A Power Prior Approach for Leveraging External Longitudinal and Competing Risks Survival Data Within the Joint Modeling Framework

Statistics in Biosciences - Tập 14 - Trang 318-336 - 2021
Md. Tuhin Sheikh1, Ming-Hui Chen1, Jonathan A. Gelfond2, Joseph G. Ibrahim3
1Department of Statistics, University of Connecticut at Storrs, Storrs, USA
2Department of Epidemiology and Biostatistics, University of Texas Health at San Antonio, San Antonio, USA
3Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, USA

Tóm tắt

In this paper, we propose a new partial borrowing-by-parts power prior for carrying out the analysis of co-longitudinal and survival data within the joint modeling framework. The borrowing-by-parts power prior facilitates borrowing the information from a subset of the data, from a subset of the model parameters, or from the different parts of the joint model. The deviance information criterion is used to quantify the gain in the fit of the current longitudinal and survival data when leveraging external co-data. A Markov chain Monte Carlo sampling algorithm is developed for carrying out Bayesian computations. The proposed methodology is motivated by two large concurrent clinical trials: Selenium and Vitamin E Cancer Prevention Trial (SELECT) and Prostate, Lung, Colon, Ovarian (PLCO) prevention trial. In both trials, the longitudinal biomarkers and competing risks survival data were collected. A detailed analysis of the PLCO and SELECT data is conducted to demonstrate the usefulness of the proposed methodology.

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