Biomedical applications of functional peptides in nano-systems

Gray, 2014, Combinatorial peptide libraries: mining for cell-binding peptides, Chem. Rev., 114, 1020, 10.1021/cr400166n Yang, 2017, Virus-derived peptides for clinical applications, Chem. Rev., 117, 10377, 10.1021/acs.chemrev.7b00100 Pinese, 2017, Bioactive peptides grafted silicone dressings: a simple and specific method, Mater. Today Chem., 4, 73, 10.1016/j.mtchem.2017.02.007 Kaur, 2018, Photochemical tuning of materials: a click chemistry perspective, Mater. Today Chem., 8, 56, 10.1016/j.mtchem.2018.03.002 Ibrahim, 2017, Recent advances on electrospun scaffolds as matrices for tissue-engineered heart valves, Mater. Today Chem., 5, 11, 10.1016/j.mtchem.2017.05.001 Torchilin, 2014, Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery, Nat. Rev. Drug Discov., 13, 813, 10.1038/nrd4333 Dissanayake, 2017, Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides, J. Control. Release, 250, 62, 10.1016/j.jconrel.2017.02.006 Svensen, 2012, Peptides for cell-selective drug delivery, Trends Pharmacol. Sci., 33, 186, 10.1016/j.tips.2012.02.002 Yan, 2018, Self-assembled peptide–lanthanide nanoclusters for safe tumor therapy: overcoming and utilizing biological barriers to peptide drug delivery, ACS Nano, 12, 2017, 10.1021/acsnano.8b00081 Li, 2017, Targeted Co-delivery of PTX and TR3 siRNA by PTP peptide modified dendrimer for the treatment of pancreatic cancer, Small, 13 Lei, 2017, Stimuli-responsive “Cluster Bomb” for programmed tumor therapy, ACS Nano, 11, 7201, 10.1021/acsnano.7b03088 Milletti, 2012, Cell-penetrating peptides: classes, origin, and current landscape, Drug Discov. Today, 17, 850, 10.1016/j.drudis.2012.03.002 Torchilin, 2012, Cell-penetrating peptides: breaking through to the other side, Trends Mol. Med., 18, 385, 10.1016/j.molmed.2012.04.012 Qin, 2015, An innovative pre-targeting strategy for tumor cell specific imaging and therapy, Nanoscale, 7, 14786, 10.1039/C5NR03862F Vlieghe, 2010, Synthetic therapeutic peptides: science and market, Drug Discov. Today, 15, 40, 10.1016/j.drudis.2009.10.009 Peer, 2007, Nanocarriers as an emerging platform for cancer therapy, Nat. Nanotechnol., 2, 751, 10.1038/nnano.2007.387 Qian, 2018, Application of nanomaterials in cancer immunotherapy, Mater. Today Chem., 7, 53, 10.1016/j.mtchem.2018.01.001 Khandare, 2012, Multifunctional dendritic polymers in nanomedicine: opportunities and challenges, Chem. Soc. Rev., 41, 2824, 10.1039/C1CS15242D Petros, 2010, Strategies in the design of nanoparticles for therapeutic applications, Nat. Rev. Drug Discov., 9, 615, 10.1038/nrd2591 Ruoslahti, 2002, Specialization of tumour vasculature, Nat. Rev. Cancer, 2, 83, 10.1038/nrc724 Levine, 2013, Peptide functionalized nanoparticles for nonviral gene delivery, Soft Matter, 9, 985, 10.1039/C2SM26633D Ruoslahti, 2010, Targeting of drugs and nanoparticles to tumors, J. Cell Biol., 188, 759, 10.1083/jcb.200910104 Bernhagen, 2017, High-affinity RGD-knottin peptide as a new tool for rapid evaluation of the binding strength of unlabeled RGD-peptides to αvβ3, αvβ5, and α5β1 integrin receptors, Anal. Chem., 89, 5991, 10.1021/acs.analchem.7b00554 Ruoslahti, 1996, RGD and other recognition sequences for integrins, Annu. Rev. Cell Dev. Biol., 12, 697, 10.1146/annurev.cellbio.12.1.697 Humphries, 2006, Integrin ligands at a glance, J. Cell Sci., 19, 3901, 10.1242/jcs.03098 Wang, 2015, Peptide REDV-modified polysaccharide hydrogel with endothelial cell selectivity for the promotion of angiogenesis, J. Biomed. Mater. Res. Part A, 103, 1703, 10.1002/jbm.a.35306 