Theoretical analysis of drug release into a finite medium from sphere ensembles with various size and concentration distributions

European Journal of Pharmaceutical Sciences - Tập 22 Số 4 - Trang 251-259 - 2004
Ya Zhou1, Jin-Ok Chu2, Xiao Yu Wu3
1AP-CAD Inc., Toronto, Ont., Canada M2N 3X2
2Yamanouchi Pharma Technologies, Inc., Norman, OK 73072, USA
3Faculty of Pharmacy, University of Toronto, Toronto, Ont., Canada, M5S 2S2

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bathe, K.J., 1982. Finite Element Procedure in Engineering Analysis, Printice-Hall, New Jersey.

Benita, 1988, Relation between individual and ensemble release kinetics of indomethacin from microspheres, Pharm. Res., 5, 178, 10.1023/A:1015917023949

Carslaw, H.S., Jaeger, J.C., 1959. Conduction of Heat in Solids. Oxford University Press.

Chu, J.S., Yang, Y., Fix, J., Tablets and methods for modified release of hydrophilic and other active agents. US Patent #6419954 B1 (July 16, 2002).

Dappert, 1978, Statistical model for controlled release microcapsules: rationale and theory, J. Membr. Sci., 4, 99, 10.1016/S0376-7388(00)83287-1

Donbrow, M., 1992. The relation of release profiles from ensembles to those of individual microcapsules and the influence of types of batch heterogeneity on release kinetics. In: Donbrow, M. (Ed.), Microcapsules and Nanoparticles in Medicine and Pharmacy. CRS Press, London.

Eshun, G., 1998. Probing the Release Mechanism of a Multiparticulate System through the Release Kinetics of AZT from Individual P(MMA/MAA) Microspheres. M.Sc. Thesis. University of Toronto, Canada.

Grassi, 2000, Drug release from an ensemble of swellable crosslinked polymer particles, J. Control. Rel., 68, 97, 10.1016/S0168-3659(00)00241-8

Gross, 1986, Fundamentals of release mechanism interpretation in multiparticulate systems: the prediction of the commonly observed release equations from statistical population models for particle ensembles, Int. J. Pharm., 29, 213, 10.1016/0378-5173(86)90118-3

Hoffman, 1986, Fundamentals of release mechanism interpretation in multiparticulate systems: determination of substrate release from single microcapsules and relation between individual and ensemble release kinetics, Int. J. Pharm., 29, 195, 10.1016/0378-5173(86)90117-1

Huang, 2000, In vitro studies and modeling of a controlled-release device for root canal therapy, J. Control. Rel., 67, 293, 10.1016/S0168-3659(00)00225-X

Lee, 1984, Novel approach to zero-order drug delivery via immobilized non-uniform drug distribution in glassy hydrogels, J. Pharm. Sci., 73, 1344, 10.1002/jps.2600731004

Lee, 1986, Initial concentration distribution as a mechanism for regulation drug release from diffusion controlled and surface erosion controlled matrix system, J. Control. Rel., 4, 1, 10.1016/0168-3659(86)90027-1

Peddie, 1901, Note on the cooling of a sphere in a masss of well-stirred liquid, Proc. Edin. Math. Soc., 19, 34, 10.1017/S0013091500032582

Ritger, 1987, A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs, J. Control. Rel., 5, 23, 10.1016/0168-3659(87)90034-4

Siegel, 2000, Theoretical analysis of inward hemispheric release above and below drug solubility, J. Control. Rel., 69, 109, 10.1016/S0168-3659(00)00292-3

Wu, 1998, Finite element analysis of diffusional drug release from complex matrix systems. II. Factors influencing release kinetics, J. Control. Rel., 51, 57, 10.1016/S0168-3659(97)00159-4

Wu, 1998, Effect of interparticulate interaction on release kinetics of microsphere ensembles, J. Pharm. Sci., 87, 586, 10.1021/js970356h

Zhou, 1997, Finite element analysis of diffusional drug release from complex matrix systems. I. Complex geometries and composite structures, J. Control. Rel., 49, 277, 10.1016/S0168-3659(97)00103-X

Zhou, 1999, Studies of diffusional release of a dispersed solute from polymeric matrixes by finite element method, J. Pharm. Sci., 88, 1050, 10.1021/js9804361

Zhou, 2003, Modeling and analysis of dispersed-drug release into a finite medium from sphere ensemble, J. Control. Rel., 90, 23, 10.1016/S0168-3659(03)00128-7

Zienkiewicz, O.C., Taylor, R.L., 1991. The Finite Element Method, fourth ed., McGraw-Hill, New York.