Survivin: A promising tumor biomarker

Cancer Letters - Tập 249 - Trang 49-60 - 2007
Michael J. Duffy1,2, Norma O’Donovan3, Donal J. Brennan4, William M. Gallagher4, Bríd M. Ryan1,2
1Department of Pathology and Laboratory Medicine, St. Vincent’s University Hospital, Dublin 4, Ireland
2UCD School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
3National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
4UCD School of Biomolecular and Biomedical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland

Tài liệu tham khảo

Altieri, 2003, Validating survivin as a cancer therapeutic target, Nat. Rev. Cancer, 3, 46, 10.1038/nrc968 Li, 2003, Survivin study: what is the next wave?, J. Cell Physiol., 197, 8, 10.1002/jcp.10327 Velculescu, 1999, Analysis of human transcriptomes, Nat. Genet., 23, 387, 10.1038/70487 Deveraux, 1999, IAP family proteins – suppressors of apoptosis, Genes Dev., 13, 239, 10.1101/gad.13.3.239 Cheung, 2006, X-linked inhibitor of apoptosis antagonism: strategies in cancer treatment, Clin. Cancer Res., 12, 3238, 10.1158/1078-0432.CCR-06-0817 Verdecia, 2000, Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement, Nat. Struct. Biol., 7, 602, 10.1038/77929 Mahotka, 1999, Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties, Cancer Res., 59, 6097 Badran, 2004, Identification of a novel splice variant of the human anti-apoptosis gene survivin, Biochem. Biophys. Res. Commun., 314, 902, 10.1016/j.bbrc.2003.12.178 Caldas, 2005, Survivin 2α: a novel survivin splice variant expressed in human malignancies, Mol. Cancer, 4, 11, 10.1186/1476-4598-4-11 Fortugno, 2002, Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function, J. Cell Sci., 115, 575, 10.1242/jcs.115.3.575 Dohi, 2004, Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis, J. Clin. Invest., 114, 1117, 10.1172/JCI200422222 Mahotka, 2002, Differential subcellular localization of divergent splice variants, Cell Death Diff., 9, 1334, 10.1038/sj.cdd.4401091 Caldas, 2005, Survivin splice variants regulate the balance between proliferation and cell death, Oncogene, 24, 1994, 10.1038/sj.onc.1208350 Rodriguez, 2002, CRM1-mediated nuclear export determines the cytoplasmic localization of the anti-apoptotic protein survivin, Exp. Cell Res., 275, 44, 10.1006/excr.2002.5492 Li, 1998, Control of apoptosis and apoptotic spindle checkpoint by survivin, Nature, 396, 580, 10.1038/25141 Li, 1999, Pleiotrophic cell-divisions defects and apoptosis induced by interference with survivin function, Nature Cell Biol., 1, 461, 10.1038/70242 Grossman, 2001, Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53, J. Clin. Invest., 108, 991, 10.1172/JCI13345 Mesri, 2001, Cancer gene therapy using a survivin mutant adenovirus, J. Clin. Invest., 108, 981, 10.1172/JCI200112983 Olie, 2000, A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy, Cancer Res., 60, 2085 Pennati, 2002, Ribozyme-mediated attenuation of survivin expression sensitizes human melanoma cells to cis-platin-induced apoptosis, J. Clin. Invest., 109, 285, 10.1172/JCI0214891 Conway, 2002, Deficiency of survivin in transgenic mice exacerbates fas-induced apoptosis via mitchondrial pathways, Gastroenterology, 123, 619, 10.1053/gast.2002.34753 Tamm, 1998, IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases and anticancer drugs, Cancer Res., 58, 5315 Shin, 2001, An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7, Biochemistry, 40, 1117, 10.1021/bi001603q Banks, 2000, Survivin does not inhibit caspase-3 activity, Blood, 96, 4002, 10.1182/blood.V96.12.4002 Chantalat, 2000, Crystal structure of human survivin reveals a bow tie-shaped dimer with 2 unusual alpha-helical extensions, Mol. Cell, 6, 183, 10.1016/S1097-2765(05)00020-1 Altieri, 2003, Survivin, versatile modulation of cell division and apoptosis in cancer, Oncogene, 22, 8581, 10.1038/sj.onc.1207113 Marusawa, 2003, HBXIP functions as a cofactor