Biosurfactants as potential and sustainable substitutes for synthetic drugs against antimicrobial resistance and drug adverse effects: a review
Advances in Traditional Medicine - Trang 1-13 - 2024
Tóm tắt
In modern medicine, one major advancement recorded is the discovery of antibiotics. For the past decades now, the use and misuse of antibiotics have led most clinically important pathogens to develop multiple drug resistance; thus, reducing the applications of these antibiotics. The challenges associated with multi-drug resistance require various strategies such as genomics and nanotechnology approaches, and these will require detailed studies on each antibiotic and response to identify the specific nature of the pathogens. The current SAR CoV-2 known as the COVID-19 pandemic, even if it is not related to this situation, has shown the emergence desire for strategies to fight such increasing public threats. New ways of studying innate compounds that have suitable effects to mitigate this problem have been extended. In recent times, there has been a dramatically increased interest in the production of biosurfactants for food processing, environmental bioremediation, improved oil recovery, and biomedical and pharmaceutical applications. Biosurfactants can produce different biological activities including antibacterial, anticancer, antiviral, antifungal, haemolytic effects, and fibrin clotting inhibition. They had shown the capacity to destroy plasma membranes, improve cell membrane permeability, and eliminate metabolites. Thus, this review discusses the mechanisms of action, roles, applications, and available commercial products of biosurfactants focusing majorly on therapeutic and pharmaceutical perspectives. With their diversity, potential, and cost-effectiveness in the biomedical field, biosurfactants can be sourced as alternative molecules to synthetic drugs.
Tài liệu tham khảo
Abdollahi S et al (2020) Evaluation of anti-oxidant and anti-biofilm activities of biogenic surfactants derived from Bacillus amyloliquefaciens and Pseudomonas aeruginosa. Iran J Pharm Res 19(2):115–126
Abdul Razak N, Abdullah N, Yatim R (2015) Solvent-less approach for the recovery of palm-based sophorolipids biosurfactant via salting-out method. J Oil Palm Res 27(2):181–189
Aghajani M, Rahimpour A, Amani H, Taherzadeh M (2018) Rhamnolipid as new bio- agent for cleaning of ultrafiltration membrane fouled by whey. Eng Life Sci 18(5):272–280
Ahmadi-Ashtiani H et al (2020) Microbial biosurfactants as key multifunctional ingredients for sustainable cosmetics. Cosmetics 7(2):46
Aiyegoro O, Adewusi A, Oyedemi S (2011) Interactions of antibiotics and methanolic crude extracts of Afzelia Africana (Smith.) against drug resistance bacterial isolates. Int J Mol Sci 12(7):4477–4487
Anton N, Vandamme T (2011) Nano-emulsions and microemulsions: clarifications of the critical differences. Pharmacognosy Res 28:978–985
Aparecida C, Freitas U, Akemi V, Silveira I, Colabone C, Pedrine M (2018) Antimicrobial applications of sophorolipid from Candida bombicola: a promising alternative to conventional drugs. Adv Biotechnol Microbiol 9(1):17–20
Asselbergh B, Curvers K, França S, Audenaert K, Vuylsteke M, Van Breusegem F (2007) Resistance to Botrytis cinerea in sitiens, an abscisic acid-deficient tomato mutant, involves timely production of hydrogen peroxide and cell wall modifications in the epidermis. Plant Physiol 144:1863–1877
Bakkiyaraj D, Sritharadol R, Padmavathi A, Nakpheng T, Srichana T (2017) Anti-biofilm properties of a mupirocin spray formulation against Escherichia coli wound infections. Biofouling, pp 1–10
