Neurosteroids, GABAA receptors, and escalated aggressive behavior

Apfelbach, 1974, Social hierarchy in monkeys (Macaca mulatta) modified by chlordiazepoxide hydrochloride, Neuropharmacology, 13, 11, 10.1016/0028-3908(74)90003-3 Arnone, 1980, Does frustration induce aggression in pigs, Appl. Anim. Ethol., 6, 351, 10.1016/0304-3762(80)90135-2 Arnone, 1980, Effects of diazepam on extinction induced aggression in pigs, Pharmacol. Biochem. Behav., 13, 27, 10.1016/0091-3057(80)90115-X Azrin, 1966, Extinction-induced aggression, J. Exp. Anal. Behav., 9, 191, 10.1901/jeab.1966.9-191 Barbaccia, 1999, Ethanol markedly increases “GABAergic” neurosteroids in alcohol-preferring rats, Eur. J. Pharmacol., 384, R1, 10.1016/S0014-2999(99)00678-0 Barbaccia, 2001, Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat, Neuropsychopharmacology, 25, 489, 10.1016/S0893-133X(01)00254-8 Barbaccia, 1996, Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress, Neuroendocrinology, 63, 166, 10.1159/000126953 Barnard, 1998, International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors, Pharmacol. Rev., 50, 291 Barnett, 1968, Influence of females on conflict among wild rats, J. Zool., 154, 391, 10.1111/j.1469-7998.1968.tb01671.x Bauen, 1970, The mink as a psychopharmacological model, Arch. Int. Pharmacodynam. Ther., 186, 133 Baulieu, 1991, Neurosteroids, Biol. Cell, 71, 3, 10.1016/0248-4900(91)90045-O Baulieu, 1990, Neurosteroids, J. Ster. Biochem. Mol. Biol., 37, 395, 10.1016/0960-0760(90)90490-C Belelli, 1990, Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex, Neurosci. Biobehav. Rev., 14, 315, 10.1016/S0149-7634(05)80041-7 Ben-Porath, 2002, The effects of diazepam (Valium) and aggressive disposition on human aggression—an experimental investigation, Addict. Behav., 27, 167, 10.1016/S0306-4603(00)00175-1 Berkowitz, 1993 Bernstein, 1974, The function of aggression in primate societies, Am. Sci., 62, 304 Betz, 1990, Ligand-gated ion channels in the brain, Neuron, 5, 383, 10.1016/0896-6273(90)90077-S Bitran, 2000, Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat, Psychopharmacology, 151, 64, 10.1007/s002130000471 Bitran, 1991, Anxiolytic effects of 3α-hydroxy-5α-pregnan-20-one, Brain Res., 561, 157, 10.1016/0006-8993(91)90761-J Bjork, 2001, Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder, Psychiatry Res., 101, 131, 10.1016/S0165-1781(01)00220-7 Bond, 1979, Benzodiazepines and aggression, 173 Bond, 1998, Drug-induced behavioural disinhibition—incidence, mechanisms and therapeutic implications, CNS Drugs, 9, 41, 10.2165/00023210-199809010-00005 Bond, 1995, Behavioural aggression in panic disorder after 8 weeks' treatment with alprazolam, J. Affect. Disord., 35, 117, 10.1016/0165-0327(95)00053-4 Bowen, 1999, Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids, J. Pharmacol. Exp. Ther., 289, 405 Brain, 1992, Hormonal and neurochemical correlates of various forms of animal aggression, Psychoneuroendocrinology, 17, 537, 10.1016/0306-4530(92)90014-X Brandon, 1999, Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors, J. Neurosci., 19, 9228, 10.1523/JNEUROSCI.19-21-09228.1999 Britton, 1991, Anxiolytic activity of steroid anesthetic alphaxalone, J. Pharmacol. Exp. Ther., 258, 124 Brussaard, 1999, Changes in properties and neurosteroid regulation of GABAergic synapses in the supraoptic nucleus during the mammalian female reproductive cycle, J. Physiol., 516, 513, 10.1111/j.1469-7793.1999.0513v.x Brussaard, 1997, Plasticity in fast synaptic inhibition of adult oxytocin neurons caused by switch in GABA(A) receptor subunit expression, Neuron, 