Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

Cell Metabolism - Tập 30 - Trang 1055-1074.e8 - 2019
Valentina Pucino1,2, Michelangelo Certo1,2, Vinay Bulusu3,4, Danilo Cucchi2, Katriona Goldmann2, Elena Pontarini2, Robert Haas2, Joanne Smith2, Sarah E. Headland2, Kevin Blighe2, Massimiliano Ruscica5, Frances Humby2, Myles J. Lewis2, Jurre J. Kamphorst3,4, Michele Bombardieri2, Costantino Pitzalis2, Claudio Mauro1,2,6,7
1Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
2William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
3Cancer Research UK Beatson Institute, Glasgow, UK
4Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
5Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy
6Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
7Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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