B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma
Tóm tắt
Từ khóa
Tài liệu tham khảo
Laurent, 2015, γ-Secretase directly sheds the survival receptor BCMA from plasma cells, Nat Commun, 6, 10.1038/ncomms8333
Garfall, 2018, Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma, JCI Insight, 3, 10.1172/jci.insight.120505
Bu, 2018, Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma, Oncotarget, 9, 25764, 10.18632/oncotarget.25359
Kalos, 2011, T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia, Sci Transl Med, 3, 10.1126/scitranslmed.3002842