19, 1103, 10.1016/S0896-6273(00)80401-8 Cascio, 2000, Pathways of dehydroepiandrosterone formation in rat brain glia, J. Ster. Biochem. Mol. Biol., 75, 177, 10.1016/S0960-0760(00)00163-1 Cascio, 1998, Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells, Proc. Natl. Acad. Sci. USA, 95, 2862, 10.1073/pnas.95.6.2862 Cherek, 1971, Fixed-interval induced aggression, Psychon. Sci., 25, 7, 10.3758/BF03335829 Cherek, 1970, Schedule-induced aggression as a function of fixed-ratio value, J. Exp. Anal. Behav., 14, 309, 10.1901/jeab.1970.14-309 Cherek, 1992, Effects of response requirement and alcohol on human aggressive responding, J. Exp. Anal. Behav., 58, 577, 10.1901/jeab.1992.58-577 Cheu, 1998, GABA receptor mediated suppression of defensive rage behavior elicited from the medial hypothalamus of the cat, Brain Res., 783, 293, 10.1016/S0006-8993(97)01357-7 Choi, 2002, Conditional rescue of protein kinase C ε regulates ethanol preference and hypnotic sensitivity in adult mice, J. Neurosci., 22, 9905, 10.1523/JNEUROSCI.22-22-09905.2002 Christmas, 1970, A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats, Neuropharmacology, 9, 17, 10.1016/0028-3908(70)90044-4 Clement, 1987, Age-dependent changes of brain GABA levels, turnover rates and shock-induced aggressive behavior in inbred strains of mice, Pharmacol. Biochem. Behav., 26, 83, 10.1016/0091-3057(87)90538-7 Cole, 1970, Laboratory evaluation of aggressive behavior of the grasshopper mouse (Onychomys), J. Pharm. Sci., 59, 969, 10.1002/jps.2600590710 Cole, 1966, The effects of some psychotropic drugs on conditioned avoidance and aggressive behaviors, Psychopharmacologia, 8, 389, 10.1007/BF00406487 Compagnone, 2000, Neurosteroids, Frontiers Neuroendocrinol., 21, 1, 10.1006/frne.1999.0188 Concas, 2000, Caffeine-induced increases in the brain and plasma concentrations of neuroactive steroids in the rat, Pharmacol. Biochem. Behav., 66, 39, 10.1016/S0091-3057(00)00237-9 Connor, 1974, Waning and recovery of conspecific aggression in the house mouse (Mus musculus L), J. Comp. Physiol. Psychol., 87, 215, 10.1037/h0036874 Corpechot, 1981, Characterization and measurement of dehydroepiandrosterone sulfate in rat brain, Proc. Natl. Acad. Sci. USA, 78, 4704, 10.1073/pnas.78.8.4704 Costa, 1991, The allosteric modulation of GABA(a) receptors, Neuropsychopharmacology, 4, 225 Crawley, 1997, Behavioral phenotypes of inbred mouse strains, Psychopharmacology, 13, 107, 10.1007/s002130050327 Crawley, 1975, Does social environment decrease propensity to fight in male mice, Behav. Biol., 15, 73, 10.1016/S0091-6773(75)92105-7 Crestani, 2000, Mechanism of action of the hypnotic zolpidem in vivo, Br. J. Pharmacol., 131, 1251, 10.1038/sj.bjp.0703717 Daderman, 1999, Flunitrazepam (Rohypnol) abuse in combination with alcohol causes premeditated, grievous violence in male juvenile offenders, J. Am. Acad. Psychiatry Law, 27, 83 Damgen, 1999, Zaleplon displays a selectivity to recombinant GABAA receptors different from zolpidem, zopiclone and benzodiazepines, Neurosci. Res. Commun., 25, 139, 10.1002/(SICI)1520-6769(199911/12)25:3<139::AID-NRC3>3.0.CO;2-W DaVanzo, 1979, Inhibition of isolation-induced aggressive behavior with GABA transaminase inhibitors, Psychopharmacology, 62, 23, 10.1007/BF00426030 de Almeida, 2002, Aggression escalated by social instigation or by discontinuation of reinforcement (“frustration”) in mice, Neuropsychopharmacology, 27, 171, 10.1016/S0893-133X(02)00291-9 de Almeida, R.M.M., Rowlett, J.K., Cook, J.M., Miczek, K.A., 2003. GABAA/α1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice. Psychopharmacology, in