Cancer stem cells and metastasis

Li, 2010, Coexistence of quiescent and active adult stem cells in mammals, Science, 327, 542, 10.1126/science.1180794 Barker, 2009, Crypt stem cells as the cells-of-origin of intestinal cancer, Nature, 457, 608, 10.1038/nature07602 Zhu, 2009, Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation, Nature, 457, 603, 10.1038/nature07589 Cozzio, 2003, Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors, Genes Dev, 17, 3029, 10.1101/gad.1143403 Visvader, 2008, Cancer stem cells in solid tumours: accumulating evidence and unresolved questions, Nat Rev Cancer, 8, 755, 10.1038/nrc2499 Bonnet, 1997, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat Med, 3, 730, 10.1038/nm0797-730 Al-Hajj, 2003, Prospective identification of tumorigenic breast cancer cells, Proc Natl Acad Sci U S A, 100, 3983, 10.1073/pnas.0530291100 O’Brien, 2007, A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature, 445, 106, 10.1038/nature05372 Ricci-Vitiani, 2007, Identification and expansion of human colon-cancer-initiating cells, Nature, 445, 111, 10.1038/nature05384 Singh, 2004, Identification of human brain tumour initiating cells, Nature, 432, 396, 10.1038/nature03128 Clarke, 2006, Cancer stem cells – perspectives on current status and future directions: AACR Workshop on cancer stem cells, Cancer Res, 66, 9339, 10.1158/0008-5472.CAN-06-3126 Thiery, 2009, Epithelial–mesenchymal transitions in development and disease, Cell, 139, 871, 10.1016/j.cell.2009.11.007 Yang, 2008, Epithelial–mesenchymal transition: at the crossroads of development and tumor metastasis, Dev Cell, 14, 818, 10.1016/j.devcel.2008.05.009 Mani, 2008, The epithelial–mesenchymal transition generates cells with properties of stem cells, Cell, 133, 704, 10.1016/j.cell.2008.03.027 Le, 2008, Tumour–stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness, Br J Cancer, 98, 1886, 10.1038/sj.bjc.6604401 Brabletz, 2001, Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment, Proc Natl Acad Sci U S A, 98, 10356, 10.1073/pnas.171610498 Brabletz, 2005, Opinion: migrating cancer stem cells – an integrated concept of malignant tumour progression, Nat Rev Cancer, 5, 744, 10.1038/nrc1694 Fodde, 2007, Wnt/beta-catenin signaling in cancer stemness and malignant behavior, Curr Opin Cell Biol, 19, 150, 10.1016/j.ceb.2007.02.007 Pantel, 2004, Dissecting the metastatic cascade, Nat Rev Cancer, 4, 448, 10.1038/nrc1370 Pantel, 2008, Detection, clinical relevance and specific biological properties of disseminating tumour cells, Nat Rev Cancer, 8, 329, 10.1038/nrc2375 Pantel, 2009, Cancer micrometastases, Nat Rev Clin Oncol, 6, 339, 10.1038/nrclinonc.2009.44 Braun, 2005, A pooled analysis of bone marrow micrometastasis in breast cancer, N Engl J Med, 353, 793, 10.1056/NEJMoa050434 Becker, 2006, Detection of cytokeratin-positive cells in the bone marrow of breast cancer patients undergoing adjuvant therapy, Breast Cancer Res Treat, 97, 91, 10.1007/s10549-005-9095-6 Becker, 2007, Primary systemic therapy does not eradicate disseminated tumor cells in breast cancer patients, Breast Cancer Res Treat, 106, 239, 10.1007/s10549-006-9484-5 Muller, 2005, Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity, Clin Cancer Res, 11, 3678, 10.1158/1078-0432.CCR-04-2469 Alix-Panabieres, 2007, Detection and characterization of putative metastatic precursor cells in cancer patients, Clin Chem, 53, 537, 10.1373/clinchem.2006.079509 Balic, 2006, Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype, Clin Cancer Res, 12, 5615, 10.1158/1078-0432.CCR-06-0169 Gassmann, 2009, CXCR4 regulates the early extravasation of metastatic tumor cells in vivo, Neoplasia, 11, 651, 10.1593/neo.09272 Huang, 2009, Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways, J Cell Physiol, 221, 204, 10.1002/jcp.21846 Muller, 2001, Involvement of chemokine receptors in breast cancer metastasis, Nature, 410, 50, 10.1038/35065016 Hermann, 2007, Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer, Cell Stem Cell, 1, 313, 10.1016/j.stem.2007.06.002 Dalerba, 2007, Phenotypic characterization of human colorectal cancer stem cells, Proc Natl Acad Sci U S A, 104, 10158, 10.1073/pnas.0703478104 Vermeulen, 2010, Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, Nat Cell Biol, 12, 468, 10.1038/ncb2048 Dieter, 2011, Distinct types of tumor-initiating cells form human colon cancer tumors and metastases, Cell Stem Cell, 9, 357, 10.1016/j.stem.2011.08.010 Pang, 2010, A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer, Cell Stem Cell, 6, 603, 10.1016/j.stem.2010.04.001 Merlos-Suarez, 