Adenovirus receptors and their implications in gene delivery

Aghi, 2005, Oncolytic viral therapies—the clinical experience, Oncogene, 24, 7802, 10.1038/sj.onc.1209037 Akiyama, 2004, Ablating CAR and integrin binding in adenovirus vectors reduces nontarget organ transduction and permits sustained bloodstream persistence following intraperitoneal administration, Mol. Ther., 9, 218, 10.1016/j.ymthe.2003.10.010 Albinsson, 1999, Adenovirus type 41 lacks an RGD alpha(v)-integrin binding motif on the penton base and undergoes delayed uptake in A549 cells, Virus Res., 64, 125, 10.1016/S0168-1702(99)00087-8 Arnberg, 2000, Adenovirus type 37 uses sialic acid as a cellular receptor, J. Virol., 74, 42, 10.1128/JVI.74.1.42-48.2000 Arnberg, 2002, Adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction, Virology, 302, 33, 10.1006/viro.2002.1503 Arnberg, 2000, Initial interactions of subgenus D adenoviruses with A549 cellular receptors: sialic acid versus alpha(v) integrins, J. Virol., 74, 7691, 10.1128/JVI.74.16.7691-7693.2000 Asaoka, 2000, Dependence of efficient adenoviral gene delivery in malignant glioma cells on the expression levels of the Coxsackievirus and adenovirus receptor, J. Neurosurg., 92, 1002, 10.3171/jns.2000.92.6.1002 Bangari, 2004, Porcine adenoviral vectors evade preexisting humoral immunity to adenoviruses and efficiently infect both human and murine cells in culture, Virus Res., 105, 127, 10.1016/j.virusres.2004.05.003 Bangari, 2005, Porcine adenovirus serotype 3 internalization is independent of CAR and alphavbeta3 or alphavbeta5 integrin, Virology, 332, 157, 10.1016/j.virol.2004.11.010 Bangari, 2006, Development of nonhuman adenoviruses as vaccine vectors, Vaccine, 24, 849, 10.1016/j.vaccine.2005.08.101 Bangari, 2005, Bovine adenovirus type 3 internalization is independent of primary receptors of human adenovirus type 5 and porcine adenovirus type 3, Biochem. Biophys. Res. Commun., 331, 1478, 10.1016/j.bbrc.2005.04.058 Bangari, 2005, Comparative transduction efficiencies of human and nonhuman adenoviral vectors in human, murine, bovine, and porcine cells in culture, Biochem. Biophys. Res. Commun., 327, 960, 10.1016/j.bbrc.2004.12.099 Bao, 2005, Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes, Prostate, 64, 401, 10.1002/pros.20265 Bayo-Puxan, 2006, Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting, J. Gen. Virol., 87, 2487, 10.1099/vir.0.81889-0 Bell, 1959, Adenoviruses isolated from Saudi Arabia. I. Epidemiologic features, Am. J. Trop. Med. Hyg., 8, 492, 10.4269/ajtmh.1959.8.492 Belousova, 2008, Modification of adenovirus capsid with a designed protein ligand yields a gene vector targeted to a major molecular marker of cancer, J. Virol., 82, 630, 10.1128/JVI.01896-07 Bennett, 1957, Adenovirus eye infections in Aberdeen, Lancet, 273, 670, 10.1016/S0140-6736(57)92109-8 Bergelson, 1997, Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5, Science, 275, 1320, 10.1126/science.275.5304.1320 Bergelson, 1998, The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses, J. Virol., 72, 415, 10.1128/JVI.72.1.415-419.1998 Berk, 2007, Adenoviridae: the viruses and their replication, 2355 Bewley, 1999, Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR, Science, 286, 1579, 10.1126/science.286.5444.1579 Bishop, 2007, Heparan sulphate proteoglycans fine-tune mammalian physiology, Nature, 446, 1030, 10.1038/nature05817 Bjorkman, 1990, Structure, function, and diversity of class I major histocompatibility complex molecules, Annu. Rev. Biochem., 59, 253, 10.1146/annurev.bi.59.070190.001345 Breidenbach, 2004, Genetic replacement of the adenovirus shaft fiber reduces liver tropism in ovarian cancer gene therapy, Hum. Gene Ther., 15, 509, 10.1089/10430340460745829 Burmeister, 2004, Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites, J. Virol., 