of surviving in apoptosis suppression, EMBO J., 22, 2729, 10.1093/emboj/cdg263 Dohi, 2004, An IAP-IAP complex inhibits apoptosis, J. Biol. Chem., 279, 34087, 10.1074/jbc.C400236200 Du, 2000, Smac a mitochondrial protein that promotes cytochrome C-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8 Song, 2003, Direct interaction between survivin and SMAC is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis, J. Biol. Chem., 278, 23130, 10.1074/jbc.M300957200 Zhu, 2004, An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy, Oncogene, 23, 7545, 10.1038/sj.onc.1208038 Yang, 2004, Cell survival in the absence of survivin, Proc. Natl. Acad. Sci. USA, 101, 15100, 10.1073/pnas.0406665101 Okada, 2004, Pathways of apoptotic and non-apoptotic death in tumour cells, Nat. Rev. Cancer, 4, 592, 10.1038/nrc1412 Uren, 2000, Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype, Curr. Biol., 10, 1319, 10.1016/S0960-9822(00)00769-7 Okada, 2004, Survivin loss in thymocytes triggers p53 mediated growth arrest and p53-independent cell death, J. Exp. Med., 199, 399, 10.1084/jem.20032092 Giodini, 2002, Regulation of microtubule stability and mitotic progression by survivin, Cancer Res., 62, 2462 Williams, 2003, Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference, Clin. Cancer Res., 9, 931 Ansell, 2004, Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin’s lymphoma, Leukemia, 18, 616, 10.1038/sj.leu.2403281 Uren, 1999, Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division, Proc. Natl. Acad. Sci. USA, 96, 10170, 10.1073/pnas.96.18.10170 Fraser, 1999, Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue (BIR-1) plays a conserved role in cytokinesis, Curr.Biol., 9, 292, 10.1016/S0960-9822(99)80137-7 Samuel, 2005, CIAP1 localizes to the nuclear compartment and modulates the cell cycle, Cancer Res., 65, 210, 10.1158/0008-5472.210.65.1 Vader, 2006, Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody, EMBO Rep., 7, 85, 10.1038/sj.embor.7400562 O’Connor, 2000, Control of apoptosis during angiogenesis by survivin expression in endothelial cells, Am. J. Pathol., 156, 393, 10.1016/S0002-9440(10)64742-6 Tran, 1999, Marked induction of IAP family antiapoptotic protein survivin and XIAP by VEGF in vascular endothelial cells, Biochem. Biophys. Res. Commun., 264, 781, 10.1006/bbrc.1999.1589 Tran, 2002, A role for survivin in chemoresistance of endothelial cells mediated by VEGF, Proc. Natl. Acad. Sci. USA, 99, 4349, 10.1073/pnas.072586399 Conway, 2003, Survivin-dependent angiogenesis in ischemic brain, molecular mechanisms of hypoxia-induced up-regulation, Am. J. Pathol., 163, 935, 10.1016/S0002-9440(10)63453-0 Kawasaki, 2001, Expression of survivin correlates with apoptosis, proliferation and angiogenesis during human colorectal carcinogenesis, Cancer, 91, 2026, 10.1002/1097-0142(20010601)91:11<2026::AID-CNCR1228>3.0.CO;2-E Tu, 2003, Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer, Cancer Res., 63, 7724 Blanc-Brude, 2003, Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis, Cancer Res., 9, 2683 Allen, 2003, Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression, Cancer Res., 63, 567 Satoh, 2001, Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors, Cancer, 92, 271, 10.1002/1097-0142(20010715)92:2<271::AID-CNCR1319>3.0.CO;2-0 Singh, 2004, Analysis of survivin expression in a spectrum of benign to malignant lesions of the breast, Appl. Immunohistochem. Mol. Morphol., 12, 296, 10.1097/00129039-200412000-00003 Krajewska, 2003, Elevated expression of inhibitor of apoptosis proteins in prostate cancer, Cancer Res., 9, 4914 Shariat, 2004, Survivin expression is associated with features of biologically aggressive carcinoma, Cancer, 100, 751, 10.1002/cncr.20039 Kim, 2002, Expression of survivin in CIN and invasive squamous cell carcinoma of uterine cervix, Anticancer Res., 22, 805 Frost, 2002, Immunohistochemical localization