Pectinase-treated Panax ginseng extract (GINST) rescues testicular dysfunction in aged rats via redox-modulating proteins

Experimental Gerontology - Tập 53 - Trang 57-66 - 2014
Yu-Jin Won1, Bo-kyung Kim2, Yong-Kyu Shin1, Seung-Hyo Jung2, Sung-Kwang Yoo1, Seock-Yeon Hwang3, Jong-Hwan Sung4, Si-Kwan Kim1
1Department of Life Science, College of Biomedical & Health Science, Konkuk University, Chungju 380-701, Republic of Korea
2Department of Physiology, College of Medicine, Konkuk University, Chungju 380-701, Republic of Korea
3Department of Biomedical Laboratory Science, College of Applied Science and Industry, Daejeon University, Daejeon 300-716, Republic of Korea
4Il Hwa Co., Ltd., Ginseng Research Institute, Guri 471-711, Republic of Korea

Tài liệu tham khảo

Aitken, 1989, Generation of reactive oxygen species, lipid peroxidation, and human sperm function, Biol. Reprod., 41, 183, 10.1095/biolreprod41.1.183 Anjum, 2011, Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse, Food Chem. Toxicol., 49, 2849, 10.1016/j.fct.2011.07.062 Bae, 2000, Constitutive β-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria, Biol. Pharm. Bull., 23, 1481, 10.1248/bpb.23.1481 Beutler, 1963, Improved method for the determination of blood glutathione, J. Lab. Clin. Med., 61, 882 Bindhu, 2004, Combined effect of alcohol and cigarette smoke on lipid peroxidation and antioxidant status in rats, Indian J. Biochem. Biophys., 41, 40 Bray, 1993, Tissue glutathione, nutrition, and oxidative stress, Can. J. Physiol. Pharmacol., 71, 746, 10.1139/y93-111 Chen, 2008, Microbial transformation of ginsenoside Rb1 by Acremonium strictum, Appl. Microbiol. Biotechnol., 77, 1345, 10.1007/s00253-007-1258-4 Choi, 1995, Clinical efficacy of Korean red ginseng for erectile dysfunction, Int. J. Impot. Res., 7, 181 Com, 2003, New insights into the rat spermatogonial proteome: identification of 156 additional proteins, Mol. Cell. Proteomics, 2, 248, 10.1074/mcp.M300010-MCP200 Du, 2011, Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities, Anti-Cancer Drugs, 22, 35, 10.1097/CAD.0b013e32833fde29 Fulcher, 1995, Identification of a unique mu-class glutathione S-transferase in mouse spermatogenic cells, Mol. Reprod. Dev., 42, 415, 10.1002/mrd.1080420407 Fuzzati, 2004, Analysis methods of ginsenosides, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 812, 119, 10.1016/j.jchromb.2004.07.039 Habig, 1974, Glutathione s-transferases. The first enzymatic step in mercapturic acid formation, J. Biol. Chem., 249, 7130, 10.1016/S0021-9258(19)42083-8 Hankinson, 2005, Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor, Arch. Biochem. Biophys., 433, 379, 10.1016/j.abb.2004.09.031 Hasegawa, 1998, Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite, Planta Med., 64, 696, 10.1055/s-2006-957560 Hasegawa, 1997, Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins, Planta Med., 63, 436, 10.1055/s-2006-957729 Hu, 2008, Optimization of ginsenosides hydrolyzing beta-glucosidase production from Aspergillus niger using response surface methodology, Biol. Pharm. Bull., 31, 1870, 10.1248/bpb.31.1870 Huang, 2005, A reference map and identification of porcine testis proteins using 2-DE and MS, Proteomics, 5, 4205, 10.1002/pmic.200401284 Huo, 2008, Identification of human spermatogenesis-related proteins by comparative proteomic analysis: a preliminary study, Fertil. Steril., 90, 1109, 10.1016/j.fertnstert.2007.07.1342 Hwang, 2004, Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzop-dioxin, BJU Int., 94, 663, 10.1111/j.1464-410X.2004.05019.x Hwang, 2010, Panax ginseng improves senile testicular function in rats, J. Ginseng Res., 34, 327, 10.5142/jgr.2010.34.4.327 Iuchi, 2009, Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress, Biochem. J., 419, 149, 10.1042/BJ20081526 Kumaran, 