Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nature - Tập 534 Số 7605 - Trang 47-54 - 2016
Serena Nik‐Zainal1, Helen Davies1, Johan Staaf2, Manasa Ramakrishna1, Dominik Głodzik1, Xueqing Zou1, Iñigo Martincorena1, Ludmil B. Alexandrov1, Sancha Martin1, David C. Wedge1, Peter Van Loo1, Young Seok Ju1, Marcel Smid3, Arie B. Brinkman4, Sandro Morganella5, Rameen Beroukhim6, Ole Christian Lingjærde7, Anita Grigoriadis6, Markus Ringnér2, Sung‐Min Ahn8, Sandrine Boyault9, Jane E. Brock10, Annegien Broeks11, Adam P. Butler1, Christine Desmedt12, Luc Dirix13, Serge Dronov1, Aquila Fatima14, John A. Foekens3, Moritz Gerstung1, Gerrit K. Hooijer15, Se Jin Jang16, David R. Jones1, Hyung Yong Kim17, Tari A. King18, Savitri Krishnamurthy19, Han‐Byoel Lee16, Jeong‐Yeon Lee20, Yilong Li1, Stuart McLaren1, Andrew Menzies1, Ville Mustonen1, Sarah O’Meara1, Iris Pauporté21, Daniel Birnbaum22, Colin A. Purdie23, Keiran Raine1, Kamna Ramakrishnan1, F. Germán Rodríguez-González3, Gilles Romieu24, Anieta M. Sieuwerts3, Peter T. Simpson25, Rebecca Shepherd1, Lucy Stebbings1, Olafur A. Stefansson26, Joshua M. Stuart1, Stefania Tommasi27, Isabelle Treilleux28, Gert G. Van den Eynden13, Peter Vermeulen13, Anne Vincent‐Salomon29, Lucy Yates1, Carlos Caldas30, Laura van’t Veer11, Andrew Tutt31, Stian Knappskog32, Benita Kiat Tee Tan33, Jos Jonkers11, Åke Borg2, Naoto T. Ueno19, Christos Sotiriou12, Alain Viari34, P. Andrew Futreal35, Paul N. Span36, Steven Van Laere13, Sunil R. Lakhani25, Jorunn E. Eyfjord26, Alastair M. Thompson23, Ewan Birney5, Hendrik G. Stunnenberg4, Marc J. van de Vijver15, John W.M. Martens3, Arto Mannermaa7, Andrea L. Richardson14, Gu Kong17, Anna Ehinger37, Michael R. Stratton1
1Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
2Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, SE-223 81, Sweden
3Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam, 3015CN, The Netherlands
4Department of Molecular Biology, Radboud University, Faculty of Science, Nijmegen, 6525GA, The Netherlands
5European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, Cambridge, UK
6Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, 0310, Norway
7K. G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, 0310, Norway
8Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Center, Incheon, South Korea
9Translational Research Lab, Centre Léon Bérard, 28, rue Laënnec, Lyon Cedex, 69373, 08, France
10Department of Pathology, Brigham and Women’s Hospital, Boston, 02115, Massachusetts, USA
11The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands
12Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, Bd de Waterloo, 121, B-1000, Brussels, Belgium
13Translational Cancer Research Unit, Center for Oncological Research, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
14Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA
15Department of Pathology, Academic Medical Center, Meibergdreef, Amsterdam, 9, 1105 AZ, The Netherlands
16Department of Pathology, Asan Medical Center, College of Medicine, Ulsan University, Ulsan, South Korea
17Department of Pathology, College of Medicine, Hanyang University, Seoul 133-791, South Korea
18Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, 10065, New York, USA
19Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard., Houston, 77030, Texas, USA
20Institute for Bioengineering and Biopharmaceutical Research (IBBR), Hanyang University, Seoul, South Korea
21Research Division, Clinical Research Department, Institut National du Cancer, 52 avenue Morizet, Boulogne-Billancourt, 92513, France
22University Hospital of Minjoz, INSERM UMR 1098, Bd Fleming, Besançon, 25000, France
23Pathology Department, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
24Oncologie Sénologie, ICM Institut Régional du Cancer, Montpellier, France
25The University of Queensland, UQ Centre for Clinical Research and School of Medicine, Brisbane, 4029, Queensland, Australia
26Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
27IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy
28Department of Pathology, Centre Léon Bérard, 28 rue Laënnec, Lyon, 69373, Cédex 08, France
29Department of Pathology and INSERM U934, Institut Curie, Paris Sciences Lettres University, 26 rue d’Ulm, Paris, 75248, Cedex 05, France
30Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
31Breast Cancer Now Research Unit, King’s College London, London, SE1 9RT, UK
32Department of Clinical Science, University of Bergen, Bergen 5020, Norway
33National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore
34Equipe Erable, INRIA Grenoble-Rhône-Alpes, 655, Avenue de l’Europe, Montbonnot-Saint, 38330, Martin, France
35Department of Genomic Medicine, UT MD Anderson Cancer Center, Houston, 77230, Texas, USA
36Department of Radiation Oncology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, 6525GA, The Netherlands
37Synergie Lyon Cancer, Centre Léon Bérard, 28 rue Laënnec, Lyon, Cedex 08, France

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Nature

Tập 534 Số 7605

47-54

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