2011, The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse, Cell Stem Cell, 8, 511, 10.1016/j.stem.2011.02.020 de Sousa, 2011, Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients, Cell Stem Cell, 9, 476, 10.1016/j.stem.2011.10.008 Ginestier, 2007, ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome, Cell Stem Cell, 1, 555, 10.1016/j.stem.2007.08.014 Chute, 2006, Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells, Proc Natl Acad Sci U S A, 103, 11707, 10.1073/pnas.0603806103 Charafe-Jauffret, 2009, Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature, Cancer Res, 69, 1302, 10.1158/0008-5472.CAN-08-2741 Croker, 2009, High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability, J Cell Mol Med, 13, 2236, 10.1111/j.1582-4934.2008.00455.x Jiang, 2009, Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer, Mol Cancer Res, 7, 330, 10.1158/1541-7786.MCR-08-0393 Chen, 2009, Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer, Biochem Biophys Res Commun, 385, 307, 10.1016/j.bbrc.2009.05.048 Sun, 2010, ALDH high adenoid cystic carcinoma cells display cancer stem cell properties and are responsible for mediating metastasis, Biochem Biophys Res Commun, 396, 843, 10.1016/j.bbrc.2010.04.170 Shipitsin, 2008, The cancer stem cell hypothesis: in search of definitions, markers, and relevance, Lab Invest, 88, 459, 10.1038/labinvest.2008.14 Huff, 2006, The paradox of response and survival in cancer therapeutics, Blood, 107, 431, 10.1182/blood-2005-06-2517 Bao, 2006, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, 444, 756, 10.1038/nature05236 Creighton, 2009, Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features, Proc Natl Acad Sci U S A, 106, 13820, 10.1073/pnas.0905718106 Li, 2008, Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells, BMC Cancer, 8, 135, 10.1186/1471-2407-8-135 Phillips, 2006, The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation, J Natl Cancer Inst, 98, 1777, 10.1093/jnci/djj495 Roth, 2011, Quiescent stem cells in intestinal homeostasis and cancer, Cell Commun Adhes, 18, 33, 10.3109/15419061.2011.615422 Aguirre-Ghiso, 2007, Models, mechanisms and clinical evidence for cancer dormancy, Nat Rev Cancer, 7, 834, 10.1038/nrc2256 Muller, 2010, Insights into minimal residual disease in cancer patients: implications for anti-cancer therapies, Eur J Cancer, 46, 1189, 10.1016/j.ejca.2010.02.038 Hanrahan, 2007, Overall survival and cause-specific mortality of patients with stage T1a,bN0M0 breast carcinoma, J Clin Oncol, 25, 4952, 10.1200/JCO.2006.08.0499 Saphner, 1996, Annual hazard rates of recurrence for breast cancer after primary therapy, J Clin Oncol, 14, 2738, 10.1200/JCO.1996.14.10.2738 Sargent, 2007, End points for colon cancer adjuvant trials: observations and recommendations based on individual patient data from 20,898 patients enrolled onto 18 randomized trials from the ACCENT Group, J Clin Oncol, 25, 4569, 10.1200/JCO.2006.10.4323 Roesch, 2010, A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth, Cell, 141, 583, 10.1016/j.cell.2010.04.020 Saito, 2010, Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML, Nat Biotechnol, 28, 275, 10.1038/nbt.1607 Pece, 2010, Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content, Cell, 140, 62, 10.1016/j.cell.2009.12.007 Gao, 2010, CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells, Oncogene, 29, 2672, 10.1038/onc.2010.35 Kusumbe, 2009, Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy, Cancer Res, 69, 9245, 10.1158/0008-5472.CAN-09-2802 Dembinski, 2009, Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma, Clin Exp Metastasis, 26, 611, 10.1007/s10585-009-9260-0 Haraguchi, 2010, CD13 is a therapeutic target in human liver cancer stem cells, J Clin Invest, 120, 3326, 10.1172/JCI42550 Knutsen, 1998, Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL, Genes Chromosomes Cancer, 23, 44, 10.1002/(SICI)1098-2264(199809)23:1<44::AID-GCC7>3.0.CO;2-6 Mickley, 1997, Gene rearrangement: a novel mechanism for MDR-1 gene activation, J Clin Invest, 99, 1947, 10.1172/JCI119362 Diehn, 2009, Association of reactive oxygen species levels and radioresistance in cancer stem cells, Nature, 458, 780, 10.1038/nature07733 Wang, 2003, Targeting Bcl-2 and Bcl-XL with nonpeptidic small-molecule antagonists, Semin Oncol, 30, 133, 10.1053/j.seminoncol.2003.08.015 Stassi, 2003, Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10, Cancer Res, 63, 6784 Todaro, 2007, Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4, Cell Stem Cell, 1, 389, 10.1016/j.stem.2007.08.001 Rich, 2007, Chemotherapy and cancer stem cells, Cell Stem Cell, 1, 353, 10.1016/j.stem.2007.09.011 