Widespread Proteome Remodeling and Aggregation in Aging C. elegans
Dirk M. Walther1, Prasad Kasturi2, Min Zheng2, Stefan Pinkert2, Giulia Vecchi3, Prajwal Ciryam3,4, Richard I. Morimoto4, Christopher M. Dobson3, Michele Vendruscolo3, Matthias Mann1, F. Ulrich Hartl2
1Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
2Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
3Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK
4Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA