Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

Nucleic Acids Research - Tập 38 Số 15 - Trang 4958-4969 - 2010
Diego Pasini1, Martina Malatesta2, Hye Ryung Jung2, Julian Walfridsson2, Anton Willer2, Linda Olsson2, Julie Skotte2, Anton Wutz3, Bo T. Porse2, Ole N. Jensen2, Kristian Helin2
1Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
2Research Institute of Molecular Pathology, Vienna, Austria
3Research Institute of Molecular Pathology, Dr Bohr Gasse 7 Vienna Austria

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Schuettengruber, 2007, Genome regulation by polycomb and trithorax proteins, Cell, 128, 735, 10.1016/j.cell.2007.02.009

Schwartz, 2007, Polycomb silencing mechanisms and the management of genomic programmes, Nat. Rev. Genet., 8, 9, 10.1038/nrg1981

Cao, 2002, Role of histone H3 lysine 27 methylation in Polycomb-group silencing, Science, 298, 1039, 10.1126/science.1076997

Czermin, 2002, Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites, Cell, 111, 185, 10.1016/S0092-8674(02)00975-3

Kuzmichev, 2002, Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein, Genes Dev., 16, 2893, 10.1101/gad.1035902

Muller, 2002, Histone methyltransferase activity of a Drosophila Polycomb group repressor complex, Cell, 111, 197, 10.1016/S0092-8674(02)00976-5

Boyer, 2006, Polycomb complexes repress developmental regulators in murine embryonic stem cells, Nature, 441, 349, 10.1038/nature04733

Bracken, 2006, Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions, Genes Dev., 20, 1123, 10.1101/gad.381706

Lee, 2006, Control of developmental regulators by Polycomb in human embryonic stem cells, Cell, 125, 301, 10.1016/j.cell.2006.02.043

Montgomery, 2005, The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation, Curr. Biol., 15, 942, 10.1016/j.cub.2005.04.051

O’Carroll, 2001, The polycomb-group gene Ezh2 is required for early mouse development, Mol. Cell. Biol., 21, 4330, 10.1128/MCB.21.13.4330-4336.2001

Pasini, 2004, Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity, EMBO J., 23, 4061, 10.1038/sj.emboj.7600402

Voncken, 2003, Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition, Proc. Natl Acad. Sci. USA, 100, 2468, 10.1073/pnas.0434312100

Bernstein, 2006, Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin, Mol. Cell. Biol., 26, 2560, 10.1128/MCB.26.7.2560-2569.2006

Cao, 2005, Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing, Mol. Cell, 20, 845, 10.1016/j.molcel.2005.12.002

Bracken, 2003, EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer, EMBO J., 22, 5323, 10.1093/emboj/cdg542

Jacobs, 1999, The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus, Nature, 397, 164, 10.1038/16476

Kleer, 2003, EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells, Proc. Natl Acad. Sci. USA, 100, 11606, 10.1073/pnas.1933744100

Koontz, 2001, Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors, Proc. Natl Acad. Sci. USA, 98, 6348, 10.1073/pnas.101132598

Varambally, 2002, The polycomb group protein EZH2 is involved in progression of prostate cancer, Nature, 419, 624, 10.1038/nature01075

Dietrich, 2007, Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus, EMBO J., 26, 1637, 10.1038/sj.emboj.7601632

Gil, 2004, Polycomb CBX7 has a unifying role in cellular lifespan, Nat. Cell Biol., 6, 67, 10.1038/ncb1077

Pasini, 2007, The polycomb group protein Suz12 is required for embryonic stem cell differentiation, Mol. Cell. Biol., 27, 3769, 10.1128/MCB.01432-06

Su, 2003, Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement, Nat. Immunol., 4, 124, 10.1038/ni876

Bryja, 2006, Derivation of mouse embryonic stem cells, Nat. Protoc., 1, 2082, 10.1038/nprot.2006.355

Schoeftner, 2006, Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing, EMBO J., 25, 3110, 10.1038/sj.emboj.7601187

Hansen, 2008, A model for transmission of the H3K27me3 epigenetic mark, Nat. Cell. Biol., 10, 1291, 10.1038/ncb1787

Somervaille, 2006, Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia, Cancer Cell, 10, 257, 10.1016/j.ccr.2006.08.020

Lamers, 2008, Retronectin-assisted retroviral transduction of primary human T lymphocytes under good manufacturing practice conditions: tissue culture bag critically determines cell yield, Cytotherapy, 10, 406, 10.1080/14653240801982961

Martin, 2003, Dimerization of MLL fusion proteins immortalizes hematopoietic cells, Cancer Cell, 4, 197, 10.1016/S1535-6108(03)00214-9

