Cytokine-adjuvanted HIV-DNA vaccination strategies

Springer Seminars in Immunopathology - Tập 28 - Trang 231-238 - 2006
Franco Lori1,2, David B. Weiner3, Sandra A. Calarota1,2,3, Laurene M. Kelly1,2, Julianna Lisziewicz4,5
1Research Institute for Genetic and Human Therapy (RIGHT), Pavia, Italy
2Research Institute for Genetic and Human Therapy (RIGHT), Bethesda, USA
3Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia USA
4Genetic Immunity, LLC, Washington, USA
5Genetic Immunity, LLC, Budapest, Hungary

Tóm tắt

This review highlights some of the most common cytokines currently being tested as adjuvants in HIV-1-DNA vaccine regimens. We discuss their use in both the prophylactic and therapeutic setting. Finally, we describe a novel dendritic cell-targeted vaccine candidate for HIV-1 treatment and prevention called DermaVir and explore the combination of the DermaVir technology with the cytokine adjuvants interleukin-7 and interleukin-15.

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Springer Seminars in Immunopathology

Tập 28

231-238

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