Matrix Metalloproteinases (MMPs) and Their Physiological Inhibitors (TIMPs) Are Differentially Expressed during Excisional Skin Wound Repair

Ågren, 1994, Gelatinase activity during wound healing, Br. J. Dermatol., 131, 634, 10.1111/j.1365-2133.1994.tb04974.x Apte, 1994, Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10, Dev. Dyn., 200, 177, 10.1002/aja.1002000302 Birkedal-Hansen, 1995, Proteolytic remodeling of extracellular matrix, Curr. Opin. Cell Biol., 7, 728, 10.1016/0955-0674(95)80116-2 Birkedal-Hansen, 1993, Matrix metalloproteinases: A review, Crit. Rev. Oral Biol. Med., 4, 197, 10.1177/10454411930040020401 Brauchle, 1995, Suppression of keratinocyte growth factor expression by glucocorticoidsin vitro, J. Invest. Dermatol., 105, 579, 10.1111/1523-1747.ep12323521 Bullen, 1995, Tissue inhibitor of metalloproteinase-1 is decreased and activated gelatinases are increased in chronic wounds, J. Invest. Dermatol., 104, 236, 10.1111/1523-1747.ep12612786 Chandler, 1997, Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-α fusion protein, Biochem. Biophys. Res. Commun., 228, 421, 10.1006/bbrc.1996.1677 Clark, 1996 DiPietro, 1995, Wound healing: The role of the macrophage and other immune cells, Shock, 4, 233, 10.1097/00024382-199510000-00001 Dong, 1997, Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma, Cell, 88, 801, 10.1016/S0092-8674(00)81926-1 Gailit, 1994, Wound repair in the context of extracellular matrix, Curr. Opin. Cell Biol., 6, 717, 10.1016/0955-0674(94)90099-X Gronski, 1997, Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase, J. Biol. Chem., 272, 12189, 10.1074/jbc.272.18.12189 Halpert, 1996, Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme, Proc. Natl. Acad. Sci. USA, 93, 9748, 10.1073/pnas.93.18.9748 Hammani, 1992, Cloning and sequencing of a cDNA encoding mouse stromelysin 1, Gene, 120, 321, 10.1016/0378-1119(92)90116-7 Henriet, 1992, Cloning and sequencing of mouse collagenase cDNA: Divergence of mouse and rat collagenases from the other mammalian collagenases, FEBS Lett., 310, 175, 10.1016/0014-5793(92)81323-E Johnson, 1987, Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C, Mol. Cell Biol., 7, 2821, 10.1128/MCB.7.8.2821 Kinoh, 1996, MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis, J. Cell Sci., 109, 953, 10.1242/jcs.109.5.953 Leco, 1992, Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts, Gene, 117, 209, 10.1016/0378-1119(92)90731-4 Madlener, 1996, Regulation of the expression of stromelysin-2 by growth factors in keratinocytes: Implications for normal and impaired wound healing, Biochem. J., 320, 659, 10.1042/bj3200659 Martin, 1997, Wound healing—Aiming for perfect skin regeneration, Science, 276, 75, 10.1126/science.276.5309.75 Matrisian, 1990, Metalloproteinases and their inhibitors in matrix remodeling, TIG, 6, 122, 10.1016/0168-9525(90)90126-Q O'Reilly, 1994, Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma, Cell, 79, 315, 10.1016/0092-8674(94)90200-3 Okada, 1995, Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas, Proc. Natl. Acad. Sci. USA, 92, 2730, 10.1073/pnas.92.7.2730 Okada, 1997, Expression of matrix metalloproteinases during rat skin wound healing: Evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A, J. Cell Biol., 137, 67, 10.1083/jcb.137.1.67 Puente, 1996, Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma, Cancer Res., 56, 944 Reponen, 1992, Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development, J. Biol. Chem., 267, 7856, 10.1016/S0021-9258(18)42592-6 Reponen, 1994, Expression of 92-kDa type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development, J. Cell Biol., 124, 1091, 10.1083/jcb.124.6.1091 Rosenthal, 1987, Primary structure and mRNA localization of protein F1, a growth-related protein kinase C substrate associated with synaptic plasticity, EMBO J., 12, 3641, 10.1002/j.1460-2075.1987.tb02696.x Saarialho-Kere, 1992, Distinct localization of collagenase and TIMP expression in wound healing associated with ulcerative pyogenic granuloma, J. Clin. Invest., 90, 1952, 10.1172/JCI116073 Saarialho-Kere, 1994, Distinct populations of keratinocytes express stromelysin-1 and -2 in chronic wounds, J. Clin. Invest., 94, 79, 10.1172/JCI117351 Salo, 1994, Expression of matrix metalloproteinase-2 and -9 during early human wound healing, Lab. Invest., 70, 176 Sato, 1994, A matrix metalloproteinase expressed on the surface of invasive tumour cells, Nature, 370, 61, 10.1038/370061a0 Shapiro, 1994, Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease, Am. J. Respir. Crit. Care Med., 150, S160, 10.1164/ajrccm/150.6_Pt_2.S160 Shapiro, 1992, Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase, J. Biol. Chem., 267, 4664, 10.1016/S0021-9258(18)42885-2 Shipley, 1996, Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice, Proc. Natl. Acad. Sci. USA, 93, 3942, 10.1073/pnas.93.9.3942 Ståhle-Bäckdahl, 1993, 92 kDa gelatinase is actively expressed by eosinophils and secreted by neutrophils invasive squamous cell carcinoma, Am. J. Pathol., 142, 995 Stricklin, 1994, Localization of mRNAs representing interstitial collagenase, 72-kDa gelatinase, and TIMP in healing porcine burn wounds, J. Invest. Dermatol., 103, 352, 10.1111/1523-1747.ep12394926 Stricklin, 1993, Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds, Am. J. Pathol., 143, 1657 Takino, 1995, Identification of the second membrane-type matrix metalloproteine (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family, J. Biol. Chem., 270, 23013, 10.1074/jbc.270.39.23013 Vaalamo, 1997, Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds, J. Invest. Dermatol., 109, 96, 10.1111/1523-1747.ep12276722 Vaalamo, 1996, Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds, Br. J. Dermatol., 135, 52, 10.1111/j.1365-2133.1996.tb03607.x Wahl, 1989, Glucocorticoids and wound healing Werner, 1992, Large induction of keratinocyte growth factor expression in the dermis during wound healing, Proc. Natl. Acad. Sci. USA, 89, 6896, 10.1073/pnas.89.15.6896 Will, 1995, cDNA sequence and mRNA tissue distibution of a novel human matrix metalloproteinase with a potential transmembrane segment, Eur. J. Biochem., 231, 602, 10.1111/j.1432-1033.1995.tb20738.x Woessner, 1991, Matrix metalloproteinases and their inhibitors in connective tissue remodeling, FASEB J., 5, 2145, 10.1096/fasebj.5.8.1850705 Wysocki, 1993, Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9, J. Invest. Dermatol., 101, 64, 10.1111/1523-1747.ep12359590 Young, 1994, Metalloproteinase activation cascade after burn injury: A longitudinal analysis of the human wound environment, J. Invest. Dermatol., 103, 660, 10.1111/1523-1747.ep12398424