, 10.1093/ajcn/58.4.468 Joseph, 1999, Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation, J. Neurosci., 19, 8114, 10.1523/JNEUROSCI.19-18-08114.1999 Joseph, 1998, Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits, J. Neurosci., 18, 8047, 10.1523/JNEUROSCI.18-19-08047.1998 Kagan, 1996, Stroke, 111 Kalaria, 1988, The glucose transporter of the human brain and blood-brain barrier, Ann. Neural., 24, 757, 10.1002/ana.410240610 Kalmijn, 1997, Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men, Am. J. Epidemiol., 145, 33, 10.1093/oxfordjournals.aje.a009029 Kalmijn, 1999, Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study, Am. J. Epidemiol., 150, 283, 10.1093/oxfordjournals.aje.a010000 Kalmijn, 2004, Dietary intake of fatty acids and fish in relation to cognitive performance at middle age, Neurology, 62, 275, 10.1212/01.WNL.0000103860.75218.A5 Kaplan, 2000, Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates, Am. J. Clin. Nutr., 72, 825, 10.1093/ajcn/72.3.825 Killiany, 2000, Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease, Ann. Neurol., 47, 430, 10.1002/1531-8249(200004)47:4<430::AID-ANA5>3.0.CO;2-I Kirk, 1999, Diet and lifestyle characteristics associated with dietary supplement use in women, Public Health Nutr., 2, 69, 10.1017/S1368980099000099 Knopman, 1998, Current pharmacotherapies for Alzheimer's disease, Geriatrics, 53, S31 Krischer, 1997, Protein-facilitated export of arachidonic acid from pig neutrophils, J Biol. Chem., 272, 10601, 10.1074/jbc.272.16.10601 Kruman, 2000, Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity, J. Neurosci., 20, 6920, 10.1523/JNEUROSCI.20-18-06920.2000 Kruman, 2002, Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease, J Neurosci., 22, 1752, 10.1523/JNEUROSCI.22-05-01752.2002 Laurin, 2002, Vitamin E and C supplements and risk of dementia, J. Am. Med. Assoc., 288, 2266, 10.1001/jama.288.18.2266 Lehmann, 1999, Identification of cognitive impairment in the elderly: homocysteine is an early marker, Dement. Geriatr. Cogn. Disord., 10, 12, 10.1159/000017092 Lethem, 1997, Antioxidants and dementia, Lancet, 349, 1189, 10.1016/S0140-6736(05)62409-9 Lindenbaum, 1988, Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis, N. Engl. J. Med., 318, 1720, 10.1056/NEJM198806303182604 Lipton, 1997, Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor, Proc. Natl. Acad. Sci. U.S.A., 94, 5923, 10.1073/pnas.94.11.5923 Lokk, 2003, News and views on folate and elderly persons, J Gerontol. A Biol. Sci. Med. Sci., 58, 354, 10.1093/gerona/58.4.M354 Lowik, 1989, Nutrition and aging: dietary intake of “apparently healthy” elderly (Dutch Nutrition Surveillance System), J. Am. Coll. Nutr., 8, 347, 10.1080/07315724.1989.10720310 Luchsinger, 2002, Caloric intake and the risk of Alzheimer disease, Arch. Neurol., 59, 1258, 10.1001/archneur.59.8.1258 Luchsinger, 2003, Antioxidant vitamin intake and risk of Alzheimer disease, Arch. Neurol., 60, 203, 10.1001/archneur.60.2.203 Malouf, 2003, Folic acid with or without vitamin B12 for cognition and dementia, Cochrane Database Syst. Rev., 10.1002/14651858.CD004514 Marcus, 1998, Refusal to eat in the elderly, Nutr. Rev., 56, 163, 10.1111/j.1753-4887.1998.tb06130.x Mark, 1997, Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation, J Neurosci., 17, 1046, 10.1523/JNEUROSCI.17-03-01046.1997 Markesbery, 1999, Oxidative alterations in Alzheimer's disease, Brain Pathol., 9, 133, 10.1111/j.1750-3639.1999.tb00215.x Martin, 1997, Vitamin E inhibits low-density lipoprotein-induced adhesion of monocytes to human aortic endothelial cells in vitro, Arterioscler. Thromb. Vasc. Biol., 17, 429, 10.1161/01.ATV.17.3.429 Martin, 2000, Effect of fruits, vegetables, or vitamin E-rich diet on vitamins E and C distribution in peripheral and