Stephan, 2015, Biopolymer implants enhance the efficacy of adoptive T-cell therapy, Nat. Biotechnol., 33, 97, 10.1038/nbt.3104 Springer, 2008, Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3, J. Cell Biol., 182, 791, 10.1083/jcb.200801146 Cheng, 2017, Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells, Chem. Sci., 8, 4571, 10.1039/C7SC00402H Sarfati, 2011, Targeting of polymeric nanoparticles to lung metastases by surface-attachment of YIGSR peptide from laminin, Biomaterials, 32, 152, 10.1016/j.biomaterials.2010.09.014 Obeid, 2009, Anticancer activity of targeted proapoptotic peptides and chemotherapy is highly improved by targeted cell surface calreticulin-inducer peptides, Mol. Cancer Therapeut., 8, 1693, 10.1158/1535-7163.MCT-09-0228 Ashley, 2011, The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers, Nat. Mater., 10, 389, 10.1038/nmat2992 Soudy, 2013, Novel peptide-doxorubucin conjugates for targeting breast cancer cells including the multidrug resistant cells, J. Med. Chem., 56, 7564, 10.1021/jm400647r Chi, 2017, Lung cancer-targeting peptides with multi-subtype indication for combinational drug delivery and molecular imaging, Theranostics, 7, 1612, 10.7150/thno.17573 Tosi, 2007, Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with loperamide and rhodamine-123, J. Control. Release, 122, 1, 10.1016/j.jconrel.2007.05.022 Zeng, 2004, A synthetic peptide containing loop 4 of nerve growth factor for targeted gene delivery, J. Gene Med., 6, 1247, 10.1002/jgm.610 Fleming, 2014, Design of nanostructures based on aromatic peptide amphiphiles, Chem. Soc. Rev., 43, 8150, 10.1039/C4CS00247D Boekhoven, 2014, 25th anniversary article: supramolecular materials for regenerative medicine, Adv. Mater, 26, 1642, 10.1002/adma.201304606 Webber, 2012, Controlled release of dexamethasone from peptide nanofiber gels to modulate inflammatory response, Biomaterials, 33, 6823, 10.1016/j.biomaterials.2012.06.003 Aida, 2012, Functional supramolecular polymers, Science, 335, 813, 10.1126/science.1205962 Webber, 2016, Supramolecular biomaterials, Nat. Mater., 15, 13, 10.1038/nmat4474 Zhou, 2017, Supramolecular biofunctional materials, Biomaterials, 129, 1, 10.1016/j.biomaterials.2017.03.014 Singh, 2017, Peptide-based molecular hydrogels as supramolecular protein mimics, Chemistry, 23, 981, 10.1002/chem.201602624 Arap, 1998, Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model, Science, 179, 377, 10.1126/science.279.5349.377 Weis, 2011, Tumor angiogenesis: molecular pathways and therapeutic targets, Nat. Med., 17, 1359, 10.1038/nm.2537 Chen, 2011, Integrin targeted delivery of chemotherapeutics, Theranostics, 1, 189, 10.7150/thno/v01p0189 Aluri, 2009, Environmentally responsive peptides as anticancer drug carriers, Adv. Drug Deliv. Rev., 61, 940, 10.1016/j.addr.2009.07.002 Eskandari, 2017, Recent advances in self-assembled peptides: implications for targeted drug delivery and vaccine engineering, Adv. Drug Deliv. Rev., 110–111, 169, 10.1016/j.addr.2016.06.013 Peng, 2016, Self-delivery of a peptide-based prodrug for tumor-targeting therapy, Nano Res., 9, 663, 10.1007/s12274-015-0945-1 Qin, 2015, Adjustable nanofibers self-assembled from an irregular conformational peptide amphiphile, Polym. Chem., 6, 519, 10.1039/C4PY01237B Zhang, 2013, Self-assembled tat nanofibers as effective drug carrier and transporter, ACS Nano, 7, 5965, 10.1021/nn401667z Ren, 2014, Self-assembling small molecules for the detection of important analytes, Chem. Soc. Rev., 43, 7257, 10.1039/C4CS00161C Chen, 2011, Construction of surfactant-like tetra-tail