DISC1 is associated with cortical thickness and neural efficiency

Akbarian, 1993, Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development, Arch. Gen. Psychiatry, 50, 169, 10.1001/archpsyc.1993.01820150007001 Allen, 2009, Endophenotypes in schizophrenia: a selective review, Schizophr. Res., 109, 24, 10.1016/j.schres.2009.01.016 Andreasen, 1992, The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology, Arch. Gen. Psychiatry, 49, 615, 10.1001/archpsyc.1992.01820080023004 Annett, 1970, A classification of hand preference by association analysis, Br. J. Psychol., 61, 303, 10.1111/j.2044-8295.1970.tb01248.x Arnold, 1999, Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology, Dev. Psychopathol., 11, 439, 10.1017/S095457949900214X Austin, 2004, Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development, Neuroscience, 124, 3, 10.1016/j.neuroscience.2003.11.010 Barrett, 2005, Haploview: analysis and visualization of LD and haplotype maps, Bioinformatics, 21, 263, 10.1093/bioinformatics/bth457 Brandon, 2009, Understanding the role of DISC1 in psychiatric disease and during normal development, J. Neurosci., 29, 12768, 10.1523/JNEUROSCI.3355-09.2009 Broome, 2009, Neural correlates of executive function and working memory in the ‘at-risk mental state’, Br. J. Psychiatry, 194, 25, 10.1192/bjp.bp.107.046789 Buchsbaum, 2005, Meta-analysis of neuroimaging studies of the Wisconsin card-sorting task and component processes, Hum. Brain Mapp., 25, 35, 10.1002/hbm.20128 Burdick, 2005, DISC1 and neurocognitive function in schizophrenia, Neuroreport, 16, 1399, 10.1097/01.wnr.0000175248.25535.f6 Callicott, 2000, Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited, Cereb. Cortex, 10, 1078, 10.1093/cercor/10.11.1078 Callicott, 2005, Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia, Proc. Natl. Acad. Sci. U. S. A., 102, 8627, 10.1073/pnas.0500515102 Cannon, 2005, Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory, Arch. Gen. Psychiatry, 62, 1205, 10.1001/archpsyc.62.11.1205 Chafee, 2000, Inactivation of parietal and prefrontal cortex reveals interdependence of neural activity during memory-guided saccades, J. Neurophysiol., 83, 1550, 10.1152/jn.2000.83.3.1550 Champod, 2010, Dissociation within the frontoparietal network in verbal working memory: a parametric functional magnetic resonance imaging study, J. Neurosci., 30, 3849, 10.1523/JNEUROSCI.0097-10.2010 Chubb, 2008, The DISC locus in psychiatric illness, Mol. Psychiatry, 13, 36, 10.1038/sj.mp.4002106 Constantinidis, 2004, The primate working memory networks, Cogn. Affect. Behav. Neurosci., 4, 444, 10.3758/CABN.4.4.444 Dale, 1999, Cortical surface-based analysis. I. Segmentation and surface reconstruction, NeuroImage, 9, 179, 10.1006/nimg.1998.0395 Di Giorgio, 2008, Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding, Eur. J. Neurosci., 28, 2129, 10.1111/j.1460-9568.2008.06482.x Draganski, 2008, Training-induced structural changes in the adult human brain, Behav. Brain Res., 192, 137, 10.1016/j.bbr.2008.02.015 Eastwood, 2009, DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release, Mol. Psychiatry, 14, 556, 10.1038/mp.2009.13 Ehrlich, 2010, The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults, NeuroImage, 53, 992, 10.1016/j.neuroimage.2009.12.046 First, 2002, Structured clinical interview for DSM-IV-TR axis I disorders Fischl, 2000, Measuring the thickness of the human cerebral cortex from magnetic resonance images, Proc. Natl. Acad. Sci. U. S. A., 97, 11050, 10.1073/pnas.200033797 Fischl, 1999, Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system, NeuroImage, 9, 195, 10.1006/nimg.1998.0396 Glahn, 2003, Spatial working memory as an endophenotype for