Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons

Cell - Tập 71 - Trang 565-576 - 1992
Karl Peter Giese1, Rudolf Martini1, Greg Lemke2, Philippe Soriano3, Melitta Schachner1
1Department of Neurobiology Swiss Federal Institute of Technology 8093 Zürich Switzerland
2Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
3Howard Hughes Medical Institute Institute for Molecular Genetics Baylor College of Medicine Houston, Texas 77030 USA

Tài liệu tham khảo

Atashi, 1992, Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes, Neuron, 8, 831, 10.1016/0896-6273(92)90197-L Bixby, 1990, Extracellular matrix molecules and cell adhesion molecules induce neurite outgrowth through different mechanisms, J. Cell Biol., 111, 2725, 10.1083/jcb.111.6.2725 Bollensen, 1987, The peripheral myelin glycoprotein P0 expresses the L2/HNK-1 and L3 carbohydrate structures shared by neural adhesion molecules, Neurosci. Lett., 82, 77, 10.1016/0304-3940(87)90174-1 Büeler, 1992, Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein, Nature, 356, 577, 10.1038/356577a0 Capecchi, 1989, Altering the genome by homologous recombination, Science, 244, 1288, 10.1126/science.2660260 Cervello, 1991, Phosphorylation-dependent regulation of axon fasciculation, 88, 10548 Cunningham, 1987, Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative splicing, Science, 236, 799, 10.1126/science.3576199 Doherty, 1991, Morphoregulatory activities of NCAM and N-Cadherin can be accounted for by G protein-dependent activation of L- and N- type neuronal Ca2+ channels, Cell, 67, 21, 10.1016/0092-8674(91)90569-K D'Urso, 1990, Protein zero of peripheral nerve myelin: biosynthesis, membrane insertion, and evidence for homotypic interaction, Neuron, 4, 449, 10.1016/0896-6273(90)90057-M Edelman, 1991, Cell adhesion molecules: implications for a molecular histology, Annu. Rev. Biochem., 60, 155, 10.1146/annurev.bi.60.070191.001103 Elkins, 1990, Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and abelson tyrosine kinase mutations, Cell, 60, 565, 10.1016/0092-8674(90)90660-7 Fahrig, 1990, Two monoclonal antibodies recognizing carbohydrate epitopes on neural adhesion molecules interfere with cell interactions, Eur. J. Neurosci., 2, 153, 10.1111/j.1460-9568.1990.tb00407.x Faissner, 1990, J1/tenascin is a repulsive substrate for central nervous system neurons, Neuron, 5, 627, 10.1016/0896-6273(90)90217-4 Faissner, 1985, Biosynthesis and membrane topology of the neural cell adhesion molecule L1, EMBO J., 4, 3105, 10.1002/j.1460-2075.1985.tb04052.x Filbin, 1990, Role of myelin P0 protein as a homophilic adhesion molecule, Nature, 344, 871, 10.1038/344871a0 Frei, 1992, Different extracellular domains of the neural adhesion molecule N-CAM are involved in different functions, J. Cell Biol., 118, 177, 10.1083/jcb.118.1.177 Greenfield, 1973, Protein composition of myelin of the peripheral nervous system, J. Neurochem., 20, 1207, 10.1111/j.1471-4159.1973.tb00089.x Hasty, 1991, Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells, Mol. Cell. Biol., 11, 4509, 10.1128/MCB.11.9.4509 Hoffman, 1983, Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule, 80, 5762 Ishaque, 1980, The P0 glycoprotein of peripheral nerve myelin, Can. J. Biochem., 58, 913, 10.1139/o80-125 Jessen, 1990, Three markers of adult non-myelin-forming Schwann cells, 217 (Ran-1), A5E3 and GFAP: development and regulation by neuron-Schwann cell interactions, Development, 109, 91, 10.1242/dev.109.1.91 Kadmon, 1990, The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions, J. Cell Biol., 110, 193, 10.1083/jcb.110.1.193 Kadmon, 1990, Functional cooperation between the neural adhesion molecules L1 and N-CAM is carbohydrate dependent, J. Cell Biol., 110, 209, 10.1083/jcb.110.1.209 Kogan, 1987, An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences, New Engl. J. Med., 317, 985, 10.1056/NEJM198710153171603 Kruse, 1984, Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1, Nature, 311, 153, 10.1038/311153a0 Kücherer, 1987, The novel carbohydrate epitope L3 is shared by some neural cell adhesion molecules, J. Cell Biol., 104, 1597, 10.1083/jcb.104.6.1597 Kuhn, 1990, The gene encoding peripheral myelin protein zero is located on mouse chromosome 1, J. Neurosci., 10, 205, 10.1523/JNEUROSCI.10-01-00205.1990 Lai, 1987, Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing, 84, 4337 Lemke, 1988, Unwrapping the genes of myelin, Neuron, 1, 535, 10.1016/0896-6273(88)90103-1 Lemke, 1985, Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin, Cell, 40, 501, 10.1016/0092-8674(85)90198-9 Lemke, 1988, Isolation and analysis of the gene encoding peripheral myelin protein zero, Neuron, 1, 73, 10.1016/0896-6273(88)90211-5 Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 Martini, 