Pro-inflammatory cytokines: The link between obesity and osteoarthritis
Tài liệu tham khảo
Henderson, 2013, Prevalence, causes, severity, impact, and management of chronic pain in Australian general practice patients, Pain Med. (Malden, Mass.), 14, 1346, 10.1111/pme.12195
Guccione, 1994, The effects of specific medical conditions on the functional limitations of elders in the Framingham Study, Am. J. Public Health, 84, 351, 10.2105/AJPH.84.3.351
Cross, 2014, The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study, Ann. Rheum. Dis., 73, 1323, 10.1136/annrheumdis-2013-204763
Jordan, 2003, EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for International Clinical Studies Including Therapeutic Trials (ESCISIT), Ann. Rheum. Dis., 62, 1145, 10.1136/ard.2003.011742
Triantaphyllidou, 2013, Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet, Osteoarthr. Cartilage, 21, 322, 10.1016/j.joca.2012.11.003
Blagojevic, 2010, Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis, Osteoarthr. Cartilage, 18, 24, 10.1016/j.joca.2009.08.010
Carman, 1994, Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study, Am. J. Epidemiol., 139, 119, 10.1093/oxfordjournals.aje.a116974
Oliveria, 1999, Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee, Epidemiology (Cambridge, Mass.), 10, 161, 10.1097/00001648-199903000-00013
Messier, 2005, Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis, Arthritis Rheum., 52, 2026, 10.1002/art.21139
Hauner, 2005, Secretory factors from human adipose tissue and their functional role, The Proceedings of the Nutrition Society, 64, 163, 10.1079/PNS2005428
Park, 2005, Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6, Diabetes Res. Clin. Pract., 69, 29, 10.1016/j.diabres.2004.11.007
Wang, 2011, Effects and relationship of ERK1 and ERK2 in interleukin-1beta-induced alterations in MMP3, MMP13, type II collagen and aggrecan expression in human chondrocytes, Int. J. Mol. Med., 27, 583
Stannus, 2010, Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults, Osteoarthr. Cartilage, 18, 1441, 10.1016/j.joca.2010.08.016
Urban, 2018, The role of fat and inflammation in the pathogenesis and management of osteoarthritis, Rheumatology (Oxford, England), 57, 10.1093/rheumatology/kex399
Cancello, 2006, Is obesity an inflammatory disease?, Journees annuelles de diabetologie de l’Hotel-Dieu, 115
Wellen, 2005, Inflammation, stress, and diabetes, J. Clin. Invest., 115, 1111, 10.1172/JCI25102
Gnacinska, 2009, Role of adipokines in complications related to obesity: a review, Adv. Med. Sci., 54, 150, 10.2478/v10039-009-0035-2
Miller, 2008, Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy, J. Am. Geriatr. Soc., 56, 644, 10.1111/j.1532-5415.2007.01636.x
Festa, 2001, The relation of body fat mass and distribution to markers of chronic inflammation, Int. J. Obes. Relat. Metab. Disord., 25, 1407, 10.1038/sj.ijo.0801792
Bullo, 2003, Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression, Obes. Res., 11, 525, 10.1038/oby.2003.74
Tilg, 2006, Adipocytokines: mediators linking adipose tissue, inflammation and immunity, nature reviews, Immunology, 6, 772
Huh, 2014, Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity, Mol. Cells, 37, 365, 10.14348/molcells.2014.0074
Frayn, 2003, Integrative physiology of human adipose tissue, Int. J. Obes. Relat. Metab. Disord., 27, 875, 10.1038/sj.ijo.0802326
Hotamisligil, 2006, Inflammation and metabolic disorders, Nature, 444, 860, 10.1038/nature05485
Dam, 2016, From neutrophils to macrophages: differences in regional adipose tissue depots, Obes. Rev., 17, 1, 10.1111/obr.12335
Mraz, 2014, The role of adipose tissue immune cells in obesity and low-grade inflammation, J. Endocrinol., 222, 10.1530/JOE-14-0283
Vieira-Potter, 2014, Inflammation and macrophage modulation in adipose tissues, Cell. Microbiol., 16, 1484, 10.1111/cmi.12336
