Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity relationships
Tóm tắt
A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50~100 times greater antitumor activities than the commercial product, Cisplatin.
Tài liệu tham khảo
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