Erectile Dysfunction and Lower Urinary Tract Symptoms

Rosen, 2005, Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), Eur Urol, 47, 824, 10.1016/j.eururo.2004.12.013 Rosen, 2006, Update on the relationship between sexual dysfunction and lower urinary tract symptoms/benign prostatic hyperplasia, Curr Opin Urol, 16, 11, 10.1097/01.mou.0000193366.53705.ce Boyle, 1991, Epidemiology of benign prostatic hyperplasia: present knowledge and studies needed, Eur Urol, 20, 3, 10.1159/000471738 NIH Consensus Conference, 1993, Impotence. NIH Consensus Development Panel on Impotence, JAMA, 270, 83, 10.1001/jama.1993.03510010089036 Feldman, 1994, Impotence and its medical and physiological correlates: results of the Massachusetts male aging study, J Urol, 151, 54, 10.1016/S0022-5347(17)34871-1 Braun, 2000, Epidemiology of erectile dysfunction: results of the “Cologne Male Survey”, Int J Impot Res, 12, 305, 10.1038/sj.ijir.3900622 Rosen, 2003, Lower urinary tract symptoms and male sexual dysfunction: the Multinational Survey of the Aging Male (MSAM-7), Eur Urol, 44, 637, 10.1016/j.eururo.2003.08.015 Gacci, 2011, Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia, Eur Urol, 60, 809, 10.1016/j.eururo.2011.06.037 De Nunzio, 2014, Metabolic syndrome and lower urinary tract symptoms in patients with benign prostatic enlargement: a possible link to storage symptoms, Urology, 84, 1181, 10.1016/j.urology.2014.07.018 Mirone, 2011, Current benign prostatic hyperplasia treatment: impact on sexual function and management of related sexual adverse events, Int J Clin Pract, 65, 1005, 10.1111/j.1742-1241.2011.02731.x Lythgoe, 2013, The use of PDE-5 inhibitors in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia, Curr Urol Rep, 14, 585, 10.1007/s11934-013-0373-2 Gacci, 2012, A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia, Eur Urol, 61, 994, 10.1016/j.eururo.2012.02.033 McVary, 2006, Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology, BJU Int, 97, 23, 10.1111/j.1464-410X.2006.06102.x Boyle, 2003, The association between lower urinary tract symptoms and erectile dysfunction in four centres: the UrEpik study, BJU Int, 92, 719, 10.1046/j.1464-410X.2003.04459.x Rosen, 2009, Lower urinary tract symptoms and sexual health: the role of gender, lifestyle and medical comorbidities, BJU Int, 103, 42, 10.1111/j.1464-410X.2009.08370.x Terai, 2004, Association of lower urinary tract symptoms with erectile dysfunction in Japanese men, Urology, 64, 132, 10.1016/j.urology.2004.02.019 Ponholzer, 2004, Association between lower urinary tract symptoms and erectile dysfunction, Urology, 64, 772, 10.1016/j.urology.2004.05.025 McVary, 2005, Erectile dysfunction and lower urinary tract symptoms secondary to BPH, Eur Urol, 47, 838, 10.1016/j.eururo.2005.02.001 Orabi, 2011, Association of lower urinary tract symptoms and erectile dysfunction: pathophysiological aspects and implications for clinical management, Int J Impot Res, 23, 99, 10.1038/ijir.2011.14 Cellek, 2014, Microvascular dysfunction and efficacy of PDE5 inhibitors in BPH–LUTS, Nat Rev Urol, 11, 231, 10.1038/nrurol.2014.53 Andersson, 2011, Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction, Pharmacol Rev, 63, 811, 10.1124/pr.111.004515 Lin, 2005, Cyclic nucleotide signaling in cavernous smooth muscle, J Sex Med, 2, 478, 10.1111/j.1743-6109.2005.00080.x Bloch, 1997, Distribution of nitric oxide synthase implies a regulation of circulation, smooth muscle tone, and secretory function in the human prostate by nitric oxide, Prostate, 33, 1, 10.1002/(SICI)1097-0045(19970915)33:1<1::AID-PROS1>3.0.CO;2-P Gacci, 2016, Latest evidence on the use of phosphodiesterase type 5 inhibitors for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia, Eur Urol, 70, 124, 10.1016/j.eururo.2015.12.048 Persson, 2000, Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I, Am J Physiol Regul Integr Comp Physiol, 279, R1112, 10.1152/ajpregu.2000.279.3.R1112 Christ, 2007, Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract, Neurourol Urodyn, 26, 