Lumeng, 2007, Obesity induces a phenotypic switch in adipose tissue macrophage polarization, J. Clin. Invest., 117, 175, 10.1172/JCI29881
Gordon, 2007, Macrophage heterogeneity and tissue lipids, J. Clin. Invest., 117, 89, 10.1172/JCI30992
Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J. Clin. Invest., 112, 1796, 10.1172/JCI200319246
Francisco, 2018, Adipokines and inflammation: is it a question of weight?, Br. J. Pharmacol., 175, 1569, 10.1111/bph.14181
Winer, 2009, Normalization of obesity-associated insulin resistance through immunotherapy, Nat. Med., 15, 921, 10.1038/nm.2001
Feuerer, 2009, Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters, Nat. Med., 15, 930, 10.1038/nm.2002
Ceddia, 2005, Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis, Int. J. Obes., 29, 1175, 10.1038/sj.ijo.0803025
Nishimura, 2009, CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity, Nat. Med., 15, 914, 10.1038/nm.1964
Winer, 2011, B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies, Nat. Med., 17, 610, 10.1038/nm.2353
Rollins, 1997, Chemokines, Blood, 90, 909, 10.1182/blood.V90.3.909
Boring, 1998, Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis, Nature, 394, 894, 10.1038/29788
Sartipy, 2003, Monocyte chemoattractant protein 1 in obesity and insulin resistance, PNAS, 100, 7265, 10.1073/pnas.1133870100
Shoelson, 2003, Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance, Int. J. Obes. Relat. Metab. Disord., 27, S49, 10.1038/sj.ijo.0802501
Kanda, 2006, MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity, J. Clin. Invest., 116, 1494, 10.1172/JCI26498
Kirk, 2008, Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected], Diabetes, 57, 1254, 10.2337/db07-1061
Cinti, 2005, Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans, J. Lipid Res., 46, 2347, 10.1194/jlr.M500294-JLR200
Murano, 2008, Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice, J. Lipid Res., 49, 1562, 10.1194/jlr.M800019-JLR200
Apovian, 2008, Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects, Arterioscler. Thromb. Vasc. Biol., 28, 1654, 10.1161/ATVBAHA.108.170316
Saberi, 2009, Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice, Cell Metab., 10, 419, 10.1016/j.cmet.2009.09.006
Jiao, 2009, Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-jun NH2-terminal kinase pathways, Diabetes, 58, 104, 10.2337/db07-1344
Margetic, 2002, Leptin: a review of its peripheral actions and interactions, Int. J. Obes. Relat. Metab. Disord., 26, 1407, 10.1038/sj.ijo.0802142
Yamamoto, 2005, Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn’s disease, Gut, 54, 789, 10.1136/gut.2004.046516
Qatanani, 2009, Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice, J. Clin. Invest., 119, 531, 10.1172/JCI37273
Wang, 2015, Metabolic triggered inflammation in osteoarthritis, Osteoarthr. Cartilage, 23, 22, 10.1016/j.joca.2014.10.002
Frederich, 1995, Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity, J. Clin. Invest., 96, 1658, 10.1172/JCI118206
MacDougald, 1995, Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes, PNAS, 92, 9034, 10.1073/pnas.92.20.9034
Friedman, 1998, Leptin and the regulation of body weight in mammals, Nature, 395, 763, 10.1038/27376
Fowler-Brown, 2015, The mediating effect of leptin on the relationship between body weight and knee osteoarthritis in older adults, Arthritis Rheumatol. (Hoboken, N.J.), 67, 169, 10.1002/art.38913
Marti, 2001, Obesity and immune function relationships, Obes. Rev., 2, 131, 10.1046/j.1467-789x.2001.00025.x
Acedo, 2013, Participation of leptin In the determination of the macrophage phenotype: an additional role In adipocyte and macrophage crosstalk, In vitro cellular & developmental biology, Animal, 49, 473
Koskinen, 2011, Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients, Clin. Exp. Rheumatol., 29, 57
