Dissociation constants and lipophilicity of catecholamines and related compounds

Albert, A., Serjeant, E. P.: Ionization constants of acids and bases, pp. 51–66. London: Methuen 1962 Armstrong, J., Barlow, R. B.: The ionization of phenolic amines, including apomorphine, dopamine and catecholamines and an assessment of zwitterion constants. Br. J. Pharmacol. 57, 501–516 (1976) Bönisch, H.: Further studies on the extraneuronal uptake and metabolism of isoprenaline in the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 121–131 (1978) Bönisch, H., Mack, F.: Dissociation constants and partition coefficients of sympathomimetic amines, their precursors and metabolites. Naunyn-Schmiedeberg's Arch. Pharmacol. 302, R50 (1978) Fiebig, R. R., Trendelenburg, U.: The neuronal and extraneuronal uptake and metabolism of 3H-(−)-noradrenaline in the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 21–35 (1978a) Fiebig, E. R., Trendelenburg, U.: The kinetic constants for the extraneuronal uptake and metabolism of 3H-(−)-noradrenaline in the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 37–45 (1978b) Graefe, K. H.: Aufnahme und Metabolisierung von 3H-(−)-Noradrenalin im isoliert durchströmten Katzen- und Kaninchenherzen. Habilitationsschrift, Würzburg 1976 Hansch, C., Maloney, P. P., Fujita, T., Muir, R. M.: Correlation of biological activity of phenoxyacetic acid with Hammet substituent constants and partition coefficients. Nature 194, 178–180 (1962) Henseling, M., Graefe, K. H., Trendelenburg, U.: The rate constants for the efflux of the metabolites of noradrenaline from rabbit aortic strips. Naunyn-Schmiedeberg's Arch. Pharmacol. 302, 207–215 (1978) Kappe, T., Armstrong, M. D.: Ultraviolet absorption spectra and apparent acidic dissociation constants of some phenolic amines. J. Med. Chem. 8, 368–374 (1965) Leo, A., Hansch, C., Elkins, D.: Partition coefficients and their uses. Chem. Rev. 71, 525–616 (1971) Levin, J. A.: The aptake and metabolism of 3H-l-and 3H-dl-norepinephrine by intact rabbit aorta and by isolated adventitia and media. J. Pharmacol. Exp. Ther. 190, 210–226 (1974) Lieb, W. R., Stein, W. D.: Biological membranes behave as nonporous polymeric sheets with respect to the diffusion of nonelectrolytes. Nature 224, 240–243 (1969) Meek, J. L., Neff, N. H.: Acidic and neutral metabolites of norepinephrine: their metabolism and transport from brain. J. Pharmacol. Exp. Ther. 181, 457–462 (1972) Mihailova, D., Testa, B.: The contribution of structural factors to the lipophilicity of phenylethylamines. Eur. J. Med. Chem. 13, 49–52 (1978) Peck, C. C., Benet, L. Z.: General methods for determining macrodissociation constants of polyprotic, amphoteric compounds from solubility measurements. J. Pharm. Sci. 67, 12–16 (1978) Scherrer, R., Howard, S. M.: Use of distribution coefficients in quantitative structure-activity relationships. J. Med. Chem. 20, 53–58 (1977) Sinistri, C., Villa, L.: Ricerche chimico-fisiche su una serie di catecolamine. Il Farmaco 17, 967–973 (1962) Snedecor, G. W., Cochran, W. G.: Statistical methods (6th edit.). Ames: Iowa State University Press 1967 Thoenen, A., Hürlimann, A., Haefely, W.: Mechanism of amphetamine accumulation in the isolated perfused heart of the rat. J. Pharm. Pharmacol. 20, 1–11 (1968) Uhlig, W., Fiebig, E. R., Trendelenburg, U.: The effect of corticosterone on the fluxes of 3H-normetanephrine into and out of the extraneuronal cpmpartments of the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 295, 45–50 (1976)