Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

World Health Organization: Schistosomiasis, Fact Sheet No 115. 2010. Available at http://www.who.int/mediacentre/factsheets/fs115/en/index.html

Cheever AW, Lenzi JA, Lenzi HL, Andrade ZA: Experimental models of Schistosoma mansoni infection. Mem Inst Oswaldo Cruz 2002, 97: 917-940. 10.1590/S0074-02762002000700002

Wilson RA, Langermans JAM, Van Dam GJ, Vervenne RA, Hall SL, Borges WC, Dillon GP, Thomas AW, Coulson PS: Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine? PLoS Negl Trop Dis 2008, 2: e290. 10.1371/journal.pntd.0000290

Pinlaor S, Prakobwong S, Hiraku Y, Kaewsamut B, Dechakhamphu S, Boonmars T, Sithithaworn P, Pinlaor P, Ma N, Yongvanit P, Kawanishi P: Oxidative and nitrative stress in Opisthorchis viverrini -infected hamsters: an indirect effect after praziquantel treatment. Am J Trop Med Hyg 2008, 78: 564-573.

Doenhoff MJ, Cioli D, Utzinger J: Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis 2008, 21(6):659-67. http://www.ncbi.nlm.nih.gov/pubmed/18978535 10.1097/QCO.0b013e328318978f

Amer N, Kamel M: Tegumental alteration and immunological changes in murine Schistosomiasis mansoni after treatment with Artemesia extract. J Egypt Med 2002, 26: 14-22.

Hammond JA, Fielding D, Bishop SC: Prospects for plant anthelmintics in tropical veterinary medicine. Vet Res Commun 1997, 21: 213-228. 10.1023/A:1005884429253

Hoareau L, Dasilva EJ: Medicinal plant: a re-emerging health aid. Electron J Biotechnol 1996, 2: 60-65.

Tanwer BS, Vijayvergia R: Phytochemical evaluation and quantification of primary metabolites of Alangium salviifolium . Int J Pharm Biosci 2010, 1: 1-6.

Zuo F, Nakamura N, Akao T, Hattori M: Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos 2006, 34: 2064-2072. 10.1124/dmd.106.011361

Birdsall TC, Kelly GS: Berberine: therapeutic potential of an alkaloid found in several medicinal plants. Altern Med Rev 1997, 2: 94-103.

Rockova L, Majekova M, Kost D, Stefek M: Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium . Structural Aspects Bioorg Med Chem 2004, 12: 4709-4715. 10.1016/j.bmc.2004.06.035

Küpeli E, Koşar M, Yeşilada E, Hüsnü K, Başer C: A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. Life Sci 2002, 72: 645-657. 10.1016/S0024-3205(02)02200-2

Kim TS, Kang BY, Cho D, Kim SH: Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4 T cells from a Th2 to a Th1 response. Immunology 2003, 109: 407-414. 10.1046/j.1365-2567.2003.01673.x

Hwang JM, Wang CJ, Chou FP, Tseng TH, Hsieh YS, Lin WL, Chu CY: Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver. Arch Toxicol 2002, 76: 664-670. 10.1007/s00204-002-0351-9

Zhang BJ, Xu D, Guo Y, Ping J, Wang H, Chen LB: Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors. Clin Exp Pharmacol Physiol 2008, 35: 303-309. 10.1111/j.1440-1681.2007.04819.x

Ishak K, Baptista A, Bianchi L, Callea F, Degroote J, Gudat F, Denk H, Desmet V, Korb G, Macsween RNM, Phillips MJ, Portmann BG, Poulsen H, Scheuer PJ: Histological grading and staging of chronic hepatitis. J Hepatol 1995, 22: 696-699. 10.1016/0168-8278(95)80226-6

Cheever AW: A quantitative post mortem study of Schistosoma mansoni in man. Am J Trop Med Hyg 1968, 17: 38-64.

Chesney J, Metz C, Stavitsky AB, Bacher M, Bucala R: Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. J Immunol 1998, 160: 419-425.

