The influence of obesity on inflammation and clinical symptoms in asthma

World Health Organization. WHO European Ministerial Conference on Counteracting Obesity. Conference report [Internet]. Denmark: WHO; 2007 [cited 2011 Dec 18]. 33p. ISBN: 978 92 890 7281 6. Available from: http://www.euro.who.int/en/what-we-do/health-topics/noncommunicable-diseases/obesity/publications/pre-2009/who-european-ministerial-conference-on-counteracting-obesity.-conference-report World Health Organization. Overweight and obesity. Fact sheet no. 311 [Internet]. Geneva: WHO; 2006 [cited 2011 Dec 18]. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/index.html. Mannino, 2002, Surveilance for asthma – United Srates, 1980-1999, MMWR Surveill Summ, 51, 1 Mosen, 2008, The relationship between obesity and asthma severity and control in adults, J Allergy Clin Immunol, 122, 507, 10.1016/j.jaci.2008.06.024 Shimizu, 2008, Prevalence in adult asthma and allergic rhinitis in Kamishihoro town, Hokkaido – association with smoking habit and obesity, Arerugi, 57, 835 Colombo, 2008, Body mass index in Th1 and Th2 disease, Immunology Letters, 117, 119, 10.1016/j.imlet.2008.01.003 Kusunoki, 2008, Obesity and the prevelance of allergic diseases in schoolchildren, Pediatr Allergy Immunol, 19, 527, 10.1111/j.1399-3038.2007.00686.x Ciprandi, 2008, Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma, Respiratory Medicine, 103, 1 Johnston, 2006, Augmented responses to ozone in obese carboxypeptidase E- deficient mice, Am J Physiol Regul Integr Comp Physiol, 290, 126, 10.1152/ajpregu.00306.2005 McClean, 2008, Obesity and the lung: Epidemiology, Thorax, 63, 649, 10.1136/thx.2007.086801 Shore, 2008, Obesity and asthma, J Allergy Clin Immunol, 121, 1087, 10.1016/j.jaci.2008.03.004 Mai, 2005, Early rapid weight gain and current overweight in relation to asthma in adolescents born with very low birth weight, Pediatr Allergy Immunol, 16, 380, 10.1111/j.1399-3038.2005.00290.x Rönmark, 2005, Obesity increases the risk of incident asthma among adults, Eur Respir J, 25, 283, 10.1183/09031936.05.00054304 Thomsen, 2005, The incidence of asthma in young adults, Chest, 127, 1928, 10.1378/chest.127.6.1928 McLachlan, 2007, Adiposity, asthma, and airway inflammation, J Allergy Clin Immunol, 119, 634, 10.1016/j.jaci.2006.10.029 Beuther, 2007, Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies, Am J Respir Crit Care Med, 175, 661, 10.1164/rccm.200611-1717OC Johnston, 2007, Allergic airway responses in obese mice, Am J Respir Crit Care Med, 176, 650, 10.1164/rccm.200702-323OC Lu, 2006, Increased pulmonary responses to acute ozone exposure in obese db/db mice, Am J Physiol Lung Cell Mol Physiol, 290, 856, 10.1152/ajplung.00386.2005 Lang, 2007, TNFα contributes to innate airway hyperresponsiveness in murine obesity, Am J Respir Crit Care Med, 175, 912 Gnacińska, 2009, Role of adipokines in complications related to obesity: a review, Adv Med Sci, 54, 150, 10.2478/v10039-009-0035-2 Fantuzzi, 2005, Adipose tissue, adipokines, and inflammation, J Allergy Clin Immunol, 115, 911, 10.1016/j.jaci.2005.02.023 Shore, 2005, Obesity, smooth muscle, and airway hyper responsiveness, J Allergy Clin Immunol, 115, 925, 10.1016/j.jaci.2005.01.064 Leivo-Korpela, 2011, Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma, J Inflamm (Lond), 8, 12, 10.1186/1476-9255-8-12 Sood, 2008, Association between asthma and serum adiponectin concentration in women, Thorax, 63, 877, 10.1136/thx.2007.090803 Holguin, 2011, Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls, J Asthma, 48, 217, 10.3109/02770903.2011.555033 Nagel, 