948, 10.1002/nau.20475 Chitaley, 2001, RhoA/Rho-kinase: a novel player in the regulation of penile erection, Int J Impot Res, 13, 67, 10.1038/sj.ijir.3900647 Schiff, 2004, The link between LUTS and ED: clinical and basic science evidence, J Androl, 25, 470, 10.1002/j.1939-4640.2004.tb02818.x Sopko, 2014, Understanding and targeting the Rho kinase pathway in erectile dysfunction, Nat Rev Urol, 11, 622, 10.1038/nrurol.2014.278 Rees, 2003, Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells, J Urol, 170, 2517, 10.1097/01.ju.0000085024.47406.6c Bing, 2003, Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase, Am J Physiol Renal Physiol, 285, F990, 10.1152/ajprenal.00378.2002 Cholesterol, 2002, Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report, Circulation, 106, 3143, 10.1161/circ.106.25.3143 Tune, 2017, Cardiovascular consequences of metabolic syndrome, Transl Res, 183, 57, 10.1016/j.trsl.2017.01.001 De Nunzio, 2012, The correlation between metabolic syndrome and prostatic diseases, Eur Urol, 61, 560, 10.1016/j.eururo.2011.11.013 McVary, 2005, Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia, J Urol, 174, 1327, 10.1097/01.ju.0000173072.73702.64 Jin, 2009, Substantial detrusor overactivity in conscious spontaneously hypertensive rats with hyperactive behaviour, Scand J Urol Nephrol, 43, 3, 10.1080/00365590802468750 Behr-Roussel, 2003, Erectile dysfunction in spontaneously hypertensive rats: pathophysiological mechanisms, Am J Physiol Regul Integr Comp Physiol, 284, R682, 10.1152/ajpregu.00349.2002 Azadzoi, 1999, Atherosclerosis-induced chronic ischemia causes bladder fibrosis and non-compliance in the rabbit, J Urol, 161, 1626, 10.1016/S0022-5347(05)68995-1 Thurmond, 2016, LUTS in pelvic ischemia: a new concept in voiding dysfunction, Am J Physiol Renal Physiol, 310, F738, 10.1152/ajprenal.00333.2015 Andersson, 2015, Chronic pelvic ischemia: contribution to the pathogenesis of lower urinary tract symptoms (LUTS): a new target for pharmacological treatment?, Low Urin Tract Symptoms, 7, 1, 10.1111/luts.12084 Azadzoi, 2011, Molecular reactions and ultrastructural damage in the chronically ischemic bladder, J Urol, 186, 2115, 10.1016/j.juro.2011.06.047 Gacci, 2015, Metabolic syndrome and benign prostatic enlargement: a systematic review and meta-analysis, BJU Int, 115, 24, 10.1111/bju.12728 Besiroglu, 2015, The relationship between metabolic syndrome, its components, and erectile dysfunction: a systematic review and a meta-analysis of observational studies, J Sex Med, 12, 1309, 10.1111/jsm.12885 Coffey, 2001, Similarities of prostate and breast cancer: evolution, diet, and estrogens, Urology, 57, 31, 10.1016/S0090-4295(00)00938-9 Rabijewski, 2015, Hormonal determinants of erectile dysfunction and lower urinary tract symptoms in middle-aged and elderly men with prediabetes, Aging Male, 18, 256, 10.3109/13685538.2015.1083972 Oudot, 2012, A new experimental rat model of erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: the testosterone-supplemented spontaneously hypertensive rat, BJU Int, 110, 1352, 10.1111/j.1464-410X.2012.11085.x Carneiro, 2010, Emerging role for TNF-α in erectile dysfunction, J Sex Med, 7, 3823, 10.1111/j.1743-6109.2010.01762.x Robert, 2009, Inflammation in benign prostatic hyperplasia: a 282 patients’ immunohistochemical analysis, Prostate, 69, 1774, 10.1002/pros.21027 De Nunzio, 2016, Inflammatory mediators in the development and progression of benign prostatic hyperplasia, Nat Rev Urol, 13, 613, 10.1038/nrurol.2016.168 Rosen, 2009, Ejaculatory dysfunction in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia, BJU Int, 104, 974, 10.1111/j.1464-410X.2009.08503.x Elliott, 2004, Obstructive lower urinary tract symptoms correlate with erectile dysfunction, Urology, 63, 1148, 10.1016/j.urology.2004.01.039 Fusco, 2013, BPH/LUTS and ED: common pharmacological pathways for a common treatment, J Sex Med, 10, 2382, 10.1111/jsm.12261 Seftel, 2013, Coexisting lower urinary tract symptoms and erectile dysfunction: a systematic review