brain tissues: implications for brain function, J Gerontol. A Biol. Sci. Med Sci., 55, B144, 10.1093/gerona/55.3.B144 Martins, 2001, Amyloid beta protein precursor metabolism as a modulator of islet beta-cell function, J Alzheimers Dis., 3, 397, 10.3233/JAD-2001-3406 Masaki, 2000, Association of vitamin E and C supplement use with cognitive function and dementia in elderly men, Neurology, 54, 1265, 10.1212/WNL.54.6.1265 Mattson, 2003, Will caloric restriction and folate protect against AD and PD?, Neurology, 60, 690, 10.1212/01.WNL.0000042785.02850.11 McCaddon, 1998, Total serum homocysteine in senile dementia of Alzheimer type, Int. J. Geriatr. Psychiatry, 13, 235, 10.1002/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8 McCaddon, 2001, Homocysteine and cognitive decline in healthy elderly, Dement. Geriatr. Cogn. Disord., 12, 309, 10.1159/000051275 McCaddon, 2003, Alzheimer's disease and total plasma aminothiols, Biol. Psychiatry, 53, 254, 10.1016/S0006-3223(02)01451-8 McCaddon, 2002, Functional vitamin B(12) deficiency and Alzheimer disease, Neurology, 58, 1395, 10.1212/WNL.58.9.1395 McGeer, 1990, 18Fluorodeoxyglucose positron emission tomography studies in presumed Alzheimer cases, including 13 serial scans, Can. J. Neural. Sci., 17, 1, 10.1017/S0317167100029930 McKhann, 1984, Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, 34, 939, 10.1212/WNL.34.7.939 Mcllroy, 2002, Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland, Stroke, 33, 2351, 10.1161/01.STR.0000032550.90046.38 Meador, 1993, Evidence for a central cholinergic effect of high-dose thiamine, Ann. Neurol., 34, 724, 10.1002/ana.410340516 Mendelsohn, 1998, Use of antioxidant supplements and its association with cognitive function in a rural elderly cohort: the MoVIES Project. Monongahela Valley Independent Elders Survey, Am. J. Epidemiol., 148, 38, 10.1093/oxfordjournals.aje.a009556 Meydani, 1997, Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial, J. Am. Med. Assoc., 277, 1380, 10.1001/jama.277.17.1380 Micheau, 1985, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation, Pharmacol. Biochem. Behav., 23, 195, 10.1016/0091-3057(85)90555-6 Miller, 2002, Homocysteine, vitamin B6, and vascular disease in AD patients, Neurology, 58, 1471, 10.1212/WNL.58.10.1471 Miller, 2003, Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging, Am J. Clin. Nutr., 78, 441, 10.1093/ajcn/78.3.441 Miller, 2004, The role of cholesterol and statins in Alzheimer's disease, Ann. Pharmacother., 38, 91, 10.1345/aph.1D104 Mirzoeva, 1996, The effect of propolis and its components on eicosanoid production during the inflammatory response, Prostaglandins Leukot. Essent. Fatty Acids, 55, 441, 10.1016/S0952-3278(96)90129-5 Moreiras, 1996, Longitudinal changes in the intake of energy and macronutrients of elderly Europeans. SENECA Investigators, Eur. J. Clin. Nutr., 50, S67 Moriguchi, 1997, Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model, Clin. Exp. Pharmacol. Physiol., 24, 235, 10.1111/j.1440-1681.1997.tb01813.x Morris, 2001, Mild cognitive impairment represents early-stage Alzheimer disease, Arch. Neurol., 58, 397, 10.1001/archneur.58.3.397 Morris, 1998, Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease, Alzheimer Dis. Assoc. Disord., 12, 121, 10.1097/00002093-199809000-00001 Morris, 2003, Dietary fats and the risk of incident Alzheimer disease, Arch. Neurol., 60, 194, 10.1001/archneur.60.2.194 Morris, 2002, Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study, J. Am. Med. Assoc., 287, 3230, 10.1001/jama.287.24.3230 Morris, 2003, Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease, Arch. Neurol., 60, 940, 10.1001/archneur.60.7.940 Morris, 2002, Vitamin E and cognitive decline in older persons, Arch. Neural., 59, 1125, 10.1001/archneur.59.7.1125 