press Delini-Stula, 1978, Modulatory effects of baclofen muscimol and gaba on interspecific aggressive behaviour in the rat, Neuropharmacology, 17, 1063, 10.1016/0028-3908(78)90039-4 Depaulis, 1983, Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist, Physiol. Behav., 30, 383, 10.1016/0031-9384(83)90141-5 DiMascio, 1973, The effects of benzodiazepines on aggression, Psychopharmacologia, 30, 95, 10.1007/BF00421423 Dollard, 1939 Dorevitch, 1999, Intramuscular flunitrazepam versus intramuscular haloperidol in the emergency treatment of aggressive psychotic behavior, Am. J. Psychiatry, 156, 142, 10.1176/ajp.156.1.142 Early, 1980, The effect of testosterone and cyproterone acetate on the concentration of γ-aminobutyric acid in brain areas of aggressive and non-aggressive mice, Pharmacol. Biochem. Behav., 12, 189 Eichelman, 1987, Neurochemical and psychopharmacologic aspects of aggressive behavior, 697 Fancsik, 2000, Neurosteroid modulation of GABA IPSCs is phosphorylation dependent, J. Neurosci., 20, 3067, 10.1523/JNEUROSCI.20-09-03067.2000 Ferrari, 1997, Differential effects of chlordiazepoxide on aggressive behavior in male mice, Psychopharmacology, 134, 258, 10.1007/s002130050448 Fish, 2002, Aggressive behavior as a reinforcer in mice, Psychopharmacology, 163, 459, 10.1007/s00213-002-1211-2 Fish, 1999, Aggression heightened by alcohol or social instigation in mice, Psychopharmacology, 146, 391, 10.1007/PL00005484 Fish, 2001, Alcohol, allopregnanolone and aggression in mice, Psychopharmacology, 153, 473, 10.1007/s002130000587 Flood, 1988, Dehydroepiandrosterone sulfate improves memory in aging mice, Brain Res., 448, 178, 10.1016/0006-8993(88)91116-X Floody, 1977, Aggressive behavior in female hamsters, J. Comp. Physiol. Psychol., 91, 443, 10.1037/h0077341 Fraile, 1987, Progesterone inhibition of aggressive behaviors in hamsters, Physiol. Behav., 39, 225, 10.1016/0031-9384(87)90013-8 Frank, 2000, Neuroprotective effects of allopregnanolone on hippocampal irreversible neurotoxicity in vitro, Prog. Neuropsychopharmacol. Biol. Psychiatry, 24, 1117, 10.1016/S0278-5846(00)00124-X Fry, 1960, A mathematical index of performance on fixed-interval schedules of reinforcement, J. Exp. Anal. Behav., 3, 193, 10.1901/jeab.1960.3-193 Frye, 1995, The neurosteroid 3 alpha, 5 apha-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy, Brain Res., 696, 113, 10.1016/0006-8993(95)00793-P Frye, 1993, 3-alpha-oh-dhp and 5-alpha-thdoc implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus, Brain Res., 612, 130, 10.1016/0006-8993(93)91653-A Frye, 1995, Neurosteroids affect spatial/reference, working, and long-term memory of female rats, Neurobiol. Learn. Mem., 64, 83, 10.1006/nlme.1995.1046 Furukawa, 1998, Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system, J. Neurochem., 71, 2231, 10.1046/j.1471-4159.1998.71062231.x Gardos, 1968, Differential actions of chlordiazepoxide and oxazepam on hostility, Arch. Gen. Psychiatry, 18, 757, 10.1001/archpsyc.1968.01740060117014 Gee, 1988, Steroid modulation of the chloride ionophore in rat brain, J. Pharmacol. Exp. Ther., 246, 803 Gee, 1995, A putative receptor for neurosteroids on the GABAA receptor complex, Crit. Rev. Neurobiol., 9, 207 Gourley, S.A., DeBold, J.F., Cook, J.M., Miczek, K.A., 2002. GABAA/alpha1, 5-HT1A, alcohol, and aggression in rats. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Program No. 607.9 Grant, 1963, A comparison of the social postures of some common laboratory rodents, Behaviour, 21, 246, 10.1163/156853963X00185 Grobin, 1998, The role of GABA(A) receptors in the acute and chronic effects of ethanol, Psychopharmacology, 139, 2, 10.1007/s002130050685 Guillot, 1998, Intermale aggression, GAD activity in the olfactory bulbs and Y chromosome effect in seven inbred mouse strains, Behav. Brain Res., 90, 203, 10.1016/S0166-4328(97)00110-1 Haefely, W., 1990. GABA and benzodiazepine receptor subtypes: molecular biology, pharmacology and clinical aspects, in: Squires, R. F. (Ed.), GABA and Benzodiazepine Receptor Subtypes. Boca Raton, FL: CRC Press. Vol. 46, pp. 231–234 Haug, 1979, Effects of treatments with testosterone and oestradiol on the attack directed by groups of gonadectomized male and female mice towards lactating intruders, Physiol. Behav., 23, 397, 10.1016/0031-9384(79)90385-8 Haug, 1984, Influence of castration and brain GABA levels in three strains of mice on aggression towards lactating intruders, Physiol. Behav., 32, 767, 10.1016/0031-9384(84)90192-6 Haug, 1983, Dehydroepiandrosterone inhibits aggressive behavior in castrated male mice, Comptes Rendus Seances Acad. Sci., 296, 975 Heiligenberg, 1974, processing governing behavioral states of readiness, Adv. Stud. Behav., 5, 173, 10.1016/S0065-3454(08)60022-4 Heise, 1961, Taming action of chlordiazepoxide, Fed. Proc., 20, 393 Hodge, 1999, Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon, Nat. Neurosci., 2, 997, 10.1038/14795 Hodge, 2002, Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase C epsilon, J. Clin. Invest., 110, 1003, 10.1172/JCI200215903 Hu, 1987, Neurosteroids, Proc. Natl. Acad. Sci. USA, 84, 8215, 10.1073/pnas.84.23.8215 Huang, 2000, Pharmacophore/receptor models for GABAA/BzR subtypes (alpha 1 beta 3 gamma 2, alpha 5 beta 3 gamma 2, and alpha 6 beta 3 gamma 2) via a comprehensive ligand-mapping approach, J. Med. Chem., 43, 71, 10.1021/jm990341r Imamura, 1998, Modulation of GABA-gated chloride ion influx in the brain by dehydroepiandrosterone and its metabolites, Biochem. Biophys. Res. Commun., 243, 771, 10.1006/bbrc.1998.8177 Inai, 2003, Seasonal changes in neurosteroid concentrations in the amphibian brain and environmental factors regulating their changes, Brain Res., 959, 214, 10.1016/S0006-8993(02)03745-9 Itil, 1978, Drug treatment of human aggression, Prog. Neuropsychopharmacol., 2, 659, 10.1016/0364-7722(78)90012-7 Janak, 1998, The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone, Alcohol. Clin. Exp. Res., 22, 1106, 10.1111/j.1530-0277.1998.tb03708.x Jensen, 1968, A two-step mechanism for the interaction of estradiol with rat uterus, Proc. Natl. Acad. Sci. USA, 59, 632, 10.1073/pnas.59.2.632 June, 2001, GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors, J. Neurosci., 21, 2166, 10.1523/JNEUROSCI.21-06-02166.2001 Kimonides, 1998, Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity, Proc. Natl. Acad. Sci. USA, 95, 1852, 10.1073/pnas.95.4.1852 Kohlert, 2001, Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters, Aggress. Behav., 27, 372, 10.1002/ab.1022 Kokate, 1994, Anticonvulsant activity of neurosteroids, J.Pharmacol. Exp. Ther., 270, 1223 Koksma, 2003, Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition, J. Neurosci., 23, 788, 10.1523/JNEUROSCI.23-03-00788.2003 Korneyev, 1993, During anesthetic-induced activation of hypothalamic–pituitary–adrenal axis, blood borne steroids fail to contribute to the anesthetic effect, Neuroendocrinology, 57, 559, 10.1159/000126405 Krsiak, 1975, Tail rattling in aggressive mice as a measure of tranquillizing activity of drugs, Act. Nerv. Super., 17, 225 Krsiak, 1981, Drug effects on attack, defense and escape in mice, Pharmacol. Biochem. Behav., 