Superior Graft-versus-Leukemia Effect Associated with Transplantation of Haploidentical Compared with HLA-Identical Sibling Donor Grafts for High-Risk Acute Leukemia: An Historic Comparison

Ringden, 1987, European experience of bone marrow transplantation for leukemia, Transplant Proc, 19, 2600 Kanda, 2003, Allogeneic hematopoietic stem cell transplantation from family members other than HLA-identical siblings over the last decade (1991-2000), Blood, 102, 1541, 10.1182/blood-2003-02-0430 Szydlo, 1997, Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings, J Clin Oncol, 15, 1767, 10.1200/JCO.1997.15.5.1767 Beatty, 1985, Marrow transplantation from related donors other than HLA-identical siblings, N Engl J Med, 313, 765, 10.1056/NEJM198509263131301 Henslee-Downey, 1997, Use of partially mismatched related donors extends access to allogeneic marrow transplant, Blood, 89, 3864, 10.1182/blood.V89.10.3864 Mehta, 2004, Bone marrow transplantation from partially HLA-mismatched family donors for acute leukemia: single-center experience of 201 patients, Bone Marrow Transplant, 33, 389, 10.1038/sj.bmt.1704391 Reisner, 1983, Transplantation for severe combined immunodeficiency with HLA-A, B, D, DR incompatible parental marrow cells fractioned by soybean agglutinin and sheep red blood cells, Blood, 61, 341, 10.1182/blood.V61.2.341.341 Aversa, 1994, Successful engraftment of T cell-depleted haploidentical “3-loci” incompatibal transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum, Blood, 84, 3948, 10.1182/blood.V84.11.3948.bloodjournal84113948 Aversa, 1998, Treatment high-risk acute leukemia with T-cell-depleted stem cells from related donors with on fully mismatched HLA haplotype, N Engl J Med, 339, 1186, 10.1056/NEJM199810223391702 Aversa, 2005, Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse, J Clin Oncol, 23, 3447, 10.1200/JCO.2005.09.117 Liu, 2004, Effect of combined T- and B-cell depletion of allogeniec HLA-mismatched bone marrow graft on the magnitude and kinetics of Epstein-Barr virus load in the peripheral blood of bone marrow transplant recipients, Clin Transplant, 18, 518, 10.1111/j.1399-0012.2004.00198.x Aversa, 2008, The haploidentical option for high-risk haematological malignancies, Blood Cells Mol Dis, 40, 8, 10.1016/j.bcmd.2007.07.004 Ciceri, 2008, A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation, Blood, 112, 3574, 10.1182/blood-2008-02-140095 Huang, 2006, Haplo-identical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of hematological malignancies, Bone Marrow Transplant, 38, 291, 10.1038/sj.bmt.1705445 Huang, 2009, Treatment of acute leukaemia with unmanipulated HLA-mismatched/haploidentical blood and bone marrow transplantation, Biol Bone Marrow Transplant, 15, 257, 10.1016/j.bbmt.2008.11.025 Huang, 2009, Partially matched related donor transplantation can achieve outcomes comparable to unrelated donor transplantation for patients with hematologic malignancies, Clin Cancer Res, 15, 4777, 10.1158/1078-0432.CCR-09-0691 Gale, 1995, Impact of cytogenetic abnormalities on outcome of bone marrow transplants in acute myelogenous leukemia in first remission, Bone Marrow Transplant, 16, 203 Huang, 2008, Modified donor lymphocyte infusion after HLA-mismatched/haplo-identical T-cell-replete hematopoietic stem cell transplantation for prophylaxis of relapse of leukemia in patients with advanced leukemia, J Clin Immunol, 28, 276, 10.1007/s10875-007-9166-z Huang, 2007, Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haplo-identical T-cell-replete hematopoietic stem cell transplantation, Haematologica, 92, 414, 10.3324/haematol.10570 Huang, 2003, An improved anti-leukemic effect achieved with donor progenitor cell infusion for relapse patients after allogeneic bone marrow transplantation, Chin Med J, 116, 736 Thomas, 1975, Bone marrow transplantation, N Engl J Med, 292, 895, 10.1056/NEJM197504242921706 Shulman, 1980, Chronic graft-versus-host syndrome in man: a long-term clinicopathologic study of 20 Seattle patients, Am J Med, 69, 204, 10.1016/0002-9343(80)90380-0 Scrucca, 2010, Regression modeling of competing risk using R: an in depth guide for clinicians, Bone Marrow Transplant, 10.1038/bmt.2009.359 Beatty, 1993, Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for 1 HLA locus, Blood, 81, 249, 10.1182/blood.V81.1.249.249 Ringdén, 2009, The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation, Blood, 113, 3110, 10.1182/blood-2008-07-163212 Drobyski, 2002, Blood, 99, 806, 10.1182/blood.V99.3.806 Carpenter, 2007, Prophylactic administration of imatinib after hematopoietic cell transplantation for high-risk Philadelphia chromosome-positive leukemia, Blood, 109, 2791, 10.1182/blood-2006-04-019836 Burke, 2009, Allo-hematopoietic cell transplantation for Ph chromosome-positive ALL: impact of imatinib on relapse and survival, Bone Marrow Transplant, 43, 107, 10.1038/bmt.2008.296 Duggan, 2002, Unrelated donor BMT recipients given pretransplant low-dose antithymocyte globulin have outcomes equivalent to matched sibling BMT: a matched pair analysis, Bone Marrow Transplant, 30, 681, 10.1038/sj.bmt.1703674 Basara, 2005, Antithymocyte globulin for the prevention of graft-versus-host disease after unrelated hematopoietic stem cell transplantation for acute myeloid leukemia: results from the multicenter German cooperative study group, Bone Marrow Transplant, 35, 1011, 10.1038/sj.bmt.1704957 Remberger, 2002, Association between pretransplant thymoglobulin and reduced non-relapse mortality rate after marrow transplantation from unrelated donors, Bone Marrow Transplant, 29, 391, 10.1038/sj.bmt.1703374 Horowitz, 1990, Graft-versus-leukemia reactions after bone marrow transplantation, Blood, 75, 555, 10.1182/blood.V75.3.555.555 Lu, 2006, Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haplo-identical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation, Blood, 107, 3065, 10.1182/blood-2005-05-2146 MacMillan, 2010, The best endpoint for acute GVHD treatment trials, Blood, 115, 5412, 10.1182/blood-2009-12-258442 Anasetti, 1990, Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma, Hum Immunol, 29, 79, 10.1016/0198-8859(90)90071-V