Colorectal cancer cell-derived microvesicles containing microRNA-1246 promote angiogenesis by activating Smad 1/5/8 signaling elicited by PML down-regulation in endothelial cells

Nami Yamada1, Nonoka Tsujimura1, Minami Kumazaki1, Haruka Shinohara1, Kohei Taniguchi1, Yoshihito Nakagawa2, Tomoki Naoe3, Yukihiro Akao1
1United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 yanagido, Gifu-city, Gifu 501-1193, Japan
2Department of Gastroenterology, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi 470-1192, Japan
3Department of Hematology and Oncology, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

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