Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

Aird, 2007, Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms, Circ. Res., 100, 158, 10.1161/01.RES.0000255691.76142.4a

Alvarez, 2008, Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity, Am. J. Physiol. Lung Cell. Mol. Physiol., 294, L419, 10.1152/ajplung.00314.2007

Atkinson, 2005, Membrane-type 1 matrix metalloproteinase is required for normal alveolar development, Dev. Dyn., 232, 1079, 10.1002/dvdy.20267

Beers, 1994, Localization, synthesis, and processing of surfactant protein SP-C in rat lung analyzed by epitope-specific antipeptide antibodies, J. Biol. Chem., 269, 20318, 10.1016/S0021-9258(17)31994-4

Beers, 2011, The three R's of lung health and disease: repair, remodeling, and regeneration, J. Clin. Invest., 121, 2065, 10.1172/JCI45961

Bhattacharya, 2005, Alveolocapillary cross-talk: Giles F. Filley lecture, Chest, 128, 553S, 10.1016/S0012-3692(15)30979-X

Butler, 2010, Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors, Nat. Rev. Cancer, 10, 138, 10.1038/nrc2791

Butler, 2010, Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells, Cell Stem Cell, 6, 251, 10.1016/j.stem.2010.02.001

Cardoso, 2001, Molecular regulation of lung development, Annu. Rev. Physiol., 63, 471, 10.1146/annurev.physiol.63.1.471

Carmeliet, 2005, Angiogenesis in life, disease and medicine, Nature, 438, 932, 10.1038/nature04478

Chapman, 2011, Epithelial-mesenchymal interactions in pulmonary fibrosis, Annu. Rev. Physiol., 73, 413, 10.1146/annurev-physiol-012110-142225

Chapman, 2011, Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice, J. Clin. Invest., 121, 2855, 10.1172/JCI57673

Chun, 2006, A pericellular collagenase directs the 3-dimensional development of white adipose tissue, Cell, 125, 577, 10.1016/j.cell.2006.02.050

Cowan, 1975, Lung growth after unilateral pneumonectomy: quantitation of collagen synthesis and content, Am. Rev. Respir. Dis., 111, 267

Del Moral, 2006, VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis, Dev. Biol., 290, 177, 10.1016/j.ydbio.2005.11.022

DeLisser, 2006, Loss of PECAM-1 function impairs alveolarization, J. Biol. Chem., 281, 8724, 10.1074/jbc.M511798200

Ding, 2010, Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration, Nature, 468, 310, 10.1038/nature09493

Giordano, 2008, Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse, J. Biol. Chem., 283, 29447, 10.1074/jbc.M804595200

Greenlee, 2007, Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted, Physiol. Rev., 87, 69, 10.1152/physrev.00022.2006

Hiraoka, 1998, Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins, Cell, 95, 365, 10.1016/S0092-8674(00)81768-7

Hooper, 2009, Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells, Cell Stem Cell, 4, 263, 10.1016/j.stem.2009.01.006

Huh, 2010, Reconstituting organ-level lung functions on a chip, Science, 328, 1662, 10.1126/science.1188302

Irie, 2005, Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP), Med. Mol. Morphol., 38, 43, 10.1007/s00795-004-0277-9

Jiang, 2005, Regulation of lung injury and repair by Toll-like receptors and hyaluronan, Nat. Med., 11, 1173, 10.1038/nm1315

Kajstura, 2011, Evidence for human lung stem cells, N. Engl. J. Med., 364, 1795, 10.1056/NEJMoa1101324

Kim, 2005, Identification of bronchioalveolar stem cells in normal lung and lung cancer, Cell, 121, 823, 10.1016/j.cell.2005.03.032

Kobayashi, 2010, Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells, Nat. Cell Biol., 12, 1046, 10.1038/ncb2108

Komarova, 2010, Regulation of endothelial permeability via paracellular and transcellular transport pathways, Annu. Rev. Physiol., 72, 463, 10.1146/annurev-physiol-021909-135833

Koshikawa, 2010, Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor, Cancer Res., 70, 6093, 10.1158/0008-5472.CAN-10-0346

Kotton, 2008, Lung stem cells, Cell Tissue Res., 331, 145, 10.1007/s00441-007-0479-2

Lammert, 2001, Induction of pancreatic differentiation by signals from blood vessels, Science, 294, 564, 10.1126/science.1064344

Lee, 2004, Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung, Nat. Med., 10, 1095, 10.1038/nm1105

Leuwerke, 2002, Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice, Am. J. Physiol. Lung Cell. Mol. Physiol., 282, L1272, 10.1152/ajplung.00490.2001

Li, 2002, Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury, Cell, 111, 635, 10.1016/S0092-8674(02)01079-6

Liu, 2011, FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa, J. Exp. Med., 208, 1473, 10.1084/jem.20102041

Matsumoto, 2001, Liver organogenesis promoted by endothelial cells prior to vascular function, Science, 294, 559, 10.1126/science.1063889