Morris, 2001, Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey, Am. J. Clin. Nutr., 73, 927, 10.1093/ajcn/73.5.927 Munro, 1981, Nutrition and ageing, Br. Med. Bull., 37, 83, 10.1093/oxfordjournals.bmb.a071681 Naurath, 1995, Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations, Lancet, 346, 85, 10.1016/S0140-6736(95)92113-3 Neugroschl, 2002, Biological markers in Alzheimer disease, Am. J. Geriatr. Psychiatry, 10, 660, 10.1176/appi.ajgp.10.6.660 Newton, 1999, Clinical and functional assessment of adults, 895 Nilsson, 1996, Hyperhomocysteinaemia—a common finding in a psychogeriatric population, Eur. J. Clin. Invest., 26, 853, 10.1111/j.1365-2362.1996.tb02129.x Nilsson, 1999, Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population, Dement. Geriatr. Cogn. Disord., 10, 476, 10.1159/000017193 Nishiyama, 1997, Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse, Exp. Gerontol., 32, 149, 10.1016/S0531-5565(96)00062-9 Ortega, 1997, Dietary intake and cognitive function in a group of elderly people, Am. J. Clin. Nutr., 66, 803, 10.1093/ajcn/66.4.803 Ortega, 2002, Cognitive function in elderly people is influenced by vitamin E status, J. Nutr., 132, 2065, 10.1093/jn/132.7.2065 Paleologos, 1998, Cohort study of vitamin C intake and cognitive impairment, Am. J. Epidemiol., 148, 45, 10.1093/oxfordjournals.aje.a009559 Panza, 2004, Macronutrients, age-related cognitive decline, and dementia, 107 Parnetti, 1997, Role of homocysteine in age-related vascular and non-vascular diseases, Aging (Milano), 9, 241 Perkins, 1999, Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey, Am. J. Epidemiol., 150, 37, 10.1093/oxfordjournals.aje.a009915 Perrig, 1997, The relation between antioxidants and memory performance in the old and very old, J. Am. Geriatr. Soc., 45, 718, 10.1111/j.1532-5415.1997.tb01476.x Petersen, 2000, Aging, mild cognitive impairment, and Alzheimer's disease, Neurol. Clin., 18, 789, 10.1016/S0733-8619(05)70226-7 Petersen, 1999, Mild cognitive impairment: clinical characterization and outcome, Arch. Neurol., 56, 303, 10.1001/archneur.56.3.303 Pietrzik, 1997, Causes and consequences of hyperhomocyst(e)inemia, Int. J. Vitam. Nutr. Res., 67, 389 Pitchumoni, 1998, Current status of antioxidant therapy for Alzheimer's Disease, J. Am. Geriatr. Soc., 46, 1566, 10.1111/j.1532-5415.1998.tb01544.x Position of the American Dietetic Association: nutrition, aging, and the continuum of care, J. Am. Diet. Assoc. 100 (2000) 580–595. Pradignac, 1995, Relationships between macronutrient intake, handicaps, and cognitive impairments in free living elderly people, Aging (Milano), 7, 67 Pratico, 2000, Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease, Am. J. Med., 109, 577, 10.1016/S0002-9343(00)00547-7 Prins, 2002, Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study, Neurology, 59, 1375, 10.1212/01.WNL.0000032494.05619.93 Quinlivan, 2002, Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease, Lancet, 359, 227, 10.1016/S0140-6736(02)07439-1 Ramassamy, 1993, Ginkgo biloba extract EGb 761 or trolox C prevent the ascorbic acid/Fe2+ induced decrease in synaptosomal membrane fluidity, Free Radic. Res. Commun., 19, 341, 10.3109/10715769309056523 Rampersaud, 2003, Folate: a key to optimizing health and reducing disease risk in the elderly, J. Am. Coll. Nutr., 22, 1, 10.1080/07315724.2003.10719270 Ravaglia, 2002, Plasma amino acid concentrations in healthy and cognitively impaired oldest-old individuals: associations with anthropometric parameters of body composition and functional disability, Br. J. Nutr., 88, 563, 10.1079/BJN2002700 Ravaglia, 2003, Homocysteine and cognitive function in healthy elderly community dwellers in Italy, Am. J. Clin. Nutr., 77, 668, 10.1093/ajcn/77.3.668 Ravaglia, 