Regulatory Regions Driving Developmental and Tissue-Specific Expression of the Essential Pancreatic Gene pdx1

Developmental Biology - Tập 238 - Trang 185-201 - 2001
Maureen Gannon1, Laura W. Gamer1, Christopher V.E. Wright1
1Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee, 37232

Tài liệu tham khảo

Ahlgren, 1996, The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice, Development, 122, 1409, 10.1242/dev.122.5.1409 Ahlgren, 1998, beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes, Genes Dev., 12, 1763, 10.1101/gad.12.12.1763 Ahlgren, 1997, Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells, Nature, 385, 257, 10.1038/385257a0 Alpert, 1988, Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons, Cell, 53, 295, 10.1016/0092-8674(88)90391-1 Apelqvist, 1999, Notch signalling controls pancreatic cell differentiation, Nature, 400, 877, 10.1038/23716 Backstrom, 2000, Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses, J. Biol. Chem., 275, 23620, 10.1074/jbc.M000922200 Duncan, 1998, Regulation of a transcription factor network required for differentiation and metabolism, Science, 281, 692, 10.1126/science.281.5377.692 Dutta, 1998, Regulatory factor linked to late-onset diabetes?, Nature, 392, 560, 10.1038/33311 Dutta, 2001, PDX:PBX complexes are required for normal proliferation of pancreatic cells during development, Proc. Natl. Acad. Sci. USA, 98, 1065, 10.1073/pnas.98.3.1065 Gannon, 2000, Mosaic Cre-mediated. recombination in pancreas using the pdx-1 enhancer/promoter, Genesis, 26, 143, 10.1002/(SICI)1526-968X(200002)26:2<143::AID-GENE13>3.0.CO;2-L Gannon, 2000, Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function, Development, 127, 2883, 10.1242/dev.127.13.2883 Gannon, 1999, Endodermal patterning and organogenesis, 583 Gerrish, 2000, Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites, J. Biol. Chem., 275, 3485, 10.1074/jbc.275.5.3485 Gerrish, 2000, Regulation of PDX1 gene expression, 251 Glick, 2000, Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter, J. Biol. Chem., 275, 2199, 10.1074/jbc.275.3.2199 Goldhamer, 1995, Embryonic activation of the myoD gene is regulated by a highly conserved distal control element, Development, 121, 637, 10.1242/dev.121.3.637 Gradwohl, 2000, neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas, Proc. Natl. Acad. Sci. USA, 97, 1607, 10.1073/pnas.97.4.1607 Guz, 1995, Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny, Development, 121, 11, 10.1242/dev.121.1.11 Harrison, 1999, Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice, Nat. Genet., 23, 71, 10.1038/12674 Hebrok, 1998, Notochord repression of endodermal Sonic hedgehog permits pancreas development, Genes Dev., 12, 1705, 10.1101/gad.12.11.1705 Hogan, 1994 Horikawa, 1997, Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MOD, Nat. Genet., 17, 384, 10.1038/ng1297-384 Jacquemin, 2000, Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene, ngn3. Mol. Cell. Biol., 20, 4445, 10.1128/MCB.20.12.4445-4454.2000 Jensen, 2000, Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation, Diabetes, 49, 163, 10.2337/diabetes.49.2.163 Jonsson, 1994, Insulin-promoter-factor 1 is required for pancreas development in mice, Nature, 371, 606, 10.1038/371606a0 Kim, 1997, Notochord to endoderm signaling is required for pancreas development, Development, 124, 4243, 10.1242/dev.124.21.4243 Krapp, 1998, The bHLH protein PTF1–p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas, Genes Dev., 12, 3752, 10.1101/gad.12.23.3752 Larsson, 1996, Pancreatic-duodenal homeobox 1-role in gastric endocrine patterning, Mech. Dev., 60, 175, 10.1016/S0925-4773(96)00609-0 Lebenthal, 1999, The ontogeny of the small intestinal epithelium, J. Parenter. Enteral Nutr., 23, S3, 10.1177/014860719902300502 Li, 1999, Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9, Nat. Genet., 23, 67, 10.1038/12669 Macfarlane, 2000, Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes, J. Clin. Invest., 106 Macfarlane, 1999, Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells, J. Biol. Chem., 274, 1011, 10.1074/jbc.274.2.1011 Macfarlane, 2000, Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+, Diabetes, 49, 418, 10.2337/diabetes.49.3.418 Menard, 1994, Morphological changes and cellular proliferation in mouse colon during fetal and postnatal development, Anat. Rec., 238, 349, 10.1002/ar.1092380309 Naya, 1997, Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice, Genes Dev., 11, 2323, 10.1101/gad.11.18.2323 Offield, 1996, PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum, Development, 122, 983, 10.1242/dev.122.3.983 Roberts, 1994, Hox11 controls the genesis of the spleen, Nature, 368, 747, 10.1038/368747a0 Sasaki, 1996, Enhancer analysis of the mouse HNF-3 beta gene: Regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements, Genes Cells, 1, 59, 10.1046/j.1365-2443.1996.04004.x Sayo, 2000, Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells, Eur. J. Biochem., 267, 971, 10.1046/j.1432-1327.2000.01080.x Schwitzgebel, 2000, Expression of neurogenin3 reveals an islet cell precursor population in the pancreas, Development, 127, 3533, 10.1242/dev.127.16.3533 Shapiro, 2000, Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen, N. Engl. J. Med., 343, 230, 10.1056/NEJM200007273430401 Sharma, 1999, The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration, Diabetes, 48, 507, 10.2337/diabetes.48.3.507 Sharma, 1997, Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1, Mol. Cell. Biol., 17, 2598, 10.1128/MCB.17.5.2598 Sharma, 1996, Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF, J. Biol. Chem., 271, 2294, 10.1074/jbc.271.4.2294 Song, 1999, Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha, Gastroenterology, 117, 1416, 10.1016/S0016-5085(99)70292-1 Sosa-Pineda, 1997, The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas, Nature, 386, 399, 10.1038/386399a0 St-Onge, 1997, Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas, Nature, 387, 406, 10.1038/387406a0 Stoffers, 1997, Early-onset type-II diabetes mellitus (MODY4) linked to IPF1, Nat. Genet., 17, 138, 10.1038/ng1097-138 Stoffers, 1997, Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence, Nat. Genet., 15, 106, 10.1038/ng0197-106 Stoffers, 1998, Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein, J. Clin. Invest., 102, 232, 10.1172/JCI2242 Stoffers, 1999, Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter, Endocrinology, 140, 5374, 10.1210/endo.140.11.7122 Sussel, 1998, Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells, Development, 125, 2213, 10.1242/dev.125.12.2213 Teitelman, 1993, Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide, Development, 118, 1031, 10.1242/dev.118.4.1031 Waeber, 1996, Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor, Mol. Endocrinol., 10, 1327 Watada, 1996, PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin, Diabetes, 45, 1826, 10.2337/diab.45.12.1826 Watada, 1996, The human glucokinase gene beta-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells, Diabetes, 45, 1478, 10.2337/diab.45.11.1478 Wessels, 1967, Early pancreas organogenesis: Morphogenesis, tissue interactions, and mass effects, Dev. Biol., 15, 237, 10.1016/0012-1606(67)90042-5 Wu, 1999, Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells, Biochem. J., 344, 813, 10.1042/0264-6021:3440813 Wu, 1997, Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene, Mol. Cell. Biol., 17, 6002, 10.1128/MCB.17.10.6002 Yamagata, 1996, Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) [see comments], Nature, 384, 458, 10.1038/384458a0 Yamagata, 1996, Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3), Nature, 384, 455, 10.1038/384455a0