78, 7727, 10.1128/JVI.78.14.7727-7736.2004 Cattaneo, 2004, Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens’ magnet, J. Virol., 78, 4385, 10.1128/JVI.78.9.4385-4388.2004 Chen, 2006, Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves, Circ. Res., 98, 923, 10.1161/01.RES.0000218041.41932.e3 Chiu, 1999, Structure of adenovirus complexed with its internalization receptor, alphavbeta5 integrin, J. Virol., 73, 6759, 10.1128/JVI.73.8.6759-6768.1999 Chretien, 1998, CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates, Eur. J. Immunol., 28, 4094, 10.1002/(SICI)1521-4141(199812)28:12<4094::AID-IMMU4094>3.0.CO;2-2 Chroboczek, 1995, Adenovirus fiber, Curr. Top. Microbiol. Immunol., 199, 163 Chu, 2001, Vascular cell adhesion molecule-1 augments adenovirus-mediated gene transfer, Arterioscler. Thromb. Vasc. Biol., 21, 238, 10.1161/01.ATV.21.2.238 Cohen, 2001, The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction, Proc. Natl. Acad. Sci. U.S.A., 98, 15191, 10.1073/pnas.261452898 Cohen, 2002, Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor, J. Gen. Virol., 83, 151, 10.1099/0022-1317-83-1-151 Crawford-Miksza, 1996, Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residues, J. Virol., 70, 1836, 10.1128/JVI.70.3.1836-1844.1996 Croyle, 2000, Development of a rapid method for the PEGylation of adenoviruses with enhanced transduction and improved stability under harsh storage conditions, Hum. Gene Ther., 11, 1713, 10.1089/10430340050111368 Davidoff, 1999, Enhanced neuroblastoma transduction for an improved antitumor vaccine, J. Surg. Res., 83, 95, 10.1006/jsre.1999.5572 Davison, 2003, Genetic content and evolution of adenoviruses, J. Gen. Virol., 84, 2895, 10.1099/vir.0.19497-0 Davison, 1999, The human HLA-A*0201 allele, expressed in hamster cells, is not a high-affinity receptor for adenovirus type 5 fiber, J. Virol., 73, 4513, 10.1128/JVI.73.5.4513-4517.1999 Davison, 2001, Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad5 fibre binding is mediated by alpha(v)beta1 integrin and can be modulated by changes in beta1 integrin function, J. Gene Med., 3, 550, 10.1002/jgm.223 Dechecchi, 2001, Heparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5, J. Virol., 75, 8772, 10.1128/JVI.75.18.8772-8780.2001 Dechecchi, 2000, Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions, Virology, 268, 382, 10.1006/viro.1999.0171 Defer, 1990, Human adenovirus-host cell interactions: comparative study with members of subgroups B and C, J. Virol., 64, 3661, 10.1128/JVI.64.8.3661-3673.1990 Di Paolo, 2007, Fiber shaft-chimeric adenovirus vectors lacking the KKTK motif efficiently infect liver cells in vivo, J. Virol., 81, 12249, 10.1128/JVI.01584-07 Dmitriev, 2000, Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells, J. Virol., 74, 6875, 10.1128/JVI.74.15.6875-6884.2000 Dmitriev, 1998, An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism, J. Virol., 72, 9706, 10.1128/JVI.72.12.9706-9713.1998 Dmitriev, 2002, Engineering of adenovirus vectors containing heterologous peptide sequences in the C terminus of capsid protein IX, J. Virol., 76, 6893, 10.1128/JVI.76.14.6893-6899.2002 Dormitzer, 2002, The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site, EMBO J., 21, 885, 10.1093/emboj/21.5.885 Dorner, 2005, Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development, J. Cell Sci., 118, 3509, 10.1242/jcs.02476 Doronin, 2001, Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy, J. Virol., 75, 3314, 10.1128/JVI.75.7.3314-3324.2001 Douglas, 2007, Adenoviral vectors for gene therapy, Mol. Biotechnol., 36, 71, 10.1007/s12033-007-0021-5 Douglas, 1996, Targeted gene delivery by tropism-modified adenoviral vectors, Nat. Biotechnol., 14, 1574, 10.1038/nbt1196-1574 Durmort, 