Bao, 2010, Leptin plays a catabolic role on articular cartilage, Mol. Biol. Rep., 37, 3265, 10.1007/s11033-009-9911-x
Balsan, 2015, Relationship between adiponectin, obesity and insulin resistance, Revista da Associacao Medica Brasileira, 61, 72, 10.1590/1806-9282.61.01.072
Luo, 2016, Adiponectin: a versatile player of innate immunity, J. Mol. Cell. Biol., 8, 120, 10.1093/jmcb/mjw012
Hao, 2011, Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis, Rheumatol. Int., 31, 1433, 10.1007/s00296-010-1516-0
Kang, 2010, Adiponectin is a potential catabolic mediator in osteoarthritis cartilage, Arthritis Res. Ther., 12, R231, 10.1186/ar3218
Chen, 2006, Evidence for a protective role for adiponectin in osteoarthritis, Biochim. Biophys. Acta, 1762, 711, 10.1016/j.bbadis.2006.06.008
Challa, 2010, Effect of adiponectin on ATDC5 proliferation, differentiation and signaling pathways, Mol. Cell. Endocrinol., 323, 282, 10.1016/j.mce.2010.03.025
Yusuf, 2011, Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis, Ann. Rheum. Dis., 70, 1282, 10.1136/ard.2010.146282
Dinarello, 1991, Interleukin-1 and interleukin-1 antagonism, Blood, 77, 1627, 10.1182/blood.V77.8.1627.1627
Akdis, 2011, Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases, J. Allergy Clin. Immunol., 127, 701, 10.1016/j.jaci.2010.11.050
Marks, 2005, Inflammatory cytokine profiles associated with chondral damage in the anterior cruciate ligament-deficient knee, Arthroscopy, 21, 1342, 10.1016/j.arthro.2005.08.034
Garlanda, 2013, The interleukin-1 family: back to the future, Immunity, 39, 1003, 10.1016/j.immuni.2013.11.010
Gabay, 2010, IL-1 pathways in inflammation and human diseases, Nature reviews, Rheumatology, 6, 232
Palomo, 2015, The interleukin (IL)-1 cytokine family--balance between agonists and antagonists in inflammatory diseases, Cytokine, 76, 25, 10.1016/j.cyto.2015.06.017
Luheshi, 1999, Leptin actions on food intake and body temperature are mediated by IL-1, Proceedings of the National Academy of Sciences of the United States of America, 96, 7047, 10.1073/pnas.96.12.7047
Matsuki, 2003, IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions, J. Exp. Med., 198, 877, 10.1084/jem.20030299
Horai, 1998, Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion, J. Exp. Med., 187, 1463, 10.1084/jem.187.9.1463
Jager, 2007, Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression, Endocrinology, 148, 241, 10.1210/en.2006-0692
De Simone, 2015, Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth, Oncogene, 34, 3493, 10.1038/onc.2014.286
Zheng, 2014, TNFalpha promotes Th17 cell differentiation through IL-6 and IL-1beta produced by monocytes in rheumatoid arthritis, J. Immunol. Res., 2014, 385352, 10.1155/2014/385352
Chung, 2009, Critical regulation of early Th17 cell differentiation by interleukin-1 signaling, Immunity, 30, 576, 10.1016/j.immuni.2009.02.007
Gulen, 2010, The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation, Immunity, 32, 54, 10.1016/j.immuni.2009.12.003
Lee, 2010, Regulating human Th17 cells via differential expression of IL-1 receptor, Blood, 115, 530, 10.1182/blood-2009-08-236521
Guo, 2009, IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, PNAS, 106, 10.1073/pnas.0906988106
Rider, 2011, IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation, J. Immunol. (Baltimore, Md.: 1950), 187, 4835, 10.4049/jimmunol.1102048
Heraud, 2000, Apoptosis in normal and osteoarthritic human articular cartilage, Ann. Rheum. Dis., 59, 959, 10.1136/ard.59.12.959
L’Hermette, 2006, Articular cartilage, degenerative process, and repair: current progress, Int. J. Sports Med., 27, 738, 10.1055/s-2005-872824
Murphy, 2011, Localizing matrix metalloproteinase activities in the pericellular environment, FEBS J., 278, 2, 10.1111/j.1742-4658.2010.07918.x
