Present Concepts on the Inflammatory Modulators with Special Reference to Cytokines*
Tóm tắt
The pro- and anti-inflammatory cytokines create a network of interactions between cells that lead to both stimulatory and inhibitory responses that maintain an effective homeostatic regulation. The anti-inflammatory cytokines are a family of peptides that modulate the pro-inflammatory cytokine response. Cytokines act in concert with non-cytokine mediators, such as prostaglandin E2, glucocorticosteroids, lipocortins, and catecholamines. This review highlights new developments in our understanding of the pathophysiology of inflammation and gives an example of a more recent approach to the modulation of acute systemic inflammatory disorders: activation of β2-adrenergic receptors on macrophages. In this respect the potent β2-adrenergic agonist clenbuterol seems of therapeutic interest.
Tài liệu tham khảo
Abraham, E.J., Morris-Hardeman, J.N., Swenson, L.M., Knoppel, E.J., Ramanathan, B., Wright, K.J., Grieger, D.M. and Minton, J.E., 1998. Pituitary function in the acute phase response in domestic farm animals: cytokines, prostaglandins, and secretion of ACTH. Domestic Animal Endocrinology, 15, 389-396
Arai, T., Hiromatsu, K., Kobayashi, N., Takano, M., Ishida, H., Nimura, Y. and Yoshikai, Y., 1995. IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. Journal of Immunology, 155, 5743-5749
Arias-Negrete, S., Keller, K. and Chadee, K., 1995. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochemical and Biophysical Research Communications, 208, 582-589
Arslan, A. and Zingg, H.H., 1996. Regulation of COX2 gene expression in rat uterus in vivo and in vitro. Prostaglandins, 52, 463-481
Atwell, D.M., Grichnik, K.P., Newman, M.F., Reves, J.G. and McBride, W.T., 1998. Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation. Annals of Thoracic Surgery, 66, 1145-1150
Baldwin, A.S., 1996. The NF-κB and kappa B proteins: new discoveries and insights. Annual Reviews of Immunology, 14, 649-683
Barnes, P.J., 1998. Anti-inflammatory action of glucocorticoids: molecular mechanisms. Clinical Science (Colchester), 94, 557-572
Barnes, P.J. and Adcock, I.M., 1997. NF-κB: a pivotal role in asthma and a new target for therapy. Trends in Pharmacological Sciences, 18, 46-50
Bernabé, J., Vandeputte-Van Messom, G. and Burvenich, C., 1986. Experimental induced fever and plasma catecholamines in lactating goats. Archives Internationales de Physiologie et de Biochemie, 94, P67-P68
Beutler, B., 2000. Tlr4: central component of the sole mammalian LPS sensor. Current Opinion in Immunology, 12, 20-26
Beutler, B., Milsark, I.W. and Cerami, A., 1985. Passive immunisation against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 229, 869-871
Bley, K.R., Hunter, J.C., Eglen, R.M. and Smith, J.A.M., 1998. The role of IP prostanoid receptors in inflammatory pain. Trends in Pharmacological Sciences, 19, 141-147
Bowlin, T.L., Borcherding, D.R., Edwards, C.K. and McWhinney, C.D., 1997. Adenosine A3 receptor agonists inhibit murine macrophage tumor necrosis factor-alpha production in vitro and in vivo. Cellular and Molecular Biology (Noisy le Grand), 48, 345-349
Buckle, D.R. and Hedgecock, C.J.R., 1997. Drug targets in inflammation and immunomodulation. Drug Discovery Today, 2, 325-332
Chaby, R., 1999. Strategies for the control of LPS-mediated pathophysiological disorders. Drug Discovery Today, 4, 209-221
Chan, C.C., Boyce, S., Brideau, C., Ford-Hutchinson, A.W., Gordon, R., Guay, D., Hill, R.G., Li, C.S., Mancini, J. and Penneton, M., 1995. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745, 337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and non-human primate stomach. Journal of Pharmacology and Experimental Therapeutics, 274, 1531-1537
Crofford, L.J., 1997. COX1 and COX2 tissue expression: implications and predictions. Journal of Rheumatology, 24(supplement 49), 15-19
Cronstein, B.N., 1994. Adenosine, an endogenous anti-inflammatory agent. Journal of Applied Physiology, 76, 5-13