of epidemiological data, Int J Clin Pract, 67, 32, 10.1111/ijcp.12044 Albisinni, 2017, New treatment strategies for benign prostatic hyperplasia in the frail elderly population: a systematic review, Minerva Urol Nefrol, 69, 119 AUA Practice Guidelines Committee, 2003, AUA guideline on management of benign prostatichyperplasia (2003). Chapter 1: diagnosis and treatment recommendations, J Urol, 170, 530, 10.1097/01.ju.0000078083.38675.79 Giuliano, 2008, Lower urinary tract symptoms and sexual dysfunction: a common approach, BJU Int, 101, 22, 10.1111/j.1464-410X.2008.07494.x Kunelius, 1998, Sexual functions in patients with benign prostatic hyperplasia before and after transurethral resection of the prostate, Urol Res, 26, 7, 10.1007/s002400050015 Blanker, 2001, Correlates for erectile and ejaculatory dysfunction in older Dutch men: a community-based study, J Am Geriatr Soc, 49, 436, 10.1046/j.1532-5415.2001.49088.x Leliefeld, 2002, Sexual function before and after various treatments for symptomatic benign prostatic hyperplasia, BJU Int, 89, 208, 10.1046/j.1464-4096.2001.01817.x Moreira, 2002, Prevalence and correlates of erectile dysfunction in Salvador, northeastern Brazil: a population-based study, Int J Impot Res, 14, S3, 10.1038/sj.ijir.3900892 Vallancien, 2003, Alf-One Study Group Sexual dysfunction in 1,274 European men suffering from lower urinary tract symptoms, J Urol, 169, 2257, 10.1097/01.ju.0000067940.76090.73 Chung, 2004, Lower urinary tract symptoms and sexual dysfunction in community-dwelling men, Mayo Clin Proc, 79, 745, 10.1016/S0025-6196(11)62626-8 Hansen, 2004, Lower urinary tract symptoms (LUTS) and sexual function in both sexes, Eur Urol, 46, 229, 10.1016/j.eururo.2004.04.005 McVary, 2004, The medical therapy of prostatic symptoms trial, Curr Urol Rep, 5, 249, 10.1007/s11934-004-0046-2 Sak, 2004, What is the relationship between male sexual function and lower urinary tract symptoms (LUTS)?, Eur Urol, 46, 482, 10.1016/j.eururo.2004.06.017 Shiri, 2005, Association between the bothersomeness of lower urinary tract symptoms and the prevalence of erectile dysfunction, J Sex Med, 2, 438, 10.1111/j.1743-6109.2005.20363.x El-Sakka, 2005, Lower urinary tract symptoms in patients with erectile dysfunction: is there a vascular association?, Eur Urol, 48, 319, 10.1016/j.eururo.2005.04.032 Li, 2005, Lower urinary tract symptoms and male sexual dysfunction in Asia: a survey of ageing men from five Asian countries, BJU Int, 96, 1339, 10.1111/j.1464-410X.2005.05831.x Paick, 2005, The relationship among lower urinary tract symptoms, prostate specific antigen and erectile dysfunction in men with benign prostatic hyperplasia: results from the PROSCAR long-term efficacy and safety study, J Urol, 173, 903, 10.1097/01.ju.0000152088.00361.a7 Liu, 2006, Are lower urinary tract symptoms associated with erectile dysfunction in aging males of Taiwan?, Urol Int, 77, 251, 10.1159/000094818 Reggio, 2007, Correlation between lower urinary tract symptoms and erectile dysfunction in men presenting for prostate cancer screening, Int J Impot Res, 19, 492, 10.1038/sj.ijir.3901557 Brookes, 2008, Relationship between lower urinary tract symptoms and erectile dysfunction: results from the Boston Area Community Health Survey, J Urol, 179, 250, 10.1016/j.juro.2007.08.167 Rhoden, 2008, Evaluation of the association between lower urinary tract symptoms and erectile dysfunction, considering its multiple risk factors, J Sex Med, 5, 2662, 10.1111/j.1743-6109.2008.00877.x Ikuerowo, 2008, Association between erectile dysfunction and lower urinary tract symptoms due to benign prostatic hyperplasia in Nigerian men, Urol Int, 80, 296, 10.1159/000127345 Mehraban, 2008, Sexual dysfunction in aging men with lower urinary tract symptoms, Urol J, 5, 260 Ozayar, 2008, The relationship between lower urinary tract symptoms (LUTS), diagnostic indicators of benign prostatic hyperplasia (BPH), and erectile dysfunction in patients with moderate to severely symptomatic BPH, Int Urol Nephrol, 40, 933, 