Supercritical Carbon Dioxide Antisolvent Fractionation for the Sustainable Concentration of Lavandula luisieri (Rozeira) Riv.- Mart Antimicrobial and Antioxidant Compounds and Comparison with Its Conventional Extracts

Plants - Tập 8 Số 11 - Trang 455
Carlota Giménez-Rota1,2, Susana Lorán3, Ana M. Mainar2, María J. Hernáiz1, C. Rota3
1Chemistry in Pharmaceutical Science Department, Pharmacy Faculty, Complutense University of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain
2GATHERS Group, Aragón Institute of Engineering Research (I3A), University of Zaragoza, c/. Mariano Esquillor s/n, 50018 Zaragoza, Spain
3Department of Animal Production and Food Science, AgriFood Institute of Aragon (IA2), University of Zaragoza-CITA, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain

Tóm tắt

Lavandula stoechas subsp. luisieri is a Spanish subspecies from the Lamiaceae family. Its essential oil has been traditionally used for several medical applications though little is known about other extracts. Similar to many other studies aiming to obtain traditional plant extracts to be used in different applications, this work evaluated the antioxidant and antimicrobial activities of Lavandula luisieri extracts and the correlation with their composition. Traditional hydrodistillation and ethanolic maceration were used to obtain the essential oil and the maceration extract, respectively. A green and sustainable methodology was applied to the maceration extract that was under a Supercritical Antisolvent Fractionation process to obtain a fine solid enriched in rosmarinic acid and the terpenes oleanolic and ursolic acids. Antimicrobial activities of all extracts and pure identified compounds (rosmarinic and ursolic acids) were evaluated against five bacterial strains; Listeria monocytogenes, Enterococcus faecium, Staphylococcus aureus, Salmonella Typhimurium and Escherichia coli and were compared with the pure compounds identified, rosmarinic and ursolic acids. All strains were sensitive against L. luisieri essential oil. The solid product obtained from the supercritical process was concentrated in the identified actives compared to the maceration extract, which resulted in higher antimicrobial and DPPH scavenging activities. The supercritical sustainable process provided L. luisieri compounds, with retention of their antimicrobial and antioxidant activities, in a powder exemptof organic solvents with potential application in the clinical, food or cosmetic fields.

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Tài liệu tham khảo

Friedman, 2015, Antibiotic-resistant bacteria: Prevalence in food and inactivation by food-compatible compounds and plant extracts, J. Agric. Food Chem., 63, 3805, 10.1021/acs.jafc.5b00778

Domingo, 2003, Plants with antimicrobial action, Rev. Esp. Quim. Publ. Soc. Esp. Quim., 16, 385

Harvey, 1999, Medicines from nature: Are natural products still relevant to drug discovery?, Trends Pharm. Sci., 20, 196, 10.1016/S0165-6147(99)01346-2

Kalim, M.D., Bhattacharyya, D., Banerjee, A., and Chattopadhyay, S. (2010). Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine. BMC Complementary Altern. Med., 10.

Gyawali, 2014, Natural products as antimicrobial agents, Food Control, 46, 412, 10.1016/j.foodcont.2014.05.047

Baldovini, 2005, Necrodane monoterpenoids from Lavandula luisieri, Phytochemistry, 66, 1651, 10.1016/j.phytochem.2005.04.040

Mohamed, 2006, Antifeedant effects and chemical composition of essential oils from different populations of Lavandula luisieri L., Biochem. Syst. Ecol., 34, 609, 10.1016/j.bse.2006.02.006

Julio, 2014, Comparative chemistry and insect antifeedant effects of conventional (Clevenger and Soxhlet) and supercritical extracts (CO2) of two Lavandula luisieri populations, Ind. Crop. Prod., 58, 25, 10.1016/j.indcrop.2014.03.021

Sanz, 2004, Analysis of volatile components of Lavandula luisieri L. by direct thermal desorption–gas chromatography–mass spectrometry, J. Chromatogr. A, 1024, 139, 10.1016/j.chroma.2003.10.024

Roach, 1990, Defense mechanisms of arthropods. 83 α- and β-Necrodol, novel terpenes from a carrion beetle (Necrodes surinamensis, Silphidae, Coleoptera), J. Org. Chem., 55, 4047, 10.1021/jo00300a020

