Advanced methods in meta‐analysis: multivariate approach and meta‐regression

Statistics in Medicine - Tập 21 Số 4 - Trang 589-624 - 2002
Hans C. van Houwelingen1, Lidia R. Arends2, Theo Stijnen2
1Department of Medical Statistics, Leiden University Medical Center, P.O. Box 9604, 2300 RC Leiden, The Netherlands,#TAB#
2Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands

Tóm tắt

AbstractThis tutorial on advanced statistical methods for meta‐analysis can be seen as a sequel to the recent Tutorial in Biostatistics on meta‐analysis by Normand, which focused on elementary methods. Within the framework of the general linear mixed model using approximate likelihood, we discuss methods to analyse univariate as well as bivariate treatment effects in meta‐analyses as well as meta‐regression methods. Several extensions of the models are discussed, like exact likelihood, non‐normal mixtures and multiple endpoints. We end with a discussion about the use of Bayesian methods in meta‐analysis. All methods are illustrated by a meta‐analysis concerning the efficacy of BCG vaccine against tuberculosis. All analyses that use approximate likelihood can be carried out by standard software. We demonstrate how the models can be fitted using SAS Proc Mixed. Copyright © 2002 John Wiley & Sons, Ltd.

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Statistics in Medicine

Tập 21 Số 4

589-624

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