Lupus gut microbiota transplants cause autoimmunity and inflammation

Yu, 2017, Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer, Gut, 66, 70, 10.1136/gutjnl-2015-309800 Liu, 2019, Alterations in the gut microbiome and metabolism with coronary artery disease severity, Microbiome, 7, 68, 10.1186/s40168-019-0683-9 De Luca, 2019, The microbiome in autoimmune diseases, Clin. Exp. Immunol., 195, 74, 10.1111/cei.13158 Justiz Vaillant, 2021, Systemic Lupus Erythematosus Hevia, 2014, Intestinal dysbiosis associated with systemic lupus erythematosus, mBio, 5, 10.1128/mBio.01548-14 He, 2016, Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus, Gut Pathog, 8, 64, 10.1186/s13099-016-0146-9 Chen, 2021, An autoimmunogenic and Proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus, Arthritis Rheum., 73, 232, 10.1002/art.41511 Mu, 2017, Control of lupus nephritis by changes of gut microbiota, Microbiome, 5, 73, 10.1186/s40168-017-0300-8 Luo, 2018, Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus, Appl. Environ. Microbiol., 84, 10.1128/AEM.02288-17 Mu, 2017, Antibiotics ameliorate lupus-like symptoms in mice, Sci. Rep., 7, 13675, 10.1038/s41598-017-14223-0 de la Visitacion, 2021, Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus, Br. J. Pharmacol., 178, 3708, 10.1111/bph.15512 Ma, 2015, Applications of next-generation sequencing in systemic autoimmune diseases, Genom. Proteomics Bioinform., 13, 242, 10.1016/j.gpb.2015.09.004 Zegarra-Ruiz, 2019, A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity, Cell Host Microbe, 25, 113, 10.1016/j.chom.2018.11.009 Azzouz, 2019, Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal, Ann. Rheum. Dis., 78, 947, 10.1136/annrheumdis-2018-214856 Chen, 2009, Development and function of IL-10 IFN-gamma-secreting CD4(+) T cells, J. Leukoc. Biol., 86, 1305, 10.1189/jlb.0609406 Elkon, 2012, Type I IFN system in the development and manifestations of SLE, Curr. Opin. Rheumatol., 24, 499, 10.1097/BOR.0b013e3283562c3e Liu, 2020, IFN-gamma mediates the development of systemic lupus erythematosus, Biomed. Res. Int., 2020, 7176515 Pabst, 2012, New concepts in the generation and functions of IgA, Nat. Rev. Immunol., 12, 821, 10.1038/nri3322 Kau, 2015, Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy, Sci. Transl. Med., 7, 10.1126/scitranslmed.aaa4877 Karin, 2020, CXCR3 ligands in Cancer and autoimmunity, Chemoattraction of effector T cells, and beyond, Front. Immunol., 11, 976, 10.3389/fimmu.2020.00976 Ost, 2018, Communication between the microbiota and mammalian immunity, Annu. Rev. Microbiol., 72, 399, 10.1146/annurev-micro-090817-062307 Ouyang, 2011, (1)H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus, Lupus, 20, 1411, 10.1177/0961203311418707 Yan, 2016, Serum metabolomic profiling in patients with systemic lupus erythematosus by GC/MS, Mod. Rheumatol., 26, 914, 10.3109/14397595.2016.1158895 Adlesic, 2007, Histamine in rheumatoid arthritis, Scand. J. Immunol., 65, 530, 10.1111/j.1365-3083.2007.01938.x Schaper-Gerhardt, 2020, The role of the histamine H4 receptor in atopic dermatitis and psoriasis, Br. J. Pharmacol., 177, 490, 10.1111/bph.14550 Tachibana, 1985, Histamine metabolism in skin of MRL/l mice, Arch. Dermatol. Res., 278, 57, 10.1007/BF00412497 Zampeli, 2009, The role of histamine H4 receptor in immune and inflammatory disorders, Br. J. Pharmacol., 157, 24, 10.1111/j.1476-5381.2009.00151.x Magoc, 2011, FLASH: fast length adjustment of short reads to improve genome assemblies, Bioinformatics, 27, 2957, 10.1093/bioinformatics/btr507 Edgar, 2011, UCHIME improves sensitivity and speed of chimera detection, Bioinformatics, 27, 2194, 10.1093/bioinformatics/btr381 Haas, 2011, Chimeric 16S rRNA sequence formation and detection in sanger and 454-pyrosequenced PCR amplicons, Genome Res., 21, 494, 10.1101/gr.112730.110 Edgar, 2013, UPARSE: highly accurate OTU sequences from microbial amplicon reads, Nat. Methods, 10, 996, 10.1038/nmeth.2604 Edgar, 2004, MUSCLE: multiple sequence alignment with high accuracy and high throughput, Nucleic Acids Res., 32, 1792, 10.1093/nar/gkh340 Weigmann, 2007, Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue, Nat. Protoc., 2, 2307, 10.1038/nprot.2007.315 Ma, 2019, Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus, Mol. Med., 25, 35, 10.1186/s10020-019-0102-5 Lugtenberg, 1999, Tomato seed and root exudate sugars: composition, utilization by Pseudomonas biocontrol strains and role in rhizosphere colonization, Environ. Microbiol., 1, 439, 10.1046/j.1462-2920.1999.00054.x