Eitzman DT, Westrick RJ, Xu Z, Tyson J, Ginsburg D: Hyperlipidemia promotes thrombosis after injury to atherosclerotic vessels in apolipoprotein E–deficient mice. Arterioscl Throm Vas 2000, 20(7):1831-1834. http://www.ncbi.nlm.nih.gov/pubmed/10894825 10.1161/01.ATV.20.7.1831

Lane DA, Philippou H, Huntington JA: Directing thrombin. Blood 2005, 06: 2605-2612.

Hanna LS, Medhat AM, Abdel-Menem HA: Biochemical changes after subchronic and chronic interaction of Schistosoma mansoni infection in Swiss albino mice with two specific compounds. J Egypt Soc Parasitol 2003, 33: 245-260.

Attallah AM, Wahba MA, Elsheikha HM, Abbas AT, Abdel Aziz MM, El-Hemaly MA: Outcomes of Schistosoma mansoni infection in outbred albino mice exposed to Larvin contaminant. Parasitol Res 2008, 103: 567-576. 10.1007/s00436-008-1011-7

La Flamme AC, Patton EA, Bauman B, Pearce EJ: IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasis. J Immunol 2001, 166: 1903-1911.

Zhu X, Guo X, Mao G, Gao Z, Wang H, He Q, Li D: Hepatoprotection of berberine against hydrogen peroxide-induced apoptosis by upregulation of sirtuin 1. Phytother Res 2012, 27: 414-421.

Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI: The central role of glutathione in the pathophysiology of human diseases. Arch Physiol Biochem 2007, 113: 234-258. 10.1080/13813450701661198

Cunha GM, Silva VM, Bessa KD, Bitencourt MA, Macêdo UB, Freire-Neto FP, Assis CF, Martins RR, Lemos TM, Freire AC, Almeida MG: Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis. Acta Parasitol 2012, 57: 160-166. 10.2478/s11686-012-0026-5

El Shenawy NS, Soliman MF, Reyad SI: The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice. Rev Inst Med Trop Sao Paulo 2008, 50: 29-36.

Rajasekaran S, Sivagnanam K, Subramanian S: Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep 2005, 57: 90-96.

Oliver L, Stirewalt MA: An efficient method for exposure of mice to cercariae of Schistosoma mansoni . J Parasitol 1952, 38: 19-23. 10.2307/3274166

Jahnke GD, Price CJ, Marr MC, Myers CB, George JD: Developmental toxicity evaluation of berberine in rats and mice. Birth Defects Res B Dev Reprod Toxicol 2006, 77: 195-206. 10.1002/bdrb.20075

Tsakiris S, Schulpis KH, Marinou K, Behrakis P: Protective effect of L-cysteine and glutathione on the modulated suckling rat brain Na+, K+, -ATPase and Mg2 + - ATPase activities induced by the in vitro galactosaemia. Pharmacol Res 2004, 49: 475-479. 10.1016/j.phrs.2003.11.006

Pelligrino J, Oliveria CA, Faria JA, Cunha AC: New approach to the screening of drugs in experimental Schistosoma mansoni in mice. Am J Trop Med Hyg 1962, 11: 201-215.

Jamshidzadeh A, Baghban M, Azarpira N, Bardbori AM, Niknahad H: Effects of tomato extract on oxidative stress induced toxicity in different organs of rats. Food Chem Toxicol 2008, 46: 3612-3615. 10.1016/j.fct.2008.09.006

Reitman S, Frankel S: A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957, 28: 56-63.

Schmidt M, Eisenburg J: Serum bilirubin determination in newborn infants: a new micromethod for the determination of serum of plasma bilirubin in newborn infants. Fortschr Med 1975, 93: 1461-1466.

Szaz G: A kinetic photometric method for serum gamma glutamyltranspeptidase. Clin Chem 1969, 15: 124-136.

Ellman GL: Tissue sulfhydryl groups. Arch Biochem Biophys 1959, 82: 70-77. 10.1016/0003-9861(59)90090-6

Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95: 351-358. 10.1016/0003-2697(79)90738-3

Berkels R, Purol-Schnabel S, Roesen R: Measurement of nitric oxide by reconversion of nitrate/nitrite to NO. J Humana Press 2004, 279: 1-8.