Identification and Characterization of Genes Susceptible to Transcriptional Cross-Talk between the Hypoxia and Dioxin Signaling Cascades

Chemical Research in Toxicology - Tập 19 Số 10 - Trang 1284-1293 - 2006
KangAe Lee1, Lyle D. Burgoon1, Laura E. Lamb1, Edward Dere1, Timothy R. Zacharewski1, John B. Hogenesch1, John J. LaPres1
1Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, Graduate Program in Cellular and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, and Center for Integrative Toxicology, Michigan State University, East...

Tóm tắt

Từ khóa


Tài liệu tham khảo

Gu, Y-Z., Hogenesch, J., and Bradfield, C. (2000)The PAS Superfamily:  Sensors of Environmental and Developmental Signals. pp 519−561, Academic Press, New York.

Schmidt J. V., 1993, J. Biol. Chem., 268

Semenza, G. L., Agani, F., Booth, G., Forsythe, J., Iyer, N., Jiang, B. H., Leung, S., Roe, R., Wiener, C., and Yu, A. (1997) Structural and functional analysis of hypoxia-inducible factor 1.Kidney Int.51, 553−555.

Reyes H., 1992, Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256, 1193−1195

Wang G. L., 1995, Proc. Natl. Acad. Sci. U.S.A. 92

Bradfield C. A., 1988, A competitive binding assay for 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands of the Ah receptor. Mol. Pharmacol. 34, 682−688

Carver L. A., 1997, J. Biol. Chem., 272, 10.1074/jbc.272.17.11452

Ma Q., 1997, J. Biol. Chem., 272

Whitlock J. P., 1989, Induction of hepatic cytochrome P450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Biol. Med. 6, 169−178

Wang G. L., 1993, J. Biol. Chem., 268

Bruick R. K., 2001, A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337−1340

Epstein A. C., 2001, Cell, 107, 54, 10.1016/S0092-8674(01)00507-4

Berra E., 2003, EMBO J., 22, 10.1093/emboj/cdg392

Brunelle J. K., 2005, Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab. 1, 409−414

Guzy R. D., 2005, Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1, 401−408

Mansfield K. D., 2005, Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell. Metab. 1, 393−399

Mole D. R., 2001, IUBMB Life., 52, 47

Semenza G. L., 1996, J. Biol. Chem., 271, 10.1074/jbc.271.51.32529

Minchenko A., 1994, Cell. Mol. Biol. Res., 40, 39

Semenza G. L., 1994, J. Biol. Chem., 269, 10.1016/S0021-9258(17)31580-6

Hogenesch J. B., 1997, J. Biol. Chem., 272, 10.1074/jbc.272.13.8581

Chan W. K., 1999, J. Biol. Chem., 274

Gassmann M., 1997, Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells. Kidney Int. 51, 567−574

Gradin K., 1996, Functional interference between hypoxia and dioxin signal transduction pathways:  competition for recruitment of the Arnt transcription factor. Mol. Cell. Biol. 16, 5221−5231

Nie M., 2001, Environ. Toxicol. Pharmacol., 10, 27

Pollenz, R. S., Davarinos, N. A., and Shearer, T. P. (1999) Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor.Mol. Pharmacol.56, 1127−1137.

Gentleman R. C., 2004, Genome Biol., 5, R80, 10.1186/gb-2004-5-10-r80

Ihaka R., 1996, J. Comp. Graph. Stats., 5

Wu Z., 2004, A model based background adjustment for oligonucleotide expression arrays

Vengellur A., 2003, Gene expression profiling of the hypoxia signaling pathway in hypoxia inducible factor 1 null mouse embryonic fibroblasts. Gene Expression 11, 181−197

Quandt K., 1995, MatInd and MatInspector:  new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23, 4878−4884

Sun Y. V., 2004, Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucleic Acids Res. 32, 4512−4523

Burgoon L. D., 2006, dbZach:  A MIAME-compliant toxicogenomic supportive relational database. Toxicol. Sci. 90, 558−568

Tajima F., 1991, J. Mol. Evol., 33, 10.1007/BF02103140

Eckel J. E., 2004, J. Biopharm. Stat., 14, 10.1081/BIP-200025656

Efron B., 2002, Genet. Epidemiol., 23, 86, 10.1002/gepi.1124

Wingender E., 2004, Silico Biol., 4, 61

Herrero J., 2003, GEPAS:  a web-based resource for microarray gene expression data analysis. Nucleic Acids Res. 31, 3461−3467

Wang L., 2004, Transcriptional crosstalk between nuclear receptors and cytokine signal transduction pathways in immunity. Cell. Mol. Immunol. 1, 416−24

Chang H., 2003, J. Biomed. Sci., 10

Ebert B. L., 1995, J. Biol. Chem., 270

Yan S-F, 1999, J. Biol. Chem., 274

Fradette C., 2004, Effect of hypoxia on cytochrome P450 activity and expression. Curr. Drug Metab. 5, 257−71

Harstad E. B., 2006, Liver deformation in Ahr-null mice:  evidence for aberrant hepatic perfusion in early development. Mol. Pharmacol. 69, 1534−1541

Lund A. K., 2003, Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure. Toxicol. Appl. Pharmacol. 193, 177−187

Lund A. K., 2006, Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (AhR) null mice. Toxicol. Appl. Pharmacol. 212, 127−135

Thackaberry E. A., 2002, Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia. Cardiovasc. Toxicol. 2, 263−274

Abbreviations AHR, aryl hydrocarbon receptor