schizophrenia, Biol. Psychiatry, 53, 624, 10.1016/S0006-3223(02)01641-4 Glahn, 2005, Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia, Hum. Brain Mapp., 25, 60, 10.1002/hbm.20138 Gogtay, 2007, Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia, Arch. Gen. Psychiatry, 64, 772, 10.1001/archpsyc.64.7.772 Goldman, 2009, Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability, Arch. Gen. Psychiatry, 66, 467, 10.1001/archgenpsychiatry.2009.24 Goldman-Rakic, 1994, Working memory dysfunction in schizophrenia, J. Neuropsychiatry Clin. Neurosci., 6, 348, 10.1176/jnp.6.4.348 Gottesman, 2003, The endophenotype concept in psychiatry: etymology and strategic intentions, Am. J. Psychiatry, 160, 636, 10.1176/appi.ajp.160.4.636 Green, 2000, Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”?, Schizophr. Bull., 26, 119, 10.1093/oxfordjournals.schbul.a033430 Gur, 2007, The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes, Schizophr. Bull., 33, 49, 10.1093/schbul/sbl055 Harrison, 1999, The neuropathology of schizophrenia. A critical review of the data and their interpretation, Brain, 122, 593, 10.1093/brain/122.4.593 Hashimoto, 2006, Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling, Hum. Mol. Genet., 15, 3024, 10.1093/hmg/ddl244 Hayashi-Takagi, 2010, Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1, Nat. Neurosci., 13, 327, 10.1038/nn.2487 Hennah, 2003, Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects, Hum. Mol. Genet., 12, 3151, 10.1093/hmg/ddg341 Hennah, 2005, A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia, Mol. Psychiatry, 10, 1097, 10.1038/sj.mp.4001731 Henseler, 2009, Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms, J. Psychiatr. Res., 44, 364, 10.1016/j.jpsychires.2009.09.003 Hodgkinson, 2004, Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder, Am. J. Hum. Genet., 75, 862, 10.1086/425586 Hollingshead, 1965 Honey, 2002, De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia, Schizophr. Res., 53, 45, 10.1016/S0920-9964(01)00154-2 Horan, 2008, Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia, Schizophr. Res., 103, 218, 10.1016/j.schres.2008.02.014 http://surfer.nmr.mgh.harvard.edu. Hulshoff Pol, 2008, What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia, Schizophr. Bull., 34, 354, 10.1093/schbul/sbm168 Jakob, 1986, Prenatal developmental disturbances in the limbic allocortex in schizophrenics, J. Neural Transm., 65, 303, 10.1007/BF01249090 Jovicich, 2006, Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data, NeuroImage, 30, 436, 10.1016/j.neuroimage.2005.09.046 Jovicich, 2009, MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths, NeuroImage, 46, 177, 10.1016/j.neuroimage.2009.02.010 Kamiya, 2005, A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development, Nat. Cell Biol., 7, 1167, 10.1038/ncb1328 Kamiya, 2008, Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses, Arch. Gen. Psychiatry, 65, 996, 10.1001/archpsyc.65.9.996 Karlsgodt, 2008, Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia, Biol. Psychiatry, 63, 512, 10.1016/j.biopsych.2007.06.017 Kim, 2003, Functional disconnection between the prefrontal and parietal cortices during working memory processing in schizophrenia: a[15(O)]H2O PET study, Am. J. Psychiatry, 160, 919, 10.1176/appi.ajp.160.5.919 Kim, 2009, Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study, Hum. Brain Mapp., 30, 3795, 10.1002/hbm.20807 Kim, 2009, Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation, Schizophr Res, 117, 42, 10.1016/j.schres.2009.12.014 Koike, 2006, Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice, Proc. Natl. Acad. Sci. U. S. A., 103, 3693, 10.1073/pnas.0511189103 Kuperberg, 2003, Regionally localized thinning of the cerebral cortex in schizophrenia, Arch. Gen. Psychiatry, 60, 878, 10.1001/archpsyc.60.9.878 Kvajo, 2008, A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition, Proc. Natl. Acad. Sci. U. S. A., 105, 7076, 10.1073/pnas.0802615105 Lipska, 2006, Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs, Hum. Mol. Genet., 15, 1245, 10.1093/hmg/ddl040 MacDonald, 2009, Imaging genetic liability to schizophrenia: systematic review of FMRI studies of patients' nonpsychotic relatives, Schizophr. Bull., 35, 1142, 10.1093/schbul/sbn053 Manoach, 2003, Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings, Schizophr. Res., 60, 285, 10.1016/S0920-9964(02)00294-3 Manoach, 1999, Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI, Biol. Psychiatry, 45, 1128, 10.1016/S0006-3223(98)00318-7 Manoach, 2000, Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance, Biol. Psychiatry, 48, 99, 10.1016/S0006-3223(00)00227-4 Mao, 2009, Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling, Cell, 136, 1017, 10.1016/j.cell.2008.12.044 Marenco, 2000, The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave, Dev. Psychopathol., 12, 501, 10.1017/S0954579400003138 Maruff, 2005, Reduced volume of parietal and frontal association areas in patients with schizophrenia characterized by passivity delusions, Psychol. Med., 35, 783, 10.1017/S0033291704003113 McIntosh, 2007, Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis, Biol. Psychiatry, 61, 1127, 10.1016/j.biopsych.2006.05.020 Meda, 2008, An fMRI study of working memory in first-degree unaffected relatives of schizophrenia patients, Schizophr. Res., 104, 85, 10.1016/j.schres.2008.06.013 Nakata, 2009, DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms, Proc. Natl. Acad. Sci. U. S. A., 106, 15873, 10.1073/pnas.0903413106 Narr, 2005, Mapping cortical thickness and gray matter concentration in first episode schizophrenia, Cereb. Cortex, 15, 708, 10.1093/cercor/bhh172 Navari, 2009, Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings, Psychol. Med., 39, 1763, 10.1017/S0033291709005315 Owen, 2005, N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies, Hum. Brain Mapp., 25, 46, 10.1002/hbm.20131 Panizzon, 2009, Distinct genetic influences on cortical surface area and cortical thickness, Cereb. Cortex, 19, 2728, 10.1093/cercor/bhp026 Parent, 1995 Park, 1995, Spatial working memory deficits in the relatives of schizophrenic patients, Arch. Gen. Psychiatry, 52, 821, 10.1001/archpsyc.1995.03950220031007 Pearlson, 1996, Schizophrenia: a disease of heteromodal association cortex?, Neuropsychopharmacology, 14, 1, 10.1016/S0893-133X(96)80054-6 Potkin, 2009, Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study, Schizophr. Bull., 35, 19, 10.1093/schbul/sbn162 Potkin, 2009, Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia, Mol. Psychiatry, 14, 416, 10.1038/mp.2008.127 Prata, 2008, Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function, Mol. Psychiatry, 13, 909, 10.1038/mp.2008.95 Quintana, 2003, Prefrontal-posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations, Biol. Psychiatry, 53, 12, 10.1016/S0006-3223(02)01435-X Rastogi, 2009, Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia, Schizophr. Res., 114, 39, 10.1016/j.schres.2009.06.019 Roffman, 2008, MTHFR 677C–>T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val–>Met, Proc. Natl. Acad. Sci. U. S. A., 105, 17573, 10.1073/pnas.0803727105 Salat, 2004, Thinning of the cerebral cortex in aging, Cereb. Cortex, 14, 721, 10.1093/cercor/bhh032 Salgado-Pineda, 2003, Sustained attention impairment correlates to gray matter decreases in first episode neuroleptic-naive schizophrenic patients, NeuroImage, 19, 