Curfs, J.H.A.J., Meis, J.F.G.M. and Hoogkamp-Korstanje, J.A.A., 1997. A primer on cytokines: sources, receptors, effects and inducers. Clinical Microbiology Reviews, 10, 742-780
Dinarello, C.A. and Wolff, S.M., 1993. The role of interleukin-1 in disease. New England Journal of Medicine, 328, 106-113
Dinarello, C.A., Gelfand, J.A. and Wolff, S.M., 1993. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. Journal of the American Medical Association, 269, 1829-1835
Dinarello, C.A., Novick, D., Puren, A.J., Fantuzzi, G., Shapiro, L., Mühl, H., Yoon, D.Y., Reznikov, L.L., Kim, S.H. and Rubinstein, M., 1998. Overview of interleukin-18: more than an interferon-γ inducing factor. Journal of Leukocyte Biology, 63, 658-664
Eder, J., 1997. Tumour necrosis factor-α and interleukin-1 signalling: do MAPKK kinases connect it all? Trends in Pharmacological Sciences, 18, 319-322
Egger, G., Sadjak, A., Porta, S., Purstner, P. and Gleispach, H., 1982. Changes in blood catecholamines, insulin, corticosterone and glucose during the course of the Sephadex inflammation. Experimental Pathology, 21, 215-219
Eigler, A., Siegmund, B., Emmerich, U., Baumann, K.H., Hartmann, G. and Endres, S., 1998. Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. Journal of Leukocyte Biology, 63, 101-107
Einstein, R., Jones, R.S., Knifton, A. and Starmer, G.A., 1994. Principles of Veterinary Therapeutics, (Longman Scientific and Technical, Harlow, Essex), 258-260
Essani, N.A., Fisher, M.A., Simmons, C.A., Hoover, J.L., Farhood, A. and Jaeschke, H., 1998. Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. Journal of Leukocyte Biology, 63, 288-296
Eykyn, S.J., Gransden, W.R. and Phillips, I., 1990. The causative organisms of septicaemia and their epidemiology. Journal of Antimicrobial Chemotherapy, 25(supplement C), 41-58
Gazzinelli, R.T., Wysocka, M., Hieny, S., Scharton-Kersten, T., Cheever, A., Kühn, R., Müller, W., Trinchieri, G. and Sher, A., 1996. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD 14 cells and accompanied by overproduction of IL-12, INF-γ, and TNF-α. Journal of Immunology, 157, 798-805
Gerard, C., Bruyns, C., Marchant, A., Abramowicz, D., Vandenabeele, P., Delvaux, A., Fiers, W., Goldman, M. and Velu, T., 1993. Interleukin-10 reduces the release of tumour necrosis factor and prevents lethality in experimental endotoxemia. Journal of Experimental Medicine, 177, 547-550
Ghosh, S., May, M.J. and Kopp, E.B., 1998. NF-κB and Rel proteins: evolutionary conserved mediators of immune responses. Annual Reviews of Immunology, 16, 225-260
Goulding, N.J., Euzger, H.S., Butt, S.K. and Perretti, M., 1998. Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation. Inflammation Research, 47(supplement 3), S158-S165
Gu, Y. and Seidel, A., 1996. Influence of salbutamol and isoproterenol on the production of TNF and reactive oxygen species by bovine alveolar macrophages and calcitrol differentiated HL-60 cells. Immunopharmacology and Immunotherapy, 18, 115-128
Hasko, G., Szabo, C., Nemeth, Z.H., Kvetan, V., Pastores, S.M. and Vizi, E.S., 1996. Adenosine receptor agonists differentially regulate IL-10, TNF-α, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. Journal of Immunology, 157, 4634-4640
Hasko, G., Nemeth, Z.H., Szabo, C., Zsilla, G., Salzman, A.L. and Vizi, E.S., 1998. Isoproterenol inhibits IL-10, TNF-α, and nitric oxide production in RAW 264.7 macrophages. Brain Research Bulletin, 45, 183-187
Henderson, B., Poole, S. and Wilson, M., 1996. Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiology Reviews, 60, 316-341
Hewett, J.A. and Roth, R.A., 1993. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacological Reviews, 45, 381-411
Howard, M., Muchamuel, T., Andrade, S. and Menon, S., 1993. Interleukin-10 protects mice from lethal endotoxemia. Journal of Experimental Medicine, 177, 1205-1208
Ingalls, R.R., Heine, H., Lien, E., Yoshimura, A. and Golenbock, D., 1999. Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors. Infectious Disease Clinics of North America, 13, 341-353