amphiphilic peptide with RGD ligand for encapsulation of porphyrin for photodynamic therapy, Biomaterials, 32, 1678, 10.1016/j.biomaterials.2010.10.047 Cai, 2017, Supramolecular “Trojan horse” for nuclear delivery of dual anticancer drugs, J. Am. Chem. Soc., 139, 2876, 10.1021/jacs.6b12322 Zhang, 2017, Targeted chemo-photodynamic combination platform based on the dox prodrug nanoparticles for enhanced cancer therapy, ACS Appl. Mater. Interfaces, 9, 13016, 10.1021/acsami.7b00927 Liu, 2013, Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery, Int. J. Nanomed., 9, 197, 10.2147/IJN.S55875 Dhandhukia, 2017, Bifunctional elastin-like polypeptide nanoparticles bind rapamycin and integrins and suppress tumor growth in vivo, Bioconjug. Chem., 28, 2715, 10.1021/acs.bioconjchem.7b00469 Xu, 2016, Smart and hyper-fast responsive polyprodrug nanoplatform for targeted cancer therapy, Biomaterials, 76, 238, 10.1016/j.biomaterials.2015.10.056 Xu, 2017, ROS-responsive polyprodrug nanoparticles for triggered drug delivery and effective cancer therapy, Adv. Mater., 29, 1700141, 10.1002/adma.201700141 Mondal, 2013, The relationship between the cyclic-RGDfK ligand and αvβ3 integrin receptor, Biomaterials, 34, 6249, 10.1016/j.biomaterials.2013.04.065 Massaguer, 2015, Integrin-targeted delivery into cancer cells of a Pt(IV) pro-drug through conjugation to RGD-containing peptides, Dalton Trans., 44, 202, 10.1039/C4DT02710H Chen, 2017, Cyclo(RGD)-decorated reduction-responsive nanogels mediate targeted chemotherapy of integrin overexpressing human glioblastoma in vivo, Small, 13 Li, 2017, Targeted soft biodegradable glycine/PEG/RGD-modified poly(methacrylic acid) nanobubbles as intelligent theranostic vehicles for drug delivery, ACS Appl. Mater. Interfaces, 9, 35604, 10.1021/acsami.7b11392 Hu, 2017, Transformable nanomaterials as an artificial extracellular matrix for inhibiting tumor invasion and metastasis, ACS Nano, 11, 4086, 10.1021/acsnano.7b00781 Graziadio, 2016, NGR tumor-homing peptides: structural requirements for effective APN (CD13) targeting, Bioconjug. Chem., 27, 1332, 10.1021/acs.bioconjchem.6b00136 Gu, 2017, NGR-modified pH-sensitive liposomes for controlled release and tumor target delivery of docetaxel, Colloids Surf. B Biointerfaces, 160, 395, 10.1016/j.colsurfb.2017.09.052 Huang, 2016, Multi-targeting NGR-modified liposomes recognizing glioma tumor cells and vasculogenic mimicry for improving anti-glioma therapy, Oncotarget, 7, 43616, 10.18632/oncotarget.9889 Corti, 2017, Glycine N-methylation in NGR-tagged nanocarriers prevents isoaspartate formation and integrin binding without impairing cd13 recognition and tumor homing, Adv. Funct. Mater., 27, 10.1002/adfm.201701245 Guthi, 2010, Mri-visible micellar nanomedicine for targeted drug delivery to lung cancer cells, Mol. Pharm., 7, 32, 10.1021/mp9001393 Byrne, 2008, Active targeting schemes for nanoparticle systems in cancer therapeutics, Adv. Drug Deliv. Rev., 60, 1615, 10.1016/j.addr.2008.08.005 Böhme, 2015, Drug delivery and release systems for targeted tumor therapy, J. Pept. Sci., 21, 186, 10.1002/psc.2753 Slowing, 2007, Mesoporous silica nanoparticles for drug delivery and biosensing applications, Adv. Funct. Mater., 17, 1225, 10.1002/adfm.200601191 Lin, 2009, Nanomedicine: veni, vidi, vici and then... vanished, Nat. Mater., 8, 252, 10.1038/nmat2413 Slowing, 2008, Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers, Adv. Drug Deliv. Rev., 60, 1278, 10.1016/j.addr.2008.03.012 Li, 2012, Mesoporous silica nanoparticles in biomedical applications, Chem. Soc. Rev., 41, 2590, 