Banat I, De Díaz RM, Quinn G (2014) Microbial biofilms: biosur- factants as antibiofilm agents. Appl Microbiol Biotechnol 99(24):15–29
Bastid J et al (2015) Inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity. Cancer Immunol Res 3(3):254–265
Bernal P, Segura A, Ramos J (2007) Compensatory role of the cis-trans-isomerase and cardiolipin synthase in the membrane fluidity of Pseudomonas putida DOT-T1E. J Environ Biol 9(7):1658–1664
Bezerra KG, Silva IG, Almeida CG, Sarubbo L (2021) Plant-derived biosurfactants: extraction, characteristics and properties for application in cosmetics. Biocatal Agric Biotechnol 34:102036
Bhattacharya B, Ghosh TK, Das N (2017) Application of bio-surfactants in cosmetics and pharmaceutical industry. Sch Acad J Pharm 6(7):320–329
Callaghan B et al (2016) Lactonic sophorolipids increase tumor burden in Apcmin+/- mice. PLoS ONE 11(6):e0156845
Cao X (2010) Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway. Chem Biol 183:357–362
Cao X, Liao Z, Wang C, Yang W, Lu M (2009) Evaluation of a lipopeptide biosurfactant from Bacillus natto Tk-1 as a potential source of anti-adhesive, antimicrobial and antitumor activities. Braz J Microbiol 40:373–379
Carrillo C, Teruel J, Aranda F, Ortiz A (2003) Molecular mechanism of membrane permeabilization by the peptide antibiotic surfactin. Bio Chim Biophys Acta 611:91–97
Çelik PA, Manga EB, Çabuk A, Banat IM (2020) Biosurfactants’ potential role in combating COVID-19 and similar future microbial threats. Appl Sci 11:334
Çelik P, Manga E, Çabuk A, Banat I (2021) Biosurfactants’ potential role in combating COVID-19 and similar future microbial threats. Appl Sci 11:334
Ceresa C, Fracchia L, Fedeli E, Porta C, Banat I (2021) Recent advances in biomedical, therapeutic and pharmaceutical applications of microbial surfactants. Pharmaceutics 13:1–25
Chansanroj K, Betz G (2010) Sucrose esters with various hydrophilic–lipophilic properties: novel controlled release agents for oral drug delivery matrix tablets prepared by direct compaction. Acta Biomater 6:3101–3109
Chen J (2006) Sophorolipid produced from the new yeast strain Wickerhamiella domercqiae induces apoptosis in H7402 human liver cancer cells. Appl Microbiol Biotechnol 72:52–59
Das P, Mukherjee S, Sen R (2009) Antiadhesive action of a marine microbial surfactant. Colloids Surf B Biointerfaces 71:183–186
de Cortés-Sánchez A, Hernández-Sánchez H, Jaramillo-Flores M (2013) Biological activity of glycolipids produced by microorganisms: new trends and possible therapeutic alternatives. Microbiol Res 168:22–32
de Guzman D (2014) Sophorolipids from Mahua Oil
Déjugnat C, Diat O, Zemb T (2011) Surfactin self-assembles into direct and reverse aggregates in equilibrium and performs selective metal cation extraction. ChemPhysChem 12(11):2138–2144
Dimkić I et al (2017) The profile and antimicrobial activity of Bacillus lipopeptide extracts of five potential biocontrol strains. Front Microbiol 8:925
Duarte C, Gudiña E, Lima C, Rodrigues L (2014) Effects of biosurfactants on the viability and proliferation of human breast cancer cells. ABM Express 40(4):1–12
Dusane D, Dam S, Nancharaiah Y, Kumar A, Venugopalan V, Zinjarde S (2012) Disruption of Yarrowia lipolytica biofilms by rhamnolipid biosurfactant. Aquat Biosyst 8:1–7
El-Sersy NA et al (2012) Antibacterial and anticancer activity of e-poly-l-lysine (e-PL) produced by a marine Bacillus subtilis sp. J Basic Microbiol 52:513–522
Emiroglu M (2011) Micafungin use in children. Expert Rev Anti Infect Ther 9:821–834
Fanun M (2012) Microemulsions as delivery systems. Curr Opin Colloid Interface Sci 17:306–313
Fariasa CBB, Almeidaa FCG, Silva I, Meira H, Souza T (2021) Production of green surfactants: market prospects. Electron J Biotechnol 51:28–39