1986, Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve, J. Cell Biol., 103, 2439, 10.1083/jcb.103.6.2439 Martini, 1988, Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerve, J. Cell Biol., 106, 1735, 10.1083/jcb.106.5.1735 Martini, 1991, Complex expression pattern of tenascin during innervation of the posterior limb buds of the developing chicken, J. Neurosci. Res., 28, 261, 10.1002/jnr.490280214 Martini, 1988, Immunocytological localization of the major peripheral nervous system glycoprotein P0 and the L2/HNK-1 and L3 carbohydrate structures in developing and adult mouse sciatic nerve, Dev. Biol., 129, 330, 10.1016/0012-1606(88)90380-6 Martini, 1990, Enhanced expression of the extracellular matrix molecule J1/tenascin in the regenerating adult mouse sciatic nerve, J. Neurocytol., 19, 601, 10.1007/BF01257247 Messing, 1992, P0 promoter directs expression of reporter and toxin genes to Schwann cells of transgenic mice, Neuron, 8, 507, 10.1016/0896-6273(92)90279-M Mirsky, 1986, Distribution of the adhesion molecules N-CAM and L1 on peripheral neurons and glia in adult rats, J. Neurocytol., 15, 799, 10.1007/BF01625196 Moos, 1988, Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin, Nature, 334, 701, 10.1038/334701a0 Neumann, 1990, Wirkung MBP-spezifischer monoklonaler Antikörper auf die Proliferation und die in-vivo-Funktion MBP-spezifischer enzephalitogener T-Lymphozytenlinien der Lewis-Ratte Nieke, 1985, Expression of the neural cell adhesion molecules L1 and N-CAM and their common carbohydrate epitope L2/HNK-1 during development and after transection of the mouse sciatic nerve, Differentiation, 30, 141, 10.1111/j.1432-0436.1985.tb00525.x Noronha, 1986, Molecular specificity of L2 monoclonal antibodies that bind to carbohydrate determinants of neural cell adhesion molecules and their resemblance to other monoclonal antibodies recognizing the myelin-associated glycoprotein, Brain Res., 385, 237, 10.1016/0006-8993(86)91069-3 Owens, 1991, Expression antisense P0 RNA in Schwann cells perturbs myelination, Development, 112, 639, 10.1242/dev.112.2.639 Palay, 1974 Pollerberg, 1987, The 180kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeletal- membrane interactions, Cell Tissue Res., 250, 227, 10.1007/BF00214676 Poltorak, 1987, Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuron-oligodendrocyte and oligodendrocyte- oligodendrocyte interaction, J. Cell Biol., 105, 1893, 10.1083/jcb.105.4.1893 Potter, 1988, Immunochemical characterization of antibodies to the myelin proteolipid protein (PLP), J. Neuroimmunol., 18, 49, 10.1016/0165-5728(88)90134-8 Puckett, 1987, Myelin-specific proteolipid protein is expressed in myelinating Schwann cells but is not incorporated into myelin sheaths, J. Neurosci. Res., 18, 511, 10.1002/jnr.490180402 Rathjen, 1984, Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion, EMBO J., 3, 1, 10.1002/j.1460-2075.1984.tb01753.x Reichardt, 1990, Neuronal receptors that regulate axon growth, 55, 341 Schachner, 1990, Functional implications of glial cell recognition molecules, Sem. Neurosci., 2, 497 Schachner, 1991, Neural recognition molecules and their influence on cellular functions, 237 Schneider-Schaulies, 1990, Recombinant peripheral myelin protein P0 confers both adhesion and neurite outgrowth-promoting properties, J. Neurosci. Res., 27, 286, 10.1002/jnr.490270307 Schuch, 1989, Neural cell adhesion molecules influence second messenger systems, Neuron, 3, 13, 10.1016/0896-6273(89)90111-6 Soriano, 1991, Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice, Cell, 64, 693, 10.1016/0092-8674(91)90499-O Swash, 1991, The inherited neuropathies, 1177 Takeichi, 1991, Cadherin cell adhesion receptors as a morphogenetic regulator, Science, 251, 1451, 10.1126/science.2006419 Trapp, 1981, Immunocytochemical localization of P0 protein in Golgi complex membranes and myelin of developing rat Schwann cells, J. Cell Biol., 90, 1, 10.1083/jcb.90.1.1 von Bohlen und Halbach, 1992, Cell-type specific effects of the neural adhesion molecules L1 and N-CAM on diverse second messenger systems, Eur. J. Neurosci. Weskamp, 1991, Evidence that the biological activity of NGF is mediated through a novel subclass of high affinity receptors, Neuron, 6, 649, 10.1016/0896-6273(91)90067-A Williams, 1988, The immunoglobulin super-family-domains for cell surface recognition, Annu. Rev. Immunol., 6, 381, 10.1146/annurev.iy.06.040188.002121 You, 1991, DNA sequence, genomic organization, and chromosomal localization of the mouse peripheral myelin protein zero gene: identification of polymorphic alleles, Genomics, 9, 751, 10.1016/0888-7543(91)90370-T Zimmer, 1992, Manipulating the genome by homologous recombination in embryonic stem cells, Annu. Rev. Neurosci., 15, 115, 10.1146/annurev.ne.15.030192.000555