10.1039/c1cs15246g Cheng, 2010, Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics-the trio of imaging, targeting and therapy, J. Mater. Chem., 20, 6149, 10.1039/c0jm00645a Fang, 2012, Ligand conformation dictates membrane and endosomal trafficking of Arginine-Glycine-Aspartate (RGD)-functionalized mesoporous silica nanoparticles, Chem. Eur J., 18, 7787, 10.1002/chem.201200023 Li, 2015, A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles, J. Mater. Chem. B, 3, 39, 10.1039/C4TB01533A Ashley, 2012, Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers, ACS Nano, 6, 2174, 10.1021/nn204102q Tian, 2016, Plasmonic nanoparticles with quantitatively controlled bioconjugation for photoacoustic imaging of live cancer cells, Adv. Sci. (Weinh), 3 Xu, 2017, Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles, Biomater. Sci., 5, 2393, 10.1039/C7BM00826K Yi, 2016, Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles, J. Control. Release, 244, 247, 10.1016/j.jconrel.2016.08.041 Kim, 2011, Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125, Small, 7, 2052, 10.1002/smll.201100927 Chen, 2013, Multifunctional gold nanostar conjugates for tumor imaging and combined photothermal and chemo-therapy, Theranostics, 3, 633, 10.7150/thno.6630 Li, 2010, RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy, Mol. Pharm., 7, 94, 10.1021/mp9001415 Huang, 2010, A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands, ACS Nano, 4, 5887, 10.1021/nn102055s Ali, 2017, Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins, Proc. Natl. Acad. Sci. U.S.A., 114, E5655, 10.1073/pnas.1703151114 Alkilany, 2014, Homing peptide-conjugated gold nanorods: the effect of amino acid sequence display on nanorod uptake and cellular proliferation, Bioconjug. Chem., 25, 1162, 10.1021/bc500174b Auzel, 2004, Upconversion and anti-stokes processes with f and d ions in solids, Chem. Rev., 104, 139, 10.1021/cr020357g Gai, 2014, Recent progress in rare earth micro/nanocrystals: soft chemical synthesis, luminescent properties, and biomedical applications, Chem. Rev., 114, 2343, 10.1021/cr4001594 Chen, 2014, Upconversion nanoparticles: design, nanochemistry, and applications in theranostics, Chem. Rev., 114, 5161, 10.1021/cr400425h Wang, 2009, Immunolabeling and NIR-excited fluorescent imaging of Hela cells by using NaYF4:Yb,Er upconversion nanoparticles, ACS Nano, 3, 1580, 10.1021/nn900491j Xiong, 2009, High contrast upconversion luminescence targeted imaging in vivo using peptide-labeled nanophosphors, Anal. Chem., 81, 8687, 10.1021/ac901960d Yu, 2010, Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation, Biomaterials, 31, 8724, 10.1016/j.biomaterials.2010.07.099 Wang, 2012, A nanoscale graphene oxide-peptide biosensor for real-time specific biomarker detection on the cell surface, Chem. Commun., 48, 9768, 10.1039/c2cc31974h Ko, 2009, In vitro derby imaging of cancer biomarkers using quantum dots, Small, 5, 1207 Zheng, 2017, Photocatalyzing CO2 to CO for enhanced cancer therapy, Adv. Mater., 29, 10.1002/adma.201703822 Miyata, 2012, Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses, Chem. Soc. Rev., 41, 2562, 10.1039/C1CS15258K Vivès, 2008, Cell-penetrating and cell-targeting peptides in drug delivery, Biochim. Biophys. Acta., Rev. Cancer, 1786, 126, 10.1016/j.bbcan.2008.03.001 Cheng, 2015, A holistic approach to targeting disease with polymeric nanoparticles, Nat. Rev. Drug Discov., 14, 239, 10.1038/nrd4503 Frankel, 1988, Cellular uptake of the TAT protein from human immunodeficiency virus, Cell, 55, 1189, 10.1016/0092-8674(88)90263-2 Green, 1988, Autonomous