10.1007/s11255-008-9386-z Li, 2008, An Asian multinational prospective observational registry of patients with benign prostatic hyperplasia, with a focus on comorbidities, lower urinary tract symptoms and sexual function, BJU Int, 101, 197 Khoo, 2008, Erectile dysfunction and comorbidities in aging men: an urban cross-sectional study in Malaysia, J Sex Med, 5, 2925, 10.1111/j.1743-6109.2008.00988.x Mondul, 2008, A prospective study of lower urinary tract symptoms and erectile dysfunction, J Urol, 179, 2321, 10.1016/j.juro.2008.01.150 Rosen, 2009, Association of sexual dysfunction with lower urinary tract symptoms of BPH and BPH medical therapies: results from the BPH Registry, Urology, 73, 562, 10.1016/j.urology.2008.05.034 Demir, 2009, Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome, Aging Male, 12, 29, 10.1080/13685530902777425 Jung, 2009, Correlation between lower urinary tract symptoms (LUTS) and sexual function in benign prostatic hyperplasia: impact of treatment of LUTS on sexual function, J Sex Med, 6, 2299, 10.1111/j.1743-6109.2009.01324.x Wong, 2009, A prospective study on the association between lower urinary tract symptoms (LUTS) and erectile dysfunction: results from a large study in elderly Chinese in southern China, J Sex Med, 6, 2024, 10.1111/j.1743-6109.2009.01295.x Tsai, 2010, The impact of irritative lower urinary tract symptoms on erectile dysfunction in aging Taiwanese males, Aging Male, 13, 179, 10.3109/13685531003586975 Nasir, 2011, The correlation between international prostate symptoms score and sexual health inventory in men with lower urinary tract symptoms, Int Urol Nephrol, 43, 625, 10.1007/s11255-010-9888-3 Lee, 2013, Association of lower urinary tract symptom/benign prostatic hyperplasia measures with International Index of Erectile Function 5 in middle-aged policemen of Korea and the role of metabolic syndrome and testosterone in their relationship, Urology, 82, 1008, 10.1016/j.urology.2013.07.003 Aktas, 2011, Impact of metabolic syndrome on erectile dysfunction and lower urinary tract symptoms in benign prostatic hyperplasia patients, Aging Male, 14, 48, 10.3109/13685538.2010.529197 Nakamura, 2012, Association between lower urinary tract symptoms and sexual dysfunction assessed using the core lower urinary tract symptom score and International Index of Erectile Function-5 questionnaires, Aging Male, 15, 111, 10.3109/13685538.2011.646342 Dutkiewicz, 2012, Assessing the influence of benign prostatic hyperplasia (BPH) on erectile dysfunction (ED) among patients in Poland, Cent Eur J Urol, 65, 135, 10.5173/ceju.2012.03.art7 Song, 2013, Lower urinary tract symptoms and erectile dysfunction in men with type 2 diabetes mellitus, Int Neurourol J, 17, 180, 10.5213/inj.2013.17.4.180 Barbosa, 2013, Interactions between lower urinary tract symptoms and cardiovascular risk factors determine distinct patterns of erectile dysfunction: a latent class analysis, J Urol, 190, 2177, 10.1016/j.juro.2013.05.048 Fwu, 2015, Cross-sectional and longitudinal associations of sexual function with lower urinary tract symptoms in men with benign prostatic hyperplasia, J Urol, 193, 231, 10.1016/j.juro.2014.08.086 Shigehara, 2014, Lower urinary tract symptoms are associated with erectile function and psychological symptoms in men with late-onset hypogonadism syndrome, LUTS Low Urin Tract Symptoms, 6, 151, 10.1111/luts.12033 Song, 2014, Lower urinary tract symptoms, erectile dysfunction, and their correlation in men aged 50 years and above: a cross-sectional survey in Beijing, China, Med Sci Monit, 20, 2806, 10.12659/MSM.891180 Gonzalez-Sanchez, 2016, The correlation between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED): results from a survey in males from Mexico City (MexiLUTS), World J Urol, 34, 979, 10.1007/s00345-015-1703-4 Korneyev, 2016, Prevalence and risk factors for erectile dysfunction and lower urinary tract symptoms in Russian Federation men: analysis from a national population-based multicenter study, Int J Impot Res, 28, 74, 10.1038/ijir.2016.8