2001, Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus, Virology, 285, 302, 10.1006/viro.2001.0967 Eto, 2008, Development of PEGylated adenovirus vector with targeting ligand, Int. J. Pharm., 354, 3, 10.1016/j.ijpharm.2007.08.025 Fauquet, C.M., Mayo, M.A., Maniloff, J., Desselberger, U., Ball, L.A., 2005. Virus taxonomy: Eighth Report of the International Committee on the Taxonomy of Viruses. Elsevier Academic Press, San Diego. Fechner, 1999, Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers, Gene Ther., 6, 1520, 10.1038/sj.gt.3301030 Fisher, 2001, Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies, Gene Ther., 8, 341, 10.1038/sj.gt.3301389 Fleischli, 2007, Species B adenovirus serotypes 3,7,11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor, J. Gen. Virol., 88, 2925, 10.1099/vir.0.83142-0 Freimuth, 1999, Coxsackievirus and adenovirus receptor amino-terminal immunoglobulin V-related domain binds adenovirus type 2 and fiber knob from adenovirus type 12, J. Virol., 73, 1392, 10.1128/JVI.73.2.1392-1398.1999 Fuxe, 2003, Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenografts, Int. J. Cancer, 103, 723, 10.1002/ijc.10891 Gaggar, 2003, CD46 is a cellular receptor for group B adenoviruses, Nat. Med., 9, 1408, 10.1038/nm952 Glasgow, 2006, Transductional targeting of adenovirus vectors for gene therapy, Cancer Gene Ther., 13, 830, 10.1038/sj.cgt.7700928 Glasgow, 2004, An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism, Virology, 324, 103, 10.1016/j.virol.2004.03.028 Greenwald, 2005, The B7 family revisited, Annu. Rev. Immunol., 23, 515, 10.1146/annurev.immunol.23.021704.115611 Gustafsson, 2006, The Arg279Gln [corrected] substitution in the adenovirus type 11p (Ad11p) fiber knob abolishes EDTA-resistant binding to A549 and CHO-CD46 cells, converting the phenotype to that of Ad7p, J. Virol., 80, 1897, 10.1128/JVI.80.4.1897-1905.2006 Haisma, 2000, Targeting of adenoviral vectors through a bispecific single-chain antibody, Cancer Gene Ther., 7, 901, 10.1038/sj.cgt.7700198 Haisma, 1999, Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM, Gene Ther., 6, 1469, 10.1038/sj.gt.3300969 Hemmi, 1998, The presence of human coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures, Hum. Gene Ther., 9, 2363, 10.1089/hum.1998.9.16-2363 Henning, 2002, Genetic modification of adenovirus 5 tropism by a novel class of ligands based on a three-helix bundle scaffold derived from staphylococcal protein A, Hum. Gene Ther., 13, 1427, 10.1089/10430340260185067 Hidaka, 1999, CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts, J. Clin. Invest., 103, 579, 10.1172/JCI5309 Hierholzer, 1974, Letter: Adenovirus type 19 keratoconjunctivitis, N. Engl. J. Med., 290, 1436, 10.1056/NEJM197406202902512 Hong, 1997, Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells, EMBO J., 16, 2294, 10.1093/emboj/16.9.2294 Huang, 1996, Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells, J. Virol., 70, 4502, 10.1128/JVI.70.7.4502-4508.1996 Huang, 1999, A single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells, J. Virol., 73, 2798, 10.1128/JVI.73.4.2798-2802.1999 Hynes, 1992, Integrins: versatility, modulation, and signaling in cell adhesion, Cell, 69, 11, 10.1016/0092-8674(92)90115-S Iacobelli-Martinez, 2005, CD46-utilizing adenoviruses inhibit C/EBPbeta-dependent expression of proinflammatory cytokines, J. Virol., 79, 11259, 10.1128/JVI.79.17.11259-11268.2005 Johansson, 2007, Multivalent sialic acid conjugates inhibit adenovirus type 37 from binding to and infecting human corneal epithelial cells, Antiviral Res., 73, 92, 10.1016/j.antiviral.2006.08.004 Kalyuzhniy, 2008, Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo, Proc. Natl. Acad. Sci. U.S.A., 105, 5483, 10.1073/pnas.0711757105 Kanerva, 2002, Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells, Clin. Cancer