Efficient down-regulation of PKC-α gene expression in A549 lung cancer cells mediated by antisense oligodeoxynucleotides in dendrosomes

Behr, 1997, The proton sponge: a trick to enter cells the viruses did not exploit, Chimia, 51, 34, 10.2533/chimia.1997.34 American Cancer Society. Cancer Facts and Figures, 2010. (http://www.cancer.org/Research/CancerFactsFigures/index?ssSourceSiteId=null). Chu, 2006, Aptamer mediated siRNA delivery, Nucleic Acids Res., 34, 10, 10.1093/nar/gkl388 Crooke, 1998, Molecular mechanisms of antisense drugs: RNase H, Antisense Nucleic Acid Drug Dev., 8, 133, 10.1089/oli.1.1998.8.133 Crooke, 1999, Molecular mechanisms of action of antisense drugs, Biochim. Biophys. Acta, 1489, 31, 10.1016/S0167-4781(99)00148-7 Dauty, 2002, Development of plasmid and oligonucleotide nanometric particles, Gene Ther., 9, 743, 10.1038/sj.gt.3301759 Davis, 2002, Non-viral gene delivery systems, Curr. Opin. Biotechnol., 13, 128, 10.1016/S0958-1669(02)00294-X Escriou, 1998, Cationic lipid-mediated gene transfer: effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes, Biochim. Biophys. Acta, 1368, 276, 10.1016/S0005-2736(97)00194-6 Esfand, 2001, Poly (amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications, Drug Discov. Today, 6, 427, 10.1016/S1359-6446(01)01757-3 Fant, 2010, Effects of PEGylation and acetylation of PAMAM dendrimers on DNA binding cytotoxicity and in vitro transfection efficiency, Mol. Pharm., 7, 1734, 10.1021/mp1001312 Farhood, 1995, The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer, Biochim. Biophys. Acta, 1235, 289, 10.1016/0005-2736(95)80016-9 Filion, 1997, Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells, Biochim. Biophys. Acta, 1329, 345, 10.1016/S0005-2736(97)00126-0 Gebhart, 2001, Evaluation of polyplexes as gene transfer agents, J. Control. Release, 73, 401, 10.1016/S0168-3659(01)00357-1 Hart, 2010, Multifunctional nanocomplexes for gene transfer and gene therapy, Cell Biol. Toxicol., 26, 69, 10.1007/s10565-009-9141-y Jevprasesphant, 2003, The influence of surface modification on the cytotoxicity of PAMAM dendrimers, Int. J. Pharm., 252, 263, 10.1016/S0378-5173(02)00623-3 Junghans, 2001, Phosphodiester and phosphorothioate oligonucleotide condensation and preparation of antisense nanoparticles, Biochim. Biophys. Acta, 1544, 177, 10.1016/S0167-4838(00)00219-3 Junghans, 2005, Cationic lipid-protamine-DNA (LPD) complexes for delivery of antisense c-myc oligonucleotides, Eur. J. Pharm. Biopharm., 60, 287, 10.1016/j.ejpb.2005.01.006 Khalil, 2006, Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery, Pharmacol. Rev., 58, 32, 10.1124/pr.58.1.8 Kodama, 2006, The features and shortcomings for gene delivery of current non-viral carriers, Curr. Med. Chem., 13, 2155, 10.2174/092986706777935276 Lahn, 2004, Expression levels of protein kinase C-alpha in non-small-cell lung cancer, Clin. Lung Cancer, 6, 184, 10.3816/CLC.2004.n.032 Lampela, 2004, Synergism in gene delivery by small PEIs and three different nonviral vectors, Int. J. Pharm., 270, 175, 10.1016/j.ijpharm.2003.10.004 Lebedeva, 2001, Antisense oligonucleotides: promise and reality, Annu. Rev. Pharmacol. Toxicol., 41, 403, 10.1146/annurev.pharmtox.41.1.403 Lee, 2002, Structural molecular dynamics studies on polyamidoamine dendrimers for a therapeutic application: effects of pH and generation, Macromolecules, 35, 4510, 10.1021/ma010354q Lewin, 2001, Ribozyme gene therapy: applications for molecular medicine, Trends Mol. Med., 7, 221, 10.1016/S1471-4914(01)01965-7 