functional domains of chemically synthesized human immunodeficiency virus TAT trans-activator protein, Cell, 55, 1179, 10.1016/0092-8674(88)90262-0 Oehlke, 1998, Cellular uptake of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically, Biochim. Biophys. Acta., Biomembr., 1414, 127, 10.1016/S0005-2736(98)00161-8 Lindgren, 2000, Cell-penetrating peptides, Trends Pharmacol. Sci., 21, 99, 10.1016/S0165-6147(00)01447-4 Futaki, 2001, An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery, J. Biol. Chem., 276, 5836, 10.1074/jbc.M007540200 Fonseca, 2009, Recent advances in the use of cell-penetrating peptides for medical and biological applications, Adv. Drug Deliv. Rev., 61, 953, 10.1016/j.addr.2009.06.001 Bechara, 2013, Cell-penetrating peptides: 20 years later, where do we stand?, FEBS Lett., 587, 1693, 10.1016/j.febslet.2013.04.031 Copolovici, 2014, Cell-penetrating peptides: design, synthesis, and applications, ACS Nano, 8, 1972, 10.1021/nn4057269 Terrone, 2003, Penetratin and related cell-penetrating cationic peptides can translocate across lipid bilayers in the presence of a transbilayer potential, Biochemistry, 42, 13787, 10.1021/bi035293y Pujals, 2007, All-D proline-rich cell-penetrating peptides: a preliminary in vivo internalization study, Biochem. Soc. Trans., 35, 794, 10.1042/BST0350794 Jobin, 2015, The role of tryptophans on the cellular uptake and membrane interaction of arginine-rich cell penetrating peptides, Biochim. Biophys. Acta, Biomembr., 1848, 593, 10.1016/j.bbamem.2014.11.013 Heitz, 2009, Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics, Br. J. Pharmacol., 157, 195, 10.1111/j.1476-5381.2009.00057.x Loudet, 2008, Non-covalent delivery of proteins into mammalian cells, Org. Biomol. Chem., 6, 4516, 10.1039/b809006h Morris, 2008, Cell-penetrating peptides: from molecular mechanisms to therapeutics, Biol. Cell, 100, 201, 10.1042/BC20070116 Kichler, 2003, Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells, Proc. Natl. Acad. Sci. U.S.A., 100, 1564, 10.1073/pnas.0337677100 Smrt, 2015, The influenza hemagglutinin fusion domain is an amphipathic helical hairpin that functions by inducing membrane curvature, J. Biol. Chem., 290, 228, 10.1074/jbc.M114.611657 Wang, 2011, Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei, J. Contr. Release, 155, 26, 10.1016/j.jconrel.2010.12.009 Escriou, 2003, NLS bioconjugates for targeting therapeutic genes to the nucleus, Adv. Drug Deliv. Rev., 55, 295, 10.1016/S0169-409X(02)00184-9 Poon, 2005, Regulation of nuclear transport: central role in development and transformation?, Traffic (Oxford, U. K.), 6, 173 Chen, 2014, Multi-functional envelope-type nanoparticles assembled from amphiphilic peptidic prodrug with improved anti-tumor activity, ACS Appl. Mater. Interfaces, 6, 593, 10.1021/am404680n Lei, 2014, Fabrication of novel reduction-sensitive gene vectors based on three-armed peptides, Macromol. Biosci., 14, 546, 10.1002/mabi.201300422 Yang, 2013, PEGylated peptide based reductive polycations as efficient nonviral gene vectors, Adv. Healthcare Mater., 2, 481, 10.1002/adhm.201200154 Yang, 2012, Reduction-sensitive polypeptides incorporated with nuclear localization signal sequences for enhanced gene delivery, J. Mater. Chem., 22, 13591, 10.1039/c2jm32223d Chen, 2013, Bioreducible polypeptide containing cell-penetrating sequence for efficient gene delivery, Pharm. Res., 30, 1968, 10.1007/s11095-013-1040-5 Alexis, 2006, Covalent attachment of low molecular weight poly(ethylene imine) improves tat peptide mediated gene delivery, Adv. Mater., 18, 2174, 