Manifold Mechanisms of Toll-Like Receptor-Ligand Recognition

Springer Science and Business Media LLC - Tập 25 - Trang 511-521 - 2005
Ken J. Ishii1,2, Cevayir Coban2,3, Shizuo Akira1,2,3
1Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
2Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), Chiyoda, Japan
321st Century COE Program, Research Institute forMicrobial Diseases, Osaka University, Osaka, Japan

Tóm tắt

Toll-like receptors recognize a diverse range of molecules derived from pathogens as well as host cells. As the number and diversity of TLR ligands and host factors increase, more questions are being raised. Here, we review recent advances toward understanding the molecular and cellular mechanisms underlying TLR-mediated direct or indirect recognition of their diverse range of ligands, including lipids, proteins, and nucleic acids. The elucidation of such mechanisms may represent a key for developing novel immunotherapeutics for infectious diseases, allergies, or cancer and to intervene in immunological disorders such as autoimmune diseases.

Tài liệu tham khảo

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