2009, Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren, Pediatr Allergy Immunol, 20, 81, 10.1111/j.1399-3038.2008.00740.x Jartti, 2009, Obesity, adipokines and asthma, Allergy, 64, 770, 10.1111/j.1398-9995.2008.01872.x Larochelle, 2007, Plasma resistin levels in asthmatics as a marker of disease state, J Asthma, 44, 509, 10.1080/02770900701495785 Kim, 2008, Relationship between adipokines and manifestations of childhood asthma, Pediatr Allergy Immunol, 19, 535, 10.1111/j.1399-3038.2007.00690.x Silswal, 2005, Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway, Biochem Biophys Res Commun, 334, 1092, 10.1016/j.bbrc.2005.06.202 Alvarez-Liamas, 2007, Charakterization of the human visceral adipose tissue secretome, Molecular and Cellular Proteomics, 64, 589, 10.1074/mcp.M600265-MCP200 Lessard, 2008, Obesity and asthma: a specific phenotype?, Chest, 134, 317, 10.1378/chest.07-2959 van Veen, 2008, Airway inflammation in obese and nonobese patients with difficult to treat asthma, Allergy, 63, 570, 10.1111/j.1398-9995.2007.01597.x Sutherland, 2008, The association between obesity and asthma, Am J Respir Crit Care Med, 178, 469, 10.1164/rccm.200802-301OC Dixon, 2006, Effect of obesity on clinical presentation and response to treatment in asthma, Journal of Asthma, 43, 553, 10.1080/02770900600859123 Soferman, 2008, HsCRP levels: measurement of airway inflammation in asthmatic children, Pediatr Int, 50, 12, 10.1111/j.1442-200X.2007.02517.x Segura, 2007, Inflamatory markers associated with asthma and body mass index, Rev Alerg Mex, 54, 196 Sutherland, 2008, Body Mass and Glucocorticoid response in asthma, Am J Respir Crit Care Med, 178, 682, 10.1164/rccm.200801-076OC Haldar, 2008, Cluster analysis and clinical asthma phenotypes, Am J Respir Crit Care Med, 178, 218, 10.1164/rccm.200711-1754OC Todd, 2007, Effect of obesity on airway inflammation:cross-sectional analysis of body mass index and sputum cell counts, Clinical and Experimental Allergy, 37, 1049, 10.1111/j.1365-2222.2007.02748.x De Winter-de Groot, 2005, Exhaled nitric oxide: missing link between asthma and obesity?, J Allergy Clin Immunol, 115, 419, 10.1016/j.jaci.2004.11.025 Kazaks, 2005, No significant relationship between exhaled nitric oxide and body mass index in people with asthma, J allery and Clin Immunol, 116, 929, 10.1016/j.jaci.2005.06.005 Barros, 2006, Obesity and airway inflammation in asthma, J Allergy Clin Immunol, 117, 1501, 10.1016/j.jaci.2006.02.027 Linneberg, 2001, Factors related to alergic sensitization to aeroallergens in a cross-sectional study in adults: The Copenhagen Alergy Study, Clin Exp Allergy, 31, 1409, 10.1046/j.1365-2222.2001.01178.x Canoz, 2008, The relationship of inflammatory cytokines with asthma and obesity, Clin Invest Med, 1, 31 Sin, 2008, Obesity and the lung: 4. Obesity and asthma, Thorax, 63, 1018, 10.1136/thx.2007.086819 Jones, 2006, The effects of the body mass index on lung volumes, Chest, 130, 827, 10.1378/chest.130.3.827 Wang, 2008, Simulated obesity-related changes in lung volume increases airway responsiveness in lean nonasthmatic subjects, Chest, 130, 834, 10.1378/chest.130.3.834 Eneli, 2008, Weight loss and asthma: a systemic review, Thorax, 63, 671, 10.1136/thx.2007.086470 Aaron, 2004, Effect of weight reduction on respiratory function and airway reactivity in obese women, Chest, 125, 2046, 10.1378/chest.125.6.2046 Maniscalco, 2008, Weight loss and asthma control in severely obese asthmatic females, Respir Med, 102, 102, 10.1016/j.rmed.2007.07.029 Ma, 2010, The Breathe Easier through Weight Loss Lifestyle (BE WELL) Intervention: a randomized controlled trial, BMC Pulm Med, 10, 16, 10.1186/1471-2466-10-16