of survivin in benign cervical mucosa, cervical dysplasia and invasive squamous cell carcinoma, Am. J. Clin. Path., 117, 738, 10.1309/6V09-38K3-JQ40-UR50 Moon, 2003, Nuclear translocation of survivin in hepatocellular carcinoma: a key to cancer cell growth?, Human Pathol., 34, 1119, 10.1053/j.humpath.2003.07.016 Ding, 2006, Nuclear expression of the antiapoptotic protein survivin in malignant melanoma, Cancer, 106, 1123, 10.1002/cncr.21727 Duffy, 2001, Clinical uses of Tumor markers: a critical review, Crit. Rev. Clin. Lab. Sci., 38, 225, 10.1080/20014091084218 Schultz, 2006, Bladder cancer diagnosis and recurrence prognosis: comparison of markers with emphasis on survivin, Clin. Chim. Acta, 368, 20, 10.1016/j.cca.2005.12.036 Smith, 2001, Urine detection of survivin and diagnosis of bladder cancer, JAMA, 285, 324, 10.1001/jama.285.3.324 Shariat, 2004, Urine detection of surviving is a sensitive marker for the non-invasive diagnosis of bladder cancer, J. Urol., 171, 626, 10.1097/01.ju.0000107826.78479.90 Weikert, 2005, Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis, Int. J. Cancer, 116, 100, 10.1002/ijc.21000 Gianani, 2001, Expression of survivin in normal, hyperplastic and neoplastic colonic tissue, Human Pathol., 42, 119, 10.1053/hupa.2001.21897 Fukuda, 2002, The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34(+) cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells, Blood, 100, 2463, 10.1182/blood.V100.7.2463 Pennartz, 2004, Purification of neuronal precursors from the adult mouse brain: comprehensive gene expression analysis provides new insights into the control of cell migration, differentiation, and homeostasis, Mol. Cell Neurosci., 25, 692, 10.1016/j.mcn.2003.12.011 Ambrosini, 1997, A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma, Nat. Med., 3, 917, 10.1038/nm0897-917 Singletary, 2002, Revision of the American Joint Committee on cancer staging system for breast cancer, J. Clin. Oncol., 20, 3628, 10.1200/JCO.2002.02.026 Pantel, 1999, Detection and clinical importance of micrometastatic disease, J. Natl. Cancer Inst., 91, 1113, 10.1093/jnci/91.13.1113 Gradilone, 2002, Survivin, bcl-2, bax and bcl-X gene expression in sentinel lymph nodes from melanoma patients, J. Clin. Oncol., 21, 306, 10.1200/JCO.2003.08.066 Duffy, 2001, CEA as a marker for colorectal cancer: is it clinically useful, Clin. Chem., 47, 624, 10.1093/clinchem/47.4.624 Adida, 1998, Anti-apoptotic gene, survivin, and prognosis of neuroblastoma, Lancet, 351, 882, 10.1016/S0140-6736(05)70294-4 Monzo, 1999, A novel anti-apoptosis gene: re-expression of survivin mRNA as a prognostic marker in non-small-cell lung cancers, J. Clin. Oncol., 17, 2100, 10.1200/JCO.1999.17.7.2100 Adida, 2000, Prognostic significance of survivin expression in diffuse large B-cell lymphomas, Blood, 96, 1921 Sarela, 2000, Expression of the antiapoptotic gene survivin, predicts death from recurrent colorectal carcinoma, Gut, 46, 645, 10.1136/gut.46.5.645 Rodel, 2002, High survivin expression is associated with reduced apoptosis in rectal cancer may predict disease-free survival after preoperative radiochemotherapy and surgical resection, Strahlenther Onkol., 178, 426, 10.1007/s00066-002-1003-y Rodel, 2005, Survivin as a radioresistance factor and prognostic and therapeutic target for radiotherapy in rectal cancer, Cancer Res., 65, 4881, 10.1158/0008-5472.CAN-04-3028 Kappler, 2001, Increased survivin transcript levels: an independent predictor of survival in soft tissue sarcoma patients, Int. J. Cancer, 95, 360 Sui, 2002, Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors, Int. J. Oncol., 21, 315 Takai, 2002, Expression of survivin is associated with malignant potential in epithelial ovarian carcinoma, Int. J. Mol. Med., 10, 211 Takai, 2002, Survivin expression correlates with clinical stage, histological grade, invasive behavior, and survival rate