14, 47, 10.1016/S0091-3057(81)80010-X Krueger, 1991, Molecular and functional characterization of peripheral-type benzodiazepine receptors in glial cells, 744 Kudryavtseva, 1991, A sensory contact model for the study of aggressive and submissive behavior in male mice, Aggress. Behav., 17, 285, 10.1002/1098-2337(1991)17:5<285::AID-AB2480170505>3.0.CO;2-P Kumar, 2002, Association of protein kinase C with GABAA receptors containing α1 and α4 subunits in the cerebral cortex, J. Neurochem., 82, 110, 10.1046/j.1471-4159.2002.00943.x Lagerspetz, 1964, Studies on the aggressive behaviour of mice, Ann. Acad. Sci. Fenn., 131, 1 Lambert, 2001, Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids, Brain Res. Rev., 37, 68, 10.1016/S0165-0173(01)00124-2 Le Roy, 1999, Genetic correlation between steroid sulfatase concentration and initiation of attack behavior in mice, Behav. Genet., 29, 131, 10.1023/A:1021664607131 Leventhal, 1981, The pharmacology of violence, 85 Lion, 1975, “Paradoxical rage reactions” during psychotropic medication, Dis. Nerv. Syst., 36, 557 Lorenz, 1966 Luddens, 1995, Biological function of GABAA/benzodiazepine receptor heterogeneity, J. Psychiatr. Res., 29, 77, 10.1016/0022-3956(94)00040-X Macdonald, 1994, GABA(A) receptor channels, Ann. Rev. Neurosci., 17, 569, 10.1146/annurev.ne.17.030194.003033 Maitra, 1999, Subunit dependent modulation of GABA(A) receptor function by neuroactive steroids, Brain Res., 819, 75, 10.1016/S0006-8993(98)01316-X Majewska, 1988, Interaction of ethanol with the GABAA receptor in the rat brain, Alcohol, 5, 269, 10.1016/0741-8329(88)90064-X Majewska, 1987, Pregnenolone-sulfate, Brain Res., 404, 355, 10.1016/0006-8993(87)91394-1 Majewska, 1990, The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor, Brain Res., 526, 143, 10.1016/0006-8993(90)90261-9 Majewska, 1986, Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor, Science, 232, 1004, 10.1126/science.2422758 McEwen, 1978, Steroid hormone action in the neuroendocrine system, 255 McKernan, 2000, Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1 subtype, Nat. Neurosci., 3, 587, 10.1038/75761 Meisel, 1990, Hypothalamic sites of progestin action on aggression and sexual behavior in female syrian hamsters, Physiol. Behav., 47, 219, 10.1016/0031-9384(90)90134-P Miczek, 1974, Intraspecies aggression in rats, Psychopharmacologia, 39, 275, 10.1007/BF00422968 Miczek, 1979, A new test for aggression in rats without aversive stimulation, Psychopharmacology, 60, 253, 10.1007/BF00426664 Miczek, 1982, Ethological analysis of drug action on aggression, defense and defeat, 225 Miczek, 2001, Oral drug self-administration in the home cage of mice, Psychopharmacology, 157, 421, 10.1007/s002130100831 Miczek, 1978, Intruder-evoked aggression in isolated and nonisolated mice, Psychopharmacology, 57, 47, 10.1007/BF00426957 Miczek, 1980, Alcohol and chlordiazepoxide increase suppressed aggression in mice, Psychopharmacology, 69, 39, 10.1007/BF00426519 Miczek, 1998, Alcohol and heightened aggression in individual mice, Alcohol. Clin. Exp. Res., 22, 1698, 10.1111/j.1530-0277.1998.tb03968.x Miczek, 2001, Benzodiazepine/GABAA receptor agonists, self-administered alcohol and aggression in mice, Soc. Neurosci. Abstr., 31, 225.8 Miczek, 1994, Alcohol, drugs of abuse, aggression and violence, Vol. 3, 377 Miczek, 1997, Alcohol, GABAA-benzodiazepine receptor complex, and aggression, Vol. 13, 139 Miczek, 2002, Social and neural determinants of aggressive behavior, Psychopharmacology, 163, 434, 10.1007/s00213-002-1139-6 Miczek, 1989, Temporal and sequential