Bruno, 2004, Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro, Mol. Cell. Biol., 24, 741, 10.1128/MCB.24.2.741-756.2004

Jung, 2010, Quantitative mass spectrometry of histone H3.2 and H3.3 in Suz12 deficient mouse ES cells reveals distinct, dynamic post-translational modifications at K27 and K36, Mol. Cell Proteomics, 10.1074/mcp.M900489-MCP200

Pasini, 2008, Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2, Genes Dev., 22, 1345, 10.1101/gad.470008

Villa, 2007, Role of the polycomb repressive complex 2 in acute promyelocytic leukemia, Cancer Cell, 11, 513, 10.1016/j.ccr.2007.04.009

Mohn, 2008, Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors, Mol. Cell, 30, 755, 10.1016/j.molcel.2008.05.007

Krumlauf, 1994, Hox genes in vertebrate development, Cell, 78, 191, 10.1016/0092-8674(94)90290-9

Ford, 1998, Homeobox genes: a link between development, cell cycle, and cancer? Cell Biol, Int., 22, 397

Thorsteinsdottir, 2002, Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion, Blood, 99, 121, 10.1182/blood.V99.1.121

Daser, 2004, Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis, Genes Dev., 18, 965, 10.1101/gad.1195504

Kumar, 2004, Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia, Blood, 103, 1823, 10.1182/blood-2003-07-2582

Moore, 2007, NUP98 dysregulation in myeloid leukemogenesis, Ann. N. Y. Acad. Sci., 1106, 114, 10.1196/annals.1392.019

Corral, 1996, An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes, Cell, 85, 853, 10.1016/S0092-8674(00)81269-6

Allis, 2007, New nomenclature for chromatin-modifying enzymes, Cell, 131, 633, 10.1016/j.cell.2007.10.039

Balasubramanyam, 2003, Small molecule modulators of histone acetyltransferase p300, J. Biol. Chem., 278, 19134, 10.1074/jbc.M301580200

Eliseeva, 2007, Characterization of novel inhibitors of histone acetyltransferases, Mol. Cancer Ther., 6, 2391, 10.1158/1535-7163.MCT-07-0159

Chen, 2008, Integration of external signaling pathways with the core transcriptional network in embryonic stem cells, Cell, 133, 1106, 10.1016/j.cell.2008.04.043

Tenney, 2005, A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin, J. Cell. Biochem., 95, 429, 10.1002/jcb.20421

Mikkelsen, 2007, Genome-wide maps of chromatin state in pluripotent and lineage-committed cells, Nature, 448, 553, 10.1038/nature06008

Ernst, 2001, MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein, Mol. Cell. Biol., 21, 2249, 10.1128/MCB.21.7.2249-2258.2001

Giles, 1998, Conjunction dysfunction: CBP/p300 in human disease, Trends Genet., 14, 178, 10.1016/S0168-9525(98)01438-3

Tie, 2009, CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing, Development, 136, 3131, 10.1242/dev.037127

Ringrose, 2007, Polycomb/Trithorax response elements and epigenetic memory of cell identity, Development, 134, 223, 10.1242/dev.02723

Pasini, 2010, JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells, Nature, 464, 306, 10.1038/nature08788

Peng, 2009, Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells, Cell, 139, 1290, 10.1016/j.cell.2009.12.002

Shen, 2009, Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells, Cell, 139, 1303, 10.1016/j.cell.2009.12.003

Tanaka, 2000, Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein, Mech. Dev., 95, 133, 10.1016/S0925-4773(00)00360-9

Yao, 1998, Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300, Cell, 93, 361, 10.1016/S0092-8674(00)81165-4

Roth, 2003, Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5, EMBO J., 22, 5186, 10.1093/emboj/cdg473

Lavau, 2000, Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia, EMBO J., 19, 4655, 10.1093/emboj/19.17.4655

Ohnishi, 2008, A complex t(1;22;11)(q44;q13;q23) translocation causing MLL-p300 fusion gene in therapy-related acute myeloid leukemia, Eur. J. Haematol., 81, 475, 10.1111/j.1600-0609.2008.01154.x

Taki, 1997, The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene, Blood, 89, 3945, 10.1182/blood.V89.11.3945

Hermanson, 2002, Nuclear receptor coregulators: multiple modes of modification, Trends Endocrinol. Metab., 13, 55, 10.1016/S1043-2760(01)00527-6

Spiegelman, 2004, Biological control through regulated transcriptional coactivators, Cell, 119, 157, 10.1016/j.cell.2004.09.037