A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors

Cell - Tập 124 - Trang 1169-1181 - 2006
P. Mathijs Voorhoeve1, Carlos le Sage1, Mariette Schrier1, Ad J.M. Gillis2, Hans Stoop2, Remco Nagel1, Ying-Poi Liu1, Josyanne van Duijse1, Jarno Drost1, Alexander Griekspoor1, Eitan Zlotorynski1, Norikazu Yabuta3, Gabriella De Vita4, Hiroshi Nojima3, Leendert H.J. Looijenga2, Reuven Agami1
1Division of Tumour Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
2Department of Pathology, Erasmus University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
3Department of Molecular Genetics, Osaka University, Japan
4Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Federico II, CEINGE Biotecnologie Avanzate, Naples, Italy

Tài liệu tham khảo

Agami, 2000, Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage, Cell, 102, 55, 10.1016/S0092-8674(00)00010-6 Almstrup, 2004, Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling, Cancer Res., 64, 4736, 10.1158/0008-5472.CAN-04-0679 Bagga, 2005, Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation, Cell, 122, 553, 10.1016/j.cell.2005.07.031 Braig, 2005, Oncogene-induced senescence as an initial barrier in lymphoma development, Nature, 436, 660, 10.1038/nature03841 Brummelkamp, 2002, A system for stable expression of short interfering RNAs in mammalian cells, Science, 296, 550, 10.1126/science.1068999 Burger, 1998, Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines, Br. J. Cancer, 77, 1562, 10.1038/bjc.1998.257 Chen, 2004, MicroRNAs modulate hematopoietic lineage differentiation, Science, 303, 83, 10.1126/science.1091903 Chen, 2005, Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis, Nature, 436, 725, 10.1038/nature03918 Collado, 2005, Tumour biology: senescence in premalignant tumours, Nature, 436, 642, 10.1038/436642a De Vita, 2005, Dose-dependent inhibition of thyroid differentiation by RAS oncogenes, Mol. Endocrinol., 19, 76, 10.1210/me.2004-0172 Doench, 2004, Specificity of microRNA target selection in translational repression, Genes Dev., 18, 504, 10.1101/gad.1184404 Duursma, 2005, p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation, Mol. Cell. Biol., 25, 6937, 10.1128/MCB.25.16.6937-6947.2005 el-Deiry, 1993, WAF1, a potential mediator of p53 tumor suppression, Cell, 75, 817, 10.1016/0092-8674(93)90500-P Forstemann, 2005, Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein, PLoS Biol., 3, e236, 10.1371/journal.pbio.0030236 Fukasawa, 1996, Abnormal centrosome amplification in the absence of p53, Science, 271, 1744, 10.1126/science.271.5256.1744 Hahn, 1999, Creation of human tumour cells with defined genetic elements, Nature, 400, 464, 10.1038/22780 Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 Hatfield, 2005, Stem cell division is regulated by the microRNA pathway, Nature, 435, 974, 10.1038/nature03816 He, 2005, A microRNA polycistron as a potential human oncogene, Nature, 435, 828, 10.1038/nature03552 John, 2004, Human MicroRNA targets, PLoS Biol., 2, e363, 10.1371/journal.pbio.0020363 Johnson, 2005, RAS is regulated by the let-7 microRNA family, Cell, 120, 635, 10.1016/j.cell.2005.01.014 Justice, 1995, The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation, Genes Dev., 9, 534, 10.1101/gad.9.5.534 Kersemaekers, 2002, Role of P53 and MDM2 in treatment response of human germ cell tumors, J. Clin. Oncol., 20, 1551, 10.1200/JCO.20.6.1551 Kolfschoten, 2005, A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity, Cell, 121, 849, 10.1016/j.cell.2005.04.017 Lewis, 2003, Prediction of mammalian microRNA targets, Cell, 115, 787, 10.1016/S0092-8674(03)01018-3 Lewis, 2005, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets, Cell, 120, 15, 10.1016/j.cell.2004.12.035 Li, 2003, Lats2, a putative tumor suppressor, inhibits G1/S transition, Oncogene, 22, 4398, 10.1038/sj.onc.1206603 Lim, 2005, Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs, Nature, 433, 769, 10.1038/nature03315 Lu, 2005, MicroRNA expression profiles classify human cancers, Nature, 435, 834, 10.1038/nature03702 Lutzker, 1996, A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation, Nat. Med., 2, 804, 10.1038/nm0796-804 Masters, 2003, Curing metastatic cancer: lessons from testicular germ-cell tumours, Nat. Rev. Cancer, 3, 517, 10.1038/nrc1120 Mayer, 2003, Molecular determinants of treatment response in human germ cell tumors, Clin. Cancer Res., 9, 767 McPherson, 2004, Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity, EMBO J., 23, 3677, 10.1038/sj.emboj.7600371 Michaloglou, 2005, BRAFE600-associated senescence-like cell cycle arrest of human naevi, Nature, 436, 720, 10.1038/nature03890 Mostert, 2000, Comparative genomic and in situ hybridization of germ cell tumors of the infantile testis, Lab. Invest., 80, 1055, 10.1038/labinvest.3780110 O'Donnell, 2005, c-Myc-regulated microRNAs modulate E2F1 expression, Nature, 435, 839, 10.1038/nature03677 Oosterhuis, 2005, Testicular germ-cell tumours in a broader perspective, Nat. Rev. Cancer, 5, 210, 10.1038/nrc1568 Ota, 2004, Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma, Cancer Res., 64, 3087, 10.1158/0008-5472.CAN-03-3773 Pillai, 2005, Inhibition of translational initiation by Let-7 MicroRNA in human cells, Science, 309, 1573, 10.1126/science.1115079 Robins, 2005, Incorporating structure to predict microRNA targets, Proc. Natl. Acad. Sci. USA, 102, 4006, 10.1073/pnas.0500775102 Serrano, 1997, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, 88, 593, 10.1016/S0092-8674(00)81902-9 Suh, 2004, Human embryonic stem cells express a unique set of microRNAs, Dev. Biol., 270, 488, 10.1016/j.ydbio.2004.02.019 Takahashi, 2005, Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers, Clin. Cancer Res., 11, 1380, 10.1158/1078-0432.CCR-04-1773 Tarapore, 2002, Loss of p53 and centrosome hyperamplification, Oncogene, 21, 6234, 10.1038/sj.onc.1205707 Toji, 2004, The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase, Genes Cells, 9, 383, 10.1111/j.1356-9597.2004.00732.x Voorhoeve, 2003, The tumor-suppressive functions of the human INK4A locus, Cancer Cell, 4, 311, 10.1016/S1535-6108(03)00223-X Weinert, 1998, DNA damage and checkpoint pathways: molecular anatomy and interactions with repair, Cell, 94, 555, 10.1016/S0092-8674(00)81597-4 Westbrook, 2005, A genetic screen for candidate tumor suppressors identifies REST, Cell, 121, 837, 10.1016/j.cell.2005.03.033 Xu, 1995, Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase, Development, 121, 1053, 10.1242/dev.121.4.1053 Zamore, 2005, Ribo-gnome: the big world of small RNAs, Science, 309, 1519, 10.1126/science.1111444