patterns of agonistic behavior, Psychopharmacology, 97, 149, 10.1007/BF00442237 Miczek, 2001, Aggressive behavioral phenotypes in mice, Behavioural Brain Res., 125, 167, 10.1016/S0166-4328(01)00298-4 Miczek, 1982, Opioid-like analgesia in defeated mice, Science, 215, 1520, 10.1126/science.7199758 Miczek, 1991, Subordinate animals, 323 Miczek, 1992, Alcohol and “bursts” of aggressive behavior, Psychopharmacology, 107, 551, 10.1007/BF02245270 Mihalek, 1999, Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice, Proc. Natl. Acad. Sci. USA, 96, 12905, 10.1073/pnas.96.22.12905 Mohler, 1995, Heterogeneity of GABA(A)-receptors, Neurochem. Res., 20, 631, 10.1007/BF01694546 Morrow, 1995, Neuroactive steroid modulators of the stress response, Analgesia, 771, 257 Morrow, 1999, Neurosteroids mediate pharmacological effects of ethanol, Alcohol Clin. Res., 23, 1933, 10.1111/j.1530-0277.1999.tb04094.x Morrow, 2001, The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence, Brain Res. Rev., 37, 98, 10.1016/S0165-0173(01)00127-8 Moss, 1996, Modulation of amino acid-gated ion channels by protein phosphorylation, Int. Rev. Neurobiol., 39, 1, 10.1016/S0074-7742(08)60662-5 Nicolas, 2001, Aggressive behavior induced by the steroid sulfatase inhibitor COUMATE and by DHEAS in CBA/H mice, Brain Res., 922, 216, 10.1016/S0006-8993(01)03171-7 Niehoff, 1998 Olive, 2000, Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCε-deficient mice, Eur. J. Neurosci., 12, 4131, 10.1046/j.1460-9568.2000.00297.x Olive, 2001, Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-epsilon, Neuroscience, 103, 171, 10.1016/S0306-4522(00)00566-2 Olivier, 1991, Ethopharmacological studies of anxiolytics and aggression, Eur. Neuropsychopharmacol., 1, 97, 10.1016/0924-977X(91)90709-4 Olivier, 1985, Maternal aggression in rats, Psychopharmacology, 86, 68, 10.1007/BF00431686 Park-Chung, 1999, Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites, Brain Res., 830, 72, 10.1016/S0006-8993(99)01381-5 Paul, 1992, Neuroactive steroids, FASEB J., 6, 2311, 10.1096/fasebj.6.6.1347506 Peeke, 1981, Modulation of aggressive behavior in fish by alcohol and congeners, Pharmacol. Biochem. Behav., 14, 79, 10.1016/S0091-3057(81)80013-5 Pernanen, 1976, Alcohol and crimes of violence, 351 Poshivalov, 1981, Pharmaco-ethological analysis of social behaviour of isolated mice, Pharmacol. Biochem. Behav., 14, 53, 10.1016/S0091-3057(81)80011-1 Potegal, 1979, The reinforcing value of several types of aggressive behavior, Aggress. Behav., 5, 353, 10.1002/1098-2337(1979)5:4<353::AID-AB2480050404>3.0.CO;2-7 Potegal, 1991, Attack priming and satiation in female golden hamsters, Aggress. Behav., 17, 327, 10.1002/1098-2337(1991)17:6<327::AID-AB2480170604>3.0.CO;2-J Potegal, 1992, Time course of aggressive arousal in female hamsters and male rats, Behav. Neural Biol., 58, 120, 10.1016/0163-1047(92)90339-6 Potegal, 1984, Behavior of attack-primed and attack-satiated female golden hamsters (Mesocricetus auratus), J. Comp. Psychol., 98, 66, 10.1037/0735-7036.98.1.66 Potegal, 1982, GABA binding in the brains of aggressive and non-aggressive female hamsters, Brain Res., 247, 315, 10.1016/0006-8993(82)91256-2 Potegal, 1983, Disinhibition of muricide and irritability by intraseptal muscimol, Pharmacol. Biochem. Behav., 19, 663, 10.1016/0091-3057(83)90342-8 Puglisi-Allegra, 1980, Effects of sodium n-dipropylacetate, muscimol hydrobromide and (R; S)nipecotic acid amide on isolation-induced aggressive behavior in mice, Psychopharmacology, 70, 287, 10.1007/BF00427887 Puglisi-Allegra, 1979, Effects of apomorphine and sodium