2000, Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment, Mech. Ageing Dev., 121, 251, 10.1016/S0047-6374(00)00221-9 Ravaglia, 2000, Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects, J Nutr. Health Aging, 4, 218 Refsum, 1998, Homocysteine and cardiovascular disease, Annu. Rev. Med., 49, 31, 10.1146/annurev.med.49.1.31 Reiman, 2001, Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A., 98, 3334, 10.1073/pnas.061509598 Reiman, 1996, Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E, N. Engl. J. Med., 334, 752, 10.1056/NEJM199603213341202 Reiman, 2004, Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia, Proc. Natl. Acad. Sci. U.S.A., 101, 284, 10.1073/pnas.2635903100 Reiter, 1995, Oxidative processes and antioxidative defense mechanisms in the aging brain, FASEB J., 9, 526, 10.1096/fasebj.9.7.7737461 Riedel, 1998, Age and cognitive function, Curr. Opin. Clin. Nutr. Metab. Care, 1, 579, 10.1097/00075197-199811000-00017 Riggs, 1996, Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study, Am. J. Clin. Nutr., 63, 306, 10.1093/ajcn/63.3.306 Rinaldi, 2003, Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease, Neurobiol. Aging, 24, 915, 10.1016/S0197-4580(03)00031-9 Ritchie, 2001, Classification criteria for mild cognitive impairment: a population-based validation study, Neurology, 56, 37, 10.1212/WNL.56.1.37 Riviere, 1998, Low plasma vitamin C in Alzheimer patients despite an adequate diet, Int. J. Geriatr. Psychiatry, 13, 749, 10.1002/(SICI)1099-1166(1998110)13:11<749::AID-GPS860>3.0.CO;2-T Rogers, 1999, Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms, Neuropsychopharmacology, 20, 322, 10.1016/S0893-133X(98)00091-8 Roman, 2002, Defining dementia: clinical criteria for the diagnosis of vascular dementia, Acta Neurol. Scand., 6, 10.1034/j.1600-0404.106.s178.2.x Roman, 1999, Executive control function: a rational basis for the diagnosis of vascular dementia, Alzheimer Dis. Assoc. Disord., 13, S69, 10.1097/00002093-199912001-00012 Roman, 1993, Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop, Neurology, 43, 250, 10.1212/WNL.43.2.250 Rosenberg, 1992, Nutritional factors in physical and cognitive functions of elderly people, Am. J. Clin. Nutr., 55, 1237S, 10.1093/ajcn/55.6.1237S Ross, 1999, Characterization of risk factors for vascular dementia: the Honolulu-Asia Aging Study, Neurology, 53, 337, 10.1212/WNL.53.2.337 Sano, 1997, A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study, N. Engl. J. Med., 336, 1216, 10.1056/NEJM199704243361704 Schmidt, 1998, Plasma antioxidants and cognitive performance in middle-aged and older adults: results of the Austrian Stroke Prevention Study, J. Am. Geriatr. Soc., 46, 1407, 10.1111/j.1532-5415.1998.tb06008.x Selhub, 2000, B vitamins, homocysteine, and neurocognitive function in the elderly, Am. J. Clin. Nutr., 71, 614S, 10.1093/ajcn/71.2.614s Selhub, 1993, Vitamin status and intake as primary determinants of homocysteinemia in an elderly population, J. Am. Med. Assoc., 270, 2693, 10.1001/jama.270.22.2693 Selley, 2002, The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease, Neurobiol. Aging, 23, 383, 10.1016/S0197-4580(01)00327-X Seshadri, 2002, Plasma homocysteine as a risk factor for dementia and Alzheimer's disease, N. Engl. J. Med., 346, 476, 10.1056/NEJMoa011613 Shea, 2002, Homocysteine, folate deprivation and Alzheimer neuropathology, J. Alzheimers Dis., 4, 261, 10.3233/JAD-2002-4401 Sheu, 1994, Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease, Ann. Neural, 35, 312, 10.1002/ana.410350311 Silverman, 2001, Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome, J. Am. Med. Assoc., 286, 2120, 10.1001/jama.286.17.2120 Sinclair, 1998, Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia, Int. J. Geriatr. Psychiatry, 13, 840, 