10.1002/adma.200502173 Jiang, 2011, Gene delivery to tumor cells by cationic polymeric nanovectors coupled to folic acid and the cell-penetrating peptide octaarginine, Biomaterials, 32, 7253, 10.1016/j.biomaterials.2011.06.015 Chen, 2013, Self-assembled bola-like amphiphilic peptides as viral-mimetic gene vectors for cancer cell targeted gene delivery, Macromol. Biosci., 13, 84, 10.1002/mabi.201200283 Qu, 2013, Avidin-biotin interaction mediated peptide assemblies as efficient gene delivery vectors for cancer therapy, Mol. Pharm., 10, 261, 10.1021/mp300392z Biswas, 2013, Surface functionalization of doxorubicin-loaded liposomes with octa-arginine for enhanced anticancer activity, Eur. J. Pharm. Biopharm., 84, 517, 10.1016/j.ejpb.2012.12.021 Liu, 2008, Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrier, Biomaterials, 29, 1509, 10.1016/j.biomaterials.2007.11.014 Qin, 2011, Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals, Int. J. Pharm. (Amst., Neth.), 420, 304, 10.1016/j.ijpharm.2011.09.008 Baguley, 2010, Multiple drug resistance mechanisms in cancer, Mol. Biotechnol., 46, 308, 10.1007/s12033-010-9321-2 Han, 2013, Synergistic gene and drug tumor therapy using a chimeric peptide, Biomaterials, 34, 4680, 10.1016/j.biomaterials.2013.03.010 Han, 2015, A tumor targeted chimeric peptide for synergistic endosomal escape and therapy by dual-stage light manipulation, Adv. Funct. Mater., 25, 1248, 10.1002/adfm.201403190 Santra, 2004, TAT conjugated, FITC doped silica nanoparticles for bioimaging, Chem. Commun., 0, 2810, 10.1039/b411916a Pan, 2012, Nuclear-targeted drug delivery of tat peptide-conjugated monodisperse mesoporous silica nanoparticles, J. Am. Chem. Soc., 134, 5722, 10.1021/ja211035w Pan, 2013, Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles, Biomaterials, 34, 2719, 10.1016/j.biomaterials.2012.12.040 Pan, 2014, MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression, Adv. Mater, 26, 6742, 10.1002/adma.201402752 Luo, 2013, Charge-reversal plug gate nanovalves on peptide-functionalized mesoporous silica nanoparticles for targeted drug delivery, J. Mater. Chem. B, 1, 5723, 10.1039/c3tb20792g Li, 2014, Stepwise-acid-active multifunctional mesoporous silica nanoparticles for tumor-specific nucleus-targeted drug delivery, ACS Appl. Mater. Interfaces, 6, 14568, 10.1021/am503846p Dykman, 2014, Uptake of engineered gold nanoparticles into mammalian cells, Chem. Rev., 114, 1258, 10.1021/cr300441a Nativo, 2008, Uptake and intracellular fate of surface-modified gold nanoparticles, ACS Nano, 2, 1639, 10.1021/nn800330a Fales, 2013, Cell-penetrating peptide enhanced intracellular Raman imaging and photodynamic therapy, Mol. Pharm., 10, 2291, 10.1021/mp300634b Liu, 2006, Paramagnetic particles carried by cell-penetrating peptide tracking of bone marrow mesenchymal stem cells, a research in vitro, Biochem. Biophys. Res. Commun., 347, 133, 10.1016/j.bbrc.2006.06.081 Li, 2011, TAT-conjugated nanodiamond for the enhanced delivery of doxorubicin, J. Mater. Chem., 21, 7966, 10.1039/c1jm10653h Chen, 2016, Programmed nanococktail for intracellular cascade reaction regulating self-synergistic tumor targeting therapy, Small, 12, 733, 10.1002/smll.201503280 Liu, 2012, Simultaneous nuclear imaging and intranuclear drug delivery by nuclear-targeted multifunctional upconversion nanoprobes, Biomaterials, 33, 7282, 10.1016/j.biomaterials.2012.06.035 Liu, 2012, TAT-modified nanosilver for combating multidrug-resistant cancer, Biomaterials, 33, 6155, 10.1016/j.biomaterials.2012.05.035 Wang, 2010, PEGlated magnetic polymeric liposome anchored