Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI

Proceedings of the National Academy of Sciences of the United States of America - Tập 95 Số 13 - Trang 7654-7658 - 1998
Anand Kumar1, Zhisong Jin2,3,4, Warren B. Bilker2,3,4, Jayaram K. Udupa2,3,4, Gary Gottlieb2,3,4
1Departments of Psychiatry, Radiology and Biostatistics and Epidemiology University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
2Departments of Psychiatry, Radiology and Biostatistics and Epidemiology University of Pennsylvania School of Medicine, Philadelphia, PA
3Section of Geri-atric Psychiatry, Ralston-Penn Center, 3615 Chestnut Street, Phila-delphia, PA 19104.
4University of Pennsylvania School of Medicine, Philadelphia, PA

Tóm tắt

The purpose of our study was to examine the neuroanatomical correlates of late-onset minor and major depression and to compare them with similar measures obtained from nondepressed controls. Our study groups were comprised of 18 patients with late-onset minor depression, 35 patients diagnosed with late-onset major depression, and 30 nondepressed controls. All subjects were scanned by using a 1.5-tesla MRI scanner. Absolute whole brain volume and normalized measures of prefrontal and temporal lobe volumes were obtained and used for comparison among groups. Our findings indicate that patients with minor depression present with specific neuroanatomical abnormalities that are comparable with the major depression group but significantly different from the controls. Normalized prefrontal lobe volumes show a significant linear trend with severity of depression, with volumes decreasing with illness severity. Whole brain volumes did not differ significantly among groups. These findings have broad implications for the biology of late-life depression and suggest that there may be common neurobiological substrates that underlie all clinically significant forms of late-onset mood disturbances.

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Tài liệu tham khảo

10.1056/NEJM198901193200306

10.1176/appi.ajp.151.6.165

10.1192/bjp.150.6.737

10.1093/geronj/44.1.M22

10.1097/00001504-199108000-00021

10.1001/archpsyc.1988.01800360048007

10.1016/0010-440X(83)90102-5

10.1016/0163-8343(87)90002-8

10.2190/AC30-P715-Y4TD-J7D2

10.1001/jama.1990.03450190056028

10.1001/jama.1992.03480110054033

10.1001/archpsyc.1992.01820100032007

10.1176/ajp.153.11.1411

10.1001/archpsyc.1994.03950070034008

10.1093/geronj/47.6.M189

10.1176/ajp.151.12.1777

10.1001/archpsyc.1992.01820100061011

10.1007/BF02191553

10.1176/appi.psychotherapy.1992.46.1.9

10.1002/(SICI)1096-8628(19960726)67:4<347::AID-AJMG6>3.0.CO;2-J

10.1001/archneur.1997.00550170085018

10.1192/bjp.147.6.612

Philipp M. (1993) Int. Clin. Psychopharmacol. 8 Suppl.1 35–37.

J M Himmelhoch, R Auchenbach, C Z Fuchs J Clin Psychiatry 43, 26–32 (1982).

10.1016/0306-4530(81)90008-1

10.1016/0165-0327(95)00061-5

10.3109/00048679609062651

10.1097/00019442-199705010-00003

10.1073/pnas.90.15.7019

10.1001/archpsyc.1990.01810130062009

10.1016/0006-3223(88)90025-X

10.1176/ajp.147.2.187

10.1001/archpsyc.1993.01820130009002

10.1176/ajp.148.5.617

10.1177/002383099300600107

10.1017/S003329170002417X

10.1017/S0033291700020420

10.1073/pnas.93.9.3908

10.1001/archpsyc.1994.03950090009002

Upadhyaya A. K. Abou-Saleh M. T. Wilson K. Grime S. J. & Critchley M. (1990) Br. J. Psychiatry 157 Suppl. 9 76–81.

10.1002/gps.930061104

Diagnostic and Statistical Manual for Mental Disorders (Am. Psychiatric Assoc., 4th Ed., Washington, DC, 1994).

10.1111/j.2044-8260.1967.tb00530.x

10.1016/0022-3956(75)90026-6

10.1111/j.1532-5415.1968.tb02103.x

10.1148/radiology.178.1.1984289

10.1097/00019442-199400210-00005

10.1523/JNEUROSCI.14-08-04748.1994

J M Fuster The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe (Lippincott, Philadelphia, 1997).

10.1037/0033-2909.95.1.3

P Goldman-Rakic Handbook of Physiology: The Nervous System, eds F Plum, V Mountcastle (Am. Phy. Soc., Bethesda, MD), pp. 373–413 (1987).

10.1176/jnp.1.3.340-a

10.1001/archpsyc.1997.01830210068007

10.1001/archpsyc.1996.01830070053009

10.1093/schbul/16.3.379

10.1097/00019442-199300120-00002

10.1093/oxfordjournals.aje.a121512

10.1016/0006-3223(94)91220-3

10.1016/0006-3223(94)91219-X

10.1016/S0193-953X(18)30518-5

10.1016/S0165-0327(97)00056-6

10.1016/S0165-0327(97)00059-1

10.1176/ajp.140.1.11

10.1016/S0165-0327(97)00057-8

10.1016/S0165-0327(97)00060-8

10.1176/ajp.140.6.689

10.1016/S0165-0327(97)00055-4

10.1016/0165-0327(90)90013-X

10.1192/bjp.149.5.574

J Angst, B Hochstrasser J Clin Psychiatry 55, 3–9 (1994).

Judd L. L. Akiskal H. S. Maser J. D. Zeller P. J. Endicott J. Coryell W. Paulus M. P. Kunovac J. L. Leon A. C. Mueller T. et al. (1998) Arch. Gen. Psychiatry in press.

10.1192/bjp.163.1.82

10.1176/ajp.151.5.791

10.2165/00002512-199506040-00003

10.1192/bjp.153.6.752

10.1016/S0165-0327(97)00064-5

10.1192/bjp.142.2.111

10.1016/S0165-0327(97)00058-X

10.2190/JF9W-9Q87-KV0F-YCY4

10.1111/j.1532-5415.1994.tb06554.x

10.1111/j.1532-5415.1997.tb03089.x

10.1016/S0193-953X(18)30519-7

Judd L. L. Rapaport M. H. Paulus M. P. & Brown J. L. (1994) J. Clin. Psychiatry 55 Suppl. 18–28.

10.1016/S0165-0327(97)00063-3

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Proceedings of the National Academy of Sciences of the United States of America

Tập 95 Số 13

7654-7658

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