Malfait, 2002, Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage, J. Biol. Chem., 277, 10.1074/jbc.M200431200
Guo, 2009, Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments, Inflammation Res., 58, 161, 10.1007/s00011-009-8090-5
Cortial, 2006, Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis, Osteoarthr. Cartilage, 14, 631, 10.1016/j.joca.2006.01.008
El Mansouri, 2011, Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes, Arthritis Rheum., 63, 168, 10.1002/art.27762
Gilman, 1988, Interleukin-1 activates phospholipase A2 in human synovial cells, Arthritis Rheum., 31, 126, 10.1002/art.1780310118
Hardy, 2002, Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants, Arthritis Rheum., 46, 1789, 10.1002/art.10356
Blanco, 1995, Chondrocyte apoptosis induced by nitric oxide, Am. J. Pathol., 146, 75
Murrell, 1996, Nitric oxide: an important articular free radical, the journal of bone and joint surgery, Am. Vol., 78, 265
Afonso, 2007, Reactive oxygen species and superoxide dismutases: role in joint diseases, Jt. Bone Spine : revue du rhumatisme, 74, 324, 10.1016/j.jbspin.2007.02.002
Xu, 2014, Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma, Int. J. Biol. Sci., 10, 664, 10.7150/ijbs.8232
Chang, 2001, Mammalian MAP kinase signalling cascades, Nature, 410, 37, 10.1038/35065000
Ahmed, 2005, Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro, J. Nutr., 135, 2096, 10.1093/jn/135.9.2096
Vincenti, 2002, Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors, Arthritis Res., 4, 157, 10.1186/ar401
Kapoor, 2011, Role of proinflammatory cytokines in the pathophysiology of osteoarthritis, nature reviews, Rheumatology, 7, 33
Liacini, 2002, Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes, Matrix Biol., 21, 251, 10.1016/S0945-053X(02)00007-0
Hashimoto, 1997, Fas/Fas ligand expression and induction of apoptosis in chondrocytes, Arthritis Rheum., 40, 1749, 10.1002/art.1780401004
Reichlin, 2000, Blood to brain transfer of leptin in normal and interleukin-1beta-treated male rats, Endocrinology, 141, 1951, 10.1210/endo.141.6.7459
Granowitz, 1997, Transforming growth factor-beta enhances and pro-inflammatory cytokines inhibit ob gene expression in 3T3-L1 adipocytes, Biochem. Biophys. Res. Commun., 240, 382, 10.1006/bbrc.1997.7663
Takahashi, 2008, JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro, American journal of physiology, Endocrinol. Metab., 294, E898
Simons, 2007, Pro-inflammatory delipidizing cytokines reduce adiponectin secretion from human adipocytes without affecting adiponectin oligomerization, J. Endocrinol., 192, 289, 10.1677/JOE-06-0047
Tracey, 1993, Tumor necrosis factor, other cytokines and disease, Annu. Rev. Cell Biol., 9, 317, 10.1146/annurev.cb.09.110193.001533
Tracey, 1994, Tumor necrosis factor: a pleiotropic cytokine and therapeutic target, Annu. Rev. Med., 45, 491, 10.1146/annurev.med.45.1.491
Clohisy, 2002, Tumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kappaB activation in osteoclast precursor cells, J. Orthopaed. Res., 20, 174, 10.1016/S0736-0266(01)00088-2
Merkel, 1999, Tumor necrosis factor-alpha mediates orthopedic implant osteolysis, Am. J. Pathol., 154, 203, 10.1016/S0002-9440(10)65266-2
Jiranek, 1993, Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization, J. Bone Jt. Surg. Am. Vol., 75, 863, 10.2106/00004623-199306000-00007
Chen, 2005, Ubiquitin signalling in the NF-kappaB pathway, Nat. Cell Biol., 7, 758, 10.1038/ncb0805-758
Hayden, 2004, Signaling to NF-kappaB, Genes Dev., 18, 2195, 10.1101/gad.1228704
Vallabhapurapu, 2009, Regulation and function of NF-kappaB transcription factors in the immune system, Annu. Rev. Immunol., 27, 693, 10.1146/annurev.immunol.021908.132641
Osta, 2014, Classical and paradoxical effects of TNF-alpha on bone homeostasis, Front. Immunol., 5, 48, 10.3389/fimmu.2014.00048