Res., 8, 275 Kawashima, 2004, Telomerase-specific replication-selective virotherapy for human cancer, Clin. Cancer Res., 10, 285, 10.1158/1078-0432.CCR-1075-3 Keriel, 2006, Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors, J. Virol., 80, 1487, 10.1128/JVI.80.3.1487-1496.2006 Kim, 2002, The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells, Eur. J. Cancer, 38, 1917, 10.1016/S0959-8049(02)00131-4 Kirby, 2000, Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein, J. Virol., 74, 2804, 10.1128/JVI.74.6.2804-2813.2000 Kirby, 2001, Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypes, J. Virol., 75, 7210, 10.1128/JVI.75.15.7210-7214.2001 Knaan-Shanzer, 2001, Highly efficient targeted transduction of undifferentiated human hematopoietic cells by adenoviral vectors displaying fiber knobs of subgroup B, Hum. Gene Ther., 12, 1989, 10.1089/104303401753204562 Ko, 2005, Development of transcriptionally regulated oncolytic adenoviruses, Oncogene, 24, 7763, 10.1038/sj.onc.1209048 Koizumi, 2003, Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob, J. Gene Med., 5, 267, 10.1002/jgm.348 Kojaoghlanian, 2003, The impact of adenovirus infection on the immunocompromised host, Rev. Med. Virol., 13, 155, 10.1002/rmv.386 Kreppel, 2008, Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide, Mol. Ther., 16, 16, 10.1038/sj.mt.6300321 Kritz, 2007, Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop, Mol. Ther., 15, 741, 10.1038/sj.mt.6300094 Kuppuswamy, 2005, Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression, Gene Ther., 12, 1608, 10.1038/sj.gt.3302581 Law, 2002, Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor, J. Virol., 76, 656, 10.1128/JVI.76.2.656-661.2002 Law, 2005, What does it take to bind CAR?, Mol. Ther., 12, 599, 10.1016/j.ymthe.2005.05.017 Leissner, 2001, Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism, Gene Ther., 8, 49, 10.1038/sj.gt.3301343 Lemckert, 2006, Generation of a novel replication-incompetent adenoviral vector derived from human adenovirus type 49: manufacture on PER.C6 cells, tropism and immunogenicity, J. Gen. Virol., 87, 2891, 10.1099/vir.0.82079-0 Leopold, 2007, Intracellular trafficking of adenovirus: many means to many ends, Adv. Drug Deliv. Rev., 59, 810, 10.1016/j.addr.2007.06.007 Li, 2001, Integrin alpha(v)beta1 is an adenovirus coreceptor, J. Virol., 75, 5405, 10.1128/JVI.75.11.5405-5409.2001 Li, 2005, Gene therapy for prostate cancer by controlling adenovirus E1a and E4 gene expression with PSES enhancer, Cancer Res., 65, 1941, 10.1158/0008-5472.CAN-04-3666 Li, 1999, Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy, Cancer Res., 59, 325 Lindahl, 2000, Human complement regulators: a major target for pathogenic microorganisms, Curr. Opin. Immunol., 12, 44, 10.1016/S0952-7915(99)00049-7 Liszewski, 2005, Emerging roles and new functions of CD46, Springer Semin. Immunopathol., 27, 345, 10.1007/s00281-005-0002-3 Luo, 2007, Structural basis of integrin regulation and signaling, Annu. Rev. Immunol., 25, 619, 10.1146/annurev.immunol.25.022106.141618 Majhen, 2006, Adenoviral vectors—how to use them in cancer gene therapy?, Virus Res., 119, 121, 10.1016/j.virusres.2006.02.001 Majhen, 2009, Differential role of alpha(v)beta(3) and alpha(v)beta(5) integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruses, Virus Res., 139, 64, 10.1016/j.virusres.2008.10.004 Marttila, 2005, CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7, J. Virol., 79, 14429, 10.1128/JVI.79.22.14429-14436.2005 Mathias, 1998, Interactions of soluble recombinant integrin alphav beta5 with human adenoviruses, J. Virol., 72, 8669, 10.1128/JVI.72.11.8669-8675.1998 McDonald, 1999, Coxsackie and adenovirus receptor (CAR)-dependent and major histocompatibility complex (MHC) class I-independent uptake