with TAT for delivery of drugs across the blood-spinal cord barrier, Biomaterials, 31, 6589, 10.1016/j.biomaterials.2010.04.057 Rong, 2015, Long-term thiol monitoring in living cells using bioorthogonal chemistry, Chem. Commun., 51, 388, 10.1039/C4CC08396B Mura, 2013, Stimuli-responsive nanocarriers for drug delivery, Nat. Mater., 12, 991, 10.1038/nmat3776 Li, 2004, GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery, Adv. Drug Deliv. Rev., 56, 967, 10.1016/j.addr.2003.10.041 Mart, 2006, Peptide-based stimuli-responsive biomaterials, Soft Matter, 2, 822, 10.1039/b607706d Zhang, 2014, Peptide dendrimers-doxorubicin conjugate-based nanoparticles as an enzyme-responsive drug delivery system for cancer therapy, Adv. Healthcare Mater, 3, 1299, 10.1002/adhm.201300601 Zhu, 2012, Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting, ACS Nano, 6, 3491, 10.1021/nn300524f Hatakeyama, 2011, Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid, Biomaterials, 32, 4306, 10.1016/j.biomaterials.2011.02.045 Chen, 2015, MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery, Chem. Commun., 51, 465, 10.1039/C4CC07563C Xiao, 2015, Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs, Chem. Commun., 51, 1475, 10.1039/C4CC08831J Ai, 2008, Fluorescent protein FRET pairs for ratiometric imaging of dual biosensors, Nat. Methods, 5, 401, 10.1038/nmeth.1207 Song, 2018, Enhanced immunotherapy based on photodynamic therapy for both primary and lung metastasis tumor eradication, ACS Nano, 12, 1978, 10.1021/acsnano.7b09112 He, 2014, MSN anti-cancer nanomedicines: chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition, Adv. Mater, 26, 2174, 10.1002/adma.201303123 Zhang, 2013, Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery, J. Am. Chem. Soc., 135, 5068, 10.1021/ja312004m Mok, 2009, PEGylated and MMP-2 specifically depegylated quantum dots: comparative evaluation of cellular uptake, Langmuir, 25, 1645, 10.1021/la803542v Mizukami, 2008, Paramagnetic relaxation-based 19F MRI probe to detect protease activity, J. Am. Chem. Soc., 130, 794, 10.1021/ja077058z Mizukami, 2009, Dual-function probe to detect protease activity for fluorescence measurement and 19F MRI, Angew. Chem Int. Ed., 48, 3641, 10.1002/anie.200806328 Wang, 2011, Graphene oxide-peptide conjugate as an intracellular protease sensor for caspase-3 activation imaging in live cells, Angew. Chem. Int. Ed., 50, 7065, 10.1002/anie.201101351 Min, 2014, Near-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticles, Angew. Chem. Int. Ed., 53, 1012, 10.1002/anie.201308834 Chen, 2013, Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo, Biomaterials, 34, 8798, 10.1016/j.biomaterials.2013.07.084 Qin, 2014, Theranostic GO-based nanohybrid for tumor induced imaging and potential combinational tumor therapy, Small, 10, 599, 10.1002/smll.201301613 Gao, 2005, Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice, J. Drug Target., 13, 391, 10.1080/10611860500376741 Liu, 2014, pH-Sensitive nano-systems for drug delivery in cancer therapy, Biotechnol. Adv., 32, 693, 10.1016/j.biotechadv.2013.11.009 Baio, 2015, Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces, Chem. Commun., 51, 273, 10.1039/C4CC07278B Christensen, 2013, Predicting transition temperatures of elastin-like polypeptide fusion proteins, Biomacromolecules, 14, 1514, 10.1021/bm400167h Moktan, 2012, Thermal targeting of an acid-sensitive doxorubicin conjugate of elastin-like polypeptide enhances the therapeutic efficacy compared with the parent compound in vivo, Mol. Cancer Therapeut., 11, 1547, 10.1158/1535-7163.MCT-11-0998