Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart

Archiv für Kreislaufforschung - Tập 96 Số 6 - Trang 528-538 - 2001
Brodde, Otto-Erich1, Bruck, Heike1, Leineweber, Kirsten1, Seyfarth, Torsten1
1Institute of Pharmacology and Toxicology, Martin-Luther-University of Halle-Wittenberg, Magdeburger Str. 4, 06097 Halle/Saale, Germany, Tel.: +49-345/557-1773, Fax: +49-345/557-1835, E-Mail: [email protected], , DE

Tóm tắt

The sympathetic and parasympathetic nervous system play a powerful role in controlling cardiac function by activating adrenergic and muscarinic receptors. In the human heart there exist α1-, β1- and β2-adrenoceptors and M2-muscarinic receptors and possibly also (prejunctional) α2-adrenoceptors. β1- and β2-adrenoceptors are quite evenly distributed in the human heart while M2-receptors are heterogeneously distributed (more receptors in atria than in ventricles). Stimulation of β1- and β2-adrenoceptors causes increases in heart rate and force of contraction while stimulation of M2-receptors decreases heart rate (directly in atria) and force of contraction (indirectly in ventricles). Pathological situations (such as heart failure) or pharmacological interventions (for example, β-blocker treatment) can alter the distribution of β1- and β2-adrenoceptors in the human heart, while M2-receptors are only marginally affected. On the other hand, relatively little is known on distribution and functional role of α1- and α2-adrenoceptor subtypes in the human heart.