in endometrial carcinoma, Cancer Lett., 184, 105, 10.1016/S0304-3835(02)00190-8 Kato, 2001, Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy, Int. J. Cancer, 95, 92, 10.1002/1097-0215(20010320)95:2<92::AID-IJC1016>3.0.CO;2-9 Grabowski, 2002, Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma, Br. J. Cancer, 88, 115, 10.1038/sj.bjc.6600696 Chakravarti, 2002, Quantitatively determined survivin expression levels are of prognostic value in human gliomas, J. Clin. Oncol., 20, 1063, 10.1200/JCO.2002.20.4.1063 Span, 2004, Survivin is an independent prognostic marker for risk stratification of breast cancer patients, Clin. Chem., 50, 1983, 10.1373/clinchem.2004.039149 Ryan, 2006, Survivin expression in breast cancer predicts clinical outcome and is associated with HER-2, VEGF, urokinase plasminogen activator and PAI-1, Ann. Oncol., 52, 345 Swana, 1999, Tumor content of the anti-apoptosis molecule survivin and recurrence of bladder cancer, N. Engl. J. Med., 341, 452, 10.1056/NEJM199908053410614 Li, 2005, Nuclear or cytoplasmic expression of survivin: what is significant?, Int. J. Cancer, 114, 509, 10.1002/ijc.20768 Mahotka, 2002, Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas, Int. J. Cancer, 100, 30, 10.1002/ijc.10450 Krieg, 2002, Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumor progression, Br. J. Cancer, 86, 737, 10.1038/sj.bjc.6600153 Ling, 2005, Differential expression of survivin-2B and survivin-Δex3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC), Lung Cancer, 49, 353, 10.1016/j.lungcan.2005.03.037 Taubert, 2005, Elevated expression of survivin splice variants predicts a poor outcome for soft-tissue sarcoma patients, Oncogene, 24, 5258, 10.1038/sj.onc.1208702 Span, 2006, Do the survivin splice variants modulate or add to the prognostic value of total survivin in breast cancer, Clin. Chem., 52, 1070, 10.1373/clinchem.2006.071613 Johnstone, 2002, Apoptosis: a link between cancer genetics and chemotherapy, Cell, 108, 153, 10.1016/S0092-8674(02)00625-6 Grossman, 2001, Inhibition of melanoma tumor growth in vivo by survivin targeting, Proc. Natl. Acad. Sci. USA, 98, 635, 10.1073/pnas.98.2.635 Zaffaroni, 2002, Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer, Cell Mol. Life Sci., 59, 1406, 10.1007/s00018-002-8518-3 Ling, 2004, Induction of survivin expression by taxol (paclitaxel) is an early event which is independent of taxol-mediated G2/M arrest, J. Biol. Chem., 279, 15196, 10.1074/jbc.M310947200 Pennati, 2004, Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells, Oncogene, 23, 386, 10.1038/sj.onc.1207071 Zhang, 2005, Adenovirus-mediated inhibition of survivin expression sensitizes prostate cancer cells to paclitaxel in vitro and in vivo, Prostate, 64, 293, 10.1002/pros.20263 Wang, 2005, Disruption of the inhibitor of apoptosis protein survivin sensitizes bcr-abl-positive cells to STI571-induced apoptosis, Cancer Res., 65, 8224, 10.1158/0008-5472.CAN-05-0303 Span, 2006, High survivin predicts a poor response to endocrine therapy but a good response to chemotherapy in advanced breast cancer, Breast Cancer Res. Treat., 98, 223, 10.1007/s10549-005-9153-0 Rodel, 2003, Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor, Int. J. Rad. Oncol. Biol. Phys., 55, 1341, 10.1016/S0360-3016(02)04618-7 Asanuma, 2000, Survivin as a radioresistance factor in pancreatic cancer, Jpn. J. Cancer Res., 91, 120, 10.1111/j.1349-7006.2000.tb00906.x Pennati, 2003, Radiosensitzation of human melanoma cells by ribozyme-mediated inhibition of survivin expression, J. Invest. Dermatol., 120, 648, 10.1046/j.1523-1747.2003.12082.x Chakravarti, 2004, Survivin enhances radiation resistance in primary glioblastoma cells via caspase-independent mechanisms, Oncogene, 23, 7494, 10.1038/sj.onc.1208049 Kanwar, 2001, Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy, J. Natl. Cancer Inst., 93, 1541, 10.1093/jnci/93.20.1541