Preliminary investigation comparing a detomidine continuous rate infusion combined with either morphine or buprenorphine for standing sedation in horses

Boscan, 2006, Evaluation of the effects of the opioid agonist morphine on gastrointestinal tract function in horses, Am J Vet Res, 67, 992, 10.2460/ajvr.67.6.992 Carregaro, 2007, Effects of buprenorphine on nociception and spontaneous locomotor activity in horses, Am J Vet Res, 68, 246, 10.2460/ajvr.68.3.246 Davis, 2011, Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse, J Vet Pharmacol Ther, 35, 52, 10.1111/j.1365-2885.2011.01284.x England, 1992, A comparison of the sedative effects of three α 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse, J Vet Pharmacol Ther, 15, 194, 10.1111/j.1365-2885.1992.tb01007.x Knych, 2014, Preliminary pharmacokinetics of morphine and its major metabolites following intravenous administration of four doses to horses, J Vet Pharmacol Ther, 37, 374, 10.1111/jvp.12098 Love, 2013, Postcastration analgesia in ponies using buprenorphine hydrochloride, Vet Rec, 172, 635, 10.1136/vr.101440 Love, 2015, Pharmacokinetic–pharmacodynamic modelling of intravenous buprenorphine in conscious horses, Vet Anaesth Analg, 42, 17, 10.1111/vaa.12165 Pakkanen, 2015, Detomidine and the combination of detomidine and MK-467 a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetised with isoflurane, Vet Anaesth Analg, 42, 527, 10.1111/vaa.12238 Solano, 2009, Behavioural and cardiorespiratory effects of a constant rate infusion of medetomidine and morphine for sedation during standing laparoscopy in horses, Equine Vet J, 41, 153, 10.2746/042516408X342984 Van Dijk, 2003, Hormonal, metabolic and physiological effects of laparoscopic surgery using a detomidine–buprenorphine combination in standing horses, Vet Anaesth Analg, 30, 71, 10.1046/j.1467-2995.2003.00097.x