Schulze-Osthoff, 1998, Apoptosis signaling by death receptors, Eur. J. Biochem., 254, 439, 10.1046/j.1432-1327.1998.2540439.x
Ramirez Alvarado, 2012, Tumor necrosis factor-alpha, insulin resistance, the lipoprotein metabolism and obesity in humans, Nutricion hospitalaria, 27, 1751
Liang, 2008, Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected wistar rats from diet-induced obesity and insulin resistance, Endocrinology, 149, 2943, 10.1210/en.2007-0978
Hotamisligil, 1995, Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance, J. Clin. Invest., 95, 2409, 10.1172/JCI117936
Petruschke, 1993, Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells, J. Clin. Endocrinol. Metab., 76, 742
Stephens, 1992, Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis, J. Biol. Chem., 267, 10.1016/S0021-9258(18)42251-X
Feingold, 1992, Role of cytokines in inducing hyperlipidemia, Diabetes, 41, 97, 10.2337/diab.41.2.S97
Hube, 1999, The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance?, Hormone Metab. Res. = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 31, 626, 10.1055/s-2007-978810
Suzawa, 2003, Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade, Nat. Cell Biol., 5, 224, 10.1038/ncb942
Wang, 2017, Pro-inflammatory cytokines: New potential therapeutic targets for obesity-related bone disorders, Curr. Drug Targets, 18, 1664, 10.2174/1389450118666170104153512
Algood, 2003, Chemokines and tuberculosis, Cytokine Growth Factor Rev., 14, 467, 10.1016/S1359-6101(03)00054-6
Harris, 2008, Tumor necrosis factor blockers influence macrophage responses to mycobacterium tuberculosis, J. Infect. Dis., 198, 1842, 10.1086/593174
Bekker, 2000, Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent, Infect. Immun., 68, 6954, 10.1128/IAI.68.12.6954-6961.2000
Mootoo, 2009, TNF-alpha in tuberculosis: a cytokine with a split personality, Inflammation Allergy Drug Targets, 8, 53, 10.2174/187152809787582543
Schaible, 2003, Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis, Nat. Med., 9, 1039, 10.1038/nm906
Balcewicz-Sablinska, 1998, Pathogenic mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha, J. Immunol. (Baltimore, Md.: 1950), 161, 2636, 10.4049/jimmunol.161.5.2636
Xue, 2013, Tumor necrosis factor-alpha induces ADAMTS-4 expression in human osteoarthritis chondrocytes, Mol. Med. Rep., 8, 1755, 10.3892/mmr.2013.1729
Goldring, 2004, The role of cytokines in cartilage matrix degeneration in osteoarthritis, Clin. Orthop., 427, S27, 10.1097/01.blo.0000144854.66565.8f
Klooster, 2005, Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte, Arthritis Res. Ther., 7, 10.1186/ar1464
Verma, 2011, ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis, J. Cell. Biochem., 112, 3507, 10.1002/jcb.23298
Lefebvre, 1990, Modulation by interleukin 1 and tumor necrosis factor alpha of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes, Biochim. Biophys. Acta, 1052, 366, 10.1016/0167-4889(90)90145-4
Murakami, 2000, Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha, J. Biol. Chem., 275, 3687, 10.1074/jbc.275.5.3687
Ye, 2014, c-Jun N-terminal kinase - c-Jun pathway transactivates Bim to promote osteoarthritis, Can. J. Physiol. Pharmacol., 92, 132, 10.1139/cjpp-2013-0228
Lopez-Armada, 2006, Mitochondrial activity is modulated by TNFalpha and IL-1beta in normal human chondrocyte cells, Osteoarthr. Cartilage, 14, 1011, 10.1016/j.joca.2006.03.008
Honorati, 2007, VEGF production by osteoarthritic chondrocytes cultured in micromass and stimulated by IL-17 and TNF-alpha, Connect. Tissue Res., 48, 239, 10.1080/03008200701541767
Guerne, 1990, IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro, J. Immunol. (Baltimore, Md.: 1950), 144, 499, 10.4049/jimmunol.144.2.499
Lotz, 1992, Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes, J. Immunol. (Baltimore, Md.: 1950), 148, 466, 10.4049/jimmunol.148.2.466
