Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Neuron - Tập 96 - Trang 115-129.e5 - 2017
Na Zhao1, Chia-Chen Liu1, Alexandra J. Van Ingelgom1, Yuka A. Martens1, Cynthia Linares1, Joshua A. Knight1, Meghan M. Painter1, Patrick M. Sullivan2,3, Guojun Bu1,4
1Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
2Departments of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
3GRECC, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
4Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China

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Neuron

Tập 96

115-129.e5

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