Matos, 2009, Antioxidant Capacity of the Essential Oils from Lavandula luisieri L. stoechas subsp. lusitanica, L. stoechas subsp. lusitanica × L. luisieri and L. viridis Grown in Algarve (Portugal), J. Essent. Oil Res., 21, 327, 10.1080/10412905.2009.9700184

Baptista, 2015, Antioxidant and Antimycotic Activities of Two Native Lavandula Species from Portugal, Evid. Based Complement. Altern. Med., 2015, 570521, 10.1155/2015/570521

Arantes, 2016, Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri, Planta Med., 82, 1266, 10.1055/s-0042-104418

Dias, 2017, Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes, Nat. Prod. Res., 31, 460, 10.1080/14786419.2016.1195379

Lai, 2012, Evaluation of the antimicrobial activity in species of a Portuguese Montado ecosystem against multidrug resistant pathogens, J. Med. Plants Res., 6, 2381

Roller, 2009, The antimicrobial activity of high-necrodane and other lavender oils on methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA), J. Altern. Complement. Med., 15, 275, 10.1089/acm.2008.0268

Zuzarte, 2012, Lavandula luisieri essential oil as a source of antifungal drugs, Food Chem., 135, 1505, 10.1016/j.foodchem.2012.05.090

Julio, 2017, Ixodicidal compounds from pre-domesticated Lavandula luisieri, Ind. Crop. Prod., 110, 83, 10.1016/j.indcrop.2017.06.044

Costa, 2018, In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components, Exp. Parasitol., 190, 34, 10.1016/j.exppara.2018.05.002

Rufino, 2015, Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaei subsp. juresianum in cell models of two chronic inflammatory diseases, Pharm. Boil., 53, 1220, 10.3109/13880209.2014.970701

Nunes, 2017, Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs, Pharm. Biol., 55, 114, 10.1080/13880209.2016.1230636

Petersen, 2003, Rosmarinic acid, Phytochemistry, 62, 121, 10.1016/S0031-9422(02)00513-7

Wolska, 2010, Antibacterial activity of oleanolic and ursolic acids and their derivatives, Cent. Eur. J. Biol., 5, 543

Jesus, 2015, Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update, Evid. Based Complement. Altern. Med., 2015, 620472, 10.1155/2015/620472

Silvestre, 2014, Supercritical fluid extraction of vegetable matrices: Applications, trends and future perspectives of a convincing green technology, J. Supercrit. Fluids, 92, 115, 10.1016/j.supflu.2014.04.007

Meneses, 2015, Antioxidant phenolic compounds recovery from Mangifera indica L. by-products by supercritical antisolvent extraction, J. Food Eng., 163, 45, 10.1016/j.jfoodeng.2015.04.025

Burt, 2004, Essential oils: Their antibacterial properties and potential applications in foods—A review, Int. J. Food Microbiol., 94, 223, 10.1016/j.ijfoodmicro.2004.03.022

Parhi, 2013, Supercritical Fluid Technology: A Review, J. Adv. Pharm. Sci. Technol., 1, 13, 10.14302/issn.2328-0182.japst-12-145

Reverchon, 2006, Supercritical fluid extraction and fractionation of natural matter, J. Supercrit. Fluids, 38, 146, 10.1016/j.supflu.2006.03.020

Martin, 2011, Supercritical antisolvent fractionation of ryanodol from Persea indica, J. Supercrit. Fluids, 60, 16, 10.1016/j.supflu.2011.03.012

Perretti, 2013, Supercritical antisolvent fractionation of lignans from the ethanol extract of flaxseed, J. Supercrit. Fluids, 75, 94, 10.1016/j.supflu.2012.12.028

Mendiola, 2016, Supercritical antisolvent fractionation of rosemary extracts obtained by pressurized liquid extraction to enhance their antiproliferative activity, J. Supercrit. Fluids, 107, 581, 10.1016/j.supflu.2015.07.019

Visentin, 2012, Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process, J. Food Eng., 109, 9, 10.1016/j.jfoodeng.2011.10.015