Inoue, H. and Tanabe, T., 1998. Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression of dexamethasone of cyclooxygenase-2 in U937 cells. Biochemical and Biophysical Research Communications, 244, 143-148
Izeboud, C.A., 2000. Immunomodulatory properties of β-adrenoceptor agonists. Concepts for therapy of acute inflammatory disorders, (PhD thesis, Utrecht University, Utrecht, The Netherlands), ISBN: 90-393-2539-1)
Izeboud, C.A., Mocking, J.A.J., Monshouwer, M., Van Miert, A.S.J.P.A.M. and Witkamp, R.F., 1999a. Participation of β-adrenergic receptors on macrophages in modulation of LPS-induced cytokine release. Journal of Receptor Signal Transduction Research, 19, 191-202
Izeboud, C.A., Monshouwer, M., Van Miert, A.S.J.P.A.M. and Witkamp, R.F., 1999b. The β-adrenoceptor against clenbuterol is a potent inhibitor of the LPS-induced production of TNF-α and IL-6 in vitro and in vivo. Inflammation Research, 48, 497-502
Izeboud, C.A., Monshouwer, M., Witkamp, R.F. and Van Miert, A.S.J.P.A.M., 2000a. Suppression of the acute inflammatory response of porcine alveolar and liver macrophages. The Veterinary Quarterly, 22, 26-30
Izeboud, C.A., Vermeulen, R.M., Zwart, A., Voss, H.P., Van Miert, A.S.J.P.A.M. and Witkamp, R.F., 2000b. Stereoselectivity at the β2-adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of β2-agonists. Naunyn-Schmiedeberg Archives of Pharmacology, 362, 184-189
Jilg, S., Barsig, J., Leist, M., Küsters, S., Volk, H.D. and Wendel, A., 1996. Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock. Journal of Pharmacology and Experimental Therapeutics, 278, 421-431
Johnston, B. and Kubes, P., 1999. The α4-integrin: an alternative pathway for neutrophil recruitment? Immunology Today, 20, 545-550
Joyce, D.A., Gibbons, D.P., Green, P., Steer, J.H., Feldman, M. and Brennan, F.M., 1994. Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. European Journal of Immunology, 24, 2699-2705
Kamal, A.M., Tetley, T.D., Witherden, I.R. and Smith, S.F., 1998. Reduction of nitric oxide release from alveolar macrophages by a lipocortin peptide. Mediators in Inflammation, 7, 93-98
Karalis, K., Muglia, L.J., Bae, D., Hilderbrand, H. and Majzoub, J.A., 1997. CRH and the immune system. Journal of Neuroimmunology, 72, 131-136
Kassis, S., Prabhakar, U. and Lee, J.C., 1993. Inhibition of interleukin-1 (IL-1) and tumor necrosis factor (TNF) production by pyridinyl imidazole compounds is independent of cAMP elevating mechanisms. Agents and Actions, 39, C64-C66
Keller, E.T., Wanagat, J. and Ershler, W.B., 1998. Molecular and cellular biology of interleukin-6 and its receptor. Frontiers in Bioscience, 1, 340-357
Klosterhalfen, B. and Bhardwaj, R.S., 1998. Septic shock (review). General Pharmacology, 31, 25-32
Kühn, R., Lohler, J., Rennick, D., Rajewsky, K., Müller, W., 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell, 75, 263-274
Lambeau, G. and Lazdunski, M., 1999. Receptors for a growing family of secreted phospholipases A2. Trends in Pharmacological Sciences, 20, 162-170
Lang, C.H. and Dobrescu, C., 1989. Sepsis-induced changes in in vivo insulin action in diabetic rats. American Journal of Physiology, 257, E301-E308
Lees, P., Landoni, M.F., Armstrong, S. and Frean, S., 2000. New insights into inflammation with particular reference to the role of COX enzymes. Proceedings of the 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jerusalem, (Blackwell, Oxford), 82 (also on CD-Rom)
Lemaire, L.C.J.M., Van Lanschot, J.J.B., Stoutenbeek, C.P., Van Deventer, S.J.H., Wells, C.L. and Gouma, D.J., 1997. Bacterial translocation in multiple organ failure: cause or epiphenomenon still unproven. British Journal of Surgery, 84, 1340-1350
Lentsch, A.B., Shanley, T.P., Sarma, V. and Ward, P.A., 1997. In vivo suppression of NF-κB and preservation of IκBα by interleukin-10 and interleukin-13. Journal of Clinical Investigation, 100, 2443-2448