Fracchia L et al (2014) Industrial applications of biosurfactants. In: Kosaric N, Sukan (Eds) Biosurfactants: production and utilization-processes, technologies and economics, pp 245–267
Fu SL et al (2008) Sophorolipids and their derivatives are lethal against human pancreatic cancer cells. J Surg Res 148:72–78
Ganesh K, Mamidyala S, Das B, Sridhar B, Devi G, Karuna M (2010) Synthesis of biosurfactant-based silver nanoparticles with purified rhamnolipids isolated from Pseudomonas aeruginosa BS-161R. J Microbiol Biotechnol 20:1061–1068
Gangwar M (2012) Recent advances in various emerging vesicular systems: an overview. Asian Pac J Trop Biomed 2:S1176–S1188
George J, Reboli A (2012) Anidulafungin: When and how? The clinician’s view. Mycoses 55:36–44
Giri S, Park S (2022) The role of biosurfactants in the advancement of veterinary medicine. In: Biomedical application of biosurfactant in medical sector, pp 205–222
Góral I, Wojciechowski K (2020) Historical perspective surface activity and foaming properties of saponin-rich plants extracts. Adv Colloid Interface Sci 279:102–145
Gudin EJ et al (2010) Isolation and functional characterization of a biosurfactant produced by Lactobacillus paracasei. Colloid Surf B Biointerfaces 76:298–304
Gudin E, Rangarajan V, Sen R, Rodrigues L (2013) Potential therapeutic applications of biosurfactants. Cell
Gudiña EJ, Pereira JF, Rodrigues LR, Coutinho JA (2012) Isolation and study of microorganisms from oil samples for application in microbial enhanced oil recovery. Int Biodeterior Biodegrad 68:56–64
Gudiña E, Rangarajan V, Sen R, Rodrigues L (2013) Potential therapeutic applications of biosurfactants. Trends Pharmacol Sci 34:667–675
Gudiña E, Teixeira J, Rodrigues L (2016) Biosurfactants produced by marine microorganisms with therapeutic applications. Mar Drugs 14(2):38
GVR (2019) Plant based biosurfactants market size, share and trends analysis report by application, regional outlook, competitive strategies, and segment forecasts, 2019 to 2025
Haque F, Sajid M, Cameotra S, Battacharyya M (2017) Anti-biofilm activity of a sophorolipid-amphotericin B niosomal formulation against Candida albicans. Biofouling 33(9):768–779
Heinemann C, Van Hylckama V, Janssen D (2000) Purification and characterization of a surface-binding protein from Lactobacillus fermentum RC-14 that inhibits adhesion of Enterococcus faecalis. FEMS Microbiol Lett 190:177–180
Huang X, Wei Z, Zhao G, Gao X (2008) Optimization of sterilization of Escherichia coli in milk by surfactin and fengycin using a response surface method. Curr Microbiol 56(4):376–381
Hussein H, AzmuddinAbdullah M (2022) Biosurfactant as a vehicle for targeted antitumor and anticancer drug delivery. In: Green sustainable process for chemical and environmental engineering and science, pp 299–317
Imtiaz S, Bashir M, Banoo S, Anwar N, Ahamed M (2022) Antitumor and anticancer activity of biosurfactant. In: Green sustainable process for chemical and environmental engineering and science, pp 495–513
Adetunji CO, Ahamed M (2022) Green sustainable process for chemical and environmental engineering and science: biomedical application of biosurfactant in medical sector
Jemil N, Ayed HB, Manresa A, Nasri M, Hmidet N (2017) Antioxidant properties, antimicrobial and anti-adhesive activities of DCS1 lipopeptides from Bacillus methylotrophicus DCS1. BMC Microbiol 17:144
Jimoh A, Lin J (2019) Biosurfactant: a new frontier for greener technology and environmental sustainability. Ecotoxicol Environ Saf 184:109–607
Joshi R, Jadhao M (2022) Application of biosurfactant as an adjuvant in medicine. In: Green sustainable process for chemical and environmental engineering and science, pp 61–79