Matthay, 2011, The acute respiratory distress syndrome: pathogenesis and treatment, Annu. Rev. Pathol., 6, 147, 10.1146/annurev-pathol-011110-130158

Metzger, 2008, The branching programme of mouse lung development, Nature, 453, 745, 10.1038/nature07005

Morris, 2003, Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema, Nature, 422, 169, 10.1038/nature01413

Morrisey, 2010, Preparing for the first breath: genetic and cellular mechanisms in lung development, Dev. Cell, 18, 8, 10.1016/j.devcel.2009.12.010

Murakami, 2011, FGF-dependent regulation of VEGF receptor 2 expression in mice, J. Clin. Invest., 121, 2668, 10.1172/JCI44762

Muzykantov, 2005, Biomedical aspects of targeted delivery of drugs to pulmonary endothelium, Expert Opin. Drug Deliv., 2, 909, 10.1517/17425247.2.5.909

Nolen-Walston, 2008, Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration, Am. J. Physiol. Lung Cell. Mol. Physiol., 294, L1158, 10.1152/ajplung.00298.2007

Oblander, 2005, Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation, Dev. Biol., 277, 255, 10.1016/j.ydbio.2004.09.033

Page-McCaw, 2007, Matrix metalloproteinases and the regulation of tissue remodelling, Nat. Rev. Mol. Cell Biol., 8, 221, 10.1038/nrm2125

Perl, 2002, Early restriction of peripheral and proximal cell lineages during formation of the lung, Proc. Natl. Acad. Sci. USA, 99, 10482, 10.1073/pnas.152238499

Petersen, 2010, Tissue-engineered lungs for in vivo implantation, Science, 329, 538, 10.1126/science.1189345

Petrache, 2005, Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice, Nat. Med., 11, 491, 10.1038/nm1238

Rawlins, 2009, The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium, Cell Stem Cell, 4, 525, 10.1016/j.stem.2009.04.002

Red-Horse, 2007, Endothelium-microenvironment interactions in the developing embryo and in the adult, Dev. Cell, 12, 181, 10.1016/j.devcel.2007.01.013

Rock, 2011, Epithelial progenitor cells in lung development, maintenance, repair, and disease, Annu. Rev. Cell Dev. Biol., 27, 493, 10.1146/annurev-cellbio-100109-104040

Ruoslahti, 2000, An address system in the vasculature of normal tissues and tumors, Annu. Rev. Immunol., 18, 813, 10.1146/annurev.immunol.18.1.813

Sakaguchi, 2008, Endothelial signals modulate hepatocyte apicobasal polazrization in zebrafish, Curr. Biol., 18, 1565, 10.1016/j.cub.2008.08.065

Schenk, 2003, Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution, J. Cell Biol., 161, 197, 10.1083/jcb.200208145

Seandel, 2008, Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene, Proc. Natl. Acad. Sci. USA, 105, 19288, 10.1073/pnas.0805980105

Shu, 2002, Wnt7b regulates mesenchymal proliferation and vascular development in the lung, Development, 129, 4831, 10.1242/dev.129.20.4831

Stratman, 2009, Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices, Blood, 114, 237, 10.1182/blood-2008-12-196451

Stratman, 2010, Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization, Blood, 116, 4720, 10.1182/blood-2010-05-286872

Stripp, 2008, Maintenance and repair of the bronchiolar epithelium, Proc. Am. Thorac. Soc., 5, 328, 10.1513/pats.200711-167DR

Vaporciyan, 1993, Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo, Science, 262, 1580, 10.1126/science.8248808

Voelkel, 2006, Vascular endothelial growth factor in the lung, Am. J. Physiol. Lung Cell. Mol. Physiol., 290, L209, 10.1152/ajplung.00185.2005

Wang, 2010, Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis, Nature, 465, 483, 10.1038/nature09002

Warburton, 2010, Lung organogenesis, Curr. Top. Dev. Biol., 90, 73, 10.1016/S0070-2153(10)90003-3

White, 2007, FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network, Development, 134, 3743, 10.1242/dev.004879

Whitsett, 2010, Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease, Annu. Rev. Med., 61, 105, 10.1146/annurev.med.60.041807.123500

Yamamoto, 2007, Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis, Dev. Biol., 308, 44, 10.1016/j.ydbio.2007.04.042

Yana, 2007, Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells, J. Cell Sci., 120, 1607, 10.1242/jcs.000679

Zhang, 2008, A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration, Nat. Genet., 40, 862, 10.1038/ng.157

Ackah, E., Yu, J., Zoellner, S., Iwakiri, Y., Skurk, C., Shibata, R., Ouchi, N., Easton, R.M., Galasso, G., Birnbaum, M.J., et al. (2005). Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J. Clin. Invest. 115, 2119–2127.

Murakami, M., Nguyen, L.T., Hatanaka, K., Schachterle, W., Chen, P.Y., Zhuang, Z.W., Black, B.L., and Simons, M. (2011). FGF-dependent regulation of VEGF receptor 2 expression in mice. J. Clin. Invest. 121, 2668–2678.