365, 10.1016/S1053-8119(03)00094-6 Scherk, 2006, Effects of antipsychotics on brain structure, Curr. Opin. Psychiatry, 19, 145, 10.1097/01.yco.0000214339.06507.d8 Schultz, 2010, Reduced cortical thickness in first episode schizophrenia, Schizophr. Res., 116, 204, 10.1016/j.schres.2009.11.001 Schurov, 2004, Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment, Mol. Psychiatry, 9, 1100, 10.1038/sj.mp.4001574 Selemon, 1999, The reduced neuropil hypothesis: a circuit based model of schizophrenia, Biol. Psychiatry, 45, 17, 10.1016/S0006-3223(98)00281-9 Seshadri, 2010, Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade, Proc. Natl. Acad. Sci. U. S. A., 107, 5622, 10.1073/pnas.0909284107 Straub, 2006, Schizophrenia genes — famine to feast, Biol. Psychiatry, 60, 81, 10.1016/j.biopsych.2006.06.002 Szeszko, 2008, DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia, Biol. Psychol., 79, 103, 10.1016/j.biopsycho.2007.10.011 Takahashi, 2009, The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia, Psychiatry Res., 172, 128, 10.1016/j.pscychresns.2009.01.005 Tan, 2007, Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia, Cereb. Cortex, 17, i171, 10.1093/cercor/bhm069 Tandon, 2008, Schizophrenia, “just the facts” what we know in 2008. 2. Epidemiology and etiology, Schizophr. Res., 102, 1, 10.1016/j.schres.2008.04.011 Thermenos, 2005, The effect of working memory performance on functional MRI in schizophrenia, Schizophr. Res., 74, 179, 10.1016/j.schres.2004.07.021 Thomson, 2005, Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population, Mol. Psychiatry, 10, 616, 10.1038/sj.mp.4001699 Thune, 2001, No deficit in total number of neurons in the prefrontal cortex in schizophrenics, J. Psychiatr. Res., 35, 15, 10.1016/S0022-3956(00)00043-1 Tomelleri, 2009, Brain structural changes associated with chronicity and antipsychotic treatment in schizophrenia, Eur. Neuropsychopharmacol., 19, 835, 10.1016/j.euroneuro.2009.07.007 Torrey, 2007, Schizophrenia and the inferior parietal lobule, Schizophr. Res., 97, 215, 10.1016/j.schres.2007.08.023 Tregellas, 2007, Gray matter volume differences and the effects of smoking on gray matter in schizophrenia, Schizophr. Res., 97, 242, 10.1016/j.schres.2007.08.019 Wager, 2003, Neuroimaging studies of working memory: a meta-analysis, Cogn. Affect. Behav. Neurosci., 3, 255, 10.3758/CABN.3.4.255 Wang, 2002, Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation, Am. J. Hum. Genet., 71, 1227, 10.1086/344398 Wang, 2010, The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function, Mol. Psychiatry Whitfield-Gabrieli Whitfield-Gabrieli, 2009, Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia, Proc. Natl. Acad. Sci. U. S. A., 106, 1279, 10.1073/pnas.0809141106 Wible, 2009, fMRI activity correlated with auditory hallucinations during performance of a working memory task: data from the FBIRN consortium study, Schizophr. Bull., 35, 47, 10.1093/schbul/sbn142 Wilkinson, 1993 Winkler, 2010, Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies, NeuroImage, 53, 1135, 10.1016/j.neuroimage.2009.12.028 Woodward, 2006, Functional connectivity reveals load dependent neural systems underlying encoding and maintenance in verbal working memory, Neuroscience, 139, 317, 10.1016/j.neuroscience.2005.05.043 Woolrich, 2001, Temporal autocorrelation in univariate linear modeling of FMRI data, NeuroImage, 14, 1370, 10.1006/nimg.2001.0931 Yendiki, 2010, Multi-site characterization of an fMRI working memory paradigm: reliability of activation indices, NeuroImage, 53, 119, 10.1016/j.neuroimage.2010.02.084 Zhou, 2007, Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI, Neurosci. Lett., 417, 297, 10.1016/j.neulet.2007.02.081