Joshi-Navare K, Prabhune A (2013) A Biosurfactant-Sophorolipid acts in synergy with antibiotics to enhance their efficiency. Biomed Res Int pp 1–8
Juma A, Lemoine P, Simpson AB, Murray J, O’Hagan BM (2020) Microscopic investigation of the combined use of antibiotics and biosurfactants on methicillin resistant Staphylococcus aureus. Front Microbiol
Kuiper I et al (2004) Characterization of two Pseudomonas putida lipopeptide biosurfactants, putisolvin I and II, which inhibit biofilm formation and break down existing biofilms. Mol Microbiol 51:97–113
Kumari A, Sumeeta K, Prasad G, Pinnaka A (2021) Antioxidant activity of biosurfactant strain CIG-6AT. Front Microbiol
La Fauci V, Alessi V (2018) Antibiotic resistance: Where are we going? Ann Di Ig 30:52–57
Lee JH et al (2012) The production of surfactin during the fermentation of Cheonggukjang by potential probiotic Bacillus subtilis CSY191 and the resultant growth suppression of MCF-7 human breast cancer cells. Food Chem 131:1347–1354
Li B, Webster T (2018) Bacteria antibiotic resistance: New challenges and opportunities for implant-associated orthopedic infections. J Orthop Res 36:22–32
Liu H et al (2022) Efficient production of acidic sophorolipid from rapeseed oil by Candida bombicola. Biofuels Bioprod Biorefining 16(4):1050–1061
Luna J, Rufino R, Sarubbo L, Rodrigues LR, Teixeira JA, de Campos-Takaki GM (2011) Evaluation antimicrobial and antiadhesive properties of the biosurfactant lunasan produced by Candida sphaerica UCP 0995. Curr Microbiol 62:1527–1534
Mandal SM, Barbosa AEAD, Franco OL (2013) Lipopeptides in microbial infection control: scope and reality for industry. Biotechnol Adv 31:338–345
Martinotti M, Allegrone G, Cavallo M, Fracchia L (2013) Biosurfactants. In: Innovative technologies for sustainable development
Mireles J, Toguchi A, Harshey R (2001) Salmonella enteric se- rovar typhimurium swarming mutants with altered biofilm forming abilities: surfactin inhibits biofilm formation. J Biotechnol 183:5848–5854
Moldes A, Vecino X, Rodríguez-López L, Rincón-Fontán M, Cruz J (2020) Biosurfactants: the use of biomolecules in cosmetics and detergents. In: In new and future developments in microbial biotechnology and bioengineering, pp 163–218
Müller F, Hönzke S, Luthardt W, Wong E, Unbehauen M, Bauer J (2017) Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. Eur J Pharm Biopharm 116:31–37
Muthusamy K, Gopalakrishnan S, Sivachidambaram P, Ravi TK (2008) Biosurfactants: properties, commercial production and application. Curr Sci 94(6):736–747
Ndlovu T, Rautenbach M, Vosloo J, Khan S, Khan W (2017) Characterisation and antimicrobial activity of biosurfactant extracts produced by Bacillus amyloliquefaciens and Pseudomonas aeruginosa isolated from a wastewater treatment plant. ABM Express 108
Newsmantraa (2022) Biosurfactant market players, key regions, product segments, applications by 2030. Urumqui Unite, Saraya, MG Intobio, BASF Cognis, Ecover. Digit J
Ngai A, Bourque M, Lupinacci R, Strohmaier K, Kartsonis N (2011) Overview of safety experience with caspofungin in clinical trials conducted over the first 15 years: A brief report. Int J Antimicrob Agents 38:540–544
Ohadi M, Forootanfar H, Rahimi H, Jafari E (2017) Antioxidant potential and wound healing activity of biosurfactant produced by Acinetobacter junii B6. Curr Pharm Biotechnol 18(11):900–908
Ortiz A, Teruel J, Espuny M, Marqués A, Manresa Á, Aranda F (2009) Interactions of a bacterial biosurfactant trehalose lipid with phosphatidylserine membranes. Chem Phys Lipids 158:46–53
Paul B, Moulik S (2001) Uses and applications of microemulsions. Curr Sci 80:990–1001
Poole K (2001) Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Molecualr Microbiol 3:255–264