2009, Senescence mediated redox imbalance in cardiac tissue: antioxidant rejuvenating potential of green tea extract, Nutrition, 25, 847, 10.1016/j.nut.2009.02.005 Lee, 2005, Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury, Liver Int., 25, 1069, 10.1111/j.1478-3231.2005.01068.x Lee, 2007, Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle, Biochim. Biophys. Acta, 1774, 848, 10.1016/j.bbapap.2007.04.018 Lee, 2009, Proteomic analysis of the anti-cancer effect of 20S-ginsenoside Rg3 in human colon cancer cell lines, Biosci. Biotechnol. Biochem., 73, 811, 10.1271/bbb.80637 Lee, 2012, Protective effect of processed Panax Ginseng, sun ginseng on UVB-irradiated human skin keratinocyte and human dermal fibroblast, J. Ginseng Res., 36, 68, 10.5142/jgr.2012.36.1.68 Lei, 1995, Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium, J. Nutr., 125, 1438 Li, 2011, Oxidatively damaged proteins in the early stage of testicular toxicities in male rats by orally administered with a synthetic oestrogen, diethylstilbestrol, Reprod. Toxicol., 31, 26, 10.1016/j.reprotox.2010.09.007 Ling, 1996, 2-Methoxyacetic acid (MAA)-induced spermatocyte apoptosis in human and rat testis: an in vitro comparison, J. Androl., 17, 538 Luo, 2006, Aging and the brown Norway rat Leydig cell antioxidant defense system, J. Androl., 27, 240, 10.2164/jandrol.05075 Ma, 2006, Proteomic analysis effects of ginsenoside Rg1 on human umbilical vein endothelial cells stimulated by tumor necrosis factor-α, Life Sci., 79, 175, 10.1016/j.lfs.2005.12.050 Mates, 2000, Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology, Toxicology, 153, 83, 10.1016/S0300-483X(00)00306-1 Oh, 2012, Efficacy of Korean red ginseng in the treatment of alopecia areata, J. Ginseng Res., 36, 391, 10.5142/jgr.2012.36.4.391 Ohkawa, 1979, Assay for lipid peroxidase in animal tissues by thiobarbituric acid reaction, Anal. Biochem., 95, 351, 10.1016/0003-2697(79)90738-3 Park, 1996, Recent studies on the chemical constituents of Korean ginseng (Panax ginseng C.A. Meyer), J. Ginseng Res., 20, 389 Rajeswary, 2007, Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats, Reprod. Toxicol., 24, 371, 10.1016/j.reprotox.2007.03.010 Rao, 2000, Role of glutathione s-transferases in oxidative stress-induced male germ cell apoptosis, Free Radic. Biol. Med., 29, 1015, 10.1016/S0891-5849(00)00408-1 Rolland, 2007, Two dimensional fluorescence difference gel electrophoresis analysis of spermatogenesis in the rat, J. Proteome Res., 6, 683, 10.1021/pr060436z Rotruck, 1973, Selenium: biochemical role as a component of glutathione peroxidase, Science, 179, 588, 10.1126/science.179.4073.588 Roveri, 1992, Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification, J. Biol. Chem., 267, 6142, 10.1016/S0021-9258(18)42673-7 Wang, 2010, Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats, Eur. J. Pharmacol., 636, 121, 10.1016/j.ejphar.2010.03.035 Wolin, 2000, Interactions of oxidants with vascular signaling systems, Arterioscler. Thromb. Vasc. Biol., 20, 1430, 10.1161/01.ATV.20.6.1430 Xiong, 2010, Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats, Diabetes, 59, 2505, 10.2337/db10-0315 Yao, 2008, Proteomic analysis of differential protein expression in rat platelets treated with notoginsenosides, Phytomedicine, 15, 800, 10.1016/j.phymed.2008.06.013 Yayeh, 2012, Korean red ginseng saponin fraction downregulates proinflammatory mediators in LPS stimulated RAW264.7 cells and protects mice against endotoxic shock, J. Ginseng Res., 36, 263, 10.5142/jgr.2012.36.3.263 Zhang, 1997, Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2, J. Biol. Chem., 272, 30615, 10.1074/jbc.272.49.30615 Zheng, 2011, Ginseng total saponins enhance neurogenesis after focal cerebral ischemia, J. Ethnopharmacol., 133, 724, 10.1016/j.jep.2010.01.064