di-n-propylacetate on the aggressive behaviour of three strains of mice, Prog. Neuropsychopharmacol., 3, 491, 10.1016/0364-7722(79)90003-1 Puglisi-Allegra, 1981, Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice, Pharmacol. Biochem. Behav., 14, 13, 10.1016/S0091-3057(81)80004-4 Puia, 1993, Does neurosteroid modulatory efficacy depend on GABA(a) receptor subunit composition, Receptors Channels, 1, 135 Puia, 1990, Neurosteroids act on recombinant human GABAA receptors, Neuron, 4, 759, 10.1016/0896-6273(90)90202-Q Puia, 1992, Different sites of action of neurosteroids and benzodiazepines on natural and recombinant GABAA receptors, 103 Purdy, 1991, Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain, Proc. Natl. Acad. Sci. USA, 88, 4553, 10.1073/pnas.88.10.4553 Rahman, 2002, Involvement of GABA and cholinergic receptors in the nucleus accumbens on feedback control of somatodendritic dopamine release in the ventral tegmental area, J. Neurochem., 80, 646, 10.1046/j.0022-3042.2001.00739.x Rainnie, 1999, Serotonergic modulation of neurotransmission in the rat basolateral amygdala, J. Neurophysiol., 82, 69, 10.1152/jn.1999.82.1.69 Randall, 1960, The psychosedative properties of methaminodiazepoxide, J. Pharmacol. Clin. Ther., 129, 163 Reddy, 1998, The effects of neurosteroids on acquisition and retention of a modified passive-avoidance learning task in mice, Brain Res., 791, 108, 10.1016/S0006-8993(98)00085-7 Reis, 1974, Central neurotransmitters in aggression, 119 Robel, 1995, Biosynthesis and assay of neurosteroids in rats and mice, J. Ster. Biochem., 53, 355, 10.1016/0960-0760(95)00074-A Rodgers, 1982, Gabaergic influences on defensive fighting in rats, Pharmacol. Biochem. Behav., 17, 451, 10.1016/0091-3057(82)90303-3 Rodgers, 1985, Benzodiazepines and their antagonists, Neurosci. Biobehav. Rev., 9, 21, 10.1016/0149-7634(85)90029-6 Roizen, 1997, Epidemiological issues in alcohol-related violence, 7 Roof, 1997, Progesterone protects against lipid peroxidation following traumatic brain injury in rats, Mol. Chem. Neuropathol., 31, 1, 10.1007/BF02815156 Rudolph, 2001, GABA(A) receptor subtypes, Trends Pharmacol. Sci., 22, 188, 10.1016/S0165-6147(00)01646-1 Rudolph, 1999, Benzodiazepine actions mediated by specific gamma-aminobutyric acid alpha receptor subtypes, Nature, 401, 796, 10.1038/44579 Rupprecht, 1999, Neuroactive steroids, Trends Neurosci., 22, 410, 10.1016/S0166-2236(99)01399-5 Sanna, 1997, Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes, Mol. Pharmacol., 51, 484 Schlegel, 1985, Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders, Physiol. Behav., 34, 867, 10.1016/0031-9384(85)90005-8 Serra, 2000, Steroidogenesis in rat brain induced by short- and long term administration of carbamazepine, Neuropharmacology, 39, 2448, 10.1016/S0028-3908(00)00086-1 Sheard, 1984, Clinical pharmacology of aggressive behavior, Clin. Neuropharmacol., 7, 173, 10.1097/00002826-198409000-00001 Sieghart, 1995, Structure and pharmacology of gamma-aminobutyric acid(A) receptor subtypes, Pharmacol. Rev., 47, 181 Sluyter, 1995, Studies on wild house mice (VIII), Behav. Genet., 25, 367, 10.1007/BF02197287 Smith, 1998, Withdrawal from 3alpha-OH-5alpha-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety, J. Neurosci., 18, 5275, 10.1523/JNEUROSCI.18-14-05275.1998 Soderpalm, 1997, In vivo administration of the 5-HT1A receptor agonist 8-OH-DPAT interferes with brain GABAA/benzodiazepine receptor complexes, Neuropharmacology, 36, 1071, 10.1016/S0028-3908(97)00105-6 Soma, 2002, Dehydroepiandrosterone (DHEA) increases territorial song and the size