Ligget, S.B., 1999. Molecular and genetic basis of β-2-adrenergic receptor function. Journal of Allergy and Clinical Immunology, 104, S42-S46
Madden, S., Sanders, V.M. and Felten, D.L., 1995. Catecholamine influences and sympathetic neural modulation of immune responsiveness. Annual Review of Pharmacology and Toxicology, 35, 417-448
Marnett, L.J. and Kalgutkar, A.S., 1999. Cyclooxygenase-2 inhibitors: discovery, selectivity and the future. Trends in Pharmacological Sciences, 20, 465-469
McBride, W.T., Armstrong, M.A., Gilliland, H. and McMurray, T.J., 1996. The balance of pro-and anti-inflammatory cytokines in plasma and bronchoalveolar lavage at pediatric cardiac surgery. Cytokine, 8, 729-737
Minghetti, L., Nicolini, A., Polazzi, E., Greco, A., Perretti, M., Parente, L. and Levi, G., 1999. Downregulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin-1. British Journal of Pharmacology, 126, 1307-1314
Monshouwer, M. and Witkamp, R.F., 2000. Cytochromes and cytokines: changes in drug disposition in animals during an acute phase response: a mini-review. The Veterinary Quarterly, 22, 17-20
Monshouwer, M., Witkamp, R.F., Nijmeijer, S.M., Van Leengoed, L.A.M., Vernooy, H.C., Verheijden, J.H.M. and Van Miert, A.S.J.P.A.M., 1996. A lipopolysaccharide-induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism. Journal of Veterinary Pharmacology and Therapeutics, 19, 382-388
Montminy, M., 1997. Transcriptional regulation by cyclic AMP. Annual Review of Biochemistry, 66, 807-822
Mukaida, W., Ishikawa, Y., Ikeda, N., Fujioka, N., Watanabe, S., Kuno, K. and Matsushima, K., 1996. Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS-receptor signaling in a cell-free system targeting NF-κB and regulation of cytokine production/action through β2 integrin in vivo. Journal of Leukocyte Biology, 59, 145-151
Nakamura, A., Johns, E.J., Imaizumi, A. and Kohsaka, T., 1998. Regulation of tumour necrosis factor and interleukin-6 gene transcription by β2-adrenoceptor in the rat astrocytes. Journal of Neuroimmunology, 88, 144-153
Neely, C.F., Jin, J. and Keith, I.M., 1997. A1-adenosine receptor antagonists block endotoxin-induced lung injury. American Journal of Physiology, 272, L353-L361
Neumann, B., Machleidt, T., Lifka, A., Pfeffer, K., Vestweber, D. and Mak, T.W., 1996. Crucial role of 55-kilodalton TNF-receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration. Journal of Immunology, 156, 1587-1593
Opal, S.M. and DePalo, V.A., 2000. Anti-inflammatory cytokines. CHEST, 117, 1162-1172
Ottonello, L., Morone, M.P., Dapino, P. and Dallegri, F., 1995. Tumour necrosis factor-alpha-induced oxidative burst in neutrophils adherent to fibronectin: effects of cyclic AMP-elevating agents. British Journal of Haematology, 91, 566-570
Ouellette, J.J., Chosy, J.J. and Reed, C.E., 1967. Catecholamine excretion and bronchial response to methacholine after Salmonella enteriditis endotoxin in a normal and an ‘asthmatic subject.’ Journal of Allergy, 39, 234-237
Parry, G.C. and Mackman, N., 1997. Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-κB-mediated transcription. Journal of Immunology, 159, 5450-5456
Perretti, M., 1997. Endogenous mediators that inhibit the leukocyte-endothelium interaction. Trends in Pharmacological Sciences, 18, 418-425
Platzer, C., Meisel, C., Vogt, K., Platzer, M. and Volk, H.D., 1995. Upregulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. International Immunology, 7, 517-523
Poltorak, A., Ricciardi-Castagnoli, P., Citterio, S. and Beutler, B., 2000. Physical contact between lipopolysaccharide and Toll-like receptor-4 revealed by genetic complementation. Proceedings of the National Academy of Sciences of the USA, 97, 2163-2167
Qureshi, S.T., Lariviere, L., Leveque, G., Clermont, S., Moore, K.J., Gros, P. and Malo, D., 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). Journal of Experimental Medicine, 189, 615-625
Robinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, F., Sana, T., Hartly, S.B., Menon, S., Kastelein, R., Bazan, F. and O'Garra, A., 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activation of IRAK and NF-κB. Immunology, 7, 571-581
Rongione, A.J., Kusske, A.M., Ashley, S.W., Reber, H.A. and McFadden, D.W., 1997. Interleukin-10 prevents early cytokine release in severe intraabdominal infection and sepsis. Journal of Surgical Research, 70, 107-112
Rouppe van der Voort, C., 2000. Alpha-1 adrenergic receptors and the immune system, (PhD thesis, Utrecht University, The Netherlands)
Sajjadi, F.G., Takabayashi, K., Foster, A.C., Domingo, R. and Firestein, G., 1996. Inhibition of TNF-α expression by adenosine. Role of A3 adenosine receptors. Journal of Immunology, 156, 3435-3442
Schumann, R.R., Leong, S.R., Flaggs, G.W., Gray, P.W., Wright, S.D. and Mathison, J.C., 1990. Structure and function of lipopolysaccharide binding protein. Science, 249, 1429-1431
Sekut, L., Champion, B.R., Page, K., Menius, J.A. and Conolly, K.M., 1995. Anti-inflammatory activity of salmeterol: down-regulation of cytokine production. Clinical and Experimental Immunology, 99, 461-466
Seldon, P.M., Barnes, P.J., Meja, K. and Giembycz, M.A., 1995. Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenyl cyclase. Journal of Pharmacology and Experimental Therapeutics, 48, 747-757
Serafimov, N., 1962. Urinary excretion of catecholamines in endotoxin-induced fever in rabbits. Acta Physiologica Scandinavica, 54, 354-358
Severn, A., Rapson, N.T., Hunter, C.A. and Liew, F.Y., 1992. Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists. Journal of Immunology, 148, 3441-3445
Sheu, J.W., Baum, M., Harkins, E.W. and Quigley, R., 1997. Maturational changes in rabbit renal cortical phospholipase A2 activity. Kidney International, 52, 71-78
Sinha, B., Semmler, J., Eisenhut, T., Eigler, A. and Endres, S., 1995. Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids. European Journal of Immunology, 25, 147-153
Smirnova, I., Poltorak, A., Chan, E.K.L., McBride, C. and Beutler, B., 2000. Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (Tlr4). Genome Biology, 1, research 002.1–002.10
Sonesson, H.R.A., Zähringer, U., Grimmecke, H.D., Westphal, O. and Rietschel, E.T., 1994. Bacterial endotoxin. Chemical structure and biological activity. In: K.L. Brigham (ed), Endotoxin and the Lungs, (Dekker, New York), 1-20
Standiford, T.J., Strieter, R.M., Lukacs, N.W. and Kunkel, S.L., 1995. Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. Journal of Immunology, 155, 2222-2229
Suberville, S., Bellocq, A., Fouqueray, B., Philippe, C., Lantz, O., Perze, J. and Baud, L., 1996. Regulation of interleukin-10 production by β-adrenergic agonists. European Journal of Immunology, 26, 2601-2605
Sugerman, K.J., Austin, G., Newsome, K.H., Hylemon, P. and Greenfield, L.J., 1982. Haemodynamics, oxygen consumption and serum catecholamine changes in progressive, lethal peritonitis in the dog. Surgery, Gynaecology and Obstetrics, 154, 8-12
Szabo, C., Hasko, G., Zingarelli, B., Nemeth, Z.H., Salzman, A.L., Kvetan, V., Pastores, S.M. and Vizi, E.S., 1997. Isoproterenol regulates TNF, IL-10, IL-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxemia. Immunology, 90, 95-100
Tsutsui, H., Matsui, K., Kawada, N., Hyodo, Y., Hayashi, N., Okamura, H., Higashino, K. and Nakanishi, K., 1997. IL-18 accounts for both TNF-α and Fas Ligand mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. Journal of Immunology, 159, 3961-3967
Van der Poll, T. and Lowry, S.F., 1997. Epinephrine inhibits endotoxin-induced IL-1β production: roles of tumor necrosis factor-α and IL-10. American Journal of Physiology, 273, R1885-R1890
Van der Poll, T. and van Deventer, S.J.H., 1999. Cytokines and anticytokines in the pathogenesis of sepsis. Infectious Disease Clinics of North America, 13, 413-426
Van der Poll, T., Coyle, S.M., Barbosa, K., Braxton, C.C. and Lowry, S.F., 1996. Epinephrine inhibits tumor necrosis factor-α and potentiates interleukin-10 production during human endotoxemia. Journal of Clinical Investigation, 97, 713-719
