Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis

European Respiratory Journal - Tập 33 Số 1 - Trang 99-106 - 2009
T. Troosters1, Daniël Langer1, Bart Vrijsen, Johan Segers1, Kristien Wouters1, Wim Janssens1, Rik Gosselink1, M. Decramer1, Lieven Dupont1
1Faculty of Kinesiology and Rehabilitation Sciences, Dept of Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.

Tóm tắt

The aim of the present study was to investigate the prevalence of muscle weakness and the importance of physical inactivity in cystic fibrosis (CF), and its relationship to exercise tolerance and muscle strength.Exercise tolerance, skeletal and respiratory muscle strength were studied in a group of 64 adults with CF (age 26±8 yrs, FEV1 % predicted65±19) and in 20 age-matched controls. Physical activity (PA) was assessed in 20 patients and all controls.Quadriceps muscle weakness was present in 56% of the patients. Peak oxygen uptake and 6-min walking distance were below normal in 89 and 75% of patients, respectively. Respiratory muscle strength was normal. The differences remained after correcting for PA. Quadriceps force was correlated to the 6-min walking distance but not to peak oxygen uptake. “Mild” PA (>3 metabolic equivalents (METS)) and the number of steps overlapped with controls, but CF patients had less moderate PA (>4.8 METS). Moderate PA was related to peak oxygen uptake and quadriceps force.Skeletal muscle weakness and exercise intolerance are prevalent in cystic fibrosis. Physical inactivity is a factor significantly contributing to exercise tolerance and skeletal muscle force in adults with cystic fibrosis, but these impairments are in excess to that expected from physical inactivity only.

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European Respiratory Journal

Tập 33 Số 1

99-106

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