Acetate Dependence of Tumors

Cell - Tập 159 - Trang 1591-1602 - 2014
Sarah A. Comerford1, Zhiguang Huang2, Xinlin Du2, Yun Wang2, Ling Cai2, Agnes K. Witkiewicz3, Holly Walters1, Mohammed N. Tantawy4,5, Allie Fu4, H. Charles Manning4,5,6, Jay D. Horton1, Robert E. Hammer2, Steven L. McKnight2, Benjamin P. Tu2
1Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390, USA
2Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA
3Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA
4Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA
5Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA
6Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA

Tài liệu tham khảo

Ariyannur, 2010, Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain, J. Comp. Neurol., 518, 2952, 10.1002/cne.22373 Berg, 1956, Acyl adenylates; an enzymatic mechanism of acetate activation, J. Biol. Chem., 222, 991, 10.1016/S0021-9258(20)89957-8 Blount, 2012, Genomic analysis of a key innovation in an experimental Escherichia coli population, Nature, 489, 513, 10.1038/nature11514 Cai, 2011, On acetyl-CoA as a gauge of cellular metabolic state, Cold Spring Harb. Symp. Quant. Biol., 76, 195, 10.1101/sqb.2011.76.010769 Cai, 2011, Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes, Mol. Cell, 42, 426, 10.1016/j.molcel.2011.05.004 Comerford, 2012, Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT’s C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver, Oncogenesis, 1, e28, 10.1038/oncsis.2012.27 De Virgilio, 1992, Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae, Yeast, 8, 1043, 10.1002/yea.320081207 Elston, 1991, Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up, Histopathology, 19, 403, 10.1111/j.1365-2559.1991.tb00229.x Fujino, 2001, Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate, J. Biol. Chem., 276, 11420, 10.1074/jbc.M008782200 Ho, 2003, 11C-acetate PET imaging in hepatocellular carcinoma and other liver masses, J. Nucl. Med., 44, 213 Jackson, 1975, Studies on highly metabolically active acetylation and phosphorylation of histones, J. Biol. Chem., 250, 4856, 10.1016/S0021-9258(19)41247-7 Jones, 1953, On the enzymatic mechanism of Coenzyme A acetylation with adenosine triphosphate and acetate, J. Am. Chem. Soc., 75, 3285, 10.1021/ja01109a517 Kaelin, 2013, Influence of metabolism on epigenetics and disease, Cell, 153, 56, 10.1016/j.cell.2013.03.004 Kawate, 1999, Amplification of c-myc in hepatocellular carcinoma: correlation with clinicopathologic features, proliferative activity and p53 overexpression, Oncology, 57, 157, 10.1159/000012024 Le, 2012, Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells, Cell Metab., 15, 110, 10.1016/j.cmet.2011.12.009 Leonardi, 2012, Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation, J. Biol. Chem., 287, 14615, 10.1074/jbc.C112.353946 Lesche, 2002, Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene, Genesis, 32, 148, 10.1002/gene.10036 Lipmann, 1945, The detection of activated carboxyl groups with hydroxylamine as interceptor, J. Biol. Chem., 161, 415, 10.1016/S0021-9258(17)41558-4 Luong, 2000, Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins, J. Biol. Chem., 275, 26458, 10.1074/jbc.M004160200 Marin-Valencia, 2012, Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo, Cell Metab., 15, 827, 10.1016/j.cmet.2012.05.001 Mashimo, 2014, Acetate is a bioenergetics substrate for human glioblastoma and brain metastases, Cell, 159, 1603, 10.1016/j.cell.2014.11.025 Metallo, 2012, Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia, Nature, 481, 380, 10.1038/nature10602 Mullen, 2012, Reductive carboxylation supports growth in tumour cells with defective mitochondria, Nature, 481, 385, 10.1038/nature10642 Nomori, 2008, 11C-Acetate can be used in place of 18F-fluorodeoxyglucose