Van Miert, A.S.J.P.A.M., 1990. Influence of febrile disease on pharmacokinetics of veterinary drugs. Annales de Recherches Vétérinaires, 21(supplement 1), 21S-28S
Van Miert, A.S.J.P.A.M., 1991. Acute phase response and non cellular defence mechanisms. In: C. Burvenich, G. Vandeputten-Van Messom and A.W. Hill (eds), New Insights into the Pathogenesis of Mastitis, (Vlaams Diergeneeskundig Tijdschrift, Ghent), 69-91
Van Miert, A.S.J.P.A.M., 1995. Pro-inflammatory cytokines in a ruminant model: pathophysiological, pharmacological and therapeutic aspects. The Veterinary Quarterly, 17, 41-50
Van Miert, A.S.J.P.A.M. and Frens, J., 1968. The reaction of different animal species to bacterial pyrogens. Zentralblatt für Veterinärmedizin, 15A, 532-543
Van Miert, A.S.J.P.A.M. and Van Duin, C.T.M., 1998. Pharmacological and pathophysiological modulation of food intake and forestomach motility in small ruminants. Journal of Veterinary Pharmacology and Therapeutics, 21, 1-17
Verghese, M.W., McConnell, R.T., Strickland, A.B., Gooding, R.C., Stimpson, S.A., Yarnall, D.P., Taylor, J.D. and Furdon, P.J., 1995. Differential regulation of human monocyte-derived TNF-alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors. Journal of Pharmacology and Experimental Therapeutics, 272, 1313-1320
Versteeg, H.H., Van Bergen en Henegouwen, P.M.P., Van Deventer, S.J.H. and Peppelenbosch, M.P., 1999. Cyclooxygenase-dependent signalling: molecular events and consequences. FEBS Letters, 445, 1-5
Walle, T., Webb, J.G., Bagwell, E.E., Walle, U.K., Daniell, H.B. and Gaffney, T.E., 1988. Stereoselective delivery and actions of beta receptor antagonists. Biochemical Pharmacology, 37, 115-124
Wells, T.N.C., Power, C.A. and Proudfoot, A.E.I., 1998. Definition, function and pathophysiological significance of chemokine receptors. Trends in Pharmacological Sciences, 19, 376-380
Wieland, K., Zuurmond, H.M., Krasel, C., IJzerman, A.P. and Lohse, M.J., 1996. Involvement of asn-293 in stereospecific agonist recognition and in activation of the beta-2-adrenergic receptor. Proceedings of the National Academy of Sciences of the USA, 93, 9276-9281
Witkamp, R.F. and Monshouwer, M., 2000. Signal transduction in inflammatory processes. Current and future therapeutic targets: a mini review. The Veterinary Quarterly, 22, 11-16
Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J. and Mathison, J.C., 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS-binding protein. Science, 249, 1431-1433
Yang, R.B., Mark, M.R., Gray, A., Huang, A., Xie, M.K., Zhang, M., Goddard, A., Wood, W.I., Gurney, A.L. and Godowski, P.J., 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature, 395, 284-288
Yang, R.B., Mark, M.R., Gurney, A.L. and Godowski, P.J., 1999. Signalling events induced by lipopolysaccharide-activated Toll-like receptor 2. Journal of Immunology, 163, 639-643
Yoshimura, T., Kurita, C., Nagao, T., Usami, E., Nakao, T., Watanabe, S., Kobayashi, J., Yamazaki, F., Tanaka, H., Inagaki, N. and Nagai, H., 1997. Inhibition of tumor necrosis factor-alpha and interleukin 1-beta production by adrenoreceptor agonists from lipopolysaccharide stimulated human peripheral blood mononuclear cells. Pharmacology, 54, 144-152
Yoshimura, A., Lien, E., Ingalls, R.R., Tuomanen, E., Dziarski, R. and Golenbock, D., 1999. Cutting edge: recognition of gram-positive bacterial cell wall compounds by the innate immune system occurs via Toll-like receptor-2. Journal of Immunology, 163, 1-5
Zhou, Y., Lin, G., Baarsch, M.J., Scamurra, R.W. and Murtaugh, M.P., 1994. Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages. Journal of Leukocyte Biology, 56, 507-513
Zouki, C., Ouellet, S. and Filep, J.G., 2000. The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells. Federation of American Societies for Experimental Biology Journal, 14, 572-580
Zurawski, G. and De Vries, J.E., 1994. Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunology Today, 15, 19-26