Reya, 2001, Stem cells, cancer, and cancer stem cells, Nature, 414, 105, 10.1038/35102167 Jones, 2009, Cancer stem cells-clinical relevance, J Mol Med (Berl), 87, 1105, 10.1007/s00109-009-0534-4 Fortini, 2009, Notch signaling: the core pathway and its posttranslational regulation, Dev Cell, 16, 633, 10.1016/j.devcel.2009.03.010 Dontu, 2004, Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells, Breast Cancer Res, 6, R605, 10.1186/bcr920 Harrison, 2010, Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor, Cancer Res, 70, 709, 10.1158/0008-5472.CAN-09-1681 Hoey, 2009, DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency, Cell Stem Cell, 5, 168, 10.1016/j.stem.2009.05.019 Li, 2008, Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3, J Biol Chem, 283, 8046, 10.1074/jbc.M800170200 Tammam, 2009, Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia, Br J Pharmacol, 158, 1183, 10.1111/j.1476-5381.2009.00389.x McGowan, 2011, Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer, Mol Cancer Res, 9, 834, 10.1158/1541-7786.MCR-10-0457 Dierks, 2008, Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation, Cancer Cell, 14, 238, 10.1016/j.ccr.2008.08.003 Hofmann, 2009, Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis, Cell Stem Cell, 4, 559, 10.1016/j.stem.2009.03.016 Merchant, 2010, Targeting Hedgehog – a cancer stem cell pathway, Clin Cancer Res, 16, 3130, 10.1158/1078-0432.CCR-09-2846 Watkins, 2003, Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer, Nature, 422, 313, 10.1038/nature01493 Xie, 1998, Activating Smoothened mutations in sporadic basal-cell carcinoma, Nature, 391, 90, 10.1038/34201 Jiang, 2008, Hedgehog signaling in development and cancer, Dev Cell, 15, 801, 10.1016/j.devcel.2008.11.010 Feldmann, 2008, An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer, Mol Cancer Ther, 7, 2725, 10.1158/1535-7163.MCT-08-0573 Nusse, 2008, Wnt signaling and stem cell control, Cold Spring Harb Symp Quant Biol, 73, 59, 10.1101/sqb.2008.73.035 Malanchi, 2008, Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling, Nature, 452, 650, 10.1038/nature06835 Reya, 2005, Wnt signalling in stem cells and cancer, Nature, 434, 843, 10.1038/nature03319 Watt, 2008, Role of beta-catenin in epidermal stem cell expansion, lineage selection, and cancer, Cold Spring Harb Symp Quant Biol, 73, 503, 10.1101/sqb.2008.73.011 Zeng, 2010, Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture, Cell Stem Cell, 6, 568, 10.1016/j.stem.2010.03.020 Fodde, 2001, APC, signal transduction and genetic instability in colorectal cancer, Nat Rev Cancer, 1, 55, 10.1038/35094067 Morin, 1997, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Science, 275, 1787, 10.1126/science.275.5307.1787 Chen, 2009, Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer, Nat Chem Biol, 5, 100, 10.1038/nchembio.137 Fujii, 2007, An antagonist of dishevelled protein–protein interaction suppresses beta-catenin-dependent tumor cell growth, Cancer Res, 67, 573, 10.1158/0008-5472.CAN-06-2726 Shan, 2005, Identification of a specific inhibitor of the dishevelled PDZ domain, Biochemistry, 44, 15495, 10.1021/bi0512602 Emami, 2004, A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected], Proc Natl Acad Sci U S A, 101, 12682, 10.1073/pnas.0404875101 He, 2005, Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations, Oncogene, 24, 3054, 10.1038/sj.onc.1208511 You, 2004, An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth, Cancer Res, 64, 5385, 10.1158/0008-5472.CAN-04-1227 Gupta, 2009, Identification of selective inhibitors of cancer stem cells by high-throughput screening, Cell, 138, 645, 10.1016/j.cell.2009.06.034 Lu, 2011, Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells, Proc Natl Acad Sci U S A, 108, 13253, 10.1073/pnas.1110431108 Tang, 2011, Salinomycin inhibits osteosarcoma by targeting its tumor stem cells, Cancer Lett, 311, 113, 10.1016/j.canlet.2011.07.016 Ginestier, 2010, CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts, J Clin Invest, 120, 485, 10.1172/JCI39397 Elwood, 2009, Aspirin, salicylates, and cancer, Lancet, 373, 1301, 10.1016/S0140-6736(09)60243-9 Cianferoni, 2001, Selective inhibition of interleukin-4 gene expression in human T cells by aspirin, Blood, 97, 1742, 10.1182/blood.V97.6.1742 Chan, 2009, Aspirin use and survival after diagnosis of colorectal cancer, Jama, 302, 649, 10.1001/jama.2009.1112 Neugut, 2009, Aspirin as adjuvant therapy for colorectal cancer: a promising new twist for an old drug, Jama, 302, 688, 10.1001/jama.2009.1145 Buijs, 2011, The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation, Oncogene