Li, 1999, Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection, Gene Ther., 6, 585, 10.1038/sj.gt.3300865 Lonez, 2010, Fusogenic activity of cationic lipids and lipid shape distribution, Cell. Mol. Life. Sci., 67, 483, 10.1007/s00018-009-0197-x Lv, 2006, Toxicity of cationic lipids and cationic polymers in gene delivery, J. Control. Release, 114, 100, 10.1016/j.jconrel.2006.04.014 Lysik, 2003, Innovations in oligonucleotide drug delivery, J. Pharm. Sci., 92, 1559, 10.1002/jps.10399 Movassaghian, 2011, Dendrosome-dendriplex inside liposomes: as a gene delivery system, J. Drug Target, 19, 925, 10.3109/1061186X.2011.628396 Navarro, 2009, Activated and non-activated PAMAM dendrimers for gene delivery in vitro and in vivo, Nanomed. Nanotechnol. Biol. Med., 5, 287, 10.1016/j.nano.2008.12.007 Nigavekar, 2004, 3H dendrimer nanoparticle organ/tumor distribution, Pharm. Res., 21, 476, 10.1023/B:PHAM.0000019302.26097.cc Orberg, 2007, Dynamic light scattering and fluorescence study of the interaction between double-stranded DNA and poly(amido amine) dendrimers, Biomacromolecules, 2, 1557, 10.1021/bm061194z Ouyang, 2011, The effect of pH on PAMAM dendrimer-siRNA complexation: endosomal considerations as determined by molecular dynamics simulation, Biophys. Chem., 158, 126, 10.1016/j.bpc.2011.06.003 Patil, 2000, Influence of divalent cations on the conformation of phosphorothioate oligodeoxynucleotides: a circular dichroism study, Nucleic Acids Res., 28, 2439, 10.1093/nar/28.12.2439 Patil, 2004, Anionic liposomal delivery system for DNA transfection, AAPS J., 6, e29, 10.1208/aapsj060429 Perrie, 2000, Liposome-entrapped plasmid DNA: characterisation studies, Biochim. Biophys. Acta, 1475, 125, 10.1016/S0304-4165(00)00055-6 Quintana, 2002, Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor, Pharm. Res., 19, 1310, 10.1023/A:1020398624602 Schäfer, 2010, Liposome-polyethylenimine complexes for enhanced DNA and siRNA delivery, Biomaterials, 31, 6892, 10.1016/j.biomaterials.2010.05.043 Seeman, 2003, At the crossroads of chemistry, biology, and materials: structural DNA nanotechnology, Chem. Biol., 10, 1151, 10.1016/j.chembiol.2003.12.002 Shah, 2011, Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA, J. Pept. Sci., 17, 470, 10.1002/psc.1347 Shcharbin, 2009, How to study dendriplexes I: Characterization, J. Control. Release, 135, 186, 10.1016/j.jconrel.2009.01.015 Sonawane, 2003, Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes, J. Biol. Chem., 278, 44826, 10.1074/jbc.M308643200 Stewart, 1980, Colorimetric determination of phospholipids with ammonium ferrothiocyanate, Anal. Biochem., 104, 10, 10.1016/0003-2697(80)90269-9 Tang, 1997, The influence of polymer structure on the interactions of cationic polymers with DNA morphologyof the resulting complexes, Gene Ther., 4, 823, 10.1038/sj.gt.3300454 Tomalia, 1990, Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter, Angew. Chem. Int. Ed. Engl., 29, 138, 10.1002/anie.199001381 Vijayanathan, 2002, DNA nanoparticles and development of DNA delivery vehicles for gene therapy, Biochemistry, 41, 14085, 10.1021/bi0203987 Wagner, 1999, Application of membrane-active peptides for nonviral gene delivery, Adv. Drug Deliv. Rev., 38, 279, 10.1016/S0169-409X(99)00033-2 Yang, 2011, Aptamer-conjugated nanomaterials and their applications, Adv. Drug Deliv. Rev., 63, 1361, 10.1016/j.addr.2011.10.002 Zhao, 2011, PEGylated thermo-sensitive poly (amidoamine) dendritic drug delivery systems, Int. J. Pharm., 409, 229, 10.1016/j.ijpharm.2011.02.005