of recombinant adenoviruses into human tumour cells, Gene Ther., 6, 1512, 10.1038/sj.gt.3301006 Mittal, 1995, Development of a bovine adenovirus type 3-based expression vector, J. Gen. Virol., 76, 93, 10.1099/0022-1317-76-1-93 Moffatt, 2000, Circumvention of vector-specific neutralizing antibody response by alternating use of human and non-human adenoviruses: implications in gene therapy, Virology, 272, 159, 10.1006/viro.2000.0350 Morrison, 2008, Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor, Mol. Ther., 16, 244, 10.1038/sj.mt.6300363 Nakayama, 2006, An adenovirus serotype 5 vector with fibers derived from ovine atadenovirus demonstrates CAR-independent tropism and unique biodistribution in mice, Virology, 350, 103, 10.1016/j.virol.2006.01.037 Nalbantoglu, 2001, Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle, J. Virol., 75, 4276, 10.1128/JVI.75.9.4276-4282.2001 Nemerow, 1999, Role of alpha(v) integrins in adenovirus cell entry and gene delivery, Microbiol. Mol. Biol. Rev., 63, 725, 10.1128/MMBR.63.3.725-734.1999 Nettelbeck, 2008, Cellular genetic tools to control oncolytic adenoviruses for virotherapy of cancer, J. Mol. Med., 86, 363, 10.1007/s00109-007-0291-1 Nettelbeck, 2001, Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105), Mol. Ther., 3, 882, 10.1006/mthe.2001.0342 Ni, 2006, Evaluation of adenovirus vectors containing serotype 35 fibers for tumor targeting, Cancer Gene Ther., 13, 1072, 10.1038/sj.cgt.7700981 Nicklin, 2005, The influence of adenovirus fiber structure and function on vector development for gene therapy, Mol. Ther., 12, 384, 10.1016/j.ymthe.2005.05.008 Nicol, 2004, Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats, Mol. Ther., 10, 344, 10.1016/j.ymthe.2004.05.020 Nord, 1997, Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain, Nat. Biotechnol., 15, 772, 10.1038/nbt0897-772 Okada, 2001, Efficient antigen gene transduction using Arg-Gly-Asp fiber-mutant adenovirus vectors can potentiate antitumor vaccine efficacy and maturation of murine dendritic cells, Cancer Res., 61, 7913 Ooboshi, 1997, Augmented adenovirus-mediated gene transfer to atherosclerotic vessels, Arterioscler. Thromb. Vasc. Biol., 17, 1786, 10.1161/01.ATV.17.9.1786 Osborn, 1989, Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes, Cell, 59, 1203, 10.1016/0092-8674(89)90775-7 Pache, 2008, Conservation of fiber structure and CD46 usage by subgroup B2 adenoviruses, Virology, 375, 573, 10.1016/j.virol.2008.02.013 Parker, 2006, Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes, Blood, 108, 2554, 10.1182/blood-2006-04-008532 Parrott, 2003, Metabolically biotinylated adenovirus for cell targeting, ligand screening, and vector purification, Mol. Ther., 8, 688, 10.1016/S1525-0016(03)00213-2 Persson, 2007, Adenovirus type 11 binding alters the conformation of its receptor CD46, Nat. Struct. Mol. Biol., 14, 164, 10.1038/nsmb1190 Philipson, 2004, The coxsackie-adenovirus receptor—a new receptor in the immunoglobulin family involved in cell adhesion, Curr. Top. Microbiol. Immunol., 273, 87 Power, 2007, Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity, Mol. Ther., 15, 123, 10.1038/sj.mt.6300039 Raschperger, 2006, The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis, Exp. Cell Res., 312, 1566, 10.1016/j.yexcr.2006.01.025 Rea, 2001, Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells, J. Immunol., 166, 5236, 10.4049/jimmunol.166.8.5236 Reddy, 1999, Porcine adenovirus-3 as a helper-dependent expression vector, J. Gen. Virol., 80, 2909, 10.1099/0022-1317-80-11-2909 Reddy, 1999, Replication-defective bovine adenovirus type 3 as an expression vector, J. Virol., 73, 9137, 10.1128/JVI.73.11.9137-9144.1999 Rein, 2006, Current developments in adenovirus-based cancer gene therapy, Future Oncol., 2, 137, 10.2217/14796694.2.1.137 