Alaaeddine, 2001, Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation, Arthritis Rheum., 44, 1633, 10.1002/1529-0131(200107)44:7<1633::AID-ART286>3.0.CO;2-Z
Martel-Pelletier, 2003, Cyclooxygenase-2 and prostaglandins in articular tissues, Semin. Arthritis Rheum., 33, 155, 10.1016/S0049-0172(03)00134-3
Jones, 2009, Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology, Osteoarthr. Cartilage, 17, 124, 10.1016/j.joca.2008.05.001
Seguin, 2003, TNFalpha suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NF-kappaB signaling pathways, J. Cell. Physiol., 197, 356, 10.1002/jcp.10371
Lu, 2011, Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-kappaB signaling in activated SW1353 cells, J. Agric. Food. Chem., 59, 4969, 10.1021/jf1046738
Zhang, 2000, Tumour necrosis factor-alpha exerts dual effects on human adipose leptin synthesis and release, Mol. Cell. Endocrinol., 159, 79, 10.1016/S0303-7207(99)00194-X
Pape, 1988, Effect of tumor necrosis factor on acetyl-coenzyme a carboxylase gene expression and preadipocyte differentiation, Mol. Endocrinol. (Baltimore, Md.), 2, 395, 10.1210/mend-2-5-395
Kirchgessner, 1997, Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes, J. Clin. Invest., 100, 2777, 10.1172/JCI119824
Yamaguchi, 1998, Autocrine inhibition of leptin production by tumor necrosis factor-alpha (TNF-alpha) through TNF-alpha type-I receptor in vitro, Biochem. Biophys. Res. Commun., 244, 30, 10.1006/bbrc.1998.8199
Grunfeld, 1996, Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters, J. Clin. Invest., 97, 2152, 10.1172/JCI118653
Sarraf, 1997, Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia, J. Exp. Med., 185, 171, 10.1084/jem.185.1.171
Berkowitz, 1998, Endotoxin-induced alteration in the expression of leptin and beta3-adrenergic receptor in adipose tissue, Am. J. Physiol., 274
Zumbach, 1997, Tumor necrosis factor increases serum leptin levels in humans, J. Clin. Endocrinol. Metab., 82, 4080, 10.1210/jcem.82.12.4408
Ranganathan, 1998, Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNFalpha expression, J. Lipid Res., 39, 724, 10.1016/S0022-2275(20)32561-X
Uysal, 1997, Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function, Nature, 389, 610, 10.1038/39335
Kern, 1995, The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase, J. Clin. Invest., 95, 2111, 10.1172/JCI117899
Iwamoto, 2001, The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes, J. Periodontol., 72, 774, 10.1902/jop.2001.72.6.774
Kappes, 2000, Influences of ionomycin, dibutyryl-cycloAMP and tumour necrosis factor-alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes, Hormone Metab. Res.= Hormon- und Stoffwechselforschung = Hormones et metabolisme, 32, 548, 10.1055/s-2007-978684
Fasshauer, 2002, Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes, Biochem. Biophys. Res. Commun., 290, 1084, 10.1006/bbrc.2001.6307
Kim, 2005, C-jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes, Biochem. Biophys. Res. Commun., 327, 460, 10.1016/j.bbrc.2004.12.026
Isa, 2008, 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes, Biochem. Biophys. Res. Commun., 373, 429, 10.1016/j.bbrc.2008.06.046
Kamon, 2004, A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance, Biochem. Biophys. Res. Commun., 323, 242, 10.1016/j.bbrc.2004.08.083
Kita, 2005, Identification of the promoter region required for human adiponectin gene transcription: association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha, Biochem. Biophys. Res. Commun., 331, 484, 10.1016/j.bbrc.2005.03.205
Maeda, 2001, PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein, Diabetes, 50, 2094, 10.2337/diabetes.50.9.2094
Ouchi, 2001, Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages, Circulation, 103, 1057, 10.1161/01.CIR.103.8.1057
