Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

Proceedings of the National Academy of Sciences of the United States of America - Tập 102 Số 7 - Trang 2273-2276 - 2005
D.G. Georganopoulou1, Lei Chang1, Jwa‐Min Nam1, C. Shad Thaxton1, Elliott J. Mufson1, William L. Klein1, Chad A. Mirkin1
1Department of Chemistry and Institute of Nanotechnology and Department of Neurobiology and Physiology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208; and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612

Tóm tắt

The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-β-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (<1 pM). This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 102 Số 7

2273-2276

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