10.1002/(SICI)1099-1166(1998120)13:12<840::AID-GPS877>3.0.CO;2-R Smith, 1999, Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion, Br. J. Psychiatry, 174, 525, 10.1192/bjp.174.6.525 Snowdon, 2000, Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study, Am. J. Clin. Nutr., 71, 993, 10.1093/ajcn/71.4.993 Solfrizzi, 2003, The role of diet in cognitive decline, J Neural Transm., 110, 95, 10.1007/s00702-002-0766-8 Solfrizzi, 2004, Italian longitudinal study on aging working group. Vascular risk factors, incidence of MCI, and rates of progression to dementia, Neurology, 63, 1882, 10.1212/01.WNL.0000144281.38555.E3 Solfrizzi, 2004, Dietary fatty acids, cognitive decline, and dementia, 91 Solfrizzi, 1999, High monounsaturated fatty acids intake protects against age-related cognitive decline, Neurology, 52, 1563, 10.1212/WNL.52.8.1563 Sparks, 2000, Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations, Ann. N.Y. Acad. Sci., 903, 335, 10.1111/j.1749-6632.2000.tb06384.x Stoll, 1996, Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse, Pharmacopsychiatry, 29, 144, 10.1055/s-2007-979561 Subramaniam, 1998, The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25–35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease, Neurochem. Res., 23, 1403, 10.1023/A:1020754807671 Swan, 1990, Heritability of cognitive performance in aging twins. The National Heart, Lung, and Blood Institute Twin Study, Arch. Neural., 47, 259, 10.1001/archneur.1990.00530030025010 Thal, 2002, Phases of A beta-deposition in the human brain and its relevance for the development of AD, Neurology, 58, 1791, 10.1212/WNL.58.12.1791 Tombaugh, 1992, The mini-mental state examination: a comprehensive review, J. Am. Geriatr. Soc., 40, 922, 10.1111/j.1532-5415.1992.tb01992.x Tucker, 1990, Nutrition status and brain function in aging, Am. J. Clin. Nutr., 52, 93, 10.1093/ajcn/52.1.93 Ueland, 1989, Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy, J. Lab. Clin. Med., 114, 473 Uemura, 2001, Amyloid beta-peptide inhibits neuronal glucose uptake by preventing exocytosis, Exp. Neurol., 170, 270, 10.1006/exnr.2001.7719 van Oort, 2003, Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study, Am. J. Clin. Nutr., 77, 1318, 10.1093/ajcn/77.5.1318 Varadarajan, 2000, Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity, J. Struct. Biol., 130, 184, 10.1006/jsbi.2000.4274 Vatassery, 1998, Vitamin E and other endogenous antioxidants in the central nervous system, Geriatrics, 53, S25 Ventura, 2001, Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects, Metabolism, 50, 1466, 10.1053/meta.2001.28079 Wahlin, 1996, Effects of serum vitamin B12 and folate status on episodic memory performance in very old age: a population-based study, Psychol. Aging, 11, 487, 10.1037/0882-7974.11.3.487 Wald, 2001, Randomized trial of folic acid supplementation and serum homocysteine levels, Arch. Intern. Med., 161, 695, 10.1001/archinte.161.5.695 Wang, 2001, Vitamin B(12) and folate in relation to the development of Alzheimer's disease, Neurology, 56, 1188, 10.1212/WNL.56.9.1188 Wenk, 1989, An hypothesis on the role of glucose in the mechanism of action of cognitive enhancers, Psychopharmacology (Berl), 99, 431, 10.1007/BF00589888 White, 1996, Prevalence of dementia in older Japanese-American men in Hawaii: The Honolulu-Asia Aging Study, J. Am. Med. Assoc., 276, 955, 10.1001/jama.276.12.955 Whitehouse, 1997, Dementia drug development: use of information systems to harmonize global drug development, Psychopharmacol. Bull., 33, 129 Xie, 2002, Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor, J Neurosci., 22, RC221, 10.1523/JNEUROSCI.22-10-j0001.2002 Zandi, 2004, Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study, Arch. Neurol., 61, 82, 10.1001/archneur.61.1.82