Rekhter, 1998, Gene transfer into normal and atherosclerotic human blood vessels, Circ. Res., 82, 1243, 10.1161/01.RES.82.12.1243 Rodriguez, 1997, Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells, Cancer Res., 57, 2559 Roelvink, 1998, The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F, J. Virol., 72, 7909, 10.1128/JVI.72.10.7909-7915.1998 Roelvink, 1999, Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae, Science, 286, 1568, 10.1126/science.286.5444.1568 Ruigrok, 1994, The fibre of bovine adenovirus type 3 is very long but bent, J. Gen. Virol., 75, 2069, 10.1099/0022-1317-75-8-2069 Russell, 2004, CD46: a complement regulator and pathogen receptor that mediates links between innate and acquired immune function, Tissue Antigens, 64, 111, 10.1111/j.1399-0039.2004.00277.x Russell, 2005, Adenoviruses, 439 Sailaja, 2002, Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector-specific immune response, Gene Ther., 9, 1722, 10.1038/sj.gt.3301858 Sakurai, 2006, Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice, Gene Ther., 13, 1118, 10.1038/sj.gt.3302749 Salone, 2003, Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5, J. Virol., 77, 13448, 10.1128/JVI.77.24.13448-13454.2003 Segerman, 2003, There are two different species B adenovirus receptors: sBAR, common to species B1 and B2 adenoviruses, and sB2AR, exclusively used by species B2 adenoviruses, J. Virol., 77, 1157, 10.1128/JVI.77.2.1157-1162.2003 Segerman, 2003, Adenovirus type 11 uses CD46 as a cellular receptor, J. Virol., 77, 9183, 10.1128/JVI.77.17.9183-9191.2003 Sharma, A., Bangari, D.S., Tandon, M., Pandey, A., HogenEsch, H., Mittal, S.K. Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model. Virology, in press 2009 Feb 9 [Epub ahead of print]. Shayakhmetov, 2005, Deletion of penton RGD motifs affects the efficiency of both the internalization and the endosome escape of viral particles containing adenovirus serotype 5 or 35 fiber knobs, J. Virol., 79, 1053, 10.1128/JVI.79.2.1053-1061.2005 Shayakhmetov, 2005, Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity, J. Virol., 79, 7478, 10.1128/JVI.79.12.7478-7491.2005 Shayakhmetov, 2000, Dependence of adenovirus infectivity on length of the fiber shaft domain, J. Virol., 74, 10274, 10.1128/JVI.74.22.10274-10286.2000 Short, 2004, Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors, Virology, 322, 349, 10.1016/j.virol.2004.02.016 Short, 2006, Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors, Virus Res., 122, 144, 10.1016/j.virusres.2006.07.009 Sirena, 2004, The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3, J. Virol., 78, 4454, 10.1128/JVI.78.9.4454-4462.2004 Smith, 2003, Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates, Hum. Gene Ther., 14, 1595, 10.1089/104303403322542248 Smith, 2003, Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice, Hum. Gene Ther., 14, 777, 10.1089/104303403765255165 Soudais, 2000, Canine adenovirus type 2 attachment and internalization: coxsackievirus-adenovirus receptor, alternative receptors, and an RGD-independent pathway, J. Virol., 74, 10639, 10.1128/JVI.74.22.10639-10649.2000 Staba, 2000, Modifications of the fiber in adenovirus vectors increase tropism for malignant glioma models, Cancer Gene Ther., 7, 13, 10.1038/sj.cgt.7700104 Stehle, 1997, High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding, EMBO J., 16, 5139, 10.1093/emboj/16.16.5139 Stevenson, 2007, Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins, Cancer Gene Ther., 14, 335, 10.1038/sj.cgt.7701022 Stevenson, 1995, Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domain, J. Virol., 69, 2850, 10.1128/JVI.69.5.2850-2857.1995 Stewart, 2007, Cell integrins: commonly used receptors for diverse viral pathogens, Trends Microbiol., 15, 500, 10.1016/j.tim.2007.10.001 