Julio, 2016, Phytotoxic and Nematicidal Components of Lavandula luisieri, J. Nat. Prod., 79, 261, 10.1021/acs.jnatprod.5b00501

Rota, 2008, Antimicrobial activity and chemical composition of Thymus vulgaris, Thymus zygis and Thymus hyemalis essential oils, Food Control, 19, 681, 10.1016/j.foodcont.2007.07.007

Radnovic, 2014, Chemical composition, antimicrobial, antioxidative and anticholinesterase activity of Satureja Montana L. ssp montana essential oil, Open Life Sci., 9, 668, 10.2478/s11535-014-0298-x

Tekwu, 2012, Investigations of antimicrobial activity of some Cameroonian medicinal plant extracts against bacteria and yeast with gastrointestinal relevance, J. Ethnopharmacol., 142, 265, 10.1016/j.jep.2012.05.005

Basch, 1968, In vitro antimicrobial activity of dimethylsulfoxide, Appl. Microbiol., 16, 1953, 10.1128/am.16.12.1953-1954.1968

Cuvelier, 1995, Use of a free radical method to evaluate antioxidant activity, LWT Food Sci. Technol., 28, 25, 10.1016/S0023-6438(95)80008-5

Bernatoniene, 2016, Novel approaches to optimize extraction processes of ursolic, oleanolic and rosmarinic acids from Rosmarinus officinalis leaves, Ind. Crop. Prod., 84, 72, 10.1016/j.indcrop.2016.01.031

Rota, 2004, In vitro antimicrobial activity of essential oils from aromatic plants against selected foodborne pathogens, J. Food Prot., 67, 1252, 10.4315/0362-028X-67.6.1252

Cabo, 1996, Characterisation of the Essential Oils of some Cultivated Aromatic Plants of Industrial Interest, J. Sci. Food Agric., 70, 359, 10.1002/(SICI)1097-0010(199603)70:3<359::AID-JSFA512>3.0.CO;2-0

Delgado, 2011, Chemical and biological profiles of Lavandula luisieri essential oils from western Iberia Peninsula populations, Biochem. Syst. Ecol., 39, 1, 10.1016/j.bse.2010.08.010

Marin, 2010, Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model, Molecules, 15, 7532, 10.3390/molecules15117532

Moreno, 2006, Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition, Free Radic. Res., 40, 223, 10.1080/10715760500473834

Bais, 2002, Root specific elicitation and antimicrobial activity of rosmarinic acid in hairy root cultures of Ocimum basilicum, Plant Physiol. Biochem., 40, 983, 10.1016/S0981-9428(02)01460-2

Lewis, 2006, Prospects for plant-derived antibacterials, Nat. Biotechnol., 24, 1504, 10.1038/nbt1206-1504

Lemos, 2014, Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives, Molecules, 19, 1317, 10.3390/molecules19011317

Messaoud, 2012, Chemical composition and antioxidant activities of essential oils and methanol extracts of three wild Lavandula L. species, Nat. Prod. Res., 26, 1976, 10.1080/14786419.2011.635343

Brantner, 2010, Evaluation of Antioxidant Potential of Lavandula x intermedia Emeric ex Loisel. ‘Budrovka’: A Comparative Study with L. angustifolia Mill, Molecules, 15, 5971, 10.3390/molecules15095971

Jauregui, 2007, Antioxidant Activity and Phenolic Composition of Lavandin (Lavandula x intermedia Emeric ex Loiseleur) Waste, J. Agric. Food Chem., 55, 8436, 10.1021/jf070236n

Ceylan, 2015, Evaluation of Antioxidant Activity, Phytochemicals and ESR Analysis of Lavandula Stoechas, Acta Phys. Pol. A, 128, 483, 10.12693/APhysPolA.128.B-483

Apak, 2006, The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas, Int. J. Food Sci. Nutr., 57, 292, 10.1080/09637480600798132

Carrasco, 2016, Lavandula angustifolia and Lavandula latifolia Essential Oils from Spain: Aromatic Profile and Bioactivities, Planta Med., 82, 163

Vasileva, 2018, Effect of lavender (Lavandula angustifolia) and melissa (Melissa Officinalis) waste on quality and shelf life of bread, Food Chem., 253, 13, 10.1016/j.foodchem.2018.01.131

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