Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora

10.1128/AEM.68.10.5005-5011.2002

10.1016/B978-0-12-289673-6.50007-5

10.1128/MMBR.64.3.573-606.2000

Crystal Data for1: C15H21ClNO4 Mr=313.11 monoclinic space group P21 a=10.4805(6) b=24.2085(13) c=12.5163(7) Å β=108.603(10)° V=3009.7(3) Å3 Z=8 ρcalcd=1.385 g cm−3; MoKαradiation λ=0.71073 Å μ=0.269 mm−1 T=−100 K. 25 627 data (13 056 unique Rint=0.0146 θ<27.52°) were collected on a Bruker SMART APEX CCD X‐ray diffractometer. The structure was solved by direct methods and refined by full‐matrix least‐squares onF2values of all data (G. M. Sheldrick SHELXTL Manual) to givewR2=0.0824 conventionalR=0.0313 forFvalues of 12 747 reflections S=1.037 and 773 parameters. Residual electron density max/min 0.448/−0.232 e Å−3. CCDC‐183413 (1) contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retrieving.html (or from the Cambridge Crystallographic Data Centre 12 Union Road Cambridge CB2 1EZ UK; fax: (+44) 1223‐336‐033; or [email protected]).

10.1074/jbc.271.13.7273

10.7164/antibiotics.44.113

10.7164/antibiotics.44.117

10.1248/cpb.47.1

10.1074/jbc.273.15.8545

10.1248/yakushi1947.120.10_935

10.1016/S0040-4020(98)01142-9

We gratefully acknowledge K. Lloyd S. Glaser B. Miller Nereus Pharmaceuticals Inc. for providing proteasome inhibition data.