Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study

Uccelli, 2011, Neuroprotective features of mesenchymal stem cells, Best Prac Res Clin Haematol, 24, 59, 10.1016/j.beha.2011.01.004 Uccelli, 2008, Mesenchymal stem cells in health and disease, Nat Rev Immunol, 8, 726, 10.1038/nri2395 Corti, 2004, Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues, Brain, 127, 2518, 10.1093/brain/awh273 Vercelli, 2008, Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in a mouse model of amyotrophic lateral sclerosis, Neurobiol Dis, 31, 10.1016/j.nbd.2008.05.016 Mazzini, 2008, Stem cell treatment in amyotrophic lateral sclerosis, J Neurol Sci, 265, 78, 10.1016/j.jns.2007.05.016 Mazzini, 2010, Mesenchymal stem cell transplantation i n amyotrophic lateral sclerosis: a phase I clinical trial, Exp Neurol, 223, 229, 10.1016/j.expneurol.2009.08.007 Mazzini, 2006, Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis, Neurol Res, 28, 523, 10.1179/016164106X116791 Appel, 2008, Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis, Neurology, 71, 1326, 10.1212/01.wnl.0000327668.43541.22 Blanquer, 2010, A surgical technique of spinal cord cell transplantation in amyotrophic lateral sclerosis, J Neurosci Meth, 191, 255, 10.1016/j.jneumeth.2010.06.014 Deda, 2009, Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up, Cytotherapy, 11, 18, 10.1080/14653240802549470 Huang, 2008, Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study, Clin Transplant, 22, 710, 10.1111/j.1399-0012.2008.00865.x Karussis, 2010, Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis, Arch Neurol, 67, 1187, 10.1001/archneurol.2010.248 Martinez, 2009, Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients, Cytotherapy, 11, 26, 10.1080/14653240802644651 Mazzini, 2009, Stem cells in amyotrophic lateral sclerosis: state of the art, Expert Opin Biol Ther, 9, 1245, 10.1517/14712590903186956 Rosland, 2009, Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation, Cancer Res, 69, 5331, 10.1158/0008-5472.CAN-08-4630 Rubio, 2005, Spontaneous human adult stem cell transformation, Cancer Res, 65, 3035, 10.1158/0008-5472.CAN-04-4194 Garcia, 2010, Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells, Exp Cell Res, 316, 1648, 10.1016/j.yexcr.2010.02.016 Torsvik, 2010, Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track. Letter, Cancer Res, 70, 6393, 10.1158/0008-5472.CAN-10-1305 Bernardo, 2007, Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms, Cancer Res, 67, 9142, 10.1158/0008-5472.CAN-06-4690 Kim, 2009, Biological characterization of long-term cultured human mesenchymal stem cells, Arch Pharm Res, 32, 117, 10.1007/s12272-009-1125-1 Tarte, 2010, Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation, Blood, 115, 1549, 10.1182/blood-2009-05-219907 Ferrero, 2008, Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients, Cell Transplant, 17, 255, 10.3727/096368908784153940 Chio, 2009, Prognostic factors in ALS: a critical review, Amyotroph Lateral Scler, 10, 310, 10.3109/17482960802566824 Wijesekera, 2009, Amyotrophic lateral sclerosis, Orphanet J Rare Dis., 4, 3, 10.1186/1750-1172-4-3 Raore, 2011, Cervical multilevel intraspinal stem cell therapy: assessment of surgical risks in Gottingen minipigs, Spine (Phila Pa 1976), 36, E164, 10.1097/BRS.0b013e3181d77a47