of an associated brain region in a male songbird, Horm. Behav., 41, 203, 10.1006/hbeh.2001.1750 Soreni, 1999, Decreased platelet peripheral-type benzodiazepine receptors in adolescent inpatients with repeated suicide attempts, Biol. Psychiatry, 46, 484, 10.1016/S0006-3223(98)00342-4 Stork, 2000, Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65, Brain Res., 865, 45, 10.1016/S0006-8993(00)02206-X Takahashi, 1985, Diencephalic sites of progesterone action for inhibiting aggression and facilitating sexual receptivity in estrogen-primed golden hamsters, Endocrinology, 116, 2393, 10.1210/endo-116-6-2393 Tecott, 2000, Designer genes and anti-anxiety drugs, Nat. Neurosci., 3, 529, 10.1038/75692 Tepper, 1995, GABAA receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons, J. Neurosci., 15, 3092, 10.1523/JNEUROSCI.15-04-03092.1995 Thompson, 1964, Visual reinforcement in fighting cocks, J. Exp. Anal. Behav., 7, 45, 10.1901/jeab.1964.7-45 Thompson, 1969, Aggressive behaviour of siamese fighting fish, 15 Thompson, 1966, Aggressive behavior and extinction-induced response-rate increase, Psychon. Sci., 5, 335, 10.3758/BF03328426 Uzunov, 1996, Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography, Proc. Natl. Acad. Sci. USA, 93, 12599, 10.1073/pnas.93.22.12599 Valzelli, 1967, Pharmacological control of aggressive behavior in mice, Eur. J. Pharmacol., 2, 144, 10.1016/0014-2999(67)90040-4 van der Poel, 1991, Long ultrasonic calls in male rats following mating, defeat and aversive stimulation, Behaviour, 119, 127, 10.1163/156853991X00409 VanDoren, 2000, Neuroactive steroid 3α-hydroxy-5α-pregnane-20-one modulates electrophysiological and behavioral actions of ethanol, J. Neurosci., 20, 1982, 10.1523/JNEUROSCI.20-05-01982.2000 Van Erp, 1997, Increased aggression after ethanol self-administration in male resident rats, Psychopharmacology, 131, 287, 10.1007/s002130050295 Van̈over, 1999, Positive allosteric modulators of the GABAA receptor, Psychopharmacology, 141, 77, 10.1007/s002130050809 Vitiello, 1997, Subtypes of aggression and their relevance to child psychiatry, J. Am. Acad. Child Adolesc. Psychiatry, 36, 307, 10.1097/00004583-199703000-00008 Wafford, 1991, Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the γ2L subunit, Neuron, 7, 27, 10.1016/0896-6273(91)90071-7 Weerts, 1996, Primate vocalizations during social separation and aggression, Psychopharmacology, 127, 255, 10.1007/BF02806001 Weerts, 1993, Prevention of the proaggressive effects of alcohol by benzodiazepine receptor antagonists in rats and in squirrel monkeys, Psychopharmacology, 111, 144, 10.1007/BF02245516 Weinbroum, 2001, The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature, Eur. J. Anaesthesiol., 18, 789, 10.1046/j.1365-2346.2001.00922.x Weisman, 1998, Effects of clorazepate, diazepam, and oxazepam on a laboratory measurement of aggression in men, Int. Clin. Psychopharmacol., 13, 183, 10.1097/00004850-199807000-00005 Wieland, 1991, Anxiolytic activity of the progesterone metabolite 5alpha-pregnan-3alpha-ol-20-one, Brain Res., 565, 263, 10.1016/0006-8993(91)91658-N Wilson, 1974 Wohlfarth, 2002, Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit, J. Neurosci., 22, 1541, 10.1523/JNEUROSCI.22-05-01541.2002 Zumpe, 1996, Social factors modulate the effects of hormones on the sexual and aggressive behavior of macaques, Am. J. Primatol., 38, 233, 10.1002/(SICI)1098-2345(1996)38:3<233::AID-AJP4>3.0.CO;2-# Zwain, 2002, A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing hormone (GnRH) release by GnRH neurons, Neuroendocrinology, 75, 375, 10.1159/000059434