for positron emission tomography imaging of non-small cell lung cancer with higher sensitivity for well-differentiated adenocarcinoma, Journal of thoracic oncology, 3, 1427, 10.1097/JTO.0b013e31818ddfdc Oyama, 2002, 11C-acetate PET imaging of prostate cancer, J. Nucl. Med., 43, 181 Peng, 1993, Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance, J. Formos. Med. Assoc., 92, 866 Pérez-Chacón, 2009, Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases, Biochim. Biophys. Acta, 1791, 1103, 10.1016/j.bbalip.2009.08.007 Psychogios, 2011, The human serum metabolome, PLoS ONE, 6, e16957, 10.1371/journal.pone.0016957 Sandgren, 1989, Oncogene-induced liver neoplasia in transgenic mice, Oncogene, 4, 715 Shahbazian, 2007, Functions of site-specific histone acetylation and deacetylation, Annu. Rev. Biochem., 76, 75, 10.1146/annurev.biochem.76.052705.162114 Shi, 2013, Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae, Proc. Natl. Acad. Sci. USA, 110, 7318, 10.1073/pnas.1302490110 Srere, 1959, The citrate cleavage enzyme. I. Distribution and purification, J. Biol. Chem., 234, 2544, 10.1016/S0021-9258(18)69735-2 Srere, 1953, An enzymatic reaction between citrate, adenosine triphosphate and Coenzyme A, J. Am. Chem. Soc., 75, 4874, 10.1021/ja01115a547 Takahashi, 2006, Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription, Mol. Cell, 23, 207, 10.1016/j.molcel.2006.05.040 Tollinger, 1979, Measurement of acetate in human blood by gas chromatography: effects of sample preparation, feeding, and various diseases, Clin. Chem., 25, 1787, 10.1093/clinchem/25.10.1787 Tsuchida, 2008, Grading of brain glioma with 1-11C-acetate PET: comparison with 18F-FDG PET, Nucl. Med. Biol., 35, 171, 10.1016/j.nucmedbio.2007.11.004 Tu, 2005, Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes, Science, 310, 1152, 10.1126/science.1120499 van den Berg, 1996, The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation, J. Biol. Chem., 271, 28953, 10.1074/jbc.271.46.28953 Warburg, 1956, On respiratory impairment in cancer cells, Science, 124, 269, 10.1126/science.124.3215.269 Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309 Waterborg, 2002, Dynamics of histone acetylation in vivo. A function for acetylation turnover?, Biochem. Cell Biol., 80, 363, 10.1139/o02-080 Watkins, 2007, Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome, J. Lipid Res., 48, 2736, 10.1194/jlr.M700378-JLR200 Wellen, 2009, ATP-citrate lyase links cellular metabolism to histone acetylation, Science, 324, 1076, 10.1126/science.1164097 Wise, 2011, Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability, Proc. Natl. Acad. Sci. USA, 108, 19611, 10.1073/pnas.1117773108 Yao, 1999, PTEN/MMAC1 mutations in hepatocellular carcinomas, Oncogene, 18, 3181, 10.1038/sj.onc.1202659 Yoshii, 2009, Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism, Cancer Sci., 100, 821, 10.1111/j.1349-7006.2009.01099.x Yoshii, 2009, Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET, Nucl. Med. Biol., 36, 771, 10.1016/j.nucmedbio.2009.05.006 Yun, 2009, The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma, J. Nucl. Med., 50, 1222, 10.2967/jnumed.109.062703 Ishibashi, 1993, Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery, J. Clin. Invest., 92, 883, 10.1172/JCI116663 Postic, 2000, DNA excision in liver by an albumin-Cre transgene occurs progressively with age, Genesis, 26, 149, 10.1002/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V Shimano, 1997, Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene, J. Clin. Invest., 100, 2115, 10.1172/JCI119746 Tang, 2013, Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging, J. Med. Chem., 56, 3429, 10.1021/jm4001874 Xu, 2014, An acetate switch regulates stress erythropoiesis, Nat. Med., 20, 1018, 10.1038/nm.3587