Priyashantha AKH, Mahendranathan C (2021) Biosurfactants: an alternative approach to synthetic surfactants. Int J Res Rev 8(2):2454–2237
Rautela R, Singh A, Shukla A, Cameotra S (2014) Lipopeptides from Bacillus strain AR2 inhibits biofilm formation by Candida albicans. Antonie Van Leeuwenhoek 105:809–821
Robbel L, Marahiel M (2010) Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J Biol Chem 285:27501–27508
Rodrigues L, Teixeira J (2010) Biomedical and therapeutic applications of biosurfactants. In: Biosurfactants
Rodrigues L, Banat I, Teixeira J, Oliveira R (2006) Biosurfactants: potential applications in medicine. J Antimicob Chemother 57(4):609–618
Sambanthamoorthy K, Feng X, Patel R, Patel S, Paranavitana C (2014) Antimicrobial and antibiofilm potential of biosurfactants isolated from Lactobacilli against multi-drug-resistant pathogens. BMC Microbiol 14:197
Sánchez M, Aranda F, Teruel J, Ortiz A (2009) Interaction of a bacterial dirhamnolipid with phosphatidylcholine membranes: a biophysical study. Chem Phys Lipids 161:51–55
Satpute S, Banpurkar A, Banat I, Sangshetti J, Patil R, Gade W (2016) Multiple roles of biosurfactants in biofilms. Curr Pharm Des 22:1429–1448
Seydlová G, Fier R, Cabala R, Kozlík P, Svobodová J, Pátek M (2013) Surfactin production enhances the level of cardiolipin in the cytoplasmic membrane of Bacillus subtilis. Biochim Biophys Acta 1828(11):2370–3237
Singh P, Cameotra S (2004) Potential applications of microbial surfactants in biomedical sciences. Trends Biotechnol 22:142–146
Singh R, Dwivedi S, Gaharwar U, Meena R, Rajamani P, Prasad T (2019) Recent updates on drug resistance in Mycobacterium tuberculosis. J Appl Microbiol 128(6):1547–1567
Sivapathasekaran C (2010) Marine bacterium derived lipopeptides: characterization and cytotoxic activity against cancer cell lines. Int J Pept Res Ther 16:215–222
Smith M, Gandolfi S, Coshall P, Rahman PKS (2020) Biosurfactants: a Covid-19 perspective. Front Microbiol 11:1–7
Sotirova A, Avramova T, Stoitsova S, Lazarkevich I, Lubenets V, Karpenko E, Galabova D (2012) The importance of rhamnolipid biosurfactant-induced changes in bacterial membrane lipids of Bacillus subtilis for the antimicrobial activity of thiosulfonates. Curr Microbiol 65(5):534–541
Subramaniam M et al (2020) Biosurfactants and anti-inflammatory activity: a potential new approach towards COVID-19. Curr Opin Environ Sci Heal 17:72–81
Thakur P, Saini NK, Thakur VK, Gupta VK, Saini RV, Saini AK (2021) Rhamnolipid the glycolipid biosurfactant: emerging trends and promising strategies in the feld of biotechnology and biomedicine. Microb Cell Fact 20(1):1–15
Tuckera I et al (2021) Adsorption and self-assembly properties of the plant based biosurfactant, Glycyrrhizic acid. J Appl Colloid Interface Sci 598:444–454
Wang C et al (2013) Surfactin-induced apoptosis through ROS-ERS-Ca2+–ERK pathways in HepG2 cells. Cell Biochem Biophys
WHO (2014) Antimicrobial resistance global report on surveillance
WHO (2017) WHO, Cancer: Key facts
www.marketsandmarkets.com/Market-Reports/biosurfactant-market (2022) Biosurfactants arket analysis recent market developments industry forecast to 2016–2022. Biosurfactants Market
Xie Y, Ye R, Liu H (2006) Synthesis of silver nanoparticles in reverse micelles stabilized by natural biosurfactant. Colloids Surf A Physicochem Eng Asp 2:175–178
Yan F, Hu H, Lu L, Zheng X (2016) Rhamnolipids induce oxidative stress responses in cherry tomato fruit to Alternaria alternata. Pest Manag Sci 72:1500–1507
Yi G, Son J, Yoo J, Park C, Koo H (2019) Rhamnolipid nanoparticles for in vivo drug delivery and photodynamic therapy. Nanomed Nanotechnol 19:12–21
