Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence

Cell Metabolism - Tập 26 - Trang 842-855.e5 - 2017
Marcos Rios Garcia1,2,3,4, Brigitte Steinbauer5, Kshitij Srivastava6, Mahak Singhal6, Frits Mattijssen1,2,3,4, Adriano Maida1,2,3,4, Sven Christian7, Holger Hess-Stumpp7, Hellmut G. Augustin6, Karin Müller-Decker5, Peter P. Nawroth1,2,3,4, Stephan Herzig1,2,3,4, Mauricio Berriel Diaz1,2,3,4
1Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany
2Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany
3Technical University Munich, 85764 Neuherberg, Germany
4Deutsches Zentrum für Diabetesforschung, 85764 Neuherberg, Germany
5Core Facility Tumor Models, German Cancer Research Center (DKFZ) and Medical Faculty Mannheim, Heidelberg University, 69120 Heidelberg, Germany
6Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ) and Medical Faculty Mannheim, Heidelberg University, 69120 Heidelberg, Germany
7Division Tumor Metabolism and Hypoxia, Bayer Health Care, 13353 Berlin, Germany

Tài liệu tham khảo

Boehm, 2007, Integrative genomic approaches identify IKBKE as a breast cancer oncogene, Cell, 129, 1065, 10.1016/j.cell.2007.03.052 Brownsey, 2006, Regulation of acetyl-CoA carboxylase, Biochem. Soc. Trans., 34, 223, 10.1042/BST0340223 Brusselmans, 2005, RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells, Cancer Res., 65, 6719, 10.1158/0008-5472.CAN-05-0571 Chaffer, 2011, A perspective on cancer cell metastasis, Science, 331, 1559, 10.1126/science.1203543 Chajès, 2006, Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival, Cancer Res., 66, 5287, 10.1158/0008-5472.CAN-05-1489 Chou, 2014, AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis, Cancer Res., 74, 4783, 10.1158/0008-5472.CAN-14-0135 Chow, 2014, Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation, Mol. Metab., 3, 419, 10.1016/j.molmet.2014.02.004 Currie, 2013, Cellular fatty acid metabolism and cancer, Cell Metab., 18, 153, 10.1016/j.cmet.2013.05.017 del Barco Barrantes, 2012, Roles of p38 MAPKs in invasion and metastasis, Biochem. Soc. Trans., 40, 79, 10.1042/BST20110676 2005, Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials, Lancet, 365, 1687, 10.1016/S0140-6736(05)66544-0 Foster, 2012, Malonyl-CoA: the regulator of fatty acid synthesis and oxidation, J. Clin. Invest., 122, 1958, 10.1172/JCI63967 Foty, 2011, A simple hanging drop cell culture protocol for generation of 3D spheroids, J. Vis. Exp., 2720 Galdieri, 2012, Acetyl-CoA carboxylase regulates global histone acetylation, J. Biol. Chem., 287, 23865, 10.1074/jbc.M112.380519 Gao, 2007, Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake, Proc. Natl. Acad. Sci. USA, 104, 17358, 10.1073/pnas.0708385104 Gao, 2016, Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia, Nat. Commun., 7, 11960, 10.1038/ncomms11960 Griss, 2015, Metformin antagonizes cancer cell proliferation by suppressing mitochondrial-dependent biosynthesis, PLoS Biol., 13, e1002309, 10.1371/journal.pbio.1002309 Guo, 2012, Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells, Biochim. Biophys. Acta, 1825, 207 Jeon, 2012, AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress, Nature, 485, 661, 10.1038/nature11066 Jiang, 2015, Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition, Oncogene, 34, 3908, 10.1038/onc.2014.321 Kaczor, 2005, Anaerobic and aerobic enzyme activities in human skeletal muscle from children and adults, Pediatr. Res., 57, 331, 10.1203/01.PDR.0000150799.77094.DE Khandekar, 2011, Molecular mechanisms of cancer development in obesity, Nat. Rev. Cancer, 11, 886, 10.1038/nrc3174 Kuhajda, 1994, Fatty acid synthesis: a potential selective target for antineoplastic therapy, Proc. Natl. Acad. Sci. USA, 91, 6379, 10.1073/pnas.91.14.6379 Lamouille, 2014, Molecular mechanisms of epithelial-mesenchymal transition, Nat. Rev. Mol. Cell Biol., 15, 178, 10.1038/nrm3758 Li, 2016, LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells, Tumour Biol., 37, 8249, 10.1007/s13277-015-4639-9 Luo, 2017, Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab, Cancer Lett., 384, 39, 10.1016/j.canlet.2016.09.020 Malik, 2011, Neuroendocrine regulation of autophagy by leptin, Cell Cycle, 10, 2917, 10.4161/cc.10.17.17067 Mihaylova, 2011, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism, Nat. Cell Biol., 13, 1016, 10.1038/ncb2329 Minokoshi, 2002, Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, Nature, 415, 339, 10.1038/415339a Protani, 2010, Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis, Breast Cancer Res. Treat., 123, 627, 10.1007/s10549-010-0990-0 Rajala, 2003, Minireview: the adipocyte—at the crossroads of energy homeostasis, inflammation, and atherosclerosis, Endocrinology, 144, 3765, 10.1210/en.2003-0580 Ríos, 2013, AMPK activation by oncogenesis is required to maintain cancer cell proliferation in astrocytic tumors, Cancer Res., 73, 2628, 10.1158/0008-5472.CAN-12-0861 Röhrig, 2016, The multifaceted roles of fatty acid synthesis in cancer, Nat. Rev. Cancer, 16, 732, 10.1038/nrc.2016.89 Rompani, 2008, Retinal progenitor cells can produce restricted subsets of horizontal cells, Proc. Natl. Acad. Sci. USA, 105, 192, 10.1073/pnas.0709979104 Santos, 2012, Lipid metabolism in cancer, FEBS J., 279, 2610, 10.1111/j.1742-4658.2012.08644.x Simonsson, 2006, The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation, J. Biol. Chem., 281, 39870, 10.1074/jbc.M607868200 Svensson, 2016, Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models, Nat. Med., 22, 1108, 10.1038/nm.4181 Tevaarwerk, 2013, Survival in patients with metastatic recurrent breast cancer after adjuvant chemotherapy: little evidence of improvement over the past 30 years, Cancer, 119, 1140, 10.1002/cncr.27819 Toyama, 2016, Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress, Science, 351, 275, 10.1126/science.aab4138 Tu, 2007, Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor beta response, J. Biol. Chem., 282, 21187, 10.1074/jbc.M700085200 Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809 Wang, 2014, A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies, Nat. Cell Biol., 16, 345, 10.1038/ncb2930 Wang, 2016, Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients, Hepatology, 63, 1272, 10.1002/hep.28415 Weigelt, 2005, Breast cancer metastasis: markers and models, Nat. Rev. Cancer, 5, 591, 10.1038/nrc1670 Wu, 2009, Circulating levels of leptin, adiposity and breast cancer risk, Br. J. Cancer, 100, 578, 10.1038/sj.bjc.6604913 Wu, 2013, Role of AMPK in UVB-induced DNA damage repair and growth control, Oncogene, 32, 2682, 10.1038/onc.2012.279 Yung, 2016, Obesity and breast cancer: risk, outcomes, and future considerations, Clin. Adv. Hematol. Oncol., 14, 790 Zaidi, 2012, ATP-citrate lyase: a key player in cancer metabolism, Cancer Res., 72, 3709, 10.1158/0008-5472.CAN-11-4112