Stoff-Khalili, 2005, A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy, Gene Ther., 12, 1696, 10.1038/sj.gt.3302588 Stone, 2006, New serotypes of adenoviral vectors, Curr. Opin. Mol. Ther., 8, 423 Tan, 2001, Defining CAR as a cellular receptor for the avian adenovirus CELO using a genetic analysis of the two viral fibre proteins, J. Gen. Virol., 82, 1465, 10.1099/0022-1317-82-6-1465 Tatsis, 2007, A CD46-binding chimpanzee adenovirus vector as a vaccine carrier, Mol. Ther., 15, 608, 10.1038/sj.mt.6300078 Tomko, 2000, Expression of the adenovirus receptor and its interaction with the fiber knob, Exp. Cell Res., 255, 47, 10.1006/excr.1999.4761 Tomko, 1997, HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses, Proc. Natl. Acad. Sci. U.S.A., 94, 3352, 10.1073/pnas.94.7.3352 Tuve, 2008, Role of cellular heparan sulfate proteoglycans in infection of human adenovirus serotype 3 and 35, PLoS Pathog., 4, e1000189, 10.1371/journal.ppat.1000189 Tuve, 2006, A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells, J. Virol., 80, 12109, 10.1128/JVI.01370-06 Ulasov, 2006, CD46 represents a target for adenoviral gene therapy of malignant glioma, Hum. Gene Ther., 17, 556, 10.1089/hum.2006.17.556 Vellinga, 2004, Spacers increase the accessibility of peptide ligands linked to the carboxyl terminus of adenovirus minor capsid protein IX, J. Virol., 78, 3470, 10.1128/JVI.78.7.3470-3479.2004 Vellinga, 2005, The adenovirus capsid: major progress in minor proteins, J. Gen. Virol., 86, 1581, 10.1099/vir.0.80877-0 Verhaagh, 2006, Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors, J. Gen. Virol., 87, 255, 10.1099/vir.0.81293-0 Vigne, 1999, RGD inclusion in the hexon monomer provides adenovirus type 5-based vectors with a fiber knob-independent pathway for infection, J. Virol., 73, 5156, 10.1128/JVI.73.6.5156-5161.1999 Waddington, 2008, Adenovirus serotype 5 hexon mediates liver gene transfer, Cell, 132, 397, 10.1016/j.cell.2008.01.016 Wadell, 1980, Genetic variability of adenoviruses, Ann. N Y Acad. Sci., 354, 16, 10.1111/j.1749-6632.1980.tb27955.x Walters, 1999, Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia, J. Biol. Chem., 274, 10219, 10.1074/jbc.274.15.10219 Wang, 1999, Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection, J. Virol., 73, 2559, 10.1128/JVI.73.3.2559-2562.1999 Weis, 1988, Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid, Nature, 333, 426, 10.1038/333426a0 Wickham, 1994, Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization, J. Cell Biol., 127, 257, 10.1083/jcb.127.1.257 Wickham, 1993, Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment, Cell, 73, 309, 10.1016/0092-8674(93)90231-E Wickham, 1996, Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types, Nat. Biotechnol., 14, 1570, 10.1038/nbt1196-1570 Wickham, 1997, Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins, J. Virol., 71, 8221, 10.1128/JVI.71.11.8221-8229.1997 Wold, 2007, Adenoviruses, 2395 Wu, 2004, Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis, J. Virol., 78, 3897, 10.1128/JVI.78.8.3897-3905.2004 Wu, 2005, Identification of sites in adenovirus hexon for foreign peptide incorporation, J. Virol., 79, 3382, 10.1128/JVI.79.6.3382-3390.2005 Wu, 2002, Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency, Hum. Gene Ther., 13, 1647, 10.1089/10430340260201734 Wu, 2001, Cancer gene therapy by adenovirus-mediated gene transfer, Curr. Gene Ther., 1, 101, 10.2174/1566523013349002 Zabner, 1997, Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection, J. Clin. Invest., 100, 1144, 10.1172/JCI119625 Zhang, 2005, Adenovirus receptors, J. Virol., 79, 12125, 10.1128/JVI.79.19.12125-12131.2005 Zheng, 2007, Fiber-knob modifications enhance adenoviral tropism and gene transfer in malignant glioma, J. Gene Med., 9, 151, 10.1002/jgm.1008