Scheller, 2011, The pro- and anti-inflammatory properties of the cytokine interleukin-6, Biochim. Biophys. Acta, 1813, 878, 10.1016/j.bbamcr.2011.01.034
Ganeshan, 2012, Regulatory T cells enhance mast cell production of IL-6 via surface-bound TGF-beta, J. Immunol., 188, 594, 10.4049/jimmunol.1102389
Naka, 2002, The paradigm of IL-6: from basic science to medicine, Arthritis Res., 4, 10.1186/ar565
Garbers, 2012, Plasticity and cross-talk of interleukin 6-type cytokines, Cytokin Growth Factor Rev., 23, 85, 10.1016/j.cytogfr.2012.04.001
Rose-John, 2015, The soluble interleukin-6 receptor and related proteins, Best practice & research, Clin. Endocrinol. Metab., 29, 787
Mullberg, 1994, The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site, J. Immunol. (Baltimore, Md.: 1950), 152, 4958, 10.4049/jimmunol.152.10.4958
Rose-John, 1994, Soluble receptors for cytokines and growth factors: generation and biological function, Biochem. J., 300, 281, 10.1042/bj3000281
Hibi, 1990, Molecular cloning and expression of an IL-6 signal transducer, gp130, Cell, 63, 1149, 10.1016/0092-8674(90)90411-7
Heinrich, 2003, Principles of interleukin (IL)-6-type cytokine signalling and its regulation, Biochem. J., 374, 1, 10.1042/bj20030407
Taniguchi, 2014, IL-6 and related cytokines as the critical lynchpins between inflammation and cancer, Semin. Immunol., 26, 54, 10.1016/j.smim.2014.01.001
Wallenius, 2002, Interleukin-6-deficient mice develop mature-onset obesity, Nat. Med., 8, 75, 10.1038/nm0102-75
Peters, 1997, Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice, J. Exp. Med., 185, 755, 10.1084/jem.185.4.755
Baumann, 1996, The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors, Proceedings of the National Academy of Sciences of the United States of America, 93, 8374, 10.1073/pnas.93.16.8374
Cui, 2004, Essential role of STAT3 in body weight and glucose homeostasis, Mol. Cell. Biol., 24, 258, 10.1128/MCB.24.1.258-269.2004
Jansson, 2003, On the site and mechanism of action of the anti-obesity effects of interleukin-6, growth hormone & IGF research : official journal of the growth hormone, Res. Soc. Int. IGF Res. Soc., 13, S28
Wallenius, 2003, The therapeutic potential of interleukin-6 in treating obesity, Expert Opin. Biol. Ther., 3, 1061, 10.1517/14712598.3.7.1061
Katsume, 2002, Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman’s disease like symptoms emerged in IL-6 transgenic mice, Cytokine, 20, 304, 10.1006/cyto.2002.2012
Hashizume, 2010, Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor, Ann. Rheum. Dis., 69, 741, 10.1136/ard.2008.104844
Trujillo, 2004, Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro, J. Clin. Endocrinol. Metab., 89, 5577, 10.1210/jc.2004-0603
Petersen, 2005, Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro, Am. J. Physiology. Endocrinol. Metab., 288, E155, 10.1152/ajpendo.00257.2004
van Hall, 2003, Interleukin-6 stimulates lipolysis and fat oxidation in humans, J. Clin. Endocrinol. Metab., 88, 3005, 10.1210/jc.2002-021687
Mihara, 2012, IL-6/IL-6 receptor system and its role in physiological and pathological conditions, Clin. Sci. (Lond., Engl.: 1979), 122, 143, 10.1042/CS20110340
Kishimoto, 1995, Interleukin-6 family of cytokines and gp130, Blood, 86, 1243, 10.1182/blood.V86.4.1243.bloodjournal8641243
Fonseca, 2009, Interleukin-6 as a key player in systemic inflammation and joint destruction, Autoimmun. Rev., 8, 538, 10.1016/j.autrev.2009.01.012
Korn, 2009, IL-17 and Th17 cells, Annu. Rev. Immunol., 27, 485, 10.1146/annurev.immunol.021908.132710
Stepkowski, 2008, STAT3: an important regulator of multiple cytokine functions, Transplantation, 85, 1372, 10.1097/TP.0b013e3181739d25
Dhodapkar, 2008, Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma, Blood, 112, 2878, 10.1182/blood-2008-03-143222
Liu, 2010, Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease, Nat. Med., 16, 191, 10.1038/nm.2077
Diveu, 2009, IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells, J. Immunol. (Baltimore, Md.: 1950), 182, 5748, 10.4049/jimmunol.0801162
Mathur, 2007, Stat3 and Stat4 direct development of IL-17-secreting Th cells, J. Immunol. (Baltimore, Md.: 1950), 178, 4901, 10.4049/jimmunol.178.8.4901
Camporeale, 2012, IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?, Front. Biosci. (Landmark ed.), 17, 2306, 10.2741/4054
Jego, 2003, Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6, Immunity, 19, 225, 10.1016/S1074-7613(03)00208-5
Neveu, 2009, IL-6 is required for airway mucus production induced by inhaled fungal allergens, J. Immunol. (Baltimore, Md.: 1950), 183, 1732, 10.4049/jimmunol.0802923
de Hooge, 2005, Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging, Osteoarthr. Cartilage, 13, 66, 10.1016/j.joca.2004.09.011
van de Loo, 1997, Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice, Am. J. Pathol., 151, 177
Poree, 2008, Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter, J. Biol. Chem., 283, 4850, 10.1074/jbc.M706387200
Rowan, 2001, Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown, Arthritis Rheum., 44, 1620, 10.1002/1529-0131(200107)44:7<1620::AID-ART285>3.0.CO;2-B
Kwan Tat, 2004, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology, Cytokine Growth Factor Rev., 15, 49, 10.1016/j.cytogfr.2003.10.005
Chenoufi, 2001, Increased mRNA expression and protein secretion of interleukin-6 in primary human osteoblasts differentiated in vitro from rheumatoid and osteoarthritic bone, J. Cell. Biochem., 81, 666, 10.1002/jcb.1104
Sakao, 2009, Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis, J. Bone Miner. Metab., 27, 412, 10.1007/s00774-009-0058-6
Wang, 2010, Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase a- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation, Am.J. Physiol. Cell Physiol., 298, C1445, 10.1152/ajpcell.00508.2009
Liu, 2006, The role of the interleukin-6/gp130 signaling pathway in bone metabolism, Vitamins Hormones, 74, 341, 10.1016/S0083-6729(06)74014-6
Sopasakis, 2004, High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator, Obes. Res., 12, 454, 10.1038/oby.2004.51
Bruun, 2002, Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro, Mol. Cell. Endocrinol., 190, 91, 10.1016/S0303-7207(02)00007-2
Fasshauer, 2003, Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes, Biochem. Biophys. Res. Commun., 301, 1045, 10.1016/S0006-291X(03)00090-1
Fang, 2018, Funct. Compr. Physiol., 8, 1031, 10.1002/cphy.c170046
Bruun, 2003, Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans, Am. J. Physiol. Endocrinol. Metab., 285, E527, 10.1152/ajpendo.00110.2003
Caron, 1996, Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression, Arthritis Rheum., 39, 1535, 10.1002/art.1780390914
Grunke, 2006, Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade, Ann. Rheum. Dis., 65, 555, 10.1136/ard.2006.053272
Dray, 2007, Arthritis and pain. Future targets to control osteoarthritis pain, Arthritis Res. Ther., 9, 212, 10.1186/ar2178
Strang, 2013, Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis, Atherosclerosis, 229, 174, 10.1016/j.atherosclerosis.2013.04.031
Ericsson, 1991, Influence of age on the metabolism of plasma low density lipoproteins in healthy males, J. Clin. Invest., 87, 591, 10.1172/JCI115034
Antoniou, 2007, Elevated triglyceride and cholesterol levels after intravenous antitumour necrosis factor-alpha therapy in a patient with psoriatic arthritis and psoriasis vulgaris, Br. J. Dermatol., 156, 1090, 10.1111/j.1365-2133.2007.07835.x
Lang, 2012, Risk of infections in rheumatoid arthritis patients treated with